• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.9C
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• pp.817-824
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• 2006

The crest factor properties of 16-QAM modulated one- and two-code assisted multi-carrier code-division multiple-access (MC-CDMA) signals employing complementary pair as spreading sequences are characterized. It is shown that a set of relationship between the two 16-QAM symbols entirely characterize the power envelope waveforms of the signals. There exists 60 different sets of relationship, which results in 16 different crest factors as a result of various equivalent transforms on the corresponding message symbols. It is also shown that the individual crest factor corresponding to each message combination is always bounded by 3dB.

• BMB Reports
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• v.32 no.5
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• pp.456-460
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• 1999

The promoter of the HSV-1 VP16 gene contains binding sites for the cellular transcription factors such as USF, CTF, and Sp1, each of which affects basal level expression of the VP16 gene. Transcription of the VP16 gene was induced by viral immediate-early proteins, ICP0 and ICP4, in a synergistic manner but repressed by ICP22. To gain further insight into the role of ICP0 in the expression of the VP16 gene during virus infection, several mutants with deletions in each of their transcriptional regulatory elements were generated. According to transient gene expression assays of these mutants using the CAT gene as a reporter, the USF and CTF binding sites were necessary for efficient induction of the promoter in the presence of transfected ICP0 or during virus infection, whereas the Sp1 binding site had little effect on ICP0-mediated VP16 expression. These results indicate that the immediate early proteins of HSV-1 regulate expression of the VP16 gene during virus infection by modulating the activities of cellular transcription factors such as USF and CTF.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1803-1806
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• 2007

The General roles of a spacer grid(SG) are providing a lateral and vertical support for fuel rods, promoting a mixing of coolant and keeping guide tubes straight so as not to impede a control rod insertion under any normal or accidental conditions. To evaluate the impact characteristics of a SG such as impact velocity, critical buckling strength and duration time, a few types of impact tests for SGs have been conducted. In a previous study, a new welding method, a through-welding method, was proposed to increase critical buckling strength of a SG without any design change or material change and was verified by impact tests with $7{\times}7$ partial SG specimens.In this paper, the effect of through-welding method in case of a $16{\times}16$ full-size SG is investigated by pendulum impact tests with $16{\times}16$ SG specimens. And the increase of critical buckling strength for full-size SGs is measured by comparison with impact results of spot-welded and through-welded SGs.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2011.07a
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• pp.348-351
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• 2011

가변적인 블록을 이용하는 H.264/AVC 인터 화면에서의 모드 결정 방법은 $16{\times}16$부터 $P8{\times}8$ 모드까지 인터 모드에 대해 비트율 왜곡값을 계산 한 뒤 공간적 상관도를 고려하기 위해 인트라 $4{\times}4$와 인트라 $16{\times}16$ 모드까지 비트율 왜곡값을 계산하고, 계산된 비트율 왜곡값 중 가장 작은 값을 갖는 모드를 최종 모드로 선택한다. 하지만 이러한 과정으로 부호기의 복잡도는 증가한다. 복잡도를 감소시키기 위해 본 논문에서는 IPPP구조에서의 인터 모드와 인트라 모드의 특징을 이용하여 고속 부호화를 제안한다. 제안하는 알고리즘은 인터 모드에 대해서 최적 모드를 결정하기 위한 비트율 왜곡값의 상관도와 시간 상관도를 이용하고, 인트라 모드에 대해서는 인트라 화면 내에서의 각 인트라 모드에 대한 최대 최소 임계값을 이용하여, 발생확률이 낮은 인터와 인트라 모드의 활성화 여부를 결정한다. 본 알고리즘의 적용 범위는 상대적으로 인터 화면에서 발생 빈도가 낮은 $16{\times}8$, $8{\times}16$, $P8{\times}8$와, 인트라 $4{\times}4$, 인트라 $16{\times}16$ 모드이다. 제안하는 알고리즘은 기존의 H.264/AVC에 비해 1.36% 비트가 증가 했고, PSNR은 0.06dB 감소했다. 즉, 부호화 효율의 큰 감소 없이 평균 42.58%의 부호화 시간을 감소시켰다.

• Clinical and Experimental Reproductive Medicine
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• v.41 no.3
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• pp.120-124
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• 2014

Objective: The aim of the present study was to examine whether interactions between polymorphisms in the thyroglobulin and ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) genes are associated with the development of premature ovarian failure (POF). Methods: A total of 75 patients with POF and 196 controls were involved in this study. We used a GoldenGate assay to genotype single nucleotide polymorphisms (SNPs). Logistic regression analysis was performed to identify POF-associated polymorphisms and synergistic interactions between polymorphisms in the thyroglobulin and ADAMTS16 genes. Results: Single gene analyses using logistic regression analysis showed no significant association between polymorphisms in the two genes and POF. In the results from interaction analyses, we found seven synergistic interactions between the polymorphisms in thyroglobulin and ADAMTS16, although there was no combination showing p-values lower than the significant threshold using the Bonferroni correction. When the AG genotype was present at the rs853326 missense SNP, the A and G alleles at the tagging SNPs rs16875268 and rs13168665 showed significant interactions (odds ratios=5.318 and 16.2 respectively; 95% confidence intervals, 1.64-17.28 and 2.08-126.4; p=0.0054 and 0.0079). Conclusion: Synergistic interactions between polymorphisms in the thyroglobulin and ADAMTS16 genes were associated with an increased risk of POF development in Korean women.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6193-6200
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• 2015

