• The Korean Society of Law and Medicine
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• v.17 no.1
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• pp.169-208
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• 2016

"Act on Remedies for Injuries from Medical Malpractive and Mediation of Medical Disputes)" has been enacted to solve medical dispute. In addition, mediation and arbitration procedures have started since April 8th, 2012 from the Establishment of Korea Medical Dispute Mediation and Arbitration Agency. The average initiation rate of mediation for the past three years turned out to be 43%. Hereupon, Establishment of Korea Medical Dispute Mediation and Arbitration Agency has created a solution for automatic initiation if relevant to particular conditions to improve initiation rate of mediation procedures and passed it through the Assembly plenary session in May, 2016 and promulgated on the 30th of the same month. However, even if mediation procedure initiation rate is increased, there is no guarantee for mediation establishment rate to be improved according to current law. If Establishment of Korea Medical Dispute Mediation and Arbitration Agency intends to increase aforementioned value, automatic initiation is not the only solution. Instead, it seems to be a major assignment to identify fundamental reasons for why major health care facilities have not participated in it and to restore reliability on them. In addition, among crimes specified on the Article 268 of Criminal Act in the Article $51^*$ of "Act on Remedies for Injuries from Medical Malpractive and Mediation of Medical Disputes)", revision must be made so that the clause of clue and death by occupational or gross negligence is applied. Furthremore, it is suggested to supplement previously insufficient policies with the operation so that mediation procedures created by Establishment of Korea Medical Dispute Mediation and Arbitration Agency are stably settled in the perspective of medical institutions including the establishment of new conditions for medical institutions founders or health and medical service personnel to claim the proxy payment for damage.

• Clean Technology
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• v.17 no.4
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• pp.285-299
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• 2011

As one of the REACH obligations, the extended safety data sheet (eSDS) should be communicated within the supply chain under the REACH Regulation. Based on technical guidance documents published on the ECHAs website and survey of EU's recent REACH-related informations, this paper includes a study on details of how to develop exposure scenarios (ES) such as structure of ES, process of ES develpoment, standard workflows and key input data to develop ES with an introduction of eSDS concept. This paper also contains an overview on operational conditions (OCs) and risk management measures (RMMs) that are what to consider when building an ES. The structure of Chesar (Chemical Safety Assessment and Report tool) developed by European Chemicals Agency (ECHA) is studied with a review of the available exposure estimation tools for workers, environment and consumers. Case example of generic exposure scenario (GES) for organic solvent is presented. To guide Korean EU-exporting companies, their participating roles in three steps of preparing ES are addressed.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.11 no.3
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• pp.215-220
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• 2018

This paper limited the participation of large corporations in the mass information market by revising the Software Industry Promotion Act in order to increase business opportunity, equality of opportunity, and capacity building for small and medium sized IT companies. However, it is a fact that the medium and small SW companies have insufficient business capacity and expose various problems such as quality degradation of public information business, inadequate risk management, and deterioration of schedule management. In order to solve this problem, this paper derived the factors of quality deterioration in the system integration project and proposed to carry out the project by using some activities of VISUALIZATION, rigorous test management and Agile Methodology as a solution. Applying these measures to healthcare IT projects developed by midsize / small-sized IT companies has improved communications, improved quantitative progress management and improved project visibility. In addition, it contributed to minimizing defect resolution time, improving the requirement coverage ratio, and shortening unnecessary meeting time.

• Environmental Analysis Health and Toxicology
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• v.9 no.1_2
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• pp.37-51
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• 1994

To evaluate the genotoxicities of workers exposed to glue and glue cleaning solution, ambient air monitoring of working place, animal study and human monitoring were carried out. By GC-MS analysis, air samples collected from shoesmaking plant were found to be toluene, xylene, cyclohexane, n-hexane, methyl ethyl ketone, trichloroethylene, butylacetate, isopropyl alcohol. Glue and glue cleaning solution from shoesmaking plant were applicated topically to the CD-1 mice. DNA was isolated from skin 24 hr following the application and analysed for DNA-adducts using the nuclease $P_1$version of $^{32}$P-postlabelling assay. RAL (Relative Adduct Labelling, adducts$10^8$ nucleotides) was significantly increased in a dose-dependent manner in the glue cleaning solution treated mice skin. Peripheral blood DNA-adducts of workers exposed to glue and glue cleaning solution were also analysed by the same method, but there were not significant differences in the peripheral blood DNA-adducts level between exposed and control workers. In addition, glue cleaning solution from shoes factory was evaluated for mutagenicity in the Salmonella plate incorporation assay using strains TA 100 and TA 1535 in the presence and absence of Arochlor 1254-induced rat liver S$_{9}$. There was evident mutagenicity for cleaning solution in TA 100 regardless of $S_9$, but TA 1535 showed positive only in the absence of $S_9$when predicted by Stead model of mutagenicity prediction (p=0.0000). The urine concentrates from workers and controls were also assayed for mutagenicity towards strain TA 100 of Salmonella typhimurium in the presence of $S_9$ using Kado's microsuspension assay, but their mutagenic activities were not found to be significant. These data suggest that shoesmaking workers are exposed to genotoxic compounds and need to be monitored by testing the mutagenicity of human urines. However, $^{32}$P-postlabelling application requires further validation for the routine monitoring of human exposure.osure.

