• Title/Summary/Keyword: 1001

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Opioid Receptor Selectivity and General Pharmacology of DK1001, New Alkaloid Analgesic (알칼로이드 진통제 DK 1001의 opioid 수용체 선택성 및 일반약리)

  • Kim, Jin-Sook;Kim, Dae-Kyung;Kwon, Tae-Hyub;Yong, Chul-Soon;Ha, Jeoung-Hee;Huh, Keon;Kim, Jung-Ae
    • Biomolecules & Therapeutics
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    • v.7 no.3
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    • pp.278-284
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    • 1999
  • DK1001 is a thebain derivative, which is newly synthesized as an alkaloid analgesic. This study was designed to study effects of DK1001 on the ligands binding to the opioid receptor subtypes, and general pharmacology of DK1001. DK1001 inhibited the binding of [$^3H$]DAMGO, a selective mu-subtype agonist, to the opioid receptor of rat forebrain in a concentration-dependent manner. $EC_{50}$ of DK1001 was significantly lower than that of morphine. DK1001 inhibited the binding of 〔$^3$H〕DPDPE, a selective delta-subtype agonist concentration-dependently. DK1001(0.5 mg/kg) had no effects on behavior, body temperature, blood pressure. respiratory rate, and intestinal charcoal propulsion of mice. In addition, DK1001 did not affect on the contractilities of isolated muscle strips of aorta, ileum, and trachea of rats. These results suggest that DK1001 might be a potent analgesic without serious side effects.

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Implementation of a spaceborne GPS signal processing device and its performance analysis (우주용 GPS 수신기를 위한 신호 처리부 구현과 성능 분석)

  • Jin, Hyeun-Pil;Park, Seong-Baek;Kim, Eun-Hyouek;Yun, Ji-Ho;Lee, Hyun-Woo
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.42 no.12
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    • pp.1065-1072
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    • 2014
  • We developed a GPS digital signal processing FPGA IP, SIGP-1001 to replace the obsolete GP2021 device, which has been used for many space-borne GPS receivers. From a series of tests, we verified that SIGP-1001 has equivalent performance to the GP2021 device under the same operating condition and concluded that SIGP-1001 can replace the GP2021 device. The reliability of a GPS receiver can be improved by using a space-grade FPGA with SIGP-1001 instead of the GP2021 device and its performance is expected to be improved by increasing the number of search channels.

The Effect of HK-1001 Pharmacopuncture on Hyperlipidemia Induced Rats (HK-1001 약침이 흰쥐의 고지혈증에 미치는 영향)

  • Kim, Ji-Nam;Hong, Kwon-Eui
    • Journal of Pharmacopuncture
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    • v.11 no.2
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    • pp.41-53
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    • 2008
  • Objective&Methods The purpose of this study is to observe the effects of HK-1001 Pharmacopuncture at GB34(Yangleungchean) on hyperlipidemia in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum, urine and liver, as well as the histological changes of liver and aorta. Results 1. HK-1001 Pharmacopuncture infusion solution increased the cell viability rate, DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. The levels of total cholesterol, free cholesterol, LDL-cholesterol, phospholipid in serum and AI(atherogenic index) were decreased, and the ratio of HDL to TCL(HDL/TCL) and the level of TG in serum were increased as compared with those of the control group. 3. In the HK-1001 group, serum GOT was significantly lower than those of the HG group and the saline group, and serum ALP was significantly higher than that of the HG group. 4. Hepatic GSH and catalase activities were significantly increased as compared with those of the saline group. Conclusion From the above results, it is suggested that HK-1001 Pharmacopuncture at GB34 has a therapeutic effect on hyperlipidemia.

Lactiplantibacillus plantarum LM1001 Improves Digestibility of Branched-Chain Amino Acids in Whey Proteins and Promotes Myogenesis in C2C12 Myotubes

  • Youngjin Lee;Yoon Ju So;Woo-Hyun Jung;Tae-Rahk Kim;Minn Sohn;Yu-Jin Jeong;Jee-Young Imm
    • Food Science of Animal Resources
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    • v.44 no.4
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    • pp.951-965
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    • 2024
  • Lactiplantibacillus plantarum is a valuable potential probiotic species with various proven health-beneficial effects. L. plantarum LM1001 strain was selected among ten strains of L. plantarum based on proteolytic activity on whey proteins. L. plantarum LM1001 produced higher concentrations of total free amino acids and branched-chain amino acids (Ile, Leu, and Val) than other L. plantarum strains. Treatment of C2C12 myotubes with whey protein culture supernatant (1%, 2% and 3%, v/v) using L. plantarum LM1001 significantly increased the expression of myogenic regulatory factors, such as Myf-5, MyoD, and myogenin, reflecting the promotion of myotubes formation (p<0.05). L. plantarum LM1001 displayed β-galactosidase activity but did not produce harmful β-glucuronidase. Thus, the intake of whey protein together with L. plantarum LM1001 has the potential to aid protein digestion and utilization.

