• Title/Summary/Keyword: 2-period model

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Effect of Ethane 1,2-Dimethane Sulfonate (EDS) on the Accessory Sex Organs in Adult Rats : A Histological Study (Ethane 1,2-Dimethane Sulfonate(EDS)가 성체 흰쥐의 부속 생식기관에 미치는 효과 : 조직학적 연구)

  • Lee, Won-Yong;Lee, Sung-Ho
    • Development and Reproduction
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    • v.13 no.2
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    • pp.105-114
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    • 2009
  • Ethane 1,2-dimethane sulfonate (EDS) is a well-known alkylating agent used as selective Leydig cell (LC) toxicant to create a testicular dysfunction model. Previous studies including our own clearly demonstrated the dramatic weight loss of the androgen dependent accessory sex organs such as epididymis, seminal vesicle and prostate gland in this 'LC knock-out' rats. The present study was performed to evaluate the effect of EDS administration on histological changes of the epididymis, seminal vesicle and prostate in adult rats. Adult male Sprague-Dawley rats (350$\sim$400 g B.W.) were injected with a single dose of EDS (75 mg/kg, i.p.) and sacrificed on weeks 0, 1, 2, 3, 4, 5, 6 and 7. Tissue weights (testis, epididymis, seminal vesicle and prostate gland) were measured. The histological changes of tissue were observed by a light microscopy using hematoxylin & eosin staining. Weights of the reproductive and accessory organs progressively declined after the EDS treatments (weeks 1, 2 and 3). After this, the decrease was stopped, then gradually returned to the normal levels. There was a partial (about 60%) recovery of the epididymis weight during weeks $6{\sim}7$. The cross section of epididymis revealed an increase in thickness of the epithelium during weeks $1{\sim}3$. In contrast, considerable reduction of epithelial thickness in seminal vesicle was observed during same period. Similarly, a reduction in thickness of prostate epithelial layer was found during weeks $1{\sim}3$, then it was back to normal thickness after week 4. Taken together, the present study demonstrated that the temporally induced androgen-deficiency by EDS treatment could result the prominent alterations in histology of the accessory sex organs. Further studies on the physiological and molecular regulation of these androgen-sensitive organs using EDS model will be helpful to understand the normal and pathological development and differentiation mechanism of these organs.

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The Impact of SSM Market Entry on Changes in Market Shares among Retailing Types (기업형 슈퍼마켓(SSM)의 시장진입이 소매업태간 시장점유율 변화에 미친 영향)

  • Choi, Ji-Ho;Yonn, Min-Suk;Moon, Youn-Hee;Choi, Sung-Ho
    • Journal of Distribution Research
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    • v.17 no.3
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    • pp.115-132
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    • 2012
  • This study empirically examines the impact of SSM market entry on changes in market shares among retailing types. The data is monthly time-series data spanning over the period from January 2000 to December 2010, and the effect of SSM market entry on market shares of retailing types is analyzed by utilizing several key factors such as the number of new SSM monthly entrants, total number of SSMs, the proportion of new SSM entrant that is smaller than $165m^2$ to total new SSM entrants. According to the Korean Standard Industrial Classification codes, the retailing type is classified into 5 groups: department stores, retail sale in other non-specialized large stores(big marts), supermarkets, convenience stores, and retail sale in other non-specialized stores with food or beverages predominating (others). The market shares of retailing types are calculated by the ratio of each retailing type monthly sales to total monthly retailing sales in which total retailing sales is the sum of each retailing type sales. The empirical model controls for the size effects with the number of monthly employees for each retailing type and the macroeconomic effects with M2. The empirical model employed in this study is as follows; $$MS_i=f(NewSSM,\;CumSSM,\;employ_i,\;under165,\;M2)$$ where $MS_i$ is the market share of each retailing type (department stores, big marts), supermarkets, convenience stores, and others), NewSSM is the number of new SSM monthly entrants, CumSSM is total number of SSMs, $employ_i$ is the number of monthly employees for each retailing type, and under165 is the proportion of new SSM entrant that is smaller than $165m^2$ to total new SSM entrants. The correlation among these variables are reported in

