• 약학회지
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• 제41권6호
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• pp.724-729
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• 1997

New 7-Halo-4-hydroxy-2-allyl-N-3-(4-methoxy-2-carboxylic acid pyrrolidinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives were synthesized through the condensation of 7-halo-4-hydroxy-2-allyl-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxide with 4-methoxy L-proline.

• 대한화학회지
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• 제33권5호
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• pp.551-557
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• 1989

아닐린과 부틸, 헥실, 옥틸기를 가진 n-알킬 알코올류로부터 6-alkylbenzofuroxan류를 합성하고, 이들과 1,3,5-trihydroxybenzene을 반응시켜 7-alkyl-1,3-dihydroxyphenazine-5,10-dioxide류를 합성하였다. 그리고 benzofuroxan과 1,3,5-trihydroxybenzene을 반응시켜 1,3-dihydroxyphenazine-5,10-dioxide도 합성하였다. 이들 phenazine dioxide 유도체의 수용액에 대한 표면장력을 측정하였는데 알킬기의 탄소수가 증가할수록 표면장력이 저하됨을 알았다. 또한 항균성을 희석법에 의하여 조사하였는데 알킬기의 탄소수가 4개인 부틸유도체의 경우가 가장 항균성이 강했으며, 알킬기가 없는 phenazine dioxide 유도체보다는 알킬기가 치환된 phenazine dioxide 유도체의 항균성이 더 강하다는 것을 알았다.

• 약학회지
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• 제45권6호
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• pp.570-574
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• 2001

In order to discover new useful NSAIDs, novel N-substituted 1,2-benzisothiazoline-3-one 1,1- dioxide derivatives, which can exhibit potentially antiinflammatory activity were synthesized. 1,2-Benz-isothiazoline-3-one-N-acetic acids 6a, b were obtained from monochloroacetic acid and sodium 1,2-benz-isothiazoline-3-ones in DMF by N-alkylation reaction. N-Substituted 1,2-benzisothiazoline-3-one 1,1-dioxide derivatives 7a-e were synthesized through the coupling of compound 6a, b and several amines (aniline, 2- aminopyridine , 2-aminothiazole, 2-aminotetrazole) with dicyclohexylcarbodiimide in methyl e no chloride.

• 대한화학회지
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• 제31권5호
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• pp.464-470
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• 1987

파라위치에 메톡시, 메틸, 아세틸 및 니트로기를 가진 아닐린유도체를 출발물질로 하여 6-substituted benzofuroxan 유도체를 합성하고, 이들과 4-아미노페놀을 반응시켜 7-Substituted 2-aminophenazine-5,10-dioxides류를 합성하였다. 그리고 benzofuroxan과 4-아미노페놀을 반응시켜 2-Aminophenazine-5,10-dioxide도 합성하였다. 이들 phenazine 유도체의 항균성을 희석법에 의하여 최소 발육저지 농도로서 조사하였는데, 전자를 주는 치환기를 가진 phenazine dioxide 유도체들이 전자를 당기는 치환기를 가진 phenazine dioxide유도체들 보다 항균성이 더 강하였다. 이 사실로부터 phenazine dioxide 유도체에서 치환기의 전자효과와 항균성사이에는 직접적인 연관성이 있다는 것을 알았다.

• 약학회지
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• 제36권5호
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• pp.440-448
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• 1992

7-Substituted 2,3-dihydroxyphenazine 5,10-dioxides were synthesized by the reaction of 1,2,4-trihydroxybenzene with 6-substituted benzofuroxan derivatives which had been obtained from aniline derivativies bearing methoxy, methyl, acetyl and nitro group at the para position. 2,3-Dihydroxyphenazine 5,10-dioxide was also prepared by the reaction of 1,2,4-trihydroxybenzene with benzofuroxan. The antimicrobial activities of these phenazine dioxide were investigated in terms of minimum inhibitory concentration by the common twofold dilution technique. It was observed that the antimicrobial activity of the phenazine dioxides bearing electron releasing substituents was stronger than that of those bearing electron withdrawing substitutents. From this result, it was concluded that the antimicrobial activity of phenazine dioxide derivatives has a direct relationship with the electronic effect of the substituents.

