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Pain Management for low back Pain and Lumbosacral Radiculopathy (요통에 대한 통증관리)

  • Kang, Keung-Mo;Ban, Jong-Seok;Min, Byung-Woo
    • The Korean Journal of Pain
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    • v.1 no.2
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    • pp.181-187
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    • 1988
  • Since the introduction of epidural corticosteroid injections for the management of sciatica, lumbosacral radiculopathy has become one of the most common pain problems encountered by anesthesiologists. In order to function effectively, anesthesiologists should be able to: (1) recognize those syndromes which may respond to nerve block; (2) understand the pathophysiology of the conditions being treated and (3) be familiar with alternate therapeutic pathways for patients not responding to merre block. There are many etiologic factors of low back pain and lumbosacral radiculopathy. Particularly, Nerve root compression caused by a protruding disc, a osteophyte or tumors are usually responsible for pain. Neural inflammation, therefore, is considered to play a major role in pain production. The use of local anesthetics in mixture with steroids is believed to break down neural inflammation. Steroids and local anesthetics were injected lumbar or caudal epidmal to 106 patients for the purpose of relieving low back pain and lumbosacral radiculopathy. The results are as follows: Excellent pain relieved group: 27 patients (25.5%) Good pain relieved group: 49 patients (46.1%) Fair pain relieved group: 15 patients(14.2%) Not effective group: 15 patients(14.2%).

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A Simulation Model for the Intermittent Hydrologic Process(I) - Alternate Renewal Process (ARP) and Continuous Probability Distribution - (간헐(間歇) 수문과정(水文過程)의 모의발생(模擬發生) 모형(模型)(I) - 교대재생과정(交代再生過程)(ARP)과 연속확률분포(連續確率分布) -)

  • Lee, Jae Joon;Lee, Jung Sik
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.14 no.3
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    • pp.509-521
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    • 1994
  • This study is an effort to develop computer simulation model that produce precipitation patterns from stochastic model. A stochastic model is formulated for the process of daily precipitation with considering the sequences of wet and dry days and the precipitation amounts on wet days. This study consists of 2 papers and the process of precipitation occurrence is modelled by an alternate renewal process (ARP) in paper (I). In the ARP model for the precipitation occurrence, four discrete distributions, used to fit the wet and dry spells, were as follows; truncated binomial distribution (TBD), truncated Poisson distribution (TPD), truncated negative binomial distribution (TNBD), logarithmic series distribution (LSD). In companion paper (II) the process of occurrence is developed by Markov chain. The amounts of precipitation, given that precipitation has occurred, are described by a Gamma. Pearson Type-III, Extremal Type-III, and 3 parameter Weibull distribution. Daily precipitation series model consists of two models, A-Wand A-G model, by combining the process of precipitation occurrence and a continuous probability distribution on the precipitation of wet days. To evaluate the performance of the simulation model, output from the model was compared with historical data of 7 stations in the Nakdong and Seomjin river basin. The results of paper (1) show that it is possible to design a model for the synthetic generation of IX)int precipitation patterns.

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Physical Properties of Surface Sediments from the KR(Korea Reserved) 5 Area, Northeastern Equatorial Pacific (북동태평양 대한민국 광구 KR5 지역 표층퇴적물의 물리적 특성)

