• Title/Summary/Keyword: 1-Carbomethoxy-$\beta$-carboline

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$\beta$-carboline alkaloids of polygala tenuifolia

  • Han, Byung-Hoon;Park, Jeong-Hill;Park, Myung-Hwan;Han, Yong-Nam
    • Archives of Pharmacal Research
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    • v.8 no.4
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    • pp.243-247
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    • 1985
  • A new $\beta$-carboline alkaloid, 1-carbobutoxy-$\beta$-carboline as well as $N_{9}$ -formylharman, 1-carboethoxy-$\beta$-carboline, 1-carbomethoxy-$\beta$- carboline, perloyrine, harman and norharman were isolated from the rhizoma of Polygala tenuifolia Willdenow. The structures were elucidated on the basis of spectroscopic studies and chemical evidence.

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Anticariogenic $\beta$-Carboline Alkaloids from Commelina communis

  • Bae, Ki-Hwan;Seo, Won-Jun;Kwon, Yae-ho;Baek, Soo-Hyun;Lee, Shin-Woong;Jin, Kap-duck
    • Archives of Pharmacal Research
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    • v.15 no.3
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    • pp.220-223
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    • 1992
  • The methanolic extract of Commelina communis (aerial part) showed antibacterial activity against a cariogenic bacterium, Streptococcus mutans OMZ 176. The active principles were identified to be $\beta$-carboline alkaloids, 1-carbomethoxy-$\beta$-carboline, norharman and harman, which were bactericidal in the minimal inhibitory concentration (MIC) of $100\;\mu{g/ml}$ against the strain.

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Studies on the Alkaloidal Components of the Fruits of Lycium chinense

  • Han, Byung-Hoon;Park, Jeong-Hill;Park, Myung-Hwan;Han, Yong-Nam
    • Archives of Pharmacal Research
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    • v.8 no.4
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    • pp.249-252
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    • 1985
  • $N_{9}$-Formylharman, 1-carbomethoxy-$\beta$-carboline and perlolyrine with an unidentified alkaloid ($C_{10}H_{13}NO_{2}$, $M^{+}$ 179.094) have been isolated from the fruits of Lycium chinense Miller (Solanaceae) and characterized on the basis of chemical and physical evidence.

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Studies on the Alkaloidal Constituents of Commelina communis (닭의장풀의 알카로이드 성분에 관한 연구(I))

  • Baek, Soo-Hyun;Seo, Won-Jun;Bae, Ki-Hwan;Jin, Kap-Duck
    • YAKHAK HOEJI
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    • v.34 no.1
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    • pp.34-39
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    • 1990
  • The alkaloidal constituents of Commelina communis(Commelinaceae) were investigated. From the ether soluble alkaloidal fraction, three ${\beta}-carboline$ type alkaloids were isolated by chromatographic purification process. Their chemical structures were identified as $1-carbomethoxy-{\beta}-carboline$, norharman and harman from the physicochemical data, which were newly isolated from this plant.

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Analysis of alkaloids in Polygala tenuifolia by HPLC (HPLC에 의한 원지 중 알칼로이드 성분의 정량)

  • Park, Man Ki;Park, Jeong Hill;Kim, Bao-Yuan;Kim, Jong Moon;Liem, Kyung-Jin;Han, Byung Hoon
    • Analytical Science and Technology
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    • v.6 no.3
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    • pp.255-259
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    • 1993
  • ${\beta}$-Carboline alkaloids of Polygala tenuifolia (Polygalaceae), an expectorant, tonic and sedative drude drug, were determined by HPLC. The alkaloids were separated by RP-18 column with gradient elution of 0.01M potassium phosphate buffer(pH=3.5) and acetonitrile and detected at UV 254nm. Two methods for the preparation of alkaloid fraction were compared. One was solvent extraction method using acid and base, and the other was solid phase extraction with ion exchange resin (Amberlyst 15). A more refined HPLC chromatogram was obtained using the solid phase extraction method. The alkaloidal contents in P. tenuifolia determined by this method were : harman $2.8{\times}10^{-3}%$, norharman $1.7{\times}10^{-3}%$, 1-carbomethoxy-${\beta}$-carboline $1.3{\times}10^{-3}%$, 1-carboethoxy-${\beta}$-carboline $1.4{\times}10^{-3}%$ and perlolyrine $3.3{\times}10^{-3}%$, respectively.

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Chemical Studies on the Alkaloidal Constituents of Codonopsis lanceolata (더덕의 알칼로이드 성분에 관한 연구)

  • 장영경;김상열;한병훈
    • YAKHAK HOEJI
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    • v.30 no.1
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    • pp.1-7
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    • 1986
  • The alkaloid components in the root of Codonopsis lanceolata were studied. From the ether soluble alkaloid fraction, four $\beta$-carboline alkaloids were isolated in crystalline state by chromatographic purification process; comp. I mp $178^{\circ}$, isolated yield 4.5$\times$$10^{-5}%$, comp. II mp $166^{\circ}$, 6.0$\times$$10^{-5}%$, comp. III mp $164^{\circ}$, 1.8$\times$$10^{-4}%$ and comp. IV mp $197^{\circ}$, 3.5$\times$$10^{-5}%$. They were identified by spectral analysis and by total synthesis as being a new component $N_9$-formylharman, and already known components in other plant 1-carbomethoxy-$\beta$-carboline, perlolyrine and norharman.

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