• Nuclear Medicine and Molecular Imaging
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• v.42 no.sup1
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• pp.140-148
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• 2008

$^{18}F-FDG$ PET showed a high sensitivity and specificity in the initial staging of malignant melanoma, and it also predicted the prognosis correctly. In addition, it had a higher sensitivity and specificity in the detection of recurrence and restaging than conventional imaging modalities. Meanwhile, there's less clinical evidence to support the use of $^{18}F-FDG$ PET in the response evaluation for chemotherapy and the diagnosis/differential diagnosis of malignant melanoma.

• 대한두경부종양학회:학술대회논문집
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• 1995.11a
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• pp.217.1-217.1
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• 1995

• The Journal of the Korean bone and joint tumor society
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• v.16 no.2
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• pp.69-73
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• 2010

Purpose: Sentinel lymph node (SLNB) is the first confronted lymph node from primary lesion of tumor through lymphatic drainage, which is important for determining early metastasis and setting guidelines for treatment. We reported significant of sentinel lymph node biopsy in malignant melanoma (MM) and squamous cell carcinoma (SCC) of lower extremities. Materials and Methods: Twenty-five cases of surgically treatment and being possible for follow up more than 1 year among the patients who were diagnosed as MM and SCC in this institution from Sep. 2005 to Jan. 2009, and 10 cases of them were performed SLNB. Average age was 64 years old, and 15 cases of male and 10 cases of female were in this group. Results: 3 years overall survival rate was 100% and 3 years disease-free survival rate was 76%. Metastasis occurred in total 6 patients, 4 cases of inguinal lymph nodes, 1 case of soft tissue around knee, 1 case of left achilles tendon. In 15 cases of not performing SLNB, overall survival rate was 93.3% and disease-free survival rate was 73.3%. In 10 cases of performing SLNB, overall survival rate was 100% and disease-free survival rate was 90%. And only 1 case showed positive finding in the biopsy, and none of the 10 cases showed metastasis in follow-up. Conclusion: SLNB leads simpler and less complications compared to prior elective lymph node dissection, and shows high degree of accuracy. Throughout the SLNB, setting guidelines for treatment by accurate staging is thought to be helpful for increasing the survival rate in the patient with MM and SCC.

• Korean Journal of Ichthyology
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• v.27 no.3
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• pp.243-248
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• 2015

Based on three scorpionfish specimens (131.8~163.4 mm SL) collected from the coastal waters of Jeju Island, we described Scorpaenopsis neglecta as the first record from Korea. They were characterized by having 12 dorsal fin spines, lacking of palatal teeth and of black pigment between the first and third dorsal fin spines, wider interorbital region than orbital diameter, no median interorbital ridge, uppermost opercular spine with multicusps, and a broad blackish band distally and numerous various sized black spots on inner side of pectoral fin. We proposed a new Korean name, "Ssol-chi-u-reug" for the species.

• Clinical and Experimental Pediatrics
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• v.49 no.2
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• pp.212-216
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• 2006

Neurocutaneous melanosis is a rare congenital syndrome characterized by the presence of large or multiple congenital melanocytic nevi and benign pigment cell tumors of the leptomeninges. Neurocutaneous melanosis is thought to represent an error in the morphogenesis of embryonal neuroectoderm. We experienced a neonate who presented with giant, dark colored pigmented nevi covering chest, abdomen, neck and arms, with satellite lesions. Magnetic resonance image showed a nodular hyperintense lesion in the amygdala of the right temporal lobe, and T1-weighted images showed hyperintensities in the adjacent leptomeninges. We report a rare case of neurocutaneous melanosis with a brief review of related literature.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.2 no.1
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• pp.25-42
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• 1996