    .
    shows the descriptive statistics of the sample. Sales is the total monthly revenue of each retailing type, employees is total number of monthly employees for each retailing type, area is total floor space of each retail type($m^2$), number of store is total number of monthly stores for each retailing type, market share is the ratio of each retailing type monthly sales to total monthly retailing sales in which total retailing sales is the sum of each retailing type sales, new monthly SSMs is total number of new monthly SSM entrants, and M2 is a money supply. The empirical results of the effect of new SSM market entry on changes in market shares among retailing types (department stores, retail sale in other non-specialized large stores, supermarkets, convenience stores, and retail sale in other non-specialized stores with food or beverages predominating) are reported in
    . The dependant variables are the market share of department stores, the market share of big marts, the market share of supermarkets, the market share of convenience stores, and the market share of others. The result shows that the impact of new SSM market entry on changes in market share of retail sale in other non-specialized large stores (big marts) is statistically significant. Total number of monthly SSM stores has a significant effect on market share, but the magnitude and sign of effect is different among retailing types. The increase in the number of SSM stores has a negative effect on the market share of retail sale in other non-specialized large stores(big marts) and convenience stores, but has a positive impact on the market share of department stores, supermarkets, and retail sale in other non-specialized stores with food or beverages predominating (others). This study offers the theoretical and practical implication to these findings and also suggests the direction for the further analysis.

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  • The Experimental Study for Myocardial Preservation Effect of Ischemic Preconditioning (허혈성 전조건화 유발이 심근보호에 미치는 영향에 관한 실험적 연구)

    • 이종국;박일환;이상헌
      • Journal of Chest Surgery
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      • v.37 no.2
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      • pp.119-130
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      • 2004
    • Decrease in cardiac function after open heart surgery is due to an ischemia induced myocardial damage during surgery, and ischemic preconditioning, a condition in which the myocardial damage does not accumulate after repeated episodes of ischemia but protects itself from damage after prolonged ischemia due to myocytes tolerating the ischemia, is known to diminish myocardial damage, which also helps the recovery of myocardium after reperfusion, and decreases incidences of arrythmia. Our study is performed to display the ischemic preconditioning and show the myocardial protective effect by applying cardioplegic solution to the heart removed from rat. Material and Method: Sprague-Dawley male rats were used, They were fixed on a modified isolated working heart model after cannulation. The reperfusion process was according to non-working and working heart methods and the working method was executed for 20 minutes in which the heart rate, aortic pressure, aortic flow and coronary flow were measured and recorded. The control group is the group which the extracted heart was fixed on the isolated working heart model, recovered by reperfusion 60 minutes after infusion and preserved in the cardioplegic solution 20 minutes after the working heart perfusion and aortic cross clamp, The thesis groups were divided into group I, which ischemic hearts that were hypoxia induced were perfused by cardioplegic solution and preserved for 60 minutes; group II, the cardioplegic solution was infused 45 seconds (II-1), 1 minutes (II-2), 3 minutes (II-3), after the ischemia induction, 20 minutes after working heart perfusion and aortic cross clamp; and group III, hearts were executed on working heart perfusion for 20 minutes and aortic cross clamp was performed for 45 seconds (III-1), 1minute (III-2), 3 minutes (III-3), reperfused for 2 minutes to recover the heart, and then aortic cross clamping was repeated for reperfusion, all the groups were compared based on hemodynamic performance after reperfusion of the heart after preservation for 60 minutes. Result: The recovery time until spontaneous heart beat was longer in groups I, II-3, III-2 and III-3 to control group (p<0.01). Group III-1 (p<0.05) had better results in terms of recovery in number of heart rates compared to control group, and recovered better compared to II-1 (p<0.05). The recovery of aortic blood pressure favored group III-1 (p<0.05) and had better outcomes compared with II-1 (p<0.01). Group III-1 also showed best results in terms of cardiac output (p<0.05) and group III-2 was better compared to II-2 (p<0.05). Group I (p<0.01) and II-3 (p<0.05) showed more cardiac edema than control group. Conclusion: When the effects of other organs are dismissed, protecting the heart by infusion of cardioplegic solution after enforcing ischemia for a short period of time before the onset of abnormal heart beats for preconditioning has a better recovery effect in the cardioplegic group with preconditioning compared to the cardioplegic solution itself. we believe that further study is needed to find a more effective method of preconditioning.

