• 한국임상약학회지
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• 제24권2호
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• pp.98-105
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• 2014

Purpose: The aim of this study was to compare retrospectively the efficacy of anti-osteoporotic agents (RAL-Raloxifene 60 mg, ALD-weekly alendronate 70 mg, RSD-weekly risedronate 35 mg, AVD3-weekly alendronate 70 mg/vitamin $D_3$ 2800IU, IBD-quarterly IV ibandronate 3 mg/3 ml, ZLD-yearly IV zoledronate 5 mg/100 ml) in postmenopausal patients with osteoporosis or osteopenia. Method: This study retrospectively reviewed medical record and compared the lumbar spine BMD percentage changes of each medicine group one year later from the baseline. 209 patients (27, 50, 60, 30, 35, and 7 patients in RAL, ALD, RSD, AVD3, IBD, and ZLD groups, respectively) are within the inclusion criteria for the study. Results: From baseline to month 12, lumbar spine BMD increased significantly larger with bisphosphonate groups, compared to SERM (p < 0.05). In all bisphosphonate groups, the lumbar spine BMD were increased significantly from baseline. Of the bisphosphonates, the changes from baseline in BMD of IV bisphosphonates were more larger than those of oral bisphosphonates, and yearly, quarterly bisphosphonates yielded significantly greater BMD gains, compared with weekly bisphosphonate groups (p<0.05). In addition, patients receiving 70 mg weekly alendronate+vitamin D3 had greater gains in BMD than alendronate Single preparation (p<0.05). Conclusion: Bisphosphonates yielded significantly greater BMD gains than SERM. Of the bisphosphonates, the changes from baseline in BMD of yearly, quarterly IV bisphosphonates yielded significantly greater BMD gains, compared with weekly oral bisphosphonate groups. In addition, vitamin D3 plays an significant role in BMD gains.

• EDISON SW 활용 경진대회 논문집
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• 제5회(2016년)
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• pp.183-189
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• 2016

In this paper, an optimization study on a helicopter rotor blade cross-section was made. Generalization was made to the baseline cross-section to simplify the analysis. To have better performance in aeroelastic response, with the aerodynamic center being the origin of the baseline, the distance between aerodynamic center and shear center, and the distance between mass center and shear center of the blade were minimized. For efficient searching of optimum solutions over the design space, grid search method, which is a method of graphical search was used. Two design variables, radius of balancing weight at leading edge, and offset of the spar from leading edge were selected for the study. Cubic spline interpolation method was used to accommodate searching of the optimum solution. 2-Leveled searching system was devised in accordance with the interpolation method. Optimum solution was found to show 6% decrease in both distance between aerodynamic center and shear center, and mass center and shear center to the baseline.

• 산업기술연구
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• 제36권
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• pp.71-76
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• 2016

In this study, we determined the precise coordinates of TBMs (Tidal Bench Marks), which used as the national reference points in coastal area of Korea, using a GPS data analysis SW for the academic and scientific applications, GAMIT/GLOBK. For accurate 3-D positioning of TBM locations, we performed the GPS point surveying according to the national surveying policy and also acquired the GPS data for 48 TBMs located in the western and southern coastal part of Korea. Considering the results of baseline analysis to each observation session obtained from GAMIT module, the baseline analysis was realized to be done precisely because the values of Normalized RMS (NRMS) were mostly less than ${\pm}0.20mm$. Before the network adjustment using GLOBK module, we evaluated the suitability of observations for each session by applying the chi-squared test (${\chi}^2$ test) to the degree of freedom in observed session. An overall distributions of ${\chi}^2$ test were less than 1.0 for all sessions, and the statistical of ${\chi}^2$ test showed the average, 0.267 with minimum and maximum value, 0.063 and 0.653, respectively. Finally, we analyzed the network adjustment for 48 TBMs to reduce the residuals of baseline analysis on each point by connecting with 42 permanent GPS stations in Korea. In the network adjustment procedure, we set up the weighted values of each permanent station to be allocated between 0.9 and 1.14, and also removed the observed points having residual exceeds 4-times of standard deviation ($4{\sigma}$).

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권9호
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• pp.3276-3292
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• 2015

Relay-assisted D2D communication extends the communication range of the D2D pairs and helps users to form D2D pairs effectively. However, due to the introduction of the multi-hop relaying, the D2D communication has to occupy extra transmission time, which may decrease the efficiency of the communication system. In this paper, we propose a scheme to make node receive D2D signal and BS signal at overlapping time to improve the spectrum efficiency according to ZigZag decoding and successive-interference-cancellation (SIC). In this way, more data can be delivered during the same duration, thus the network throughput can be further improved. Numerical results verify the performance improvement of the proposed scheme when compared with a baseline scheme. Moreover, we expand the proposed scheme from one-hop relay scenario to multi-hop relay scenario.

