• Clinical and Experimental Pediatrics
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• v.53 no.2
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• pp.215-221
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• 2010

Purpose : Interleukin-17 (IL-17) is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA nephropathy (IgAN). Our aim was to investigate the association between single-nucleotide polymorphisms (SNPs) in IL-17 receptor A (IL-17RA) gene and childhood IgAN. Methods : We analyzed the SNPs in the IL-17RA in 156 children with biopsy-proven IgAN and 245 healthy controls. We divided the IgAN patients into 2 groups and compared them with respect to proteinuria (${\leq}4$ and >$4mg/m^2/h$, ${\leq}40$ and >$40mg/m^2/h$, respectively) and the presence of pathological levels of biomarkers of diseases such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : No difference was observed between the SNP genotypes rs2895332, rs1468488, and rs4819553 between IgAN patients and control subjects. In addition, no significant difference was observed between allele frequency of SNPs rs2895 332, rs1468488, and rs4819553 between patients in the early and advanced stage of the disease. However, significant difference was observed between the genotype of SNP rs2895332 between patients with proteinuria (>$4mg/m^2/h$) and those without proteinuria (codominant model OR 0.36, 95% CI 0.19-.66, P <0.001; dominant model OR 0.35, 95% CI 0.17-.69 P =0.002; recessive model OR 0.12, 95% CI 0.01-.06 P =0.025). Conclusion : Our results indicate that the SNP in IL-17RA (rs2895332) may be related to the development of proteinuria in IgAN patients.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.6
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• pp.317-322
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• 2016

While PFOS sodium salt ($C_8F_{17}SO_3Na$) was not degraded by microorganisms for 28 days, the 4 alternatives were biodegraded at the rates of 21.6% for $C_{25}F_{17}H_{32}S_3O_{13}Na_3$, 20.5% for $C_{15}F_9H_{21}S_2O_8Na_2$, 15.8% for $C_{23}F_{18}H_{28}S_2O_8Na_2$ and 6.4% for $C_{17}F_9H_{25}S_2O_8Na_2$, respectively. The acute toxicity test using Daphnia magna was conducted for 48 hours, the half effective concentration ($EC_{50}$) of PFOS sodium salt ($C_8F_{17}SO_3Na$) was evaluated in 54.5 mg/L. While the 4 alternatives did not show any effect at 500.0 mg/L. The surface tension of the PFOS salt ($C_8F_{17}SO_3Na$) is 46.2 mN/m at a concentration of 500.0 mg/L. While the surface tension of the 4 alternatives was found to be superior to PFOS sodium salt ($C_8F_{17}SO_3Na$). The surface tension of $C_{23}F_{18}H_{28}S_2O_8Na_2$ (20.9 mN/m) has the lowest, followed by $C_{15}F_9H_{21}S_2O_8Na_2$ (23.4 mN/m), $C_{17}F_9H_{25}S_2O_8Na_2$ (27.3 mN/m), $C_{25}F_{17}H_{32}S_3O_{13}Na_3$ (28.2 mN/m). The four kinds of alternatives ($C_{15}F_9H_{21}S_2O_8Na_2$, $C_{17}F_9H_{25}S_2O_8Na_2$, $C_{23}F_{18}H_{28}S_2O_8Na_2$, $C_{25}F_{17}H_{32}S_3O_{13}Na_3$) were found to be superior to PFOS sodium salt ($C_8F_{17}SO_3Na$) in terms of biodegradation, Daphnia sp. acute toxicity and surface tension, and thus they were considered applicable as PFOS alternatives. Especially biodegradation rate of $C_{15}F_9H_{21}S_2O_8Na_2$, $C_{23}F_{18}H_{28}S_2O_8Na_2$ and $C_{25}F_{17}H_{32}S_3O_{13}Na_3$ was relatively high as 15.8~21.6%, and Daphnia sp. acute toxicity and surface tension were considerably superior (surface tension 39~55%) to PFOS sodium salt. Therefore, these alternatives are considered to be available as an alternative of PFOS.

• Monthly Korean Chicken
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• v.23 no.17 s.83
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• pp.17-21
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• 2002

• 비료회보
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• v.13 no.17 s.361
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• pp.11-17
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• 1988

• 발명특허
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• v.19 no.12 s.226
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• pp.17-17
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• 1994

• 발명특허
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• v.18 no.11 s.213
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• pp.17-17
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• 1993

• Journal of Life Science
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• v.28 no.9
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• pp.1042-1047
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• 2018

The red algae Gracilaria vermiculophylla is widespread on seashores worldwide and has been used as food in Asian countries. Previous studies have reported that extracts of Gracilaria red algae have beneficial anti-oxidant and anti-inflammatory effects. The present study examined the anti-senescence effects of Gracilaria vermiculophylla extracts (GV-Ex) in replicatively senescent human bone marrow mesenchymal stem cells (hBM-MSCs). GV-Ex pretreatment improved the cellular viability of hBM-MSCs that had been injured by oxidative stress. These effects of GV-Ex were confirmed by MTT assay and immunoblot analysis using the apoptotic proteins p53 and cleaved caspase-3. The reactive oxygen species (ROS) levels were examined in long-term cultured Passages 17 (P-17) mesenchymal stem cells (MSC) and compared to P-7 MSC. The ROS accumulation was greater in the P-17 than in the P-7. However, these increased ROS levels in the P-17 were decreased significantly after treatment with GV-Ex, and restoration of the levels of the anti-oxidant enzymes SOD1, SOD2, and CAT was also observed under these conditions. In addition, P-17 hBM-MSC treated with GV-Ex had decreased levels of the senescence proteins p53, p21, and p16. The results show that the ability of P-17 hBM-MSC to differentiate into osteocytes and adipocytes was improved by GV-Ex treatment, suggesting that GV-Ex ameliorates the functional decline of senescent stem cells.