    Fisheries Management of an Abalone Haliotis diversicolor in the Eastern Coastal Waters of Jeju Island using Yield-per-recruit Model (가입당생산량(yield-per-recruit) 모델을 이용한 제주 동부연안 오분자기류(Haliotis diversicolor)의 어업관리)

    • Ko, Joon-Chul;Yoo, Joon-Taek;Choi, Young-Min;Kim, Jae-Woo;Im, Yang-Jae
      • The Korean Journal of Malacology
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      • v.24 no.2
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      • pp.143-151
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      • 2008
    • We studied the management policy for Haliotis diversicolor fisheries in the coastal area of Sungsanpo using Yield-per-recruit model from 2004 to 2006. The age at first capture($t_c$) and fishing mortality(F) annually estimated during the study period decreased and increased, respectively. The maximum yield-per-recruit in 2004 was increased by increasing $t_c$ from the 2.012 year of current $t_c$ to 2.7 year or increasing F from the 0.574/year of current F to 0.800/year, and that in 2005 was increased by increasing $t_c$ from the 1.946 year of current $t_c$ to 2.5 year or increasing F from the 0.578/year of current F to 0.880/year. In 2006, the maximum yield-per-recruit was increased by increasing $t_c$ from the 1.926year of current $t_c$ to 3.1 year or decreasing F from the 1.088/year of current F to 0.810/year. Further, although the current F in 2004 and 2005 was lower than the estimated $F_{MAX}$, that in 2006 was higher than the estimated $F_{MAX}$. These results indicate that the likelihood of growth overfishing with increasing catch of smaller H. diversicolor in 2006 was greater than in 2004 and 2005. As action that could prevent growth overfishing in fisheries management of H. diversicolor, increasing for the current $t_c$ could be a more appropriate policy because the artificial decrease of the number of woman divers related F is actually difficult.

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    Study on the Small Grain Bin for the Improvement of Grain Drying and Storage (곡물건조저장법 개선을 위한 농가용 Grain Bin에 관한 연구)

    • 김성래
      • Magazine of the Korean Society of Agricultural Engineers
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      • v.16 no.1
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      • pp.3263-3291
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      • 1974
    • Experimental work of grain bin was carried out to develop the methods of natural air in-bin drying and storage. The method is considered to be more economical, labour saving, and an effective countermeasure to grain loss. To examine the possibility of farm use of the grain bin and to analyze the related factors concerned with in-bin grain drying and storage, ambient air conditions (especially the change of air temperature and relative humidity) and grain quality during drying and storage periods were investigated. A laboratory model bin was constructed to investigate the effect of different forced air conditions on the drying characteristics of rice. In addition, a grain bin with 2.2m diameter and 1.8m height, considered to be the optimum size for the average Korean farm, was constructed and tested to examine the drying and storing characteristics of rice. The weather data analyzed in this study was the nine-year (from 1964 to 1972) record of air temperature and relative humidity in the Suweon area, and the thirty-year (from 1931 to 1960) record of pentad normal relative humidity and air temperature in the Seoul area. From the results of the weather data analyses, the adequate air delivery hours (which was arbitrary defined as the condition to give less than 75% relative humidity) to dry the rice during October were about nine hours (from approximately 10 A.M. to 7 P.M, ) a day, in which the average air temperature was about 15.9$^{\circ}C$ and average relative humidity was 66%. The occurence of days having three hours of such conditions was 1, 2, and 1-day within the 1st, 2nd add last 10-day periods for the month of October, respectively. Therefore, it may be considered that the weather condition in October was satisfactory for the forced natural air drying. The results of the laboratory model bin test were analyzed to obtain the drying curve and drying rate for different drying stages and grain layers in the bin corresponding to various conditions of forced natural air. A drying experiment with a prototype grain bin showed that an approximate 5 percent grain moisture gradient through a 1.6 meter grain deposit was observed after 80 hours of intermittent drying, giving an over dried zone in the lower grain layers and an extremely high grain moisture zone in the upper layers. This indicates that an effective measure should be taken to reduce this high moisture gradient. In order to investigate the drying characteristics of bulk grain in a layerturning operation a grain bin test was performed. This showed a significant improvement of uniform drying. In this test, approximate 107 hours were required to dry a depth of 1.6 meter of grain from an initial moisture content of 22.2 percent to a moisture content of 16.7 percent using an air delivery rate of 2.8 cubic meter per a minute per every cubic meter of grain. This resulted in a 2 percent moisture gradient from the top to the bottom of the bin. During storage period, till the end of June the average temperature of grain was 2~3$^{\circ}C$ higher than ambient air temperature. But during July when the grain moisture content went up slightly (less than 1 percent), the average temperature of the grain also increased to 3~5$^{\circ}C$ higher than ambient air temperature. It is therefore recommended that for safe grain storage, grain should not be stored in sheet metal bins after mid May. From the above results, in-bin rice drying and storage can be used effectively on Korean farms. It is strongly recommended that the use of grain-bin system should be implemented for farm use to improve farm drying and storage of rice.

