• Title/Summary/Keyword: 2-methyl a-ziridine

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Synthesis of Phenolbetaine Derivatives and Their Anti-cancer Activity: Chemical Transformation of C-ring of Protoberberine (페놀베타인 유도체합성 및 항암 활성검토: 프로토베르베린에서 C-환의 화학적 변환)

  • U, Seong-Ju;Park, Ye-Jin;Hwang, Sun-Ho;Hong, Yu-Hwa;Lee, Ma-Se;Kim, Dong-Hyeon;Kim, In-Jong;Kim, Sin-Gyu
    • YAKHAK HOEJI
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    • v.40 no.5
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    • pp.487-490
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    • 1996

  • The 13-hydroxyberbine(1), derived from berberinephenolbetaine, has been derivatized to furnish a variety of compounds such as 13-oxoberbine(2), 13-thioberbine(3), 13-chloroberbi ne(4), 13-(2-methylaziridine)berbine(5) and 13-carbolactoneberbine(6). Antitumor activity of these compounds was tested.

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