  • Lee, Hyun-Bok;Chi, Sang-Bum;Hyeong, Ki-Seong;Park, Cheong-Kee;Kim, Ki-Hyune;Oh, Jae-Kyung
    • Ocean and Polar Research
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    • v.28 no.4
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    • pp.475-484
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    • 2006
  • In order to reveal the vertical variation of physical properties in deep-sea sediments, deep-sea sediment cores were collected at 78 stations using a multiple corer in the KR5 area, one of the Korea contract areas for manganese nodule exploration, located in the northeast equatorial Pacific. Based on the color of sediments, sampled sediment cores were characterized into three lithologic units (unit 1,2, and 3). In all sediment cores, three units appear systematically; unit 1 lies at the top of cores and unit 2 and/or unit 3 appear to underlie unit 1 or alternate with unit 3. Unit 1 layer from the top of cores shows dark grayish brown to dark brown with mean thickness of 10.2cm. Unit 2 and 3 layers show very dark brown to black color and yellowish brown to brown color, respectively. According to the physical properties of the deep-sea sediment cores, sediment column can be divided into three sections. Section A $(0{\sim}15cm)$ in subbottom depth consists mostly of unit 1. Mean values of physical properties of section B $(15{\sim}30cm)$ in subbottom depth are similar to those of section C (>30 cm) in subbottom depth. However, the physical properties of section B were more variable than those of section C because of the high activity of bioturbation in section B. These results will provide valuable information for selecting suitable sites for mining manganese nodules in the Korea contract areas.

Synthesis of Metal-free Organic Dye for Dye-sensitized Solar Cell (염료감응 태양전지를 위한 무금속 유기염료의 합성)

  • Pattarith, K.;Pungwiwat, N.;Laosooksathit, S.
    • Journal of the Korean Chemical Society
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    • v.55 no.2
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    • pp.279-282
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    • 2011
  • Dye-sensitized solar cell (DSSC); an alternate energy source harvester has gained some attractive features such as high-energy conversion efficiency low production cost. Dye-sensitizer is a basic component of DSSC, which affecting the performance of the energy conversion efficiency. Current research has been focusing on development of high efficiency, metal-free dye-sensitizers, which would be more environmental friendly. We had successfully explored synthetic route to 6,6'-(1,2,5-oxadiazole-3,4-diyl)dipyridine-2,4-dicarboxylic acid (3A) which has been used as organic sensitizer. Investigation of light conversion efficiency (${\eta}$) of the compound uses standard measurement condition (one sun simulated irradiation, AM 1.5, 100 mW/$cm^2$) showed that it could reach 1.00% ($J_{SC}=2.63\;mAcm^{-2}$, $V_{OC}$=0.64 V and FF=0.59). Under the same conditions, the ruthenium complex (N719) gave the conversion efficiency as high as 4.02%($J_{SC}=10.50\;mAcm^{-2}$, $V_{OC}$=0.67V and FF=0.57).

The Effect of Long-term Steroid Therapy Combined with Azathioprine in Henoch-$Sch{\ddot{o}}nlein$ Nephritis (Henoch-$Sch{\ddot{o}}nlein$(HS) 신염에서 장기 스테로이드와 Azathioprine의 병합치료 효과)

  • Moon, Kyoung-Sang;Jin, So-Young;Kim, Eun-Mi
    • Childhood Kidney Diseases
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    • v.2 no.2
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    • pp.118-124
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    • 1998
  • Purpose : There is no specific treatment guidelines for Henoch-$Sch{\ddot{o}}nlein$(HS) nephritis. Therefore we performed this study to observe the effect of long term steroid therapy combined with azathioprine Methods : Treatment protocols; 1) Steroid pulse therapy: methylprednisolon 30 mg/kg/dose, maximum 1 gm, intravenolisly 6 times for alternate day. 2) Oral steroid was given 2 mg/kg/day for 1 month, 1 mg/kg/day for following 1 month and alternate day oral steroid combined with azathioprine 2 mg/kg/day for 2 years. Results : Time period from HSP to onset of HS nephritis was between 2 weeks to 5 months with mean $7.4{\pm}7.4$ weeks. Clinical remission were seen in 4 cases out of 5 ($80\%$). Mean time period with disappearance of proteinuria and microscopic hematuria were $5{\pm}2.4$ month and $13.3{\pm}2.9$ month respectively. On pathologic findings by ISKDC, 3 cases were grade IIIb, 2 cases were grade IV in first kidney biopsies and showed pathologic improvement in follow up tidneybiopsiesafterlyearstreatment. Conclusion : As there is no definitive treatment for HS nephritis so far, our study of long term oral steroid therapy with azathioprine was effective in clinical and histologic aspect. Therefore further study in HS nephritis with in a large group will be needed in the future.