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    Analysis of the Long-Range Transport Contribution to PM10 in Korea Based on the Variations of Anthropogenic Emissions in East Asia using WRF-Chem (WRF-Chem 모델을 활용한 동아시아의 인위적 배출량 변동에 따른 한국 미세 먼지 장거리 수송 기여도 분석)

    • Lee, Hyae-Jin;Cho, Jae-Hee
      • Journal of the Korean earth science society
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      • v.43 no.2
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      • pp.283-302
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      • 2022
    • Despite the nationwide COVID-19 lockdown in China since January 23, 2020, haze days with high PM10 levels of 88-98 ㎍ m-3 occurred on February 1 and 2, 2020. During these haze days, the East Asian region was affected by a warm and stagnant air mass with positive air temperature anomalies and negative zonal wind anomalies at 850 hPa. The Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) was used to analyze the variation of regional PM10 aerosol transport in Korea due to decreased anthropogenic emissions in East Asia. The base experiment (BASE), which applies the basic anthropogenic emissions in the WRF-Chem model, and the control experiment (CTL) applied by reducing the anthropogenic emission to 50%, were used to assess uncertainty with ground-based PM10 measurements in Korea. The index of agreement (IOA) for the CTL simulation was 0.71, which was higher than that of BASE (0.67). A statistical analysis of the results suggests that anthropogenic emissions were reduced during the COVID-19 lockdown period in China. Furthermore, BASE and CTL applied to zero-out anthropogenic emissions outside Korea (BASE_ZEOK and CTL_ZEOK) were used to analyze the variations of regional PM10 aerosol transport in Korea. Regional PM10 transport in CTL was reduced by only 10-20% compared to BASE. Synthetic weather variables may be another reason for the non-linear response to changes in the contribution of regional transport to PM10 in Korea with the reduction of anthropogenic emissions in East Asia. Although the regional transport contribution of other inorganic aerosols was high in CTL (80-90%), sulfate-nitrate-ammonium (SNA) aerosols showed lower contributions of 0-20%, 30-60%, and 30-60%, respectively. The SNA secondary aerosols, particularly nitrates, presumably declined as the Chinese lockdown induced traffic.

