• Journal of Biomedical Engineering Research
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• v.34 no.2
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• pp.63-68
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• 2013

Activeness of exercise is critical for stroke rehabilitation so that application of stimulation in response to patient's intention would be effective in FES cycling. The purpose of this study was to investigate the relationship between muscle reaction force (MRF) and electromyogram (EMG) during cycling exercise, for the future usage of MRF as patients' intention signal. Seven young men ($24{\pm}1.63$ yrs) participated in this study. Cycling speed was set to 20 RPM and 60 RPM. MRF and EMG were measured in the vastus lateralis muscle of right leg. Active cycling was performed at the maximal load (16 Nm) of an ergometer. Angle dependent artifact in MRF was measured from passive cycling and was subtracted from the MRF of active cycling. The delay of MRF with respect to EMG envelope and their correlation coefficients were derived from the best of cross correlation. MRF was significantly correlated with EMG amplitude in all subjects (p<0.01). Their mean correlations were 0.84 and 0.91 for 20 RPM and 60 RPM, respectively. Mean delay in MRF was 59.14 ms and 53.14 ms for 20 RPM and 60 RPM, respectively. The result suggests that MRF can be used to assess patient's intention for exercise as a substitute to EMG. The method may be applied to FES cycling to encourage patient's effort which is critical for stroke rehabilitation.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.6
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• pp.615-620
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• 2013

There is considerable interest in developing energy sources capable of larger power densities. In our previous works, we proved that by coupling an exothermic chemical reaction with 1D nanostructures, a self-propagating reactive wave can be driven along its length with a concomitant electrical pulse of high specific power, which we identified as a thermopower wave. Herein, we discuss details about many different aspects of a thermopower wave. Different alignment degree in vertically aligned CNT films is evaluated in the reactive wave speed and correlated with its thermal reaction that affects the change in the magnitude of energy generation. The effects of the temperature-dependent properties of chemical fuels and CNTs are evaluated. Furthermore, we explore the convection and radiation portions in this thermal wave as well as the synchronization between the thermal reaction transfer and the oscillation of the electrical signal.

• Molecular & Cellular Toxicology
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• v.1 no.4
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• pp.248-255
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• 2005

To understand the response of cancer cells to anticancer drugs at the gene expression level, we examined the gene expression changes in response to five anticancer drugs, 5-fluorouracil, cytarabine, cisplatin, paclitaxel, and cytochalasin D in NCI-H460 human lung cancer cells. Of the five drugs, 5-fluorouracil had the most distinctive gene expression signature. By clustering genes whose expression changed significantly, we identified three clusters with unique gene expression patterns. The first cluster reflected the up-regulation of gene expression by cisplatin, and included genes involved in cell death and DNA repair. The second cluster pointed to a general reduction of gene expression by most of the anticancer drugs tested. A number of genes in this cluster are involved in signal transduction that is important for communication between cells and reception of extracellular signals. The last cluster represented reduced gene expression in response to 5-fluorouracil, the genes involved being implicated in DNA metabolism, the cell cycle, and RNA processing. Since the gene expression signature of 5-fluorouracil was unique, we investigated it in more detail. Significance analysis of microarray data (SAM) identified 808 genes whose expression was significantly altered by 5-fluorouracil. Among the up-regulated genes, those affecting apoptosis were the most noteworthy. The down-regulated genes were mainly associated with transcription-and translation-related processes which are known targets of 5-fluorouracil. These results suggest that the gene expression signature of an anticancer drug is closely related to its physiological action and the response of caner cells.

• Journal of Internet Computing and Services
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• v.12 no.1
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• pp.27-38
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• 2011

In this paper, we propose a multiple access scheme using MHP(Modified Hermite Polynomial) pulse and ternary code for high-data and low-data rate for Out-body WBAN(Wireless Body Area Network). To satisfy the requirement of WBAN system, UWB-IR has been considered as a promising candidate for Out-body WBAN. The proposed multiple access scheme, using orthogonal MHP pulse and ternary code sets, reduces multi-user interference and distinguishes user signal from multi-user signals. We propose two algorithms for synchronous and asynchronous WBAN system. The symbol is constructed by MHP pulses and time hopping duration to reduce multi-user interference in the synchronous WBAN system. The symbol also is constructed by ternary code to avoid collision between pulse trains in the asynchronous WBAN system. The results of the proposed multiple access scheme show a clear improvement of BER.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.6B
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• pp.579-585
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• 2002

The investigation into the effect of various feedback errors on system performance can help the robust feedback channel design and transmission of exact feedback channel information as well. In this paper, we address the algorithm that determines space combining weight vector maximizing received signal power at mobile on frequency flat fading channel and investigate the performance degradation by feedback channel delay in the FDD/CDMA systems employing transmit beamforming. We observe the effect of feedback channel delay corresponding to the number of transmit antennas and the temporal/spatial correlation of channel. The results show that performance is more sensitive to feedback delay with the larger number of antennas when fadings at transmit antennas are not spatially correlated.

• Proceedings of the KIEE Conference
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• 2001.11b
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• pp.216-218
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• 2001

The transformer role is very important in power system operation and control; also its price is very expensive. Therefore many kinds of the efforts for transformer protection have been executed. So for as, current differential relay(87) has been mainly used for transformer protection. But current differential relaying method has several troubles as followings. Differential current can be occurred by transformers inrush current between winding1 and winding2 of transformer when transformer is initially energized. Also harmonic restrained element used in current differential relaying method is one of the causes of relays mal-operation because recently harmonics in power system gradually increase by power switching devices(SVC, FACTS, DSC, etc). Therefore many kinds of effort have been executed to solve the trouble of current differential relay and one of them is method using ratio of increment of flux linkages(RIFL) of the primary and secondary windings. This paper introduces a novel protective relay for power transformers using RIFL of the primary and secondary windings. Novel protective relay successfully discriminates between transformer internal faults and normal operation conditions including inrush and this paper includes real time test results using RTDS(Real Time Digital Simulator) for novel protective relay. A novel protective relay was designed using the TMS320C32 digital signal processor and consisted of DSP module. A/D converter module, DI/DO module, MMI interface module and LCD display module and developed by Xelpower co., Ltd.

