• Applied Biological Chemistry
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• 제46권3호
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• pp.155-164
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• 2003

Biological Hammett Equation에 기초하여 Hansch-Fujita식으로 제안된 정량적인 구조 활성상관(QSAR) 기법 (Sung, Nack-Do (2002) Development of new agrochemicals by quantitative structure-activity relationship (QSAR) methodology. Kor. J. Pestic. Sci. 6: 166-174, 231-243 및 7: 1-11)에 따른 새로운 농약의 탐색과 개발에 관련하여 1990년도를 전후한 국내에서 이루어진 QSAR 기법중 주로 2D QSAR기법의 활용연구 현황에 대하여 조명하였다.

• 한국전자파학회논문지
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• 제17권8호
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• pp.725-731
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• 2006

Feedforward와 defected ground structure(DGS)를 이용한 새로운 주파수 체배기를 제안하였다. 제한된 주파수 체배기는 feedforward 구조에 의해 기본 주파수$(f_0)$가 제거되고, 아령 또는 나선형 모양의 DGS 구조에 의해 2차, 3차 또는 4차의 원하지 않는 고조파 성분들을 제거할 수 있었다. 결국 feedforward와 DGS 구조에 의해서 체배하고자 하는 성분을 제외한 나머지 고조파들이 제거되었다. 기본 주파수를 1 GHz로 하여 주파수 체배기를 설계하고, 측정하였다. 입력 전력을 0dBm으로 하였을 때 2체배기, 3체배기와 4체배기의 출력 전력은 각각 -2.59 dBm, -5.36 dBm과 -4.57 dBm이었다.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2004년도 추계학술대회 논문집
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• pp.382-387
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• 2004

As the increasing needs in the industrial filed, many studies for the 3D CAD system are carried out. There are two types of 3D CAD system. One is manifold modeler, the other is non-manifold modeler. In the manifold modeler only 3D objects can be modeled. In the non-manifold modeler 3D, 2D, 1D, and 0D objects can be modeled in a unified data structure. Recently there are many studies on the non-manifold modeler. Most of them are focused on finding unknown topological entities and representing all kinds of topological entities found. In this paper, efficient data structure is selected. The boundary information on a face and an edge is included in this data structure. The boundary information on a vertex is excluded considering the frequency of usage. Because the disk cycle information is not required in most case of modeling. It is compact. It stores essential non-manifold information such as loop cycle and radial cycle. A suitable Euler-Poincare equation is studied and selected. Using the efficient data structure and the selected Euler-Poincare equation, 18 basic Euler operators are implemented. Several 3D models are created using the implemented modeler. A non-manifold modeling can be carried out using the implemented 3D CAD system. The results of this paper could be used in the further studies such as an implementation of Boolean operators, and a translation of 2D CAD drawings to 3D models.

• 대한전자공학회논문지SD
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• 제45권1호
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• pp.56-63
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• 2008

본 논문에서는 WCDMA 통신용 송신기에 적용 가능한 12비트 1GS/s 전류구동 방식의 혼합형 DAC를 설계하였다. 제안된 DAC는 혼합형 구조로써 하위 4비트는 이진 가중치 구조, 중간비트와 상위비트는 4비트 온도계 디코더 구조로 12비트를 구성하였다. 제안된 DAC는 혼합형 구조에서 발생되는 지연시간에 따른 성능 저하를 개선하기 위해 지연시간보정 회로를 사용하였다. 지연시간보정 회로는 위상주파수 검출기, 전하펌프, 제어회로로 구성되어 이진 가중치 구조와 온도계 디코더 구조에서 발생하는 지연시간을 감소시킨다. 제안한 DAC는 CMOS $0.18{\mu}m$ 1-poly 6-metal n-well 공정을 사용하여 제작되었고 측정된 INL/DNL은 ${\pm}0.93LS/$ 0.62LSB 이하로 나타났다. 입력 주파수 1MHz에서 SFDR은 약 60dB로 측정되었고 SNDR은 51dB로 측정되었다. 단일 DAC의 전력소모는 46.2mW로 나타났다.

