• Title/Summary/Keyword: 2-stage cycle

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Numerical Analysis of Multi-dimensional Consolidation Based on Non-Linear Model (비선형 모델에 의한 다차원 압밀의 수치해석)

  • Jeong, Jin-Seop;Gang, Byeong-Seon;Nam, Gung-Mun
    • Geotechnical Engineering
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    • v.1 no.1
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    • pp.59-72
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    • 1985
  • This paper deals with the numerical analysis by the (mite element method introducing Biot's theory of consolidation and the modified Cambridge model proposed by Roscoe school of Cambridge University as constitutive equation and using Christian-Boehner's technique. Especially, time interval and division of elements are investigated in vies of stability and economics. In order to check the validity of author's program, the program was tested with one-dimensional consolidation case followed by Terzaghi's exact solution and with the results of the Magnan's analysis for existing banking carried out for study at Cubzac-les-ports in France. The main conclusions obtained are summarized as follows: 1. In the case of one-dimensional consolidation, the more divided the elements are near the surface of the foundation, the higher the accuracy of the numerical analysis is. 2. For the time interval, it is stable to divide 20 times per 1-lg cycle. 3. At the element which has long drain distance, the Mandel-fryer effect appears due to time lag. 4. Lateral displacement at an initial loading stage predicted by author's program, in which the load was assumed as not concentrative. but rather in grid form, is well consistent with the value of observation. 5. The pore water pressure predicted by author's program has a better accordance with the value of observation compared with Magnan's results. 6. Optimum construction control by Matsuo-Kawamura's method is possible with the predicted lateral displacement and settlement by the program.

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Out-of-Hospital Resuscitation of Cardiac Arrest by 119 Emergency Medical Service System (119구급대에 의해 소생한 병원 전 심장정지 환자 1례)

  • Yun, Hyeong-Wan;Lee, Jae-Min;Jung, Ji-Yeon
    • Fire Science and Engineering
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    • v.24 no.5
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    • pp.142-149
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    • 2010
  • The aim of this study was to report the out-of-hospital resuscitation of cardiac arrest along with literature consideration. CPR is technology of resuscitating patient by maintaining oxygen supply to organ, by preventing progression from clinical death to biological death, and by recovering heart beat and circulation, through circulatory support of mechanical ventilation. It is not what every patient with cardiac standstill is revived even if being implemented CPR. Patient's survival rate is decided by how quickly and correctly CPR was executed. A patient, who wasn't witnessed the cardiac arrest on the field, was performed 5-cycle CPR for 2 minutes on the field before being transferred to hospital, and was allowed to be used AED. A person, who was observed, is recommended to be used AED immediately, and then is said to be needed ACLS (advanced cardiac life support). In the Out-of-Hospital stage, it is rare in a case that 119 Emergency Medical Service System transfers by being ROSC and in a case of executing ACLS. Cardiac arrest was witnessed on the field, but CPR wasn't executed. First-aid staff executed CPR after arriving, and led to ROSC on the field with ACLS, there by having experienced 1 case of a patient's surviving to leave hospital by being ROSC on the field.

Floating Point Converter Design Supporting Double/Single Precision of IEEE754 (IEEE754 단정도 배정도를 지원하는 부동 소수점 변환기 설계)

  • Park, Sang-Su;Kim, Hyun-Pil;Lee, Yong-Surk
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.48 no.10
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    • pp.72-81
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    • 2011
  • In this paper, we proposed and designed a novel floating point converter which supports single and double precisions of IEEE754 standard. The proposed convertor supports conversions between floating point number single/double precision and signed fixed point number(32bits/64bits) as well as conversions between signed integer(32bits/64bits) and floating point number single/double precision and conversions between floating point number single and double precisions. We defined a new internal format to convert various input types into one type so that overflow checking could be conducted easily according to range of output types. The internal format is similar to the extended format of floating point double precision defined in IEEE754 2008 standard. This standard specifies that minimum exponent bit-width of the extended format of floating point double precision is 15bits, but 11bits are enough to implement the proposed converting unit. Also, we optimized rounding stage of the convertor unit so that we could make it possible to operate rounding and represent correct negative numbers using an incrementer instead an adder. We designed single cycle data path and 5 cycles data path. After describing the HDL model for two data paths of the convertor, we synthesized them with TSMC 180nm technology library using Synopsys design compiler. Cell area of synthesis result occupies 12,886 gates(2 input NAND gate), and maximum operating frequency is 411MHz.

