• Title/Summary/Keyword: 2-cyanopyridine

Search Result 8, Processing Time 0.027 seconds

Substitution Reactions of Cyanopyridines with Organometallics (유기금속화합물에 의한 Cyanopyridines의 치환반응에 관한 연구)

  • Kim, Jung-Gyun;Yu, Dong-Sik;Moon, Sung-Hwan;Park, Jin-Il;Park, Won-Woo
    • Journal of the Korean Chemical Society
    • /
    • v.37 no.9
    • /
    • pp.826-831
    • /
    • 1993
  • 3-Cyanopyridine, when treated with organolithium or Grignard reagents, gives addition to the 6-position and provides a series of 2-substituted 5-cyanopyridines (6-substituted 3-cyanopyridines). Alternatively, 2-and 4-cyanopyridine react with $CH_3Li$ or $CH_3Mgl$ and provide 2-acetylpyridine and 4-acetylpyridine, respectively.

  • PDF

Effect of Dehydration on DMC Synthesis over Ceria Catalysts (Ceria 촉매상에서 탈수가 DMC 합성에 미치는 영향)

  • You, Jiin;Woo, Je-Min;Kim, Hyunuk;Park, Young Cheol;Park, Jong-Ho;Moon, Jong-Ho
    • Clean Technology
    • /
    • v.22 no.3
    • /
    • pp.196-202
    • /
    • 2016
  • In this study, ceria- based catalysts were prepared for dimethyl carbonate (DMC) synthesis and reaction conditions were evaluated for finding the optimal reaction route. In order to find optimal catalysts for DMC synthesis, calcination temperature and Cu(II) impregnation amount were evaluated. The oxidative carbonylation using methanol, carbon monoxide and oxygen and the direct synthesis using methanol and carbon dioxide were introduced for producing DMC. Following the law of Le Chatelier, the dehydration reaction was applied for enhancing the reactivity (methanol conversion) as removing water during the reaction. 2-cyanopyridine, as a chemical dehydration agent, was used. In the case of the oxidative carbonylation, methanol conversion rate increased from 15.1% to 38.7% and the DMC selectivity increased from 0% to 98.8%. In the case of the direct synthesis, methanol conversion rate increased from 1.0% to 77.8% and the DMC selectivity increased from 41.2% to 100.0%.

Metal-Nitrosyl Complexes(II) : Synthesis and Characterization of Dinitrosyltungsten(O) Complexes (금속-니트로실 착물 (제 2 보) : 디니트로실 텅스텐(O) 착물의 합성과 특성)

  • Sang-Oh Oh;Seong-Jong Mo
    • Journal of the Korean Chemical Society
    • /
    • v.36 no.6
    • /
    • pp.906-913
    • /
    • 1992
  • The polymeric compound [{$W(NO)_2Cl_2$}$_n$] were prepared by reductive nitrosylation of $WNaNO_2$ and acidified $WFeSO_4$ with $WWCl_6$ at room temperature. The reactions of [{$W(NO)_2Cl_2$}$_n$] with unidentate and bidentate ligands afforded neutral monomeric [$W(NO)_2Cl_2L_2$(or L-L)] in a relative high yields (70$\sim$90%). 3,5-lutidine, ${\gamma}$-cyanopyridine, 1,2-phenylenediamine, 1,10-phenanthroline, sym-diphenylethylenediamine, 9,10-phenanthrenequinone, 1,3-bis(diphenylphosphino)propane, 1,1'-bis(diphenylphosphino)ferrocene and 8-hydroxyquinoline were used as coordinating ligands. These dinitrosyltungsten complexes were characterized by elemental analysis, $^1H$-NMR, infrared, and UV-visible spectroscopy are reported. The spectral data indicated that geometric structures of the products were cis-dinitrosyl-trans-dichloro-cis-$L_2$ of $C_{2v}$ symmetry.