    Improvement of turbid water prediction accuracy using sensor-based monitoring data in Imha Dam reservoir (센서 기반 모니터링 자료를 활용한 임하댐 저수지 탁수 예측 정확도 개선)

    • Kim, Jongmin;Lee, Sang Ung;Kwon, Siyoon;Chung, Se Woong;Kim, Young Do
      • Journal of Korea Water Resources Association
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      • v.55 no.11
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      • pp.931-939
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      • 2022
    • In Korea, about two-thirds of the precipitation is concentrated in the summer season, so the problem of turbidity in the summer flood season varies from year to year. Concentrated rainfall due to abnormal rainfall and extreme weather is on the rise. The inflow of turbidity caused a sudden increase in turbidity in the water, causing a problem of turbidity in the dam reservoir. In particular, in Korea, where rivers and dam reservoirs are used for most of the annual average water consumption, if turbidity problems are prolonged, social and environmental problems such as agriculture, industry, and aquatic ecosystems in downstream areas will occur. In order to cope with such turbidity prediction, research on turbidity modeling is being actively conducted. Flow rate, water temperature, and SS data are required to model turbid water. To this end, the national measurement network measures turbidity by measuring SS in rivers and dam reservoirs, but there is a limitation in that the data resolution is low due to insufficient facilities. However, there is an unmeasured period depending on each dam and weather conditions. As a sensor for measuring turbidity, there are Optical Backscatter Sensor (OBS) and YSI, and a sensor for measuring SS uses equipment such as Laser In-Situ Scattering and Transmissometry (LISST). However, in the case of such a high-tech sensor, there is a limit due to the stability of the equipment. Therefore, there is an unmeasured period through analysis based on the acquired flow rate, water temperature, SS, and turbidity data, so it is necessary to develop a relational expression to calculate the SS used for the input data. In this study, the AEM3D model used in the Water Resources Corporation SURIAN system was used to improve the accuracy of prediction of turbidity through the turbidity-SS relationship developed based on the measurement data near the dam outlet.

    Characteristics of posteroanterior cephalometric analysis in children with skeletal Class I malocclusion (성장기 골격성 I 급 부정교합 환자의 정모두부방사선 계측의 특징)

    • Moon, Yoon-Shik;Kim, Jung-Kook;Jung, Hyun-Sung;Sung, Sang-Jin
      • The korean journal of orthodontics
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      • v.31 no.2 s.85
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      • pp.159-172
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      • 2001
    • Three dimensional analysis of malocclusion and craniofacial deformation is essential for the successful orthodontic treatment. But the orthodontists are not familiar with diagnosis and treatment plane based on lateral cephalometric analysis. Since orthodontists do not posses a sufficient knowledge in standard value of posteroanterior cephalometric anaysis and of clinical importance for transverse jaw growth. In this study male(n=130) and female(n=171) aged from 6 to 16 and diagnosed as Class I malocclusion were selected to analysis width of cranium, maxilla and mandible on the posteroanterior cephalogram. The changes as a function of chronologic age and cervical vertebrae maturity index(CVXI) were examined. The Proper regression model was selected by sex with polynominal regression models and method of variable selection. Mean of each measurements and 70% confidence interval of individual measurement according to age was assesed and a graphs were made. Results are as follows :1. All the measurements for the width are gradually incresed as increase in chronologic age and CVMI. From the total amount of change between age 6 and 16, there is a tendency that mandibular width is broader than maxillary width and the width of male is broader than female. 2. There is no statistically significant sexual difference in Mx-Mn difference, Mx-Mn width differential, Mx/Mn ratio according to age and CVMI. 3. Mean of each measurement and 70% confidence interval of individual measurement according to age and sex were assessed and graphs were made for maxillary width, mandibular width, Mx-Mn difference, Mx/Mn ratio. 4. The width of maxilla and mandible in Korean children are broader than Western children during growth period.

