• Journal of Life Science
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• v.19 no.12
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• pp.1712-1717
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• 2009

The purpose of this study was to compare $VO_2$max, maximal power output, and presence of $VO_2$ plateau across 4 protocol durations (5, 8, 12, and 16 min) during incremental cycling exercise to $VO_2$max. Twenty moderately to highly trained subjects ($24.9{\pm}6.6$) participated in the study. The mean $VO_2$max in the 5-min ($3.55{\pm}0.80\;l/min$) and 8-min ($3.66{\pm}0.88\;l/min$) duration protocols had higher and significantly higher mean value in the 8-min duration protocol compared to the 12-min ($3.49{\pm}0.76\;l/min$) and 16-min ($3.45{\pm}0.73\;l/min$) duration protocols. The AMPO across four protocols showed a significant difference. The AMPO for the 5-min protocol was 12%, 24%, and 35% higher than AMPO for the 8-min, 12-min and 16-min protocols. The presence of plateau was 12.5% for the 5 min protocol, 56.25% for the 8 min protocol, 37.5% for the 12 min protocol, and 56.25% for the 16 min protocol. This study indicates that the short duration protocol (<8 min) is a more valid measurement for $VO_2$ max than optimal duration protocol (8-12 min) in moderate to highly trained individuals on the cycle ergometer.

• Journal of Internet Computing and Services
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• v.9 no.4
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• pp.11-20
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• 2008

IEEE 802.16e has adopted sleep mode to minimize energy consumption of mobile nodes with high speed mobility. If the Base Station (BS) has no data to be sent to a Mobile Subscriber Station (MSS) at the instant of ending sleep window of the MSS, the MSS increases its sleep window interval by double until the window interval reaches to the maximum sleep window interval. Thus, during the operation of sleep mode, MSS repeatedly performs switch on/off action until there exist frames to be received from BS. The switch on/off operation significantly consumes energy of MSS. To effectively deal with the energy of the MSS, this paper proposes an algorithm which decides the minimum sleep window interval that will be used in next sleep mode based on the current sleep window interval. We evaluate the performance of IEEE 802.16e sleep mode algorithm and our proposed algorithm in terms of energy consumption and blocking probability. Compared with the current sleep mode algorithm used in IEEE 802.16e, the proposed algorithm decreases the energy consumption by about 30% without increasing blocking probability.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.10
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• pp.2149-2156
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• 2011

In this paper, design of a new 3-dimensional (3-D) 16-ary signal constellation with constant envelope is presented and analyzed. Unlike the conventional 16-ary constellations, all signal points of the new constellation are uniformly located on the surface of a sphere so that they have a unique amplitude level and a symmetrical structure. When average power of the constellations is normalized, the presented 16-ary constellation has around 11.4% increased minimum Euclidean distance (MED) as compared to the conventional ones that have non-constant envelope. As a result, a digital communication system which exploits the presented constellation has 1.2dB improved symbol error rate (SER). While signal points of the conventional constant-envelope constellation are not distributed uniformly on the surface of a sphere, those of the proposed constellation has a completely symmetric distribution. In addition, the new signal constellation has much lower computational complexity for practical implementation than the conventional one. Hence, the proposed 3-D 16-ary signal constellation is appropriate for the application to a communication system which strongly requires a constant-envelope characteristic.

• The Korean Journal of Food And Nutrition
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• v.16 no.4
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• pp.423-429
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• 2003

Kimchi has been worldwide recognized as a traditional Korean fermented food, In the Chinese cabbage's pickling, salt content of evenly penetrate into the tissue affects on the texture of matured kimchi, But the previous method which usually using brine salting has a disadvantage of uneven penetration of salt into the leaves and stems. The purpose of the study is to develope the method which produce superior kimchi by evenly penetrate the salt into the tissue rapidly, The dry salting method is directly spread the salt on the surface of chinese cabbage as percentage in weight with 10, 12, 14, 16%(s) and pickled in this state for 5 hours. Brine salting method is soaking chinese cabbage in the 16% salt solution(16%B) for 20 hours. Sensory evaluation, contents of salt, properties of mechanical hardness and micro structure were studied among fresh cabbage, 16%B and 10, 12, 14, 16%(s) cabbage, The result of salt contents in all groups of pickled chinese cabbage were significantly increased compared with fresh cabbage. The compressive force of cabbage's steams by mechanical measurement was significantly decreased but cutting force was increased. In pickled cabbage, the cutting force was the highest correlated with salt content, In the sensory evaluation, the salty taste of leaves and chewy degree were significantly increased, but the hardness and crips of the stems were significantly decreased by increasing salt contents. Therefore the dry salting is the most excellent pickling method in small amount of kimchi production by saving salt amount and time, furthermore due to even penetration of salt into leaves and stems.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.34 no.6
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• pp.672-677
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• 2001