• Environmental Analysis Health and Toxicology
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• v.15 no.3
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• pp.107-113
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• 2000

Chlorophenoxy acids are one of the most useful classes of chlorinated herbicides. Specially 2, 4-D and 2, 4, 5-T were known to endocrine distruptors. In this study, these pesticides in water samples were extracted by liquid-liquid extration at acidic conditions and then derivatization of acidic group was carried out various esterifications using by CH$_3$I/Acetone -K$_2$CO$_3$, H$_2$SO$_4$/MeOH or TFAA/TFE. That result, Sensitivities of TFE derivatized 2, 4-D and 2, 4, 5-T are prior to the others. The recoveries of 2, 4-D and 2, 4, 5-T were 98% and 82% respectively using diethyl ether as an extracting solvent.

• Environmental Analysis Health and Toxicology
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• v.21 no.2 s.53
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• pp.147-151
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• 2006

난생 생물의 알 생성유도 단백질인 비텔로제닌(viteILogenin, VTG)을 성숙한 암컷 황소개구리 (Rana catesbeiana)혈청으로부터 음이온 교환 크로마토그래피를 이용하여 정제 하였으며 정제한 비텔로제닌을 BALB/c mice에 주사하여 폴리크로날 항체를 생산하였고 이것은 protein A column으로 정제 하였다. 이렇게 정제된 폴리크로날 항체를 이용하여 황소개구리 비탈로제닌 측정용 효소면역측정법을 개발하였으며 그 측정 범위는 $12{\sim}1,560ng/mL$였다. 또한 이 효소면역측정법을 평가하기 위해 성숙한 수컷 황소개구리를 청정지역과 폐수처리장 하류 하천에서 서식하는 황소개구리 혈액 속의 비텔로제닌을 측정하였다. 그 결과 폐수처리장 하류 하천에 서식하는 수컷 황소개구리 비텔로제닌이 청정지역보다 현저하게 높게 유도됨을 알 수 있었다.

• Environmental Analysis Health and Toxicology
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• v.24 no.4
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• pp.333-339
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• 2009

In this study, we investigated the biological toxicity of nano-scale Zn (0.1, 0.5, and 1 mol%)-doped $TiO_2$ and pure $TiO_2$ nanoparticles using zebrafish embryogenesis as our model organism. Zn-doped $TiO_2$ nanoparticles were prepared using a conventional hydrothermal method for the insertion of zinc into the $TiO_2$ framework. The characters of Zn-doped $TiO_2$ (0.1%, 0.5%, 1%Zn) and pure $TiO_2$ were about 7~8 nm. These sizes were smaller than 100~200 nm of $TiO_2$ was prepared using the sol-gel method. Particularly, in this study, we found no significant biological toxicity in the hatching rate and abnormal rate under expose pure $TiO_2$ and Zn-doped $TiO_2$ nanoparticles were prepared using a conventional hydrothermal method of zebrafish. It was different from the biological damage under $TiO_2$ nanoparticles were prepared using sol-gel method. We assessed that the damage was not linked to the particle's nanometer size, but rather due to the prepare method. Moreover, $TiO_2$ nanoparticles were prepared using a hydrothermal method were not shown to cause cytotoxic effects, like apoptosis and necrosis, that are the major markers of toxicity in organisms exposed to nanomaterials. Therefore, there is some relationship with biological toxicity of nanoparticles and the prepare method of nanometer size particles.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.186-186
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• 2016