• Journal of Ginseng Research
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• 제35권2호
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• pp.226-234
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• 2011

We investigated the clinical effects of Korean red ginseng on attention deficit hyperactivity disorder (ADHD) in children. Eighteen subjects aged between 6 and 14 diagnosed with ADHD based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition diagnosis criteria were enrolled. Korean red ginseng (Panax ginseng) at 1,000 mg b.i.d. was administered to the subjects for 8 weeks. Eighteen children completed the questionnaire and clinical assessment by visiting the hospital at baseline, then in the first, fourth and eighth weeks. Clinical assessments were performed by using the ADHD Diagnostic System (ADS, a computerized attention assessment program), the abbreviated Conners' rating scale in addition to psychiatric interviews. After 8 weeks, significant differences were found in the omisssion errors of ADS ($78.56{\pm}43.33$ at baseline, $55.17{\pm}21.44$ at 8 weeks, p<0.023), Conners ADHD Rating Scale ($13.78{\pm}6.32$ at baseline, $9.50{\pm}4.80$ at 8 weeks, p<0.042) and Spielberger State Anxiety Scale ($30.94{\pm}6.25$ at baseline, $28.83{\pm}6.23$ at 8 weeks, p<0.024). In the Korean Personality Inventory for Children, a significant reduction of score was found in the physical development scale ($56.44{\pm}9.63$ at baseline, $50.94{\pm}8.91$ at 8 weeks, p<0.017) and social dysfunction scale ($56.33{\pm}6.82$ at baseline, $51.94{\pm}7.13$ at 8 weeks, p<0.025). These results suggest that Korean red ginseng may be effective in improving inattentiveness in ADHD children, but it remains uncertain if it improves the general severity of ADHD, depression, anxiety personality and behavioral changes.

• 운동영양학회지
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• 제13권1호
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• pp.1-7
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• 2009

It has been shown that both caloric restriction and exercise, enhances glucose uptake through translocation of GLUT-4 protein. It remains unclear how exercise and caloric restriction affect the changes in VAMP (vesicle-associated membrane protein) in skeletal muscle and GLUT-2 in liver. This study investigated the effects of exercise training and caloric restriction on the expressions of glucose transport relating proteins in muscle and liver tissues in diabetic rats. Forty male Sprague-Dawley rats (250±10 g; 8 week in age) were assigned equally to four different groups; control (C), exercise only (E), dietary restriction only (D) and dietary restriction and exercise (DE). Daily food consumption was monitored to establish baseline intake. Both C and E groups consumed baseline food intake while D and DE groups were provided with only 60% of baseline total food intake. Forty-eight hours after intraperitoneal injection of STZ (50 mg/kg), diabetes was confirmed (8-hr fasting blood glucose levels ≥300 mg/dl). Rats in the E and DE groups exercised on a motorized treadmill for 30 min/d, 5 days/week for 4 weeks (5 min running at 3 m/min, 0% grade; 8 m/min for the next 5min, and then 15 m/min for 20 min). Rats were sacrificed 48 hrs after the last bout of exercise. Soleus muscle and liver were extracted to analyze for GLUT-4, VAMP-2, and GLUT-2, respectively. All variables were analyzed using the Western Blotting technique. All values were expressed as optical volume measured by optical density. A Two-way ANOVA was used to examine the difference between groups and applied Duncan's test for post-hoc. No significant differences in GLUT-2 expression were found among groups. However, E (280133±13228 arbitrary units{AU}) and DE (268833±14424 AU) groups showed significantly higher (p<.001) levels of GLUT-4 as compared with C (34461±2099 AU) and D groups (27847±703 AU). VAMP-2 protein expression increased (p<.001) in E (184137±7803 AU) and DE (189800±10856 AU) groups as compared to C (74201±8296AU) and D (72967±863 AU) groups. These results suggest that either exercise with or without caloric restriction increases the up-regulation of GLUT-4 and VAMP-2 in skeletal muscle of diabetic rats. However, GLUT-2 protein in liver was not affected by either exercise or exercise with caloric restriction.

• Clinical and Experimental Reproductive Medicine
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• 제26권2호
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• pp.179-183
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• 1999

This study was performed to determine the significance of a baseline ovarian cyst on the response to controlled ovarian hyperstimulation and the outcome of IVF-ET. One hundred one patients who underwent IVF-ET were enrolled in this study. The outcome of 31 patients, who had an ovarian cyst of >10mm detected at ultrasound examination performed on day 3, was compared with that of 70 patients who underwent a similar protocol and did not have an ovarian cyst. E2 level on the day of hCG administration, the number of follicles, the number of oocytes retrieved, the number of embryo transferred and the pregnancy rate were evaulated. The E2 level on the day of hCG adminstration and the number of mature oocytes retrieved were lower in the group with a baseline cyst. The pregnancy rate also was significantly lower in the group with a cyst (21% versus 38%). Therefore a baseline ovarian cyst on cycle day 3 was associated with a poorer outcome after IVF-ET.