There was an outbreak of food poisoning due to eating well-cooked imported tropical fish, Stromateus stellatus on May, 2000, in Korea. Gastrointestinal symptoms such as diarrhea ($92\%$), nausea ($77\%$), abdominal pain ($54\%$), vomiting ($46\%$) and headache ($23\%$) were experienced within $0.5\~2$ hours (median 1 hour) after eating, Any specific natural toxins were not confirmed concerned to those poisoning, but large amount of abnormal lipid ($23\%$) was found from the muscle such as 1-O-diacyl glyceryl ethers (DAGE), which was consisted of $61.8\%$ of total lipid. The 16:0 ($66.3\%$) and 18:1 ($15.8\%$) alkyl chains were dominant in all alkyl chains of DAGE which were presumed as the causative agent for the diarrheal food poisoning. O1eic acid (18:1) was found as a major fatty acid at the sn-2 or 3 in DAGEs. O-16:0-18:1-18:1 ($16.2\%$),O-16:0-18:1-22:1 ($14.7\%$) and O-18:0-18:1-22:1 ($11.0\%$) were contained as the major molecular species of DAGEs by RI-HPLC.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.37 no.3
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• pp.211-218
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• 2011

Effects of Kenpaullone, a specific inhibitor of GSK3${\beta}$, on melanin synthesis in B16 melanoma cells and human melanocytes were investigated. Kenpaullone showed a melanogenesis stimulation activity in a concentrationdependent manner in murine B16 melanoma cells and human melanocytes without any significant effects on cell proliferation. Tyrosinase activity was increased 48 h after treatment of B16 cells with Kenpaullone. The protein expression level of tyrosinase was dose-dependently enhanced after the treatment with Kenpaullone. At the same time, the expression level of tyrosinase mRNA was also increased after addition of Kenpaullone. The stimulatory effect of Kenpaullone mainly resulted from increased expression of tyrosinase. These findings suggest that the application of GSK3${\beta}$ inhibitors may be a potential therapeutic agent for the treatment of hypopigmentation disorder.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.12
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• pp.45-51
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• 2010

The main issue in mobile cloud computing is how to support a seamless service to a mobile mode. Mobile IPv6 (MIPv6) is a mobility supporting protocol which is standardized by the Internet Engineering Task Force (IETF). Mobile IPv6 fast handovers (FMIPv6) is the extension of MIPv6 which is proposed to overcome shortcomings of MIPv6. Recently, fast handovers for Mobile IPv6 over IEEE 802.16e which is one of broadband wireless access systems has been proposed by the IETF. It was designed for supporting cross-layer fast handover. In this paper, we propose an enhanced cross-layering mobile IPv6 fast handover over IEEE 802.16e networks. In our scheme, a new access router generates a new address for the mobile node by using a layer 2 trigger. We utilize a layer 2 message which is sent from a new base station to the new access router in order to inform the new access router of information of the mobile node. A previous access router sends a binding update message to the mobile node's home agent when it acquires the new address of the mobile node. We evaluate the performance of the proposed scheme compared with the existing schemes in terms of the signaling cost and the handover latency. From the results, we observe that the proposed scheme can support fast handover effectively over IEEE 802.16e networks than existing schemes.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.1
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• pp.46-54
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• 2007