Draft genome sequence of Fusobacterium polymorphum KCOM 1001 isolated from a human subgingival dental plaque of gingivitis lesion (사람 치은염 병소 치은연하치면 세균막에서 분리된 Fusobacterium polymorphum KCOM 1001의 유전체 염기서열 해독)

  • Park, Soon-Nang;Lim, Yun Kyong;Shin, Ja Young;Roh, Hanseong;Kook, Joong-Ki
    • Korean Journal of Microbiology
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    • v.54 no.1
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    • pp.71-73
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    • 2018
  • Recently, Fusobacterium nucleatum subsp. polymorphum was reclassified as Fusobacterium polymorphum based on the average nucleotide identity and genome-to-genome distance analyses. F. polymorphum is a Gram-negative, anaerobic, and filament-shaped bacterium. F. polymorphum is a part of normal flora of oral cavity and causative agent of periodontal diseases. F. polymorphum KCOM 1001 (= ChDC F119) was isolated from a human subgingival plaque of gingivitis lesion. Here, we present the complete genome sequence of F. polymorphum KCOM 1001.

Effects of GV1001 on Language Dysfunction in Patients With Moderate-to-Severe Alzheimer's Disease: Post Hoc Analysis of Severe Impairment Battery Subscales

  • Hyuk Sung Kwon;Seong-Ho Koh;Seong Hye Choi;Jee Hyang Jeong;Hae Ri Na;Chan Nyoung Lee;YoungSoon Yang;Ae Young Lee;Jae-Hong Lee;Kyung Won Park;Hyun Jeong Han;Byeong C. Kim;Jinse Park;Jee-Young Lee;Kyu-Yong Lee;Sangjae Kim
    • Dementia and Neurocognitive Disorders
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    • v.22 no.3
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    • pp.100-108
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    • 2023
  • Background and Purpose: The efficacy and safety of GV1001 have been demonstrated in patients with moderate-to-severe Alzheimer's disease (AD). In this study, we aimed to further demonstrate the effectiveness of GV1001 using subscales of the Severe Impairment Battery (SIB), which is a validated measure to assess cognitive function in patients with moderate-to-severe AD. Methods: We performed a post hoc analysis of data from a 6 month, multicenter, phase 2, randomized, double-blind, placebo-controlled trial with GV1001 (ClinicalTrials.gov, NCT03184467). Patients were randomized to receive either GV1001 or a placebo for 24 weeks. In the current study, nine subscales of SIB-social interaction, memory, orientation, language, attention, praxis, visuospatial ability, construction, and orientation to name-were compared between the treatment (GV1001 1.12 mg) and placebo groups at weeks 12 and 24. The safety endpoints for these patients were also determined based on adverse events. Results: In addition to the considerable beneficial effect of GV1001 on the SIB total score, GV1001 1.12 mg showed the most significant effect on language function at 24 weeks compared to placebo in both the full analysis set (FAS) and per-protocol set (PPS) (p=0.017 and p=0.011, respectively). The rate of adverse events did not differ significantly between the 2 groups. Conclusions: Patients with moderate-to-severe AD receiving GV1001 had greater language benefits than those receiving placebo, as measured using the SIB language subscale.

DENTAL NEWS

  • The Korean Dental Association
    • The Journal of the Korean dental association
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    • v.28 no.12 s.259
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    • pp.1001-1001
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    • 1990
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덴탈 뉴-스

  • The Korean Dental Association
    • The Journal of the Korean dental association
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    • v.22 no.12 s.187
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    • pp.1001-1001
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    • 1984
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DENTAL NEWS

  • The Korean Dental Association
    • The Journal of the Korean dental association
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    • v.23 no.12 s.199
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    • pp.1001-1001
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    • 1985
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