  • PDF

Metal-Nitrosyl Complexes (I) Synthesis and Characterization of Dinitrosylmolybdenum (O) Complexes (금속-니트로실 착물 (제 1 보) 디니트로실몰리브덴(O) 착물의 합성과 특성)

  • Oh Sang-Oh;Mo Seong-Jong
    • Journal of the Korean Chemical Society
    • /
    • v.36 no.5
    • /
    • pp.661-668
    • /
    • 1992
  • The polymeric compound [{Mo(NO)_2Cl_2}n] was prepared by reductive nitrosylation of NaNO_2 and acidified FeSO_4 with MoCl_5. The reactions of [{Mo(NO)_2Cl_2}n] with unidentate and bidentate ligands afforded neutral monomeric $[Mo(NO)_2Cl_2L_2(or L-L)] in high yield (80∼90%). 3,5-Lutidine, {\gamma}-Cyanopyridine, 1,2-Phenylenediamine, 1,10-Phenanthroline, sym-Diphenylethylenediamine, 9,10-Phenanthrenequinone, 1,3-Bis(diphenylphosphino)propane and 8-Hydroxyquinoline were used as coordinating ligands. The preparation and characterization of these dinitrosylmolybdenum complexes by elemental analysis, 1H NMR, infrared, and UV-Visible spectroscopy are reported. The infrared spectra indicate that in all of the compounds prepared, the NO groups occupy cis-positions in the octahedral group of ligands.

  • PDF

Effects of Axial Ligand Basicity on the Isotropic NMR Shifts in Pyridine-Type Ligands Coordinated to the Paramagnetic Polyoxometalate, $[SiW_{11}Co^{11}O_{39}]^{6-}$

  • 김지영;박석민;소현수
    • Bulletin of the Korean Chemical Society
    • /
    • v.18 no.4
    • /
    • pp.369-373
    • /
    • 1997
  • When 1H NMR spectra of pyridine, 4-amino-, 4-methyl-, and 4-cyanopyridine coordinated to the paramagnetic polyoxometalate, [SiW11CoⅡO39]6- in D2O are compared, both α- and β-proton peaks are shifted upfield as the basicity of the ligand decreases. The isotropic shifts are separated into contact and pseudocontact contributions by assuming that the contact shifts are proportional to the isotropic shifts of the same ligands coordinated to [SiW11NiⅡO39]6-. This separation reveals that the shift variations with the axial ligand basicity are dominated by changes in the magnetic anisotropy (pseudocontact shift) of [SiW11CoⅡ(ptl)O39]6- (ptl=pyridine-type ligand). The magnitude of the magnetic anisotropy in a series of pyridine-type ligands increases linearly as the pKa of their conjugate acids decreases.

Synthesis of New Uraci1-5-Sulphonamide-p-Phenyl Derivatives and Their Effect on Biomphalaria alexandrina Snail's Nucleoproteins

  • Fathalla, O.A.;Gad, H.S.M.;Maghaby, A.S.
    • Archives of Pharmacal Research
    • /
    • v.23 no.2
    • /
    • pp.128-138
    • /
    • 2000
  • In continuation of the previous work (Fathalla, 1992) on the synthesis of some heterocycles containing uracil moiety, we report herein the incorporation of uracil moiety into cyan-opyridine thione, thiosemecarbazone, semicarbazone, cyanopyridine, ami nocyano pyridine, isoxazoline, pyrazoline, pyrimidine, triazolo pyrimidine, pyran, selena and thiazole derivatives which might modify their biological activities. The biological studies revealed that the chemical compound III f showed high molluscicdal activity than other compounds. The profile of the nucleoprotein extracted from chemically (compound IIIc, e, f and g) treated or UV-irradiated B.alexandrina snails did not show appreciable differences when compared to non-treated (native) snails by using SDS-PAGE, where no obvious qualitative or quantitative differences were observed. Immunization of experimental animals with the nucleoprotein extracted from native, chemically (compound III f & g) treated or physically treated B.alexandrina snails induced significant protection against challenge with normal S.mansoni cercariae, as compared to the non-immunized challenged control. As well as , a decrease in the number of granuloma formation and the size range of granuloma was also observed in immunized animals. It is concluded that, compounds III f and g have a potent molluscicidal activity. They also induced chemical modification comparable to that induced by physical treatment in the snail's nucleoprotein, which could possibly be used in immunization against S. mansoni infection.

