• Natural Product Sciences
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• 제9권1호
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• pp.28-30
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• 2003

A sesquiterpene lactone, 1-O-acetyl-4R,6S-britannilactone (1) which has a new stereochemistry was isolated from the flowers of Inula britannica L. var.chinensis (Rupr.) Reg. Its stereostructure was determined by a x-ray crystallography.

• Archives of Pharmacal Research
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• 제27권1호
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• pp.83-85
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• 2004

A sesquiterpene lactone, 1-O-acetyl-4R,6S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an iNOS inhibitory constituent for the first time with an $IC_{50}$ value of 22.1 $\mu$ M which is more potent than the positive control, L-$N^6$-(1-iminoethyl)lysine ($IC_{50} =33.7 \mu$ M). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.