• Steel and Composite Structures
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• v.19 no.6
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• pp.1549-1560
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• 2015

This paper presents the characterization of fatigue crack in the A283 Grade C steel using the MMM method by identifying the effects of magnetic flux leakage towards the crack growth rate, da/dN, and crack length. The previous and current research on the relation between MMM parameters and fatigue crack effect is still unclear and requires specific analysis to validate that. This method is considered to be a passive magnetic method among other Non-Destructive Testing (NDT) methods. The tension-tension fatigue test was conducted with a testing frequency of 10 Hz with 4 kN loaded, meanwhile the MMM response signals were captured using a MMM instrument. A correlation between the crack growth rate and magnetic flux leakage produces a sigmoid shape curve with a constant values which present the gradient, m value is in the ranges of 1.4357 to 4.0506, and the y-intercept, log C in the ranges of $4{\times}10^{-7}$ to 0.0303. Moreover, a linear relation was obtained between the crack length and magnetic flux leakage which present the R-Squared values is at 0.830 to 0.978. Therefore, MMM method has their own capability to investigate and characterize the fatigue crack effects as a main source of fracture mechanism for ferrous-based materials.

• Bulletin of the Korean Chemical Society
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• v.30 no.10
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• pp.2387-2392
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• 2009

A composite film of multi-walled carbon nanotube (MWCNT)/sol-gel-derived zinc oxide(ZnO)/Nafion has been utilized as an efficient immobilization matrix for the construction of a highly sensitive and stable tris(2,2'-bipyridyl) ruthenium(II) (Ru(${bpy)_3}^{2+})$ electrogenerated chemiluminescence (ECL) sensor. The electrochemical and ECL behaviors of Ru(${bpy)_3}^{2+})$ ion-exchanged into the composite film were strongly dependent upon the sol-gel preparation condition, the amount of MWCNT incorporated into the ZnO/Nafion composite film, and the buffer solution pH. The synergistic effect of MWCNTs and ZnO in the composite films increased not only the sensitivity but also the long-term stability of the ECL sensor. The present ECL sensor based on the MWCNT/ZnO/Nafion gave a linear response ($R^2$ = 0.999) for tripropylamine concentration from 500 nM to 1.0 mM with a remarkable detection limit (S/N = 3) of 15 nM. The present ECL sensor showed outstanding long-term stability (94% initial signal retained for 5 weeks). Since the present ECL sensor exhibits large response towards NADH, it could be applied as a transduction platform for the ECL biosensor in which the NADH is produced from the dehydrogenase-based enzymatic reaction in the presence of NA$D^+$ cofactor.

• Korean Journal of Medicinal Crop Science
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• v.18 no.1
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• pp.15-21
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• 2010

This study was conducted to investigate the effects of Lycii fructus and Astragalus membranaceus mixed extracts on immunomodulators and prevention in a streptozotocin-induced diabetes rat model. A total of 28 male rats were divided into four dietary groups and fed a commercial diet (A), commercial diet plus induced diabetes by a streptozotocin (STZ) injection (B), induced diabetes by STZ plus medicinal crop extracts(I&$H^{(R)}$) diet (C), and medicinal crop extracts (I&$H^{(R)}$) diet (D). Immunoblotting analyses revealed cytokine expression, and ELISA analyses revealed immunoglobulin E and nitric oxide production. As a results, the tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and inducible nitric oxide synthase (iNOS) as a inflammatory cytokine were decreased. Interleukin-6 (IL-6) and signal transducer and activation of transcription 3 (STAT3) cytokine related in diabetes expression through JAK/STAT3 pathway were also decreased. Furthermore, immunoglobulin E and nitric oxide production were decreased in the serum and lens, respectively. These results suggest that Lycii fructus and Astragalus membranaceus mixed extracts provide positive effects on immunomodulators and prevention in diabetes and eye disease complications.

• IMMUNE NETWORK
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• v.11 no.4
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• pp.216-222
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• 2011

Background: The ligand for CD137 (CD137L; also called 4-1BBL) is mainly expressed on activated APCs such as dendritic cells, B cells and macrophages. Even though CD137L functions as a trigger of the CD137 signaling pathway for T cell activation and expansion, engagement of CD137L can deliver a signal leading to the production of proinflammatory cytokines in macrophages. Methods: We generated cell-permeable TAT-CD137L cytoplasmic domain fusion protein (TAT-CD137Lct) and examined its ability to initiate the CD137L reverse signaling pathway. Results: Treatment of TAT-CD137Lct induced the production of high levels of IL-6 and TNF-${\alpha}$ mRNAs and proteins in peritoneal macrophages. TAT-CD137Lct increased phosphorylation of Erk, p38 MAPK and Jnk, and activated transcription factors C/EBP and CREB. However, TAT-CD137Lct did not visibly affect the degradation of the inhibitor of NF-${\kappa}B$ ($IkB{\alpha}$). We further demonstrated that JNK activation was required for TAT-CD137Lct-induced production of TNF-${\alpha}$, while activation of Erk and p38 MAPK were involved in IL-6 and TNF-${\alpha}$ production. Conclusion: Our results suggest that TATCD137Lct is an effective activator for the CD137L reverse signaling pathway.