• 한국자기학회지
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• 제21권2호
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• pp.43-47
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• 2011

Fe-Al 계의 전이금속 화합물은 구조적 안정성과 자성에 대한 이견이 많은 것으로 알려져 있다. 본 연구에서는 B2, $L1_2$, 및 $D0_3$ 구조를 갖는 Fe-Al 계 화합물의 자성과 원자구조의 상관관계를 논의하기 위해 전전자 총퍼텐셜선형보강평면파(all-electron fullpotential linearized augmented plane wave; FLAPW) 방법을 이용하여 일반기울기 근사(generalized gradient approximation; GGA) 하에서 계산하였다. 고려한 모든 구조에서 강자성이 비자성에 비해 안정한 것으로 계산되었다. Fe 원자의 계산된 스핀 자기모멘트는 B2, $L1_2$ 구조에서 각각 0.771 ${\mu}_B$, 2.373 ${\mu}_B$의 값을 얻었고, $D0_3$ 구조의 Fe(I) 및 Fe(II) 원자들은 각각 2.409 ${\mu}_B$, 1.911 ${\mu}_B$로 계산 되었다. $Fe_3Al$의 같은 조성을 갖는 $L1_2$와 $D0_3$ 구조간의 안정성을 조사하기 위하여 형성 엔탈피 계산을 통해 강자성 상태에서 16 meV/atom의 에너지 차이로 $D0_3$ 구조가 $L1_2$ 구조보다 더 안정함을 확인하였다. 이 결과는 실험연구와 잘 일치하며, 원자구조와 전자구조의 분석을 통해 구조적 안정성과 자성에 대해 이해하였다.

• ETRI Journal
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• 제28권1호
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• pp.9-16
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• 2006

In this paper, we analyzed and measured the electrical crosstalk characteristics of a 1.25 Gbps triplexer module for Ethernet passive optical networks to realize fiber-tothe-home services. Electrical crosstalk characteristic of the 1.25 Gbps optical triplexer module on a resistive silicon substrate should be more serious than on a dielectric substrate. Consequently, using the finite element method, we analyze the electrical crosstalk phenomena and propose a silicon substrate structure with a dummy ground line that is the simplest low-crosstalk layout configuration in the 1.25 Gbps optical triplexer module. The triplexer module consists of a laser diode as a transmitter, a digital photodetector as a digital data receiver, and an analog photodetector as a cable television signal receiver. According to IEEE 802.3ah and ITU-T G.983.3, the digital receiver and analog receiver sensitivities have to meet -24 dBm at $BER=10^{-12}$ and -7.7 dBm at 44 dB SNR. The electrical crosstalk levels have to maintain less than -86 dB from DC to 3 GHz. From analysis and measurement results, the proposed silicon substrate structure that contains the dummy line with $100\;{\mu}m$ space from the signal lines and 4 mm separations among the devices satisfies the electrical crosstalk level compared to a simple structure. This proposed structure can be easily implemented with design convenience and greatly reduce the silicon substrate size by about 50 %.

• Korea Journal of Cosmetic Science
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• 제1권1호
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• pp.19-29
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• 2019

In this work, we fabricated liquid crystal (LC) emulsions with fatty alcohol in order to stabilize high content ceramide in cosmetic formulation. We investigated the role of fatty alcohol and surfactant in the formation of higher order structure. As a result, we found that they play a crucial role to form higher order structure. SAXS study shows that ceramide can be incorporated up to 3% in cosmetic formulation with higher order structure and its stability was maintained up to 12 weeks at room temperature. According to WAXS study, the higher order structure can suppress the re-crystallization of ceramide in cosmetic formulation. Finally, we performed in vivo skin barrier recovery test for the damaged skin. LC emulsions with ceramide and O/W emulsions show significant effect in skin barrier recovery at D 1, D 2 and D 6 compared to the untreated condition. While only LC emulsions show significant skin recovery effect at D 14. We expect that LC emulsions are the promising skin carrier to stabilize ceramide and LC emulsions with ceramide can improve the skin barrier function.