  • PDF

Synthesis and Characterization of Substituted Pyridine Complexes of Molybdenum (Ⅳ). Oxotrichlorobis(substituted pyridine) molybdenum (Ⅴ) (몰리브덴의 피리딘계 착물합성과 그 성질 (제4보) 옥소삼클로로비스(치환피리딘)몰리브덴 (V))

  • Chang Su Kim;Sang Oh Oh
    • Journal of the Korean Chemical Society
    • /
    • v.26 no.6
    • /
    • pp.378-382
    • /
    • 1982
  • Green crystalline salts of substituted pyridinium oxopentachloromolybdates(V) were obtained from concentrated hydrochloric acid solution of molybdenum(V)-thiocyanate extract. $MoOCl_3(X-py)_2$ (X-py were 4-and 3-cyanopyridine, 2-amino-4-picoline and 4-acetylpyridine) were obtained by reflux of the corresponding substituted pyridinium salts of oxopentachloromolybdates(Ⅴ) in absolute ethanol. ($X-pyH_2$)[$MoOCl_5$]$H_2$O containing the $MoO^{3+}$ group are dissolved and hydrolysed in water but $MoOCl_3(X-py)_2$ are insoluble in water, alcohol and acetone. The complexes are paramagnetic compounds.

  • PDF

Synthesis and Characterization of Substituted Pyridine Complexes of Molybdenum(Ⅴ). Di-${\mu}$-oxo-dioxodichlorobis(substituted pyridines) dimolybdenum(Ⅴ) and Substituted Pyridinium Di-${\mu}$-oxo-dioxohexaisothiocyanatodimolybdates(Ⅴ) (몰리브덴의 피리딘계 착물합성과 그 성질 (제5보). 이-${\mu}$ -옥소-이옥소이클로로비스(치환피리딘) 이 몰리브덴 (Ⅴ) 와 이-${\mu}$- 옥소-이옥소육이소티오시아나토 이 몰리브덴 (Ⅴ) 산 치환피리딘늄)

  • Kim, Chang-Su;Sang Oh Oh
    • Journal of the Korean Chemical Society
    • /
    • v.26 no.6
    • /
    • pp.383-388
    • /
    • 1982
  • $Mo_2O_4Cl_2$$(X-py)_4{\cdot}2H_2$O and $(X-pyH)_4$[$Mo_2O_4(NCS)_6)$]${\cdot}H_2$O have been prepared. The infrared, electronic and reflectance spectra, molar conductances and magnetic susceptibility data of complexes are reported. $Mo_2O_4Cl_2$$(X-py)_4{\cdot}2H_2$O (X-py were 3-and 4-cyanopyridine, nicotinamide, 3,5-lutidine and 2-amino-4-picoline) were obtained by hydrolysis of the corresponding substituted pyridinium oxopentachloromolybdates(Ⅴ). Addition of water and substituted pyridines to molybdenum(Ⅴ)-thiocyanate ethylacetate extract yielded brown compounds, $(X-pyH)_4$[$Mo_2O_4(NCS)_6)$]${\cdot}H_2$O where X-py were pyridine, ${\alpha}$, 3-bromopyridine 3,5-lutidine, 3-benzoylpyridine and 4-acetylpyridine. Binuclear, $Mo_2O_4Cl_2(X-py)_4{\cdot}2H_2$ prepared from hydrolysis of $(X-pyH)_2[MoOCl_5]{\cdot}H_2O$ were diamagnetic and nonelectrolytes. The anion of $(X-pyH)_4$[$Mo_2O_4(NCS)_6)$]${\cdot}H_2$O was formulated as dimer and electrolyte.

  • PDF