Head and neck cancer, including oral cancer, is the sixth most common cancer in humans worldwide. More than 90% of oral cancers are of squamous cell carcinoma type. Recent studies have shown a strong relationship between human papillomavirus (HPV) infection and head and neck cancer, especially oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC). Moreover, the incidence of HPV-related OSCC appears to be on the rise while HPV-unrelated OSCC tends to have stabilized in the past decades. p16, a tumor suppressor gene, normally functions as a regulator of the cell cycle. Upon infection with high-risk types of HPV (HR-HPV), particularly types 16, 18, 31, 33, 34, 35, 39, 51, 52, 56, 58, 59, 66, 68, and 70, the expression of p16 is aberrantly overexpressed. Therefore, the expression of p16 is widely used as a surrogate marker for HPV infection in head and neck cancer.

• BMB Reports
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• v.31 no.1
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• pp.48-52
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• 1998

$p16^{INK4}$, which is a 16-kDa polypeptide protein, inhibits the catalytic activity of the CDK4-cyclinD complex to suppress rumor growth. Both unlabeled and isotope-labeled human tumor suppressor $p16^{INK4}$ protein were overexpressed and purified to characterize biochemical and structural properties. The purified p16 binds to monomeric GST-CDK4 and exists in a monomer conformation for several weeks at $4^{\circ}C$. The circular dichroism (CD) data indicates that p16 contains high percentage of ${\alpha}$-helix and that the helix percentage maximized at pH value of 7.0. One-and two-dimensional nuclear magnetic resonance (NMR) data suggest that purified p16 from our construct has a unique folded conformation under our experimental conditions and exhibits quite stable conformational characteristics.

• BMB Reports
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• v.41 no.2
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• pp.132-138
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• 2008

AtbZIP16 and AtbZIP68 are two putative G group bZIP transcription factors in Arabidopsis thaliana, the other three members of G group bZIPs are GBF1-3 which can bind G-box. Members of G group have conservative protein structure: highly homological basic region and a proline-rich domain in the N-terminal region. Here, we report that AtbZIP16 and AtbZIP68 could bind cis elements with ACGT core, such as G-box, Hex, C-box and As-1, but with different binding affinities which from high to low were G-box > Hex > C-box > As-1; AtbZIP16 and AtbZIP68 could form homodimer and form heterodimer with other members of G group; N-terminal proline rich domain of AtbZIP16 had transactivation activity in yeast cells while that of AtbZIP68 did not; AtbZIP16 and AtbZIP68 GFP fusion protein localized in the nucleus of onion epidermal cells. These results indicated that AtbZIP16 and AtbZIP68 were two new members of GBFs. In Arabidopsis, AtbZIP16 and AtbZIP68 may also participate in light-responsive process in which GBF1-3 are involved.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5269-5273
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• 2013

Aim: We conducted a case-control matched study to investigate the role of IL-16 gene polymorphisms, rs4072111, rs1131445, rs4778889 and rs11556218, in the risk of gastric cancer in a Chinese population, also performing subgroup analysis by subsites. Methods: To test the hypothesis of involvement, we analyzed the four SNPs of IL16 in 347 cancer patients and 368 controls. Demographic data and other information were collected using a newly designed questionnaire. Genotyping of IL16 (rs4072111, rs1131445, rs4778889 and rs11556218) was performed in a 384-well plate format on the MassARRAY(R) platform. Results: In our study, we found the gastric cancer patients were more likely to be male and have a family history of cancer (P<0.05). We found the rs4778889 CC and rs11556218 GG genotype was significantly associated with 1.97 and 1.84-fold increased risk of non-cardia gastric cancer, while we did not find significant association between the four IL-16 SNPs and cardia gastric cancer. Conclusions: In conclusion, our study indicated that IL-16 rs4778889 CC and rs11556218 GG genotypes are associated with an increased risk of non-cardia gastric cancer in a Chinese population. Our results offer insights into the influence of IL-16 on development of gastric cancer.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.272-272
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• 2010

The structural and electronic properties of $XAu_{16^-}$ (X = S or O) have been studied by the scalar relativistic all-electron density functional calculations, in which a particular attention is paid to the stability of various $XAu_{16^-}$ structures. We find that an X-encapsulated golden cage ($XAu_{16^-}$) represents an ionic character whereas in the other structures, adsorption characters are represented by covalent bonding. Especially, in S@$Au_{16^-}$, electrons are donated from the S atom to $Au_{16^-}$. The most stable $XAu_{16^-}$ structures exhibit a small HOMO-LUMO energy gap, indicating that they could be chemically reactive. We also calculated the activation energy barriers of the transition between the most stable exohedral and endohedral adsorption configurations as well as their reaction energies. Our results demonstrate that the activation barrier in the $OAu_{16^-}$ is lower than in $SAu_{16^-}$. This is associated with the smaller atomic radius of oxygen than that of sulfur.