• The Korean Journal of Pesticide Science
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• v.5 no.3
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• pp.36-40
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• 2001

A series of new 2-N-benzyl-5-phenoxy-3-isothiazolone derivatives were synthesized and their in vitro antifungal activities against resistant Phytophthora capsici (RPC) & sensitive Phytophthora capsici (SPC) with metalaxyl fungicide have been measured. In addition, influence of substituted 5-phenoxy group on the -antifungal activities ($pI_{50}$) and the reactivity of substrates were investigated. From the results, reactivity of none substituted substrate showed tendency displaying orbital-controlled reaction. The substituents on the 5-phenoxy ring showed selective fungicidal activity between SPC and RPC. Especially, the 4-fluoro substituent, 6 in the RPC and 4-nitro substituent, 3 in SPC exhibited strongly selective antifungal activity among them. The activities on the SPC would depend largely on the optimal molar refractivity ($MR_{(opt.)}=7.37cm^3/mol$) whereas the activities on the RPC would depend largely on the optimal highest occupied molecular orbital energy ($HOMO_{(opt.)}=-9.2137e.v.$) and weak electron donating (${\sigma}<0$) group. And Free-Wilson analyses revealed that the antifungal activity against RPC depends on the methoxy and bromo-substituent and all of the substituents contribute to antifungal activities against SPC.

• The Korean Journal of Pesticide Science
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• v.6 no.1
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• pp.25-30
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• 2002

Quantitative structure-toxicity relationships (QSTRs) between various physicochemical parameters of substituents in new herbicidal N-phenyl-3,4-dimethylphthalimide derivatives and their discriminate score (DS) for chronic and acute toxicities against mouse and rat evaluated using TOPKAT calculation were discussed quantitatively. From the basis on the findings, it was shown that carcinogenicities of female was higher than that of male and mouse had higher tendency than rat. The STR analyses results of Hansch-Fujita type equations suggested that mouse (female & male) and rat male except rat female are dependent on LUMO energy commonly in carcinogenicity. The selective carcinogenicity factor of two species between male mouse and female mouse is dependent on optimal value (ca. $(L)_{opt.}=5.0{\AA}$) for length of $R_2$-substituent mainly. According to Free-Wilson approach, in the case of rat male, alkyl and aryl substituents were superior and in the other case, contribution of fluoro group substituents were superior to chronic toxicity.

• The Journal of the Korea Contents Association
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• v.21 no.5
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• pp.996-1003
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• 2021

The purpose of this study is to evaluate the reliability of repeated measurements of several dental scanners. Blue-lighted scanners, white-light scanners and optical-type scanners are used in the study of repeatability in this study. The measurement results were calculated as root mean square (RMS) and the significance level was confirmed by applying the 1-way ANOVA statistical technique (𝛼=.05). According to the statistical analysis, the scanner with the largest RMS value was Z-opt group (38.2 ㎛. Next, D-white was 35.2 ㎛ and the group with the lowest RMS value was I-blue (34.1 ㎛). The comparison of RMS means between each group was not significant (p>.05). From this result, the blue light had the lowest error in repeatability of dental scanners, but no statistical significance. The conclusion of this study is that the study results are clinically acceptable.

• Proceedings of the IEEK Conference
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• 2002.07a
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• pp.34-37
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• 2002

This paper presents a new stochastic binary neural network based on the Hopfield model. We apply the proposed network to TSP and compare it with other methods by computer simulations. Furthermore, we apply 2-opt to the proposed network to improve the performance.

• The Optical Journal
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• s.132
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• pp.22-26
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• 2011

일본의 광산업 동향을 보면 기본적으로 알렉트로닉스 전체와 거의 유사한 상황에 있는 것을 알 수 있다. 일본 광산업의 생산금액은 과거 20년간 2.5조엔에서 8조엔까지 확대됐지만 IT버블을 경계로 성장률은 둔화하고 있다. 본 고는 Optronics 2011년 1월호에 게재된 (주)노무라종합연구소 정보 통신컨설팅부 상급컨설턴트 후지나미 케이씨가 기고한 내용으로서 일본외 광 일렉트로닉스산업을 에워싸는 현상의 주요한 조류와 이후 전망에 관해서 소개하고 있다.

• Proceedings of the SAREK Conference
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• 2005.11a
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• pp.223-228
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• 2005

This study develops an optimization program to use optimum design of building HVAC system reducing building energy use and cost. Doe20pt developed is an interface program between DOE2 and GenOpt to perform the optimization procedure more easily. The optimum results can be used to estimate the economical efficiency concerning the building management.

