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Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma

  • Nakajima, Hiroshi;Hirose, Koichi
    • IMMUNE NETWORK
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    • v.10 no.1
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    • pp.1-4
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    • 2010

  • Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing $CD4^+$ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells, are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.

  • https://doi.org/10.4110/in.2010.10.1.1 인용 PDF KSCI

Interleukin 17-expressing Innate Synovial Cells Drive K/BxN Serum-induced Arthritis

  • Cho, Wang Sik
    • Proceedings of the Korea Contents Association Conference
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    • 2018.05a
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    • pp.551-552
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    • 2018

  • K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of serum-induced arthritis, we injected wild-type and $IL-17^{-/-}$ mice with K/BxN serum and evaluated them for signs of arthritis. Unlike wild-type mice, $IL-17^{-/-}$ mice did not show any signs of arthritis. IL-17 was produced predominantly by $CD3^-CD4^-gdTCR^-NK1.1^-Sca1^{int}Thy1^{hi}$ cells residing in the inflamed synovial tissue. When synovial cells extracted from normal joints were stimulated with IL-23 or autoantibody-containing immune complexes, a substantial fraction of $Sca1^{int}Thy1^{hi}$ cells produced IL-17. Thus, we have identified a novel population of IL-17-producing innate synovial cells that play a crucial role in the development of K/BxN serum-induced arthritis.

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ITU-T SG17 보안구조 및 네트워크 보안 국제표준화 동향

  • Heung-Ryong Oh;Heung Youl Youm
    • Review of KIISC
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    • v.34 no.4
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    • pp.17-21
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    • 2024

  • ITU-T SG17 국제표준화기구는 정보통신(Telecommunication) 관점에서 정보보호 표준들을 개발하고 있는 UN 산하 국제표준화기구이다. SG17 산하에 12개의 연구과제(Question)가 존재하고 있으며, 각 연구범위에서 국제표준을 개발 및 연구하고 있다. 이 중에 연구과제 2(Question 2, Q2/17)는 보안구조 및 네크워크 보안 주제를 다루고 있으며, 5G 보안(IMT-2020) 국제표준을 주도적으로 개발하고 있다[1]. 본 논문에서는 최근 SG17 국제회의를 통해 Q2/17에서 네트워크 보안 관련 새롭게 개발된 국제표준과 현재 개발 중에 있는 국제표준화 동향에 대해 살펴보고자 한다.

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Interpretation of screening for congenital adrenal hyperplasia in preterm infants (미숙아에서의 선천 부신 과형성에 대한 선별검사의 해석)

  • Chung, Hye Rim;Shin, Choong Ho;Yang, Sei Won;Yun, Kyong Ah;Lee, Young Ah;Park, So Eun;Choi, Chang Won;Kim, Byung Il;Choi, Jung Hwan;Song, and Junghan
    • Clinical and Experimental Pediatrics
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    • v.51 no.6
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    • pp.616-621
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    • 2008

  • Purpose : This study was undertaken to identify factors that influence 17-OHP levels in preterm infants and to suggest a reasonable follow-up schedule of screening for congenital adrenal hyperplasia (CAH) in preterm infants. Methods : The 17-OHP concentrations in filter paper blood spots of 427 preterm infants were obtained. The effects of gestational age (GA), systemic diseases, and antenatal dexamethasone on screening and follow-up 17-OHP values were investigated. Results : The screening 17-OHP values were markedly variable (range: 0.1-143.3 ng/mL). The screening 17-OHP levels were negatively correlated with GA (r=-0.535, P<0.01). In infants with GA<32 weeks, the screening 17-OHP levels were significantly higher in sick infants or infant with hypotension than in healthy infants. The screening values of prenatal dexamethasone-treated infants had a tendency to be low. In infants with initial 17-OHP values ${\geq}20ng/mL$, the intervals until rescreening 17-OHP <10 ng/mL or serum 17-OHP <20 ng/mL were negatively correlated with GA (r=-0.541, P<0.01) and were prolonged in infants with bronchopulmonary dysplasia (P<0.01). None of the preterm infants were confirmatively diagnosed with CAH. Conclusion : The 17-OHP values of preterm infants were influenced by GA, prenatal dexamethasone, and postnatal diseases. Because the 17-OHP values of preterm infants were markedly variable, a follow-up schedule should be developed considering both 17-OHP values and clinical status.

  • https://doi.org/10.3345/kjp.2008.51.6.616 인용 PDF KSCI