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Aqueous extract of Petasites japonicus leaves promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells

  • Kim, Eun Ji;Jung, Jae In;Jeon, Young Eun;Lee, Hyun Sook
    • Nutrition Research and Practice
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    • v.15 no.5
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    • pp.579-590
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    • 2021
  • BACKGROUND/OBJECTIVES: Petasites japonicus Maxim (P. japonicus) has been used as an edible and medicinal plant and contains many bioactive compounds. The purpose of this study is to investigate the effect of P. japonicus on osteogenesis. MATERIALS/METHODS: The leaves and stems of P. japonicus were separated and extracted with hot water or ethanol, respectively. The total phenolic compound and total polyphenol contents of each extract were measured, and alkaline phosphatase (ALP) activity of each extract was evaluated to determine their effect on bone metabolism. To investigate the effect on osteoblast differentiation of the aqueous extract of P. japonicus leaves (AL), which produced the highest ALP activity among the tested extracts, collagen content was measured using the Sirius Red staining method, mineralization using the Alizarin Red S staining method, and osteocalcin production through enzyme-linked immunosorbent assay analysis. Also, real-time reverse transcription polymerase chain reaction was performed to investigate the mRNA expression levels of Runt-related transcriptional factor 2 (Runx2) and Osterix. RESULTS: Among the 4 P. japonicus extracts, AL had the highest values in all of the following measures: total phenolic compounds, total polyphenols, and ALP activity, which is a major biomarker of osteoblast differentiation. The AL-treated MC3T3-E1 cells showed significant increases in induced osteoblast differentiation, collagen synthesis, mineralization, and osteocalcin production. In addition, mRNA expressions of Runx2 and Osterix, transcription factors that regulate osteoblast differentiation, were significantly increased. CONCLUSIONS: These results suggest that AL can regulate osteoblasts differentiation, at least in part through Runx2 and Osterix. Therefore, it is highly likely that P. japonicus will be useful as an alternate therapeutic for the prevention and treatment of osteoporosis.

Taxonomic Reassessment of the Genus Polysiphonia (Rhodomelaceae, Rhodophyta): Morphology and Reproduction of Neosiphonia decumbens and N. harlandii (홍조 붉은실속 식물의 분류학적 재검토: 누은새붉은실과 가시새붉은실의 형태와 생식)

  • Kim, Myeong-Suk
    • ALGAE
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    • v.18 no.2
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    • pp.107-119
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    • 2003
  • Neosiphonia is separated from the traditionally well known genus Polysiphonia (Rhodomelaceae, Rhodophyta) and 12 species includes in Korea. In this study, the vegetative and reproductive developments of two Neosiphonia species, N. decumbens (Segi) M.S. Kim et I.K. Lee and N. harlandii (Harvey) M.S. Kim et I.K. Lee, are reinvestigated. N. decumbens is diagnosed by following combination of the characters: plants 1-3 cm high, dwarf, decumbent, main axes indistinct, irregularly branched in dichotomous manner, and alternately or secundly ramified with wide angles above. N. harlandii is distinguished by the features: plants 4-8 cm high, usually solitary and saxicolous, erect, densely corticated at base of distinct main axes, rather irregularly alternate in branch, and with cicatrigenous branchlets developed numerously on every part of frond. The two species share typical characteristics of the genus Neosiphonia, such as a base attached by unicellular rhizoids, cut off by cross wall, pericentral cells in 4, trichoblasts moderately developed near the apex of branches, leaving persistent scar-cells, tetrasporangia arranged in a spiral series, procarps with 3-celled carpogonial branch, and spermatangial branches arising as a primary branch of trichoblast. Taxonomy of the two Neosiphonia in regard to Polysiphonia is discussed.