산업안전보건법에 따르면 결함수 분석기법(Fault Tree Analysis, FTA)은 주로, 설계 또는 운전단계에 있는 공정 위험성 평가 시 사고의 발생빈도와 예상사고 시나리오를 추정하는데 적용되어왔다. 따라서 일반적인 결함수 분석에서 정상 사상은 시스템 자체의 사용불능을 야기하는 가장 큰 원인을 의미한다. 그러나 상수도의 유지관리를 위해 FTA를 적용한 경우 정상 사상은 일반적인 FTA에서의 정상 사상과는 다르게 정의되어야 한다. 즉, 용수공급의 경우 관망 전체에 영향을 미치는 정상 사상이란 수원지의 오염이나, 수원지에서 직접적으로 나오는 관로에 문제가 생겼다거나 하는 사건을 의미하므로, 이러한 방식의 정상 사건 정의는 관망의 관로 및 절점에서 발생되는 문제를 분석하기 어렵게 만든다. 따라서 본 연구에서는 관망의 특정 지점에 용수공급이 원활하게 되지 않는 경우를 FTA의 정상사상으로 정의하였다. 또한, 개개의 관로 노후도 평가 점수와 FTA를 이용하여 관망의 특정 절점에 용수를 공급하기 위한 관로들의 노후도 평가 평균 점수를 산출하였다. 개발한 프로그램에서는 평균 노후도 평가 점수를 산출하기 위해서, 특정 절점 값을 입력 받고 각 파이프와 그로 인해 생기는 고립구간(세그먼트 + 비의도적 고립구간) 에 포함되는 절점들의 관계를 나타낸 자료를 이용하여 파이프에 문제가 생길 시 단수되는 절점을 역으로 검색해서 각 파이프의 노후도 평가 점수를 산술평균 하였다. 본 연구에서는 특정지점에 용수 공급이 원활하지 못 한 정상사상에 대하여 관로의 수리 또는 교체를 해야 하는 구간을 찾아 노후도 평가 점수를 산정하는 것이 목표이다. 이를 위해 특정 절점에 용수를 공급하기 위하여 지나가는 관로들에 대해서 평균 점수를 구함으로써, 절점에 용수가 원활히 공급 될 가능성을 산정하여 FTA와 관로 노후도 평가 점수를 이용하고 특정 절점에 용수를 공급하기 위하여 지나가는 관로들에 대해서 평균 점수를 산정하였다. 절점에서 용수를 공급하는 중요도에 따라 절점으로 이어지는 관로의 평균 노후도를 일정 점수 이하로 유지시키는 방법을 이용함으로써 관로의 유지관리 필요성에 대해 지표로써 사용할 수 있다.

• Journal of Digital Convergence
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• v.17 no.6
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• pp.315-326
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• 2019

This study is a review of research articles on the characteristics of probiotics. Probiotics are effective at ameliorating immune disease, alleviating glucose intolerance, and improving constipation and diarrhea. Furthermore, they have anticancer and antitumor effects, preventive effects against cardiovascular disease, antidiabetic effects, antioxidant effects, antibacterial effects, and they produce useful metabolites. It has been demonstrated that oral probiotics are effective in eliminating halitosis and forming a favorable oral ecosystem, by creating an environment that is not readily inhabited by harmful bacteria, such as Streptococcus mutans, which produces lactic acid and causes tooth decay, or Porphyromonas gingivalis, which causes gum disease.As a result, oral probiotics are being considered not only as therapeutics against diseases, but also as preventive agents for the maintenance of a healthy oral balance. In spite of some limitations, clinical trials are currently underway, and this study can provide evidence to support the use of probiotics to improve oral health conditions, including dental caries, periodontal disease, and Candida colonization.

• Journal of the Korean Society of Radiology
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• v.13 no.5
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• pp.819-824
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• 2019

In this study, we proposed a method for identifying isotopes generated from high-energy proton $^{nat}Pb$(p,xn) nuclear reactions through the difference of gamma rays generated through nuclear reactions using different proton energies. The experiment was performed by using a high energy proton generated from a 100 MeV proton linear accelerator of the Korea Atomic Energy Research Institute. Gamma rays generated by various nuclides generated through proton nuclear reactions were measured using a gamma-ray spectroscopy system composed of HPGe detectors. Gamma-ray standard sources were used for accurate energy calibration and efficiency measurements of HPGe gamma-ray detectors. For the proposed method, 100 and 60 MeV proton energy beams were used for the same natural lead samples. This method was found to be very effective in identifying nuclides produced by comparing gamma rays generated from the same sample with each other. The results of this study are expected to be very effective in obtaining other proton nuclear reaction results in the future.