In order to study the effect of Sikbuntang on the in vitro Cell-cytotoxicity, this study had put through MTT Assay. And to investigate the effects of Sikbuntang on the ICR mice which had Abdominal tumor induced by Sarcoma-180 cell line, C57Bl/6 mice which had pulmonary melanoma induced by B16 cell line. After Sarcoma-180 cell line and B16 cell line were transplanted, the extract of Sikbuntang was orally administered to the mice to observe the extension of survival time of the mice, inhibition of solid tumor, inhibition of pulmonary melanoma metastasis, productivity of Interleukin-2, NK-Activity. The results were summarized as follows : 1. On the MTT assay, in case of $100{\mu}g/ml$ and $10{\mu}g/ml$ of Sikbuntang concentration were inhibited cell viability significantly. But $1{\mu}g/ml$ of Sikbuntang concentration just had tend to inhibit cell viability. 2. In the effect of life extension, Sikbuntang treated group appeared to survive longer than the control group, but which were not significant. 3. In the effect of inhibition solid tumor, Sikbuntang treated group appeared to decrease than the control group, but which were not significant. 4. In the effect of inhibition melanoma pulmonary metastasis, Sikbuntang treated group appeared to inhibit than the control group significantly. 5. In the productivity of Interleukin-2, on 7 and 14 day, Sikbuntang treated group increased than control group significantly. But on 21 day, Sikbuntang treated group had tend to increase with no significance. 6. In the NK-Activity, the ratio of effector cell and target cell. In case which the ratio was 50:1, Sikbuntang treated group showed increase than control group significantly. But in another cases, they showed increase with no significance.

• Progress in Medical Physics
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• v.18 no.1
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• pp.1-6
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• 2007

A system to non-invasively fix and monitor eye by a head mounted display (HMD) with a CCD camera for stereotactic radiotherapy (SRS) of uveal melanoma has been developed and implemented clinically. The eye fixing and monitoring system consists of a HMD showing patient a screen for fixing eyeball, a CCD camera monitoring patient's eyeball, and an immobilization mask. At flrst, patient's head was immobilized with a mask. Then, patient was Instructed to wear HMD, to which CCD camera was attached, on the mask and see the given reference point on its screen. While patient stared at the given point in order to fix eyeball, the camera monitored Its motion. Four volunteers and one patient of uveal melanoma for SRS came into this study. For the volunteers, setup errors and the motion of eyeball were analyzed. For the patient, CT scans were peformed, with patient's wearing HMD and fixing the eye to the given point. To treat patient under the same condition, daily CT scans were also peformed before every treatment and the motion of lens was compared to the planning CT Setup errors for four volunteers were within 1mm and the motion of eyeball was fixed within the clinically acceptable ranges. For the patient with uveal melanoma, the motion of lens was fixed within 2mm from daily CT scans. An eye fixing and monitoring system allowed Immobilizing patient as well as monitoring eyeball and was successfully implemented in the treatment of uveal melanoma for SRS.

• Korean Journal of Ichthyology
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• v.13 no.2
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• pp.117-122
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• 2001

Three species, Gymnogobius urotaenia, G. sp. 1 and G. sp. 2, collected at Hosan-river, Hosan-ri, Samcheock-si, Gangwon-do, Korea, were examined for the study of sexual dimorphism. The three species have peculiar nuptial pigmentation during the breeding season: all females of the three species showed an intense black coloration on the ventral part of the head, the pelvic fin, the anal fin and the margin of the first dorsal fin. There was a difference between G. sp. 1 and the other two species in 1/3 from margin of first dorsal fin. Namely, G. sp. 1 showed an intense black coloration, whereas the other two species had an intense yellow coloration. All females of the three species showed the same, intensely yellow coloration in the ventral part of the body. Males of G. urotaenia and G. sp. 2 had almost the same nuptial pigmentation, however the former showed diffuse black coloration in the anal fin, whereas the latter had an intensely black anal fin. Males of G. sp. 1 differed from those of the other two species in their yellow color on the ventral part of the head, the pelvic f ins, the anal fin, in contrast to the diffuse black coloration in those parts in the other species. The genital papilla of males was triangle-shaped, but that of females was heart-shaped. Significant differences between sexes include: G. urotaenia, 7 characters (body depth, head length, snout length, upper jaw length, head depth, pectoral fin ray length, eye diameter); G. sp. 1, 11 characters (body depth, head length, caudal peduncle length, caudal peduncle depth, snout length, upper jaw length, head width, head depth, anal fin ray length, pectoral fin ray length and caudal fin ray length); G. sp. 2, 10 characters (body depth, head length, caudal peduncle depth, snout length, upper jaw length, head width, anal fin ray length, pectoral f in ray length, caudal fin ray length and eye diameter). Of the 5 characters which showed differences in all three species (body depth, head length, snout length, upper jaw length and pectoral fin ray length), females had higher values than males only in body depth, whereas males values in all other characters. The upper jaw length was the most distinctive sexually dimorphic feature, the upper jaw extended beyond the posterior margin of the eyes (p<0.001) in males but not in females.