PURPOSE Osteosarcoma occurring in the head and neck region is known as a malignant tumor that shows a relatively poor prognosis and, despite various treatments, clinicians have often been confounded by it. The existence or non-existence of the mutation of the gene $p16^{INK4a}$ has been used in prognosis assessment. In this study, author have attempted to determine whether methylation of the gene $p16^{INK4a}$ could be applied to forecast the progress of osteosarcomas in the head and neck region having been given poor prognoses in the diagnostic process and the early stage of treatment. RESEARCH SUBJECT AND METHOD Clinicopathologic investigations, immunohistochemical examinations, a methylation specific polymerase reaction (MSP) analysis, and a survival analysis were conducted on the tissues of 20 patients with mandibulofacial osteosarcoma. RESULTS Neither age, sex, size, smoking or non-smoking, nor region have showed a statistical significance with methylation or unmethylation of the gene $p16^{INK4a}$ and expression rates demonstrated by immunohisto- chemical examinations. A chi-square test indicated that recurrence inclination has no relation with the expression rate of p16 protein (p=0.6615), but it showed a statistical significance with methylation of the gene $p16^{INK4a}$ (p=0.0033). With respect to investigations of the survival rates, a Kaplan-Meier survival analysis found that the manifestation rate of p16 protein did not have an impact on survival (p=0.8864), but that the methylation of the gene $p16^{INK4a}$ resulted in significant differences in survival rates (p=0.0105). CONCLUSIONS The above results show that methylation of the gene $p16^{INK4a}$ could be one of the major factors that help determine the recurrence inclination and prognosis of osteosarcomas occurring in the head and neck region.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.1
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• pp.43-50
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• 2008

Ceramides, a constituent of stratum corneum lipids, play a crucial role in the formation and maintenance of the epidermal permeability barrier. As in many other skin disorders, atopic dermatitis and psoriasis show decrease and transformation of the ceramides. The application of ceramide has been demonstrated to be efficient in the repair of these skin disorders. Nevertheless, natural ceramides are still too expensive and small in quantity to be used as a cosmetic ingredient. Although a lot of pseudo-ceramides have been developed and on the market until now, those pseudo-ceramides did not fully meet the consumer's needs, therefore, there is still a demand for a novel pseudo-ceramides. We synthesized a novel pseudo-ceramide BPC-16 from 2-(2-amino-ethylamino)-ethanol(AEEA), which was characterized by structures having both amide bonds and hydroxyl groups as hydrophilic units, as well as two long alkyl chains. We formulated emulsion with BPC-16, cholesterol, stearic acid, and other components to make an emulsion. These emulsion showed a typical optical anisotropy on cross-polarized microscopy. This 'Maltese cross' appearance is a characteristic figure observed in concentric lamellar emulsion under cross-polarized microscopy. In cytotoxicity assay using MTT in monolayer and three dimension(3D) cell culture, a BPC-16 showed only negligible cytotoxicity up to the effective concentration for barrier repair and moisturization(less than 10 mM). In the measurement of TEWL, this BPC-16 showed significant recovery of water-retaining properties when it was topically applied to either SDS-induced dry skin or normal skin compared to that of base cream. This novel pseudo-ceramide BPC-16 showed as effective in skin barrier repair and moisturization as natural ceramides.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7575-7581
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• 2015

Corticotropin-releasing factor(CRF), one of the stress driven neuropeptides, was widely proposed to influence hair loss and re-growth. For the development of receptor antagonists, the screening system based on intracellular calcium signal process was developed and optimized. The aequorin parental cells were transfected with CRF1 receptor and alpha 16 promiscuous G protein cDNA to establish HEK293a16/hCRF1, a stable cell line for the human CRF1 receptor. In HEK293a16/hCRF1 cells, the range of sauvagine dose response was 12-fold higher($EC_{50}:15.21{\pm}1.83nM$) than in the transiently expressed cells, hence essential conditions for the antagonist screening experiments such as the robust signals and high solvent tolerance were secured. The standard antagonists for the CRF1 receptor, antalarmin and CP154526, resulted $IC_{50}$ values of $414.1{\pm}5.5$ and $290.7{\pm}1.9nM$, respectively. Similar results were presented with frozen HEK293a16/hCRF1 cells. Finally, our HEK293a16/hCRF1 cells with the aequorin based cellular functional assay can be a model system for the development of functional cosmetics and modulators that can have a clinical efficacy on hair re-growth.