• Journal of the Korean Wood Science and Technology
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• v.48 no.2
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• pp.196-205
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• 2020

The purpose of this study was to investigate a method for improving the physical and mechanical properties of laminated board made from oil palm trunk (OPT). The effects of pretreating the lamina with heat-pressure and altering the lamina composition of the laminated board were investigated. The outer third of OPT in cross-section had high-density wood, while the underlying third had low to medium density. The hot press was applied to pretreat the lamina that had low to medium density. The lamina were 1.5 cm in thickness, 5 cm in width, and 65 cm in length. The hot press was applied at 2.94 MPa or 4.41 MPa at 150 ℃ for 60 minutes, and the target thickness of the lamina was 1 cm. The three layers of the laminated board samples were bonded with isocyanate adhesive at a glue spread of 300 g/㎡ and cold pressed at 0.98 MPa for 3 h. The laminated board samples were tested according to Japanese Agricultural Standard (JAS) 234-2003. The results showed that the densification of the inner lamina did not significantly affect the physical-mechanical properties of the laminated board produced. However, the laminated board made with high-density laminas for the outer layers fulfilled the JAS 234-2003 standard for the modulus of elasticity and the modulus of rupture.

• Nutrition Research and Practice
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• v.8 no.6
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• pp.638-643
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• 2014

BACKGROUND/OBJECTIVES: Kimchi is a traditional Korean fermented vegetable containing several ingredients. We investigated the protective activity of methanol extract of kimchi under different fermentation stages against oxidative damage. MATERIALS/METHODS: Fresh kimchi (Fresh), optimally ripened kimchi (OptR), and over ripened kimchi (OvR) were fermented until the pH reached pH 5.6, pH 4.3, and pH 3.8, respectively. The radical scavenging activity and protective activity from oxidative stress of kimchi during fermentation were investigated under in vitro and cellular systems using LLC-$PK_1$ cells. RESULTS: Kimchi exhibited strong radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl, nitric oxide, superoxide anion, and hydroxyl radical. In addition, the free radical generators led to loss of cell viability and elevated lipid peroxidation, while treatment with kimchi resulted in significantly increased cell viability and decreased lipid peroxidation. Furthermore, the protective effect against oxidative stress was related to regulation of cyclooxygenase-2, inducible nitric oxide synthase, nuclear factor-${\kappa}B$ p65, and $I{\kappa}B$ expression. In particular, OvR showed the strongest protective effect from cellular oxidative stress among other kimchi. CONCLUSION: The current study indicated that kimchi, particularly OptR and OvR, played a protective role against free radical-induced oxidative stress. These findings suggest that kimchi is a promising functional food with an antioxidative effect and fermentation of kimchi led to elevation of antioxidative activity.

• Journal of Animal Science and Technology
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• v.59 no.9
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• pp.20.1-20.9
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• 2017

Background: Ribonuclease (RNase) is one of the few toxic proteins that are present constantly in snake venoms of all types. However, to date this RNase is still poorly studied in comparison not only with other toxic proteins of snake venom, but also with the enzymes of RNase group. The objective of this paper was to investigate some properties of RNase from venom of Vietnam cobra Naja atra. Methods: Kinetic methods and gel filtration chromatography were used to investigate RNase from venom of Vietnam cobra. Results: RNase from venom of Vietnam cobra Naja atra has some characteristic properties. This RNase is a thermostable enzyme and has high conformational stability. This is the only acidic enzyme of the RNase A superfamily exhibiting a high catalytic activity in the pH range of 1-4, with $pH_{opt}=2.58{\pm}0.35$. Its activity is considerably reduced with increasing ionic strength of reaction mixture. Venom proteins are separated by gel filtration into four peaks with ribonucleolytic activity, which is abnormally distributed among the isoforms: only a small part of the RNase activity is present in fractions of proteins with molecular weights of 12-15 kDa and more than 30 kDa, but most of the enzyme activity is detected in fractions of polypeptides, having molecular weights of less than 9 kDa, that is unexpected. Conclusions: RNase from the venom of Vietnam cobra is a unique member of RNase A superfamily according to its acidic optimum pH ($pH_{opt}=2.58{\pm}0.35$) and extremely low molecular weights of its major isoforms (approximately 8.95 kDa for RNase III and 5.93 kDa for RNase IV).

• Journal of the Korea Society of Computer and Information
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• v.26 no.9
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• pp.143-153
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• 2021

In this paper, we propose "flexible routing with flex" to provide fast delivery by using the flexible routing for the delivery vehicle and crowd-shipper named flex. To this end, we have introduced an algorithm that can build the delivery plan for delivery vehicles and flexes. The introduced algorithm uses the 2-opt algorithm to construct routes with low complexity and acceptable quality, and the revised saving algorithm to assign customer orders to the flex. The algorithm allows the vehicle and the flex to function complement each other without separating the delivery vehicle from the flex. The experiments consider the 3 different instances named Random, Mixed, Cluster, and show that "the flexible routing with flex" has a better result than "vehicle only". The sensitivity analysis of the flex cost and time penalty shows "the flexible routing with flex" can provide better service not only to the customers who are serviced by flex but also to the customers who are serviced by the delivery vehicle.