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Synthesis and in vitro Antitumor Activity of 2-Alkyl, 2-Aryl, and 2-Piperazinyl Benzimidazole-4, 7-dione Derivatives

  • Ahn, Chan-Mug;Tak, Jung-Ae;Choi, Sun-Ju
    • Archives of Pharmacal Research
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    • v.23 no.4
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    • pp.288-301
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    • 2000
  • A series of 2-alkyl, 2-aryl, and 2-piperazinyl benzimidazole-4,7-dione derivatives (7a-h) and 16m-o) were prepared, and their cytotoxicities were tested against three cancer cell lines (mouse lymphocytic leukemia cell line P388, and human gastric carcinoma cell lines SNU-1 and SNU-16). These compounds showed potent cytotoxicity against all of three cell lines tested, and especially SNU-16 was sensitive to them. 2-Aryl (7g,h) and 2-piperazinyl benzimidazole-4,7-dione derivative (I6 m) were more potent than mitomycin C against P388 and SNU-16. Among benzimidazole-4,7-dione derivatives with alkyl group at position 2, 7a had the most potent cytotoxicity against all of the cell lines tested.

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Improving IPTV Forwarding Masechanism in IEEE 802.16j MMR Networks Based on Aggregation

  • Brahmia, Mohamed-El-Amine;Abouaissa, Abdelhafid;Lorenz, Pascal
    • ETRI Journal
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    • v.35 no.2
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    • pp.234-244
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    • 2013
  • Internet protocol television (IPTV) service depends on the network quality of service (QoS) and bandwidth of the broadband service provider. IEEE 802.16j mobile multihop relay Worldwide Interoperability for Microwave Access networks have the opportunity to offer high bandwidth capacity by introducing relay stations. However, to actually satisfy QoS requirements for offering IPTV services (HDTV, SDTV, Web TV, and mobile TV) for heterogeneous users' requests, providers must use a video server for each IPTV service type, which increases the network load, especially bandwidth consumption and forwarding time. In this paper, we present a solution for forwarding IPTV video streaming to diverse subscribers via an 802.16j broadband wireless access network. In particular, we propose a new multicast tree construction and aggregation mechanism based on the unique property of prime numbers. Performance evaluation results show that the proposed scheme reduces both bandwidth consumption and forwarding time.

First Record of Zoarces elongatus (Perciformes: Zoarcidae) from Korea (변산반도 주변해역에서 채집된 등가시치과 한국미기록종, Zoarces elongatus)

  • Ko, Myeong-Hun;Park, Jong-Young
    • Korean Journal of Ichthyology
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    • v.20 no.1
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    • pp.70-73
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    • 2008
  • Eight specimens (330.2~431.3 mm TL) of the family Zoarcidae were collected from the costal waters of the Byeonsanbando, Yellow Sea, Korea. They were identified as a Zoarces elongatus Kner based on the following characters: a dorsal fin with 14~16 notch-shaped spinous rays, irregular 13~16 dark spots in a row along the median body and 126~132 vertebrae. We proposed a new Korean name, 'Mu-jeom-deung-ga-si-chi', for the species.

Coverage Extension of Non-transparent Mode in IEEE 802.16j Mobile Multi-hop Relay Networks (IEEE 802.16j MMR 네트워크에서 Non-transparent 모드의 커버리지 확대)

  • Lee, Ju-Ho;Lee, Goo-Yeon;Jeong, Choong-Kyo
    • Journal of Industrial Technology
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    • v.32 no.A
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    • pp.3-8
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    • 2012
  • In IEEE 802.16j standard document, two modes about usage of RS are proposed; one is transparent mode to enhance data throughput and the other is non-transparent mode to extend coverage. In this paper, we focus on non-transparent mode and find that the mode also affects data throughput. We analyze data throughput on various RS topology and their extended coverage area in non-transparent mode. From the analysis, we see that higher throughput can be obtained when MR-BS and RS are located distantly.

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The abundant presence of nonpolyadenylated SV40 late 19S spliced RNA in the nucleus of monkey cell (Poly A tail을 결핍한 Simian virus 40 spliced RNA의 세포내 분포)

  • ;Mertz, Janet
    • Korean Journal of Microbiology
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    • v.26 no.2
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    • pp.106-112
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    • 1988
  • We have examined the structures and cellular distributions of the SV40 late RNAs present in monkey cells at late times after infection. One particular RNA species, spliced at residue 373(373-RNA), was found to be as abundant as the major late 16S RNAs. This result was unexpected since previous reports showed that the molecular ratio of the 373-spliced 19S RNA to 16S RNA is approximately 0.1 among either cytoplasmic polyadenylated or polysomal viral RNAs. Both sedimentation and electrophoretic analysis indicated that the 373-RNA was approximately 16S to 19S in size. Therefore, it was not a splicing intermediate or the product of premature termination of transcription within the late leader region. Whereas most SV40 late 16S RNA is polyadenylated and located in the cytoplasm, the majority of 373-RNA was found to lack poly A, and be located in the nucleus.