• 한국군사과학기술학회지
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• 제9권2호
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• pp.60-69
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• 2006

The PMB(performance measurement baseline) is the total time-phased budget plan against which program performance is measured. Additionally it is the schedule for expenditure of the resources allocated to accomplish program scope and schedule objectives, and is formed by the budget assigned. In this paper, we suggest an improvement of the R & D(research and development) program for defense acquisition by using the PMB and an application of the IBR(integrated baseline review) to review the PMB for project manager of the defense agency.

• 한국전자파학회논문지
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• 제28권8호
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• pp.653-660
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• 2017

본 논문에서는 신호의 고각과 방위각을 추정하기 위한 위상비교 방식의 방향탐지 정확도에 대해 분석하였다. 안테나 4개를 균일 배치한 구조와 3개를 균일 배치한 구조의 고각과 방위각 추정에 대한 분석적 표현을 제시하였고, 방향탐지 오차를 분석하였다. 또한 정확도, 형상, 채널수 관점에서 두 구조를 비교하여 방향탐지 장치 설계에 대한 방향을 제시하였다. 방향탐지 분석결과는 시뮬레이션 결과와 유사한 분포를 나타내고, $1.2^{\circ}RMS$ 이내의 차이를 갖는 것을 확인하였다. 분석 결과로부터 SNR 20 dB, 베이스라인 길이가 반파장일 때, 안테나 4개를 균일 배치한 구조의 경우, 안테나 3개를 배치한 구조에 비해 고각 방향탐지 정확도는 1.15 배 높으며, 방위각 방향탐지 정확도는 서로 동일함을 확인하였다. 또한 2차원 방향탐지 구조는 1차원 방향탐지 구조에서 발생하는 코닝에러가 제거되는 것을 확인하였다.

• Journal of Periodontal and Implant Science
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• 제33권3호
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• pp.485-497
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• 2003

Grapefruit seed extract has been reported to have antimicrobial effect. The purpose of this study was to evaluate the antimicrobial and anti-gingivitis effect of chewing gum containing grapefruit seed extract and xylitol. 40 healthy subjects with gingivitis or early periodontitis were divided into two groups. Subjects in the experimental group chewed gum containing grapefruit seed extract and xylitol while subjects in the control group chewed gum containing only xylitol. All subjects received scaling and tooth brushing instruction. 1 week after scaling was set as baseline. Gingival index and plaque index were scored at baseline, 1 week, 2 week, 3 week and 4 week. Bleeding index, probing pocket depth and clinical attachment level were scored at baseline, 2 week and 4 week. The number of total bacteria and Streptococcus mutans in unstimulated saliva of experimental group were counted at 1 week, 2 week, 3 week and 4 week. Gingival indices of experimental group and control group at baseline, 1 week, 2 week, 3 week and 4 week were 0.850${\pm}$0.298, 0.575${\pm}$0.345, 0.533${\pm}$0.332, 0.459${\pm}$0.311, 0.408${\pm}$0.224 and 0.758${\pm}$0.379, 0.592${\pm}$0.276, 0.563${\pm}$0.281, 0.454${\pm}$0.194, 0.413${\pm}$0.199 (mean${\pm}$SD), respectively. Plaque indices of experimental group and control group at baseline, 1 week. 2 week, 3 week and 4 week were 0.497${\pm}$0.500, 0.375${\pm}$0.484, 0.332${\pm}$0.471, 0,286${\pm}$0.452, 0.210${\pm}$0.407 and 0.411${\pm}$0.492, 0.375${\pm}$0.484, 0.354${\pm}$0.479, 0.313${\pm}$0.463, 0.193${\pm}$0.395, respectively. Bleeding indices of experimental group and control group at baseline, 2 week and 4 week were 0.377${\pm}$0.177, 0.298${\pm}$0.152, 0.192${\pm}$0.108 and 0.383${\pm}$0.124, 0.318${\pm}$0.153, 0.225${\pm}$0.126, respectively. Probing pocket depth of experimental group and control group at baseline, 2 week and 4 week were 2.56${\pm}$1.00, 2.40${\pm}$0.65, 2.23${\pm}$0.64 and 2.45${\pm}$0.682.37${\pm}$0.57, 2.19${\pm}$0.57, respectively. Clinical attachment level of experimental group and control group at baseline, 2 week and 4 week were 2.58${\pm}$1.01, 2.43${\pm}$0.67, 2.26${\pm}$0.65 and 2.49${\pm}$0.70, 2.40${\pm}$0.59, 2.22${\pm}$0.62, respectively. The % of reduction of total bacteria in saliva of experimental group at 2 week, 3 week and 4 week were 46 ${\pm}$ 53%, 53 ${\pm}$ 5% and 69 ${\pm}$ 33%. The % of reduction of Streptococcus mutans count in saliva of experimental group at 2 week, 3 week and 4 week were 52${\pm}$69%, 88${\pm}$30% and 89${\pm}$17%. From these findings, it can be concluded that regular use of grapefruit seed extract /xylitol chewing gum may be effective to control and prevent gingivitis and may have caries-preventive effect.