Knockdown of Archvillin by siRNA Inhibits Myofibril Assembly in Cultured Skeletal Myoblast

  • Lee, Yeong-Mi;Kim, Hyun-Suk;Choi, Jun-Hyuk;Choi, Jae-Kyoung;Joo, Young-Mi;Ahn, Seung-Ju;Min, Byung-In;Kim, Chong-Rak
    • Biomedical Science Letters
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    • v.13 no.4
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    • pp.251-261
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    • 2007
  • A myofiber of skeletal muscle is composed of myofibrils, sarcolemma (plasma membrane), and constameres, which anchor the myofibrils to the sarcolemma. Achvillin is a recently identified F-actin binding muscle protein, co-isolates with dystrophin and caveolin-3 in low-density sarcolemma of striated muscle, and colocalizes with dystrophin at costameres, the specialized adhesion sites in muscle. Archvillin also binds to nebulin and localizes at myofibrillar Z-discs, the lateral boundaries of the sarcomere in muscle. However other roles of archvillin on the dynamics of myofibrillogenesis remain to be defined. The goal of this study is, by using siRNA-mediated gene silencing technique, to investigate the effect of archvillin on the dynamics of myofibrillogenesis in cell culture of a mouse skeletal myogenic cell line (C2C12), where presumptive myoblasts withdraw from the cell cycle, fuse, undergo de novo myofibrillogenesis, and differentiate into mature myotubes. The roles of archvillin in the assembly and maintenance of myofibril and during the progression of myofibrillogenesis induced in skeletal myoblast following gene silencing in the cell culture were investigated. Fluorescence microscopy demonstrated that the distribution of archvillin was changed along the course of myofibril assembly with nebulin, vinculin and F-actin and then located at Z-lines with nebulin. Fluorescence microscopy demonstrated that knockdown of mouse archvillin expression led to an impaired assembly of new myofibrillar clusters and delayed fusion and myofibrillogenesis although the mouse archvillin siRNA did not affect those expressions of archvillin binding proteins, such as nebulin and F-actin. This result is corresponded with that of RT-PCR and western blots. When the perturbed archvillin was rescued by co-transfection with GFP or Red tagged human archvillin construct, the inhibited cell fusion and myotube formation was recovered. By using siRNA technique, archvillin was found to be involved in early stage of myofibrillogenesis. Therefore, the current data suggest the idea that archvillin plays critical roles on cell fusion and dynamic myofibril assembly.

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Incorporation of Winter Rapeseed (Brassica napus) as Green Manure on Mineralization and Uptake of Nitrogen to Succeeding Corn (Zea mays L.) (유채의 녹비 환원에 의한 질소무기화 및 옥수수의 질소 흡수)

  • Choi, Bong-Su;Hong, Ki-Chan;Sung, Jwa-Kyung;Nam, Jae-Jak;Lim, Jung-Eun;Lee, Hyeon-Yong;Yang, Jae-E.;Ok, Yong-Sik
    • Korean Journal of Organic Agriculture
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    • v.17 no.3
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    • pp.381-391
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    • 2009
  • Crop production can be secured by the cycle of green manure crops as an alternative of the chemical fertilizer. Recently, rapeseed (Brassica napus L.) has been cultivated in the south part of Korea for the production of biodiesel. In this research, we focused on recycling rapeseed residue, which is produced after harvesting the rapeseed for biodiesel, as a potential source of nitrogen to the succeeding crop. Pot experiment was conducted to evaluate the effects of winter rapeseed as green manure on mineralization and uptake of nitrogen to the succeeding corn (Zea mays L.). Result showed that total nitrogen and C/N ratio of rapeseed at the harvesting stage was 0.54% and 63, respectively. The incorporation of rapeseed without decomposition period slightly inhibited nitrogen uptake to the succeeding corn compared to those with 30 days decomposition period. The pH and EC values of soils increased by increasing the period of decomposition of rapeseed from 5.2 to 6.4 and from 0.05 dS/m to 0.21 dS/m, respectively. Significant amounts of $NH_4^+$ and $NO_3^-$ are released by incorporation of rapeseed. The succeeding corn took up 86% and 88% of inorganic nitrogen released from the rapeseed with and without decomposition period, respectively. The overall results suggested that the utilization of rapeseed residue as green manure can be an alternative source of nitrogen in corn-rapeseed double cropping system.