• Applied Biological Chemistry
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• 제27권2호
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• pp.95-99
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• 1984

3-Oxo-1,2-benzisothiazole-1, 1-dioxide의 몇몇 유도체를 합성하고 이들 유도체의 Pyricuria oryzae에 대한 항균성을 조사하였다. 이들 유도체의 $I_{50}$값은 각각 다음과 같다 ; 3-chloro (37.8ppm), 2-chloro (318.7ppm), MCS (20.1ppm), 3-(P-nitrophenyloxy) (35.4ppm), 3-(o-nitrophenyloxy) (11.8ppm), 3-(p-aminophenyloxy) (1643.2ppm) 2-allyl (946.2ppm), 2-(hydroxymethyl) (248.4), 2-chloromethyl 유도체 (192.7ppm)

• Bulletin of the Korean Chemical Society
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• 제12권4호
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• pp.438-440
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• 1991

Each aqueous solution (pH = 1) of acetic acid, acetamide, and acetonitrile produces carbon dioxide and hydrogen at 300 K when irradiated in the presence of semiconductors such as titanium dioxide, platinized titanium dioxide, etc. Similar results were obtained for each of benzoic acid, benzamide, and benzonitrile. Based on the relative amount of carbon dioxide, nitrile is believed to be transformed into carboxylic acid through the intermediacy of amide. A mechanism in which hydrogen atom and hydroxyl radical are involved is presented.

• 한국염색가공학회지
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• 제33권1호
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• pp.10-23
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• 2021

In order to synthesize the dye suitable for supercritical carbon dioxide(ScCO2) dyeing, a series of azo based disperse dyes were prepared using various aniline derivatives as diazo components and indol derivatives as coupling components. Dyeing process in ScCO2 of the synthesized dyes was performed on PET fiber at 120℃ for 2 hrs under 250bar pressure with 0.5% o.w.f. of dye concentration. The absorption maxima varied from 400 to 580nm depending on the substituted groups in aniline derivatives and the indol derivatives. The dyes showed high molar extinction coefficients(ε) of 27,000~61,000M-1cm-1. Dyed PET fiber exhibited excellent brightness and good light, washing and perspiration(acid/alkali) fastness properties.

• 대한화학회지
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• 제48권4호
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• pp.385-393
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• 2004

Benzofuroxan과 ethyl acetoacetate를 반응시켜 2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide (8)를 합성하고, 이것을 hydrazine hydrate 또는 selenium dioxide와 반응시켜 2-hydrazinocarbonyl-3-methylquinoxaline 1,4-dioxide (9) 또는 2-ethoxycarbonyl-3-formylquinoxaline 1,4-dioxide (10)를 합성하였다. 화합물 9를 alkanoyl chloride류, benzoyl chloride류, heteroacyl chloride류 및 benzenesulfonyl chloride류와 반응시켜 3-methyl-2-(substituted hydrazinocarbonyl)quinoxaline 1,4-dioxide류 (11-14)를 합성하였다. 화합물 9를 sodium nitrite와 반응시켜 2-azidocarbonyl- 3-methylquinoxaline 1,4-dioxide (15)를 합성한 다음, 이것을 디옥산/알코올류 용매하에서 환류시켜 Curtius 자리옮김반응에 의한 N-(3-methyl-1,4-dioxoquinoxalin-2-yl)-alkyl carbamate류 (16)를 합성하였다. 그리고 화합물 15를 치환 아닐린류와 반응시켜 2-(3-substituted phenylureido)-3-methylquinoxaline 1,4-dioxide류 (17)를 합성하였다. 한편 화합물 10을 benzoic hydrazide 또는 치환 아닐린류와 반응시켜 quinoxaline 1,4-dioxide류 (18, 19)를 각각 합성하였다. 그리고 합성한 화합물들에 대한 제초력과 살균력도 조사하였다.

• 대한화학회지
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• 제30권1호
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• pp.126-134
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• 1986

Aniline과 n-alkyl alcohol類로 부터 6-alkylbenzofuroxan을 얻고 이것과 4-aminophenol을 反應시켜 butyl, hexyl, octyl기를 가진 7-Alkyl-2-aminophenazine-5,10-dioxide를 合成하였다. 그리고 benzofuroxane과 4-aminophenol을 反應시켜 2-aminophenazine-5,10-dioxide도 合成하였다. 生成物들은 IR, NMR, 元素分析등으로 확인하였다. 이들 phenazine 誘導體의 수용액에 대한 表面張力을 測定하였는데 alkyl기의 탄소수가 증가할수록 表面張力이 底下됨을 알았다. 또한 抗菌性을 稀釋法에 의하여 調査하였는데 alkyl기의 탄소수가 4개인 butyl 誘導體의 경우가 가장 抗菌性이 강했으며, alkyl기가 없는 2-aminophenazine-5,10-dioxide보다는 alkyl기가 置換된 2-aminophenazine-5,10-dioxide의 抗菌性이 더 강하다는 것을 알았다.