• Nuclear Engineering and Technology
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• v.26 no.1
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• pp.119-125
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• 1994

Transient power level of the fuel rod is one of the key parameters for the transient fuel behavior. Through the analysis of the fuel performance data bases and sensitivity analyses of such parameters as rod power history, fast neutron flux, fuel enrichment and cycle length, which can affect the transient fuel behavior, a methodology generally applicable to find the allowable transient power level during the ANS Conditions I and II below which the mechanical integrity of the fuel rod is maintained was derived, and allowable transient power levels for the 17$\times$17 KOFA fuel rod have been determined as a function of the burnup. With the introduction of this methodology, design analysis of the transient fuel behavior currently being calculated every cycle can be replaced by the simple check of the peak transient power level achievable during the cycle, and an operational flexibility of the reactor can be obtained by allowing higher transient power level up to 689.5 w/cm at low burnup range than current maximum allowable transient power level, 591 w/cm for the 17$\times$17 KOFA fuel.

• Reproductive and Developmental Biology
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• v.35 no.3
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• pp.307-311
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• 2011

Heat shock protein 90 (Hsp90) is ATPase-directed molecular chaperon and affects survival of several cells. In our previous study, inhibitory effect of Hsp90 by inducing cell cycle arrest and apoptosis in the pig embryonic and primary cells was reported. However, its role during early bovine embryonic development is not sufficient. In this study, we traced the effects of Hsp90 inhibitor, 17-allylamino-17-demethoxygeldanamycin (17-AAG), on early bovine embryonic development. We also investigated several indicators of developmental potential, including structural integrity, gene expression (apoptosis-related genes), and apoptosis, which are affected by 17-AAG. Bovine embryos were cultured in the CR1-aa medium with or without 17-AAG for 7 days. In result, significant differences in developmental potential were detected between the embryos that were cultured with or without 17-AAG ($33.1{\pm}9.6$ vs $21.7{\pm}8.3%$). The structural integrity of the blastocysts was examined by differential staining. Blastocysts from the dbcAMP-treated group had higher numbers of ICM, TE, and total cells than those from the untreated group. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) showed that the number of containing fragmented DNA at the blastocyst stage increased in the 17-AAG treated group compared with control (11.2 vs 3.9, respectively). Blastocysts that developed in the 17-AAG treated group had low structural integrity and high apoptotic nuclei than those of the untreated control, resulting in decrease the embryonic qualities of preimplantation bovine blastocysts. The mRNA expression of the pro-apoptotic gene (Bax) increased in 17-AAG treated group, whereas expression of the antiapoptotic gene (Bcl-XL) decreased. In conclusion, Hsp90 also appears to play a direct role in bovine early embryo developmental competence including structural integrity of blastocysts. Also, these results indicate that Hsp90 is closely associated with apoptosis-related genes expression in developing bovine embryos.

• The Research Journal of the Costume Culture
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• v.2 no.2
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• pp.395-413
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• 1994

Costume is mirror of diverse life styles and attitudes in human life. It has a meaning beyond "clothing" . Fashion illlustration is to express these costumes with a picture. So, it can be said that it is a ′mirror of costumes′ in historical side. The purpose of this study is to find the meaning of fashion illustration of 17th century, which called its first one and to look into its characteristics and costumes of 17th century respotlighting fashion illustrators and painters related with fashion illustration in those days. This study is based on Western Europe by literatures. The fashion illustration in 17th century designed by painters and fashion illustrators. They are Wenceslaus Hollar, Abraham Bosse, Jacques Callot, Jean de st Jean, N. Bonar, A. Trouvain, A. Arnoult in France and so on. The characteristics of fashion illustration in 17th century are as follows : 1. There was a quickening of modern civil consciousness in 17th century. As the subject of costume culture moved from noble class to the working class which began to have a free, the fashion illustration changed to the direction of informing their social class and job. 2. The fashion illustrations of 17th century showed storng realism which was a base of modern picture. 3. The most of them showed costume plates. It was not to transmit adding intended forecast but to describe sincerely in costumes′ record. However, the fashion illustration since the middle of 17th century was designed considering fashion. 4. It could be said that the fashion illustration of 17th century was the forest one of today. It was expressed by Wenceslaus Hollar′s ones. And it is found in his suggestion of popular costumes before and behind and delicate description like accessories. 5. They were transmitted by fashion magazines internationally. Le Mercure Galant, which printed mode plates in 1678, was the first modern fashion magazine aiming at general readers. The fashion illustration of 17th century can divide into ones for court, for working classes, costume plates. The fashion illustrations for court designed by court painters. There were court costumes of early time, spanish Mode and of lately time, French Court Culture. They had baroque elements with a bunddle of ribbons and race decoration. On the other hand, the fashion iooustrations for working class were under the influence on Netherlands styles. They were designed for the purpose of god function and much use. That′s why was under the influence of puritanical life creed. In this situation, the costume plates directed the fashion in those days. At that time, they were supplied widely and it amy be an attempt of popularization. The fashion illustrations of 17th century appeared that they had transmissible character and artistics expression. On the basis of them, we can look into the fashion illustrations of today.