• 제목/요약/키워드: 1,4-Dihydripyridine

검색결과 1건 처리시간 0.018초

Synthesis of 1,4-Dihydropyridine Carboxylic Acids (III)

  • Suh, Jung-Jin;Hong, You-Hwa;Bae, Myn
    • Archives of Pharmacal Research
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    • 제14권4호
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    • pp.359-363
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    • 1991
  • 2,6-Dimethyl-4-(3'-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 5-(2'-cyanoethyl) ester 10a reacted with chloromethyl methylsulfide to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methylthiomethyl 5-(2'-cyanoethyl) ester 11a in 88.1% yield. The synthesis of 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicrboxylic acid 3-methylthiomethyl ester 2a was achieved in 83% yield by alkaline hydrolysis of compound 11a in aqueous EtOH.

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