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    Computer Game Addiction and Physical Health of Korea Children : Mediating Effects of Anxiety (아동의 컴퓨터 게임 중독과 신체 증상: 불안의 매개효과)

    • Kwon, Sun-Jung;Kim, Kyo-Heon;Lee, Hong-Seock
      • Survey Research
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      • v.6 no.2
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      • pp.33-50
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      • 2005
    • The purpose of this study was to investigate whether Korean children's being addiction to computer game had an effect on physical health(headache, insomnia, indigestion, cardivascular). We considered both direct effects of that addiction and indirect effects which caused an negative emotion(anxiety). For this study, we collected data from 800 students of grades and 6 in Daejeon, Korea. Among them, we analyzed the data of 572 students[408 boys(71.3%) and 164 girls(28.7%) respectively] who had played computer games for a long period of time(two years or more). Reliability of the scale used on this study was a proper level by $.64{\sim}.91$ and we operated an analysis of structural equation pattern to make relationships of variable causes clear. As a result of examining an index of fitness of each model, it was proved for the fitness of every model(all GFI >.931, all CFI >.939, all NNFI >.929, all RMSEA <.046) to be acceptable. Not only the computer game addiction affected(all ps<.001) directly on physical symptoms(headache ${\beta}$=.211, insomnia ${\beta}$=.289, indigestion ${\beta}$ =.214, cardivascular ${\beta}$=.349), but also it affected(${\beta}$=.458, p<.001) on anxiety. In addition, the effect of anxiety on physical symptoms(headache ${\beta}$=.419, insomnia ${\beta}$=.375, indigestion ${\beta}$=.498, cardivascular ${\beta}$=.328) was significant. As a result of yielding the indirect effects of computer game abuse mediated by anxiety, headache was measured up ${\beta}$=.192, insomnia ${\beta}$=.172, indigestion ${\beta}$ =.228 and cardivascular ${\beta}$=.151. The computer game addiction caused 21% of anxiety and this mediate model proved that the computer game addiction caused 30% of headache, 32% of insomnia, 39% of indigestion, and 34% of cardivascular symptom. As a result of this study, the computer game addiction has a negative effect on physical health both directly and indirectly. Especially, cardivascular was influenced most extremely, then insomnia, indigestion, and headache in order. The implications gleaned from this study were discussed with considerations for future study and practical aspect.

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    A Theoretical Model for the Analysis of Residual Motion Artifacts in 4D CT Scans (이론적 모델을 이용한 4DCT에서의 Motion Artifact 분석)

    • Kim, Tae-Ho;Yoon, Jai-Woong;Kang, Seong-Hee;Suh, Tae-Suk
      • Progress in Medical Physics
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      • v.23 no.3
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      • pp.145-153
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      • 2012
    • In this study, we quantify the residual motion artifact in 4D-CT scan using the dynamic lung phantom which could simulate respiratory target motion and suggest a simple one-dimension theoretical model to explain and characterize the source of motion artifacts in 4DCT scanning. We set-up regular 1D sine motion and adjusted three level of amplitude (10, 20, 30 mm) with fixed period (4s). The 4DCT scans are acquired in helical mode and phase information provided by the belt type respiratory monitoring system. The images were sorted into ten phase bins ranging from 0% to 90%. The reconstructed images were subsequently imported into the Treatment Planning System (CorePLAN, SC&J) for target delineation using a fixed contour window and dimensions of the three targets are measured along the direction of motion. Target dimension of each phase image have same changing trend. The error is minimum at 50% phase in all case (10, 20, 30 mm) and we found that ${\Delta}S$ (target dimension change) of 10, 20 and 30 mm amplitude were 0 (0%), 0.1 (5%), 0.1 (5%) cm respectively compare to the static image of target diameter (2 cm). while the error is maximum at 30% and 80% phase ${\Delta}S$ of 10, 20 and 30 mm amplitude were 0.2 (10%), 0.7 (35%), 0.9 (45%) cm respectively. Based on these result, we try to analysis the residual motion artifact in 4D-CT scan using a simple one-dimension theoretical model and also we developed a simulation program. Our results explain the effect of residual motion on each phase target displacement and also shown that residual motion artifact was affected that the target velocity at each phase. In this study, we focus on provides a more intuitive understanding about the residual motion artifact and try to explain the relationship motion parameters of the scanner, treatment couch and tumor. In conclusion, our results could help to decide the appropriate reconstruction phase and CT parameters which reduce the residual motion artifact in 4DCT.


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