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LIFE CYCLE AND CHEMOTHERAPEUTIC CONTROL OF A FILARIAN WORM, PHILOMETROIDES CARASSII PARASITIC IN CARASSIUS AURATUS (붕어에 기생하는 철사충 Philometroides carassii의 생활사와 치료에 관하여)

  • OUK Dae-Han;CHUN Seh-Kyu
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.6 no.3_4
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    • pp.112-122
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    • 1973
  • Philometroides carassii (ISHII, 1931) is a parasitic nematode of Carassius auratus and gold fish. Recently a large number of parasitized fishes by this nematode have been reported by fish farmers in Korea. The present investigation was aimed to find out the life cycles of the parasites and effects of chemotherapeutic medicines on the emerged larvae from the adult parasites. Results of the study are summarized as follows : 1. Intermediate host of p. cararsii is a freshwater copepod, Cyclops sp. and the invaded lavae in the body cavity of copepod are capable for parasitizing the fish host after 3 hours of invasion. 2. The lavae eaten directly by the fish host are digested or excreted. 3. The larvae invaded in the fish intestine through the intermediate host pass into the body cavity in 1 to 10 days, and become subadult stage. After 18 to 20 months the subadults parasitic in the body cavity of the Carassius auratus, penetrate through muscle fissile into tile caudal fin where they become adults. Whereas those parasitic in the body cavity of the gold fish, 7 to 8 months the sutadults penetrate through muscle tissue into the caudal fin where they become adults. 1. Male subadults found in the body cavity of the Carassius auratus and gold fish, were larger than females, This is the first record of male subadults occurring in the fish host. 5. Among four different :drugs tested, most of all larvae died in 4 ppm of dipterex in 5 days. But no adults were harmed even in 6 ppm dipterex in 11 days.

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Review and Comparative Analysis of Forest Biomass Estimation Using Remotely Sensed Data: from Five Different Perspectives (원격탐사자료를 이용한 국외 산림 바이오매스 추정 현황 및 비교분석: 다섯 가지 관점에서의 고찰)

  • Cho, Kyung-Hun;Heo, Joon;Jung, Jae-Hoon;Kim, Chang-Jae;Kim, Kyung-Min
    • Journal of Korean Society for Geospatial Information Science
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    • v.19 no.1
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    • pp.87-96
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    • 2011
  • Carbon emissions and storages that are strongly related to global warming has have emerged as one of the important issues while many governments and researchers have been interested in climate change and pollution. In this regards, forest biomass estimation is quite importance since forest biomass works as an important medium of the global carbon cycle between the atmosphere and soil. Forest biomass estimation through field survey needs lots of time and labors, and has accessibility issues. Hence, many researchers have focused on the forest biomass approaches based on remotely sensed data. This research comprehensively reviewed forty one international studies using remote sensing data according to five different categories (i.e., location of study area, size of study area, biome, used remote sensing data, and estimation technology). It would be expected that the results of this study can be used for suggesting domestic research directions; domestic research in this field is at the beginning stage in terms of level of technologies and useful materials. As results, 39% out of the reviewed studies used the areas located in North America. 59% out of the researches dealt with small size of the study areas (less than 3,600km2). In case of biome, around 30% of the studies focused on the boreal/taiga areas. Moreover, 35% and 16% of the studies were carried out using Landsat series and Lidar data, respectively. Finally, regression analysis method was most frequently used for forest biomass estimation by 71% out of 41 studies.

Experimental Study on the Diagnosis and Failure Prediction for Long-term Performance of ESP to Optimize Operation in Oil and Gas Wells (유·가스정 최적 운영을 위한 ESP의 장기 성능 진단 및 고장 예측 실험 연구)

  • Sung-Jea Lee;Jun-Ho Choi;Jeong-Hwan Lee
    • Journal of the Korean Institute of Gas
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    • v.27 no.2
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    • pp.71-78
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    • 2023
  • In general, electric submersible pumps (ESPs), which have an average life of 1.0 to 1.5 years, experience a decrease in performance and a reduction in life of the pump depending on oil and gas reservoir characteristics and operating conditions in wells. As the result, the failure of ESP causes high well workover costs due to retrieval and installation, and additional costs due to shut down. In this study, a flow loop system was designed and established to predict the life of ESP in long­term operation of oil and gas wells, and the life cycle data of ESP from the time of installation to the time of failure was acquired and analyzed. Among the data acquired from the system, flow rate, inlet and outlet temperature and pressure, and the data of the vibrator installed on the outside of ESP were analyzed, and then the performance status according to long-term operation was classified into five stages: normal, advice I, advice II, maintenance, and failed. Through the experiments, it was found that there was a difference in the data trend by stage during the long­term operation of the ESP, and then the condition of the ESP was diagnosed and the failure of the pump was predicted according to the operating time. The results derived from this study can be used to develop a failure prediction program and data analysis algorithm for monitoring the condition of ESPs operated in oil and gas wells.