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Radix-trellis Viterbi Decoding of TCM/PSK using Metric Quantization (TCM/PSK의 양지화 Radix-trellis Viterbi 복호)

    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.11 no.5
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    • pp.731-737
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    • 2000
  • In this paper we propose a decoding algorithm of Ungerboeck TCM/PSK in the concept of Radix-trellis, which has been applied to the decoding of convolutional codes for the high speed decoding. As an example we choose 16-state trellis coded 8-ary PSK. For Radix-4 and Radix-16 trellis decoding, we explain the path metric(PM) and the branch metric(BM) calculation. By using the simulation, we evaluate the bit error rate(BER) performance according to the number of binary digits for I-Q value, PM and BM registers. The proper number of binary digits of each register has been derived.

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A Plan of Improving the Reliability of the Election Forecasting Survey - A Case of the 16th General Election (선거예측조사의 신뢰성 증진방안 - 16대 총선을 중심으로)

  • Ryu, Jea-Bok
    • Survey Research
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    • v.1 no.2
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    • pp.15-34
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    • 2000
  • Since the results of the election forcasting survey that was executed jointly by T.V. stations and survey research companies in the 16th Korea General Election(April 13, 2000) had many errors, the reliability of the election forecating survey was greatly damaged. Therefore, in order to recover the reliability and to increase the accuracy of the election forecasting survey in the future, we figure out the sources of the survey's errors and suggest methods of reducing them through deeply analyzing the forecasting data from many angles. In addition, we discuss some problems and an improvable direction on exit poll executed for the first time.

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Lightweight Implementation of SHA-256 Hash Function using 16-bit Datapath (16-비트 데이터 패스를 이용한 SHA-256 해시함수의 경량화 구현)

  • Lee, Sang-Hyun;Shin, Kyung-Wook
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2017.05a
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    • pp.194-196
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    • 2017
  • 본 설계에서는 임의의 길이의 메시지를 256-비트의 해시 코드로 압축하는 해시 알고리듬인 SHA-256(Secure Hash Algorithm-256) 해시함수를 경량화 구현 설계 하였다. 미국 표준 기술연구소 NIST에서 발표한 표준문서 FIPS 180-4에 정의16된 32-비트의 데이터 패스를 16-비트로 설계하여 경량화 구현하였다. Verilog HDL로 설계된 SHA-256 해시함수는 Xilinx ISim를 사용하여 시뮬레이션 검증을 하였다. CMOS 표준 셀 라이브러리로 합성한 결과 100MHz 동작주파수에서 18,192 GE로 구현되었으며, 192MHz의 최대 동작주파수를 갖는다.

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A 16kW Rotating Anode type Monoblock X-ray Generator (16kW 회전 Anode형 모노블럭 X-선 발생장치)

  • Oh, Jun-Yong;Yoon, Ju-Sun;Kim, Si-Woo;Sung, Ki-Bong;Kim, Hack-Seong
    • Proceedings of the KIPE Conference
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    • 2005.07a
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    • pp.159-161
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    • 2005
  • 본 논문은 회전형 대용량의 진단 X-선 발생장치를 모노 블록 형태로 설계, 병원의 모바일 진단장치나, 산업용 X-선 장치로의 적용이 가능한 16kw급 X-선 발생장치에 관한 연구이다. 본 장치는 X-선 발생을 위한 고전압 발생부에 회전형 Anode 형의 X-선관을 사용하였고, X-선관의 로터를 구동할 수 있는 로터 구동회로를 추가 하였다. 고주파 고전압용 인버터에는 IGBT(600/300A)를 100kHz로 고주파 스위칭 함으로서 고전압 변압기를 비롯한 고전압 발생부의 크기와 무게를 최소화하였다. 또한, 기존의 16kw급 대용량 진단 X-선 발생장치를 X-선관과 고전압부를 일체화한 모노블록 형태로 설계, 제작하여 부하변동에 따른 X-선 관전압과 관전류의 동작특성을 실험을 통하여 입증하였다.

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SN-Protected Network Entry Process for IEEE 802.16 Mesh Network (IEEE 802.16 메쉬 네트워크에서의 SN-Protected 네트워크 엔트리 프로세스)

  • Lixiang, Lin;Yoo, Sang-Jo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.35 no.6B
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    • pp.875-887
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    • 2010
  • The workgroup of IEEE 802 proposed the IEEE 802.16 standard, also known as WiMAX, to provide broadband wireless access (BWA). The standard specifies two operational modes, one is popular PMP mode, and the other is optional mesh mode. In the mesh mode, the network entry process-NetEntry is the pivotal procedure for mesh network topology formulation and thus, influences the accessibility of whole mesh network. Unfortunately, the NetEntry process suffers from the hidden neighbor problem, in which new neighborship emerges after a new node comes in and results in possible collisions. In this paper, we propose a new SN-protected NetEntry process to address the problem. Simulation results show that the new proposed NetEntry process is more stable compared with the standard-based NetEntry process.