• Archives of Pharmacal Research
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• v.23 no.3
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• pp.222-225
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• 2000

A series of conformationally controlled 2-PAM derivatives were prepared from 2-acetylpyridine and 2,3-pyrido[b]cycloalkenones in two steps and their reactivities towards parathion poisoned AChE were evaluated. The most planar 2,3-pyrido[b]cyclohexanone oxime methiodide showed an activity comparable to 2-PAM Implying E-syn is that the most active comformation of 2-PAM in the biological system.