A Study on the Application Effect of DSSC BIPV Window System in Office Building Considering Cooling.Heating.Lighting Energy (냉.난방 및 조명에너지를 통합 고려한 DSSC BIPV창호의 사무소건물 적용 효과 연구)

  • Sim, Se-Ra;Yoon, Jong-Ho;Shin, U-Cheul
    • Journal of the Korean Solar Energy Society
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    • v.31 no.3
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    • pp.67-72
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    • 2011
  • The aim of this study is to evaluate how much would the building energy consumption be saved by applying DSSC BIPV window which is possible to control the transmittance and express the color in the office building. For this, physical characteristics such as transmittance and reflectance, U-factor of DSSC areanalyzed and an annual energy consumption that is connected to dimming control is calculated when DSSC BIPV window is applied by alternate clear window system. As a result, It is possible to reduce the anannual energy consumption as much as4.1% by just change the clear double window system to DSSC BIPV double window system because the major factor to reduce energy consumption in the office that has much cooling load than other building is SHGC. When the thermal insulation properties of DSSC BIPV window with low-e coating and making triple window are improved, energy saving ratio is about 9%. Plus, energy saving ratio of 25~28% in lighting energy consumption is possible when the dimming control system with DSSC BIPV window is adopt.

Histological Studies of the Infundibulum of the Oviduct of the Korean Native Pheasants(Phasianus colchicus korpowi) (한국산 꿩 난관깔때기의 조직학적 연구)

  • 최성도;이영훈;김인식;양홍현
    • Korean Journal of Poultry Science
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    • v.26 no.3
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    • pp.171-177
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    • 1999
  • This study was conducted for the histological observation of the infundibulum of the oviduct of the laying Korean native pheasants. The results are as follows : 1. The infundibular wall is composed of the epithelium, lamina propria, muscle layer(inner circular and outer longitudinal muscle), and serosa. The funnel lip is divided into the inner, and outer lip of the epithelium and muscle layer. 2. The epithelium of the funnel lip and most region of the cranial part of the funnel are composed of ciliated columnar cells. In the surface and lateral part of the folds, ciliated cells and non-ciliated secretory cells tend to alternate in the epithelium of the caudal funnel and the necks, but are also found in groups of the simple cuboidal epithelium at the bases of the grooves between the ridges and tubular glands found in the subepithelium. 3. The secretory material of the non-ciliated secretory cills contains PAS-positive and alcian blue-positive granules, and these materials show purple colour in the basic fuchsin-methylene blue stain. 4. The cells of the glandular groove and tubular gland of the neck portion of the oviduct mostly show weak PAS-positive, and alcian blue stain negative reaction. The tubular gland cells of the infndibulum contain pink of purple colour granules, and without reaction in the anterior neck portion of the infundibulum in basic fuchsin and methylene blue stain.

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Analysis of Strength and Displacement of Jig Body in Index Machine (Index Machine의 Jig Body 강도 및 변위해석)

  • 한근조;오세욱;김광영;안성찬;전형용
    • Journal of the Korean Society for Precision Engineering
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    • v.15 no.3
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    • pp.24-30
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    • 1998
  • Strength and displacement of jig body in index machine utilized for multiprocess machining such as drilling, boring and tapping, etc, at the same time were analyzed by the use of finite element analysis soft ware ANSYS 5.2A. The whole geometry was constructed by 4048 elements and 7016 nodes employing 8 node brick element. The analyses were carried out on five loading cases combining vertical and horizontal machining to simulate the case occurring large displacement and the one occurring small displacement one and provided following conclusions. (1) Jig body had sufficient strength because its safety factor was 6.95 even in the most severe loading case. (2) The largest displacement in Z direction was 549 m and that in radial direction was 43.7 m. (3) In order to reduce the displacement, vertical machining rather than horizontal or two or three processes should be adopted in the same station. (4) Alternate change of horizontal machining direction at consecutive stations can reduce the displace ment. (5) The dimension of the slider should be increased to reduce the displacement by the tolerance in the sliding part. (6) A bypass idle piston head needs to be installed to give a counterpart supporting load from opposite direction for a single horizontal machining case.

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