• Biomolecules & Therapeutics
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• v.7 no.3
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• pp.278-284
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• 1999

DK1001 is a thebain derivative, which is newly synthesized as an alkaloid analgesic. This study was designed to study effects of DK1001 on the ligands binding to the opioid receptor subtypes, and general pharmacology of DK1001. DK1001 inhibited the binding of [$^3H$]DAMGO, a selective mu-subtype agonist, to the opioid receptor of rat forebrain in a concentration-dependent manner. $EC_{50}$ of DK1001 was significantly lower than that of morphine. DK1001 inhibited the binding of 〔$^3$H〕DPDPE, a selective delta-subtype agonist concentration-dependently. DK1001(0.5 mg/kg) had no effects on behavior, body temperature, blood pressure. respiratory rate, and intestinal charcoal propulsion of mice. In addition, DK1001 did not affect on the contractilities of isolated muscle strips of aorta, ileum, and trachea of rats. These results suggest that DK1001 might be a potent analgesic without serious side effects.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.12
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• pp.1065-1072
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• 2014

We developed a GPS digital signal processing FPGA IP, SIGP-1001 to replace the obsolete GP2021 device, which has been used for many space-borne GPS receivers. From a series of tests, we verified that SIGP-1001 has equivalent performance to the GP2021 device under the same operating condition and concluded that SIGP-1001 can replace the GP2021 device. The reliability of a GPS receiver can be improved by using a space-grade FPGA with SIGP-1001 instead of the GP2021 device and its performance is expected to be improved by increasing the number of search channels.

• Journal of Pharmacopuncture
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• v.11 no.2
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• pp.41-53
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• 2008

Objective&Methods The purpose of this study is to observe the effects of HK-1001 Pharmacopuncture at GB34(Yangleungchean) on hyperlipidemia in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum, urine and liver, as well as the histological changes of liver and aorta. Results 1. HK-1001 Pharmacopuncture infusion solution increased the cell viability rate, DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. The levels of total cholesterol, free cholesterol, LDL-cholesterol, phospholipid in serum and AI(atherogenic index) were decreased, and the ratio of HDL to TCL(HDL/TCL) and the level of TG in serum were increased as compared with those of the control group. 3. In the HK-1001 group, serum GOT was significantly lower than those of the HG group and the saline group, and serum ALP was significantly higher than that of the HG group. 4. Hepatic GSH and catalase activities were significantly increased as compared with those of the saline group. Conclusion From the above results, it is suggested that HK-1001 Pharmacopuncture at GB34 has a therapeutic effect on hyperlipidemia.

• Korean Journal of Microbiology
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• v.54 no.1
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• pp.71-73
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• 2018

Recently, Fusobacterium nucleatum subsp. polymorphum was reclassified as Fusobacterium polymorphum based on the average nucleotide identity and genome-to-genome distance analyses. F. polymorphum is a Gram-negative, anaerobic, and filament-shaped bacterium. F. polymorphum is a part of normal flora of oral cavity and causative agent of periodontal diseases. F. polymorphum KCOM 1001 (= ChDC F119) was isolated from a human subgingival plaque of gingivitis lesion. Here, we present the complete genome sequence of F. polymorphum KCOM 1001.

• The Journal of the Korean dental association
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• v.28 no.12 s.259
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• pp.1001-1001
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• 1990

• Proceedings of the Korean Environmental Sciences Society Conference
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• 1993.10a
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• pp.1001-1001
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• 1993

• The Journal of the Korean dental association
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• v.22 no.12 s.187
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• pp.1001-1001
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• 1984

• The Journal of the Korean dental association
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• v.23 no.12 s.199
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• pp.1001-1001
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• 1985

• Proceedings of the Korea Water Resources Association Conference
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• 2005.09b
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• pp.1001-1001
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• 2005

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.1001-1001
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• 2005