• Korean Journal of Ichthyology
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• v.28 no.3
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• pp.164-174
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• 2016

Tanakius kitaharae and Glyptocephalus stelleri, belonging to the family Pleuronectidae, were very similar in external morphology not only during adult periods, but also during larval periods. In this study, we compared larval development and growth of the two pleuronectids species in detail. Fifty-eight specimens of T. kitaharae larvae and five specimens of G. stelleri larvae were collected from the East Sea, southern Korean Strait, and the adjacent waters of Jeju Island during 2014~2016, and were identified using morphological and molecular markers. Flexion larvae of T. kitaharae (10.23~16.77 mm total length, TL) and G. stelleri (14.33 mm TL) were similar in morphometrics, but can be distinguished by the melanophores in the fin membranes (present in the former vs. absent in the latter), and the melanophores at posterior margin of shoulder girdle (absent in the former vs. present in the latter). Postflexion larvae of T. kitaharae (17.12~24.92 mm TL) and G. stelleri (27.71~32.95 mm TL) differed in the number of melanophores on the mid-lateral caudal region (two in the former vs. five in the latter), and that on the dorsal and anal fin pterygiophores (five or six in the former vs. one row in the latter). Tanakius kitaharae and G. stelleri larvae differed in size at the beginning of metamorphosis. The left eye of T. kitaharae larvae between 23.13~24.92 mm TL reached the dorsal margin of the head while that of G. stelleri larvae between 38.66~42.67 mm TL did not reached yet.

• Journal of Society of Preventive Korean Medicine
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• v.2 no.1
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• pp.13-30
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• 1998

Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorou.a.il (5). were tested for their growth inhibitory effects against SK-MEL-3 cell lines using two different 3-(4,5-dimethylthiazol- 2yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. These compounds showed inhibitory activity in vitro in the micromolar range against SK-MEL-3 cell lines. In general, the antitumor activity of these compounds (1, 2, 3, 4 and 5) was in a dose-dependent over the micromolar concentration range $1\;to\;100{\mu}M$. The comparison of $IC_{50}$ values of these compounds in tumor cell lines shows that their susceptibility to these compounds decrease in the following order : OLVTL > CBG > CBD > 5-FU > CRNL in MTT assay, CBG > OLVTL > CBD > GRNL > 5-FU in SRB assay. Cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their cytotoxic effects on NIH 373 fibroblasts using two different MTT assay and SRB assay. These compounds exhibited potent cytotoxic activities in vitro in the micromolar range against NIH 373 fibroblasts. In general, the cytotoxic activities of these compounds (3, 4 and 5) were in a dose-dependent over the micromolar concentration range $1\;to\;100{\mu}M$. The comparison of $CD_{50}$ values of these compounds on NIH 373 fibroblasts shows that their susceptibility to these compounds decrease on the following order ; CBD > 5-FU > CBG in MTT assay and SRB assay. Cannabigerol (3) was shown the least cytotoxic activity on NIH 373 fibroblasts. Cannabigerol (3) exhibited the most growth-inhibitory activity against SK-MEL-3 cell lines.