• Bulletin of the Korean Chemical Society
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• 제35권11호
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• pp.3267-3274
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• 2014

In order to investigate the effects of the double replacement of $\small{L}$-Pro, $\small{D}$-Pro, $\small{D}$-Leu or Nleu (the peptoid residue for Leu) in the hydrophobic face (positions 9 and 13) of amphipathic ${\alpha}$-helical non-cell-selective antimicrobial peptide $L_8K_9W_1$ on the structure, cell selectivity and mechanism of action, we synthesized a series of $L_8K_9W_1$ analogs with double replacement of $\small{L}$-Pro, $\small{D}$-Pro, $\small{D}$-Leu or Nleu in the hydrophobic face of $L_8K_9W_1$. In this study, we have confirmed that the double replacement of $\small{L}$-Pro, $\small{D}$-Pro, or Nleu in the hydrophobic face of $L_8K_9W_1$ let to a great increase in the selectivity toward bacterial cells and a complete destruction of ${\alpha}$-helical structure. Interestingly, $L_8K_9W_1$-$\small{L}$-Pro, $L_8K_9W_1$-$\small{D}$-Pro and $L_8K_9W_1$-Nleu preferentially interacted with negatively charged phospholipids, but unlike $L_8K_9W_1$ and $L_8K_9W_1$-$\small{D}$-Leu, they did not disrupt the integrity of lipid bilayers and depolarize the bacterial cytoplasmic membrane. These results suggested that the mode of action of $L_8K_9W_1$-$\small{L}$-Pro, $L_8K_9W_1$-$\small{D}$-Pro and $L_8K_9W_1$-Nleu involves the intracellular target other than the bacterial membrane. In particular, $L_8K_9W_1$-$\small{L}$-Pro, $L_8K_9W_1$-$\small{D}$-Pro and $L_8K_9W_1$-Nleu had powerful antimicrobial activity (MIC range, 1 to $4{\mu}M$) against methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Pseudomonas aeruginosa (MDRPA). Taken together, our results suggested that $L_8K_9W_1$-$\small{L}$-Pro, $L_8K_9W_1$-$\small{D}$-Pro and $L_8K_9W_1$-Nleu with great cell selectivity may be promising candidates for novel therapeutic agents, complementing conventional antibiotic therapies to combat pathogenic microorganisms.

• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.2917-2924
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• 2012

Four novel metal-organic complexes $[Cd_2(IP)_2(TBZ)_2(H_2O)_2]{\cdot}(H_2O)$ (1), $[Zn_4(IP)_4(TBZ)_4]{\cdot}2(H_2O)$ (2), $[Zn_2(BTC)(TBZ)_2(CO_2H)]$ (3), [Co(PDC)(TBZ)] (4) (where IP = isophthalate; TBZ = thiabendazole; BTC = 1,3,5-benzenetricarboxylate; PDC = pyridine-3,4-dicarboxylate) have been prepared and characterized by IR spectrum, elemental analysis, thermogravimetric analysis, and single-crystal X-ray diffraction. X-ray structure analysis reveals that 1, 2, and 3 are one-dimensional chain polymers, while 4 is a two-dimensional network polymer. The TBZ acts as a typical chelating ligand coordinated to the metal center in all complexes. The 1D chain architecture of 1 is constructed from isophthalates and cadmium atoms. A simultaneous presence of chelating, monodentate and bidentate coordination modes of IP ligands is observed in complex 2. In complex 3, the 16-membered rings are alternately arranged forming an infinite 1D double-chain structure. The 2D skeleton of 4 is formed by cobalt ions as nodes and PDC dianions as spacers, through coordination bonds. The hydrogen bonds and ${\pi}-{\pi}$ stacking play important roles in affecting the final structure where complexes 1 and 3 have 2D supramolecular networks, while complexes 2 and 4 have 3D supramolecular architectures.

• Bulletin of the Korean Chemical Society
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• 제31권6호
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• pp.1743-1746
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• 2010