A Study on Application Methodology of SPDL Based on IEC 62443 Applicable to SME Environment (중소기업환경에서 적용 가능한 IEC 62443 기반의 개발 보안 생애주기 프로세스 적용 방안 연구)

  • Jin, Jung Ha;Park, SangSeon;Kim, Jun Tae;Han, Keunhee
    • KIPS Transactions on Computer and Communication Systems
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    • v.11 no.6
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    • pp.193-204
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    • 2022
  • In a smart factory environment in a small and medium-sized enterprise (SME) environment, sensors and actuators operating on actual manufacturing lines, programmable logic controllers (PLCs) to manage them, human-machine interface (HMI) to control and manage such PLCs, and consists of operational technology server to manage PLCs and HMI again. PLC and HMI, which are in charge of control automation, perform direct connection with OT servers, application systems for factory operation, robots for on-site automation, and production facilities, so the development of security technology in a smart factory environment is demanded. However, smart factories in the SME environment are often composed of systems that used to operate in closed environments in the past, so there exist a vulnerable part to security in the current environment where they operate in conjunction with the outside through the Internet. In order to achieve the internalization of smart factory security in this SME environment, it is necessary to establish a process according to the IEC 62443-4-1 Secure Product Development Life cycle at the stage of smart factory SW and HW development. In addition, it is necessary to introduce a suitable development methodology that considers IEC 62443-4-2 Component security requirements and IEC 62443-3 System security requirements. Therefore, this paper proposes an application plan for the IEC 62443 based development security process to provide security internalization to smart factories in an SME environment.

A Prospective Randomized Trial Comparing the Seciuence of Adiuvant Chemotherapy and Radiotherapy following Curative Resection of Stage II, III Rectal Cancer (직장암의 근치적 수술 루 방사선치료와 화학요법의 순서에 대한 고찰 -전향적 무작위 3상 임상연구 중간 결과 보고-)

  • Kim Kyoung Ju;Kim Jong Hoon;Choi Eun Kyung;Chang Hyesook;Ahn Seung Do;Lee Je Hwan;Kim Jin Cheon;Yu Chang Sik
    • Radiation Oncology Journal
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    • v.18 no.1
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    • pp.17-25
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    • 2000
  • Purpose : To evaluate the side effects, pattern of failure, and survival rate according to the sequence of postoperative adjuvant radiotherapy and chemotherapy, patients with stages II and III rectal cancer who had undergone curative resection were randomized to 'early radiotherapy group (arm I)' or' late radiotherapy group (arm II)', then we intend to determine the most effective sequence of the radiotherapy and chemotherapy. Materials and Methods . From January 1996 to March 1999, 313 patients with curatively resected stages II and III rectal cancer have been randomized to' early' or' late' radiation therapy group and received combined chemotherapy (5-FU 375 mg/m$^{2}$/day, ieucovorin 20 mg/m$^{2}$, IV bolus daily Dl-5, 8 cycles) and radiation therapy (whole pelvis with 45 Gy/25 fractions/s weeks). Arm I received radiation therapy from day 1 with first cycle of chemotherapy and arm II received radiation therapy from day 57 with third cycle of chemotherapy after completion of first two cycles. Preliminary analysis was peformed with 228 patients registered up to Jun 1998. Two out of the 228 patients were excluded because of double primary cancer. Median follow-up period was 23 months. Results :Local recurrence occurred in 11 patients (9.7$\%$) for arm I and 9 patients (8$\%$) for arm 11. There was no significant difference between both groups ( p=0.64). However, distant metastasis was found in 22 patients (19.5$\%$) for arm I and 35 patients (31.0$\%$) for arm II and which showed statistically significant difference between the two groups ( p=0.046). And neither 3-year disease-free survival (70.2$\%$ vs 59.2$\%$, p=0.2) nor overall survival (89.4$\%$ vs 88.0$\%$, p=0.47) showed significant differences. The incidence of leukopenia during radiation therapy and chemotherapy was 78.3$\%$ and 79.9$\%$ respectively but leukopenia more than RTOG grade 3 was only 2.1$\%$ and 6.0$\%$ respectively. The incidence of diarrhea more than 10 times per day was significantly higher in the patients for arm I than for arm II (71.2$\%$ vs 41.6$\%$, p=0.02) but this complication was controlled with supportive cares. Conclusion : Regardless of the sequence of postoperative adjuvant radiation therapy and chemotherapy after curative resection for rectal cancer, local recurrence rate was low with combined chemoradlotherapy. But distant metastasis rate was lower in early radiation therapy group than in late radiation therapy group and the reason is unclear. Most patients completed these treatments without severe complication, so these were thought to be safe treatments but the treatment compliance should be improved.

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