• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.4
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• pp.99-106
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• 2014

In order to study the reasonable design thermal loads, the steel box girder bridge specimen which have no concrete slab was manufactured with the real size dimension. The temperature data were measured for 5 month at the 18 thermo gauges which were attached according to height. The temperature differences between the top and bottom flange in steel box girder specimen were calculated and the temperature gradient models were proposed by the probabilistic method. This proposed model showed a correlation of approximately 97% when compared with the similar model of Euro Code. Thus, the temperature gradient models which were suggested in this study may be used as the basis data in calculating the design load temperature.

• Journal of the Korean Society for Railway
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• v.12 no.5
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• pp.678-686
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• 2009

A trial run of locally-developed tilting train has been in process on Chungbuk line since the test vehicle was first produced. For the system stabilization, interface verification among the systems including track, structure, catenary and signaling system, not to mention the rolling stock, is very crucial. Therefore, in this study, the dynamic rail force of the tilting (Hanvit 200), high-speed (KTX) and general (Mugunghwa) vehicle caused by driving in transition curve track was measured. And, it compared the tilting response with the other by using the measured rail force data in transition curve track, and then evaluated probability the range of load fluctuation for the variable dynamic vertical and lateral wheel load. As a result, a range of rail force by occurred a change of cant from the high-speed and general vehicle which had fixed bogie structure was distributed throughout small deviation. Otherwise, in case of the tilting train which was consisted of the pendulum bogie structure was distributed wide range about large deviation by changed of cant.

• Aerospace Engineering and Technology
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• v.9 no.1
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• pp.50-59
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• 2010

In this paper, the alignment and navigation results by INGU(Inertial Navigation and Guidance Unit) onboard software and by Inertial Explorer which is a post-processing software specialized for IMU(Inertial Measurement Unit) are compared for identification of inertial sensor error models and estimation of alignment and navigation errors for KSLV-I INGU. For verification of the IMU error estimated by Kalman Filter of Inertial Explorer, the covariance parameters of inertial sensor error model state are identified by using stochastic error model of inertial sensors estimated by Allan variance and the alignment and navigation test with static condition and the land navigation test with dynamic condition are carried out. The validity of inertial sensor model for KSLV-I INGU is verified by comparison the alignment and navigation results of INGU on-board software and Inertial Explorer.

• Korean Journal of Clinical Pharmacy
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• v.23 no.1
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• pp.1-13
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• 2013

희귀질환이란 일반적으로 그 유병율이 인구 일만 명당 5명 이하인 질환을 말한다. 세계에는 약 7,000여종의 희귀질환이 알려져 있고 학술지에 매 주 대략 5종의 새로운 희귀질환이 보고되고 있다. 희귀 의약품(orphan drug)이란 희귀질환치료제 또는 수익성이 없어 개발을 기피하는 일반질환 치료제로서 정부가 지정한 의약품을 말한다. Orphan 의약품의 개발에는 많은 장점이 있다. Orphan 의약품으로 정부의 지정을 받으면 세금감면을 통한 연구비 지원, 임상시험 비용 지원, 신약허가 심사비 면제, 시장독점권 부여 등의 특혜가 주어진다. 희귀질환의 대부분은 단순한 유전적 결함에 의하는 경우가 많아 치료제의 표적발견이 비교적 쉬우므로 개발 성공률이 높고, 임상시험기간이 짧으며, 시판허가를 받을 확률이 높아 연구개발비용이 적게 든다. 그 결과 전세계 orphan 의약품 시장은 최근 매년 6%씩 성장하여 2014년에는 약 1,120억달러의 시장을 형성할 것으로 추정된다. Orphan 의약품 시장은 현재 매년 8.9%씩 성장하고 글로벌 시장의 51%를 점유하는 미국을 중심으로 확장되어 가고 있으며, 총매출액의 64.3%가 유전자재조합의약품에 의한 것으로 알려져 있다. 이러한 의약품시장의 변화와 사회적 요구에 부응하여 한국 또한 희귀질환 치료제 개발의 활성화를 위해 재정적 지원체계를 구축하고, 허가관리를 개선하며, 법률적 제도를 완비하는 과정에 있다. 현재 희귀질환의 치료적 타겟을 찾아 신물질이나 기존의 약물을 발굴하는 과정이 주로 대학이나 연구 중심 병원에서 이루어지고 있다. 제도가 잘 정립되어 있는 미국 시장을 겨낭하여 orphan 의약품 개발을 전략적으로 수행한다면 큰 성공을 거둘 수 있을 것으로 기대된다.

• Journal of Navigation and Port Research
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• v.45 no.3
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• pp.87-94
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• 2021

The IMO has adopted emission standards that strictly restrict the use of bunker C oil for vessels. Accordingly, research and bunkering pilot projects for LNG fueled ships are being actively carried out, which is expected to substantially reduce environmental pollution. In this study, we have adopted the turret moored Floating LNG Bunkering Terminal (FLBT) designed to receive the LNG from LNGCs and to transfer LNG to LNG bunkering shuttles in ship to ship moored condition. Numerical simulations have been performed with a 1-year return period of wind, wave, and current. Damping values of numerical model were adjusted from the results of model tests to obtain accurate simulation results. The results confirm safe berthing operation during the 1-year return period of environmental condition. Safety depends on the direction of environment, with increasingly stable operation facilitated by the application of heading-control function of FLBT to avoid beam-sea conditions.

• Journal of the Korean Applied Science and Technology
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• v.40 no.6
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• pp.1330-1339
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• 2023

In order to verify whether the serum using the medicinal plant Coptis japonica is effective in anti-aging of the skin, the improvement rate was analyzed by measuring the skin elasticity and radiance of the subjects, and the satisfaction was evaluated through a questionnaire. Twenty-two female subjects were given a serum containing 3% Coptis Japonica extract on one cheek for 4 weeks, and the test site was measured, and the skin elasticity increased by 5.73% from 0.8505 ± 0.0395 R2 (mm) before use to 0.8993 ± 0.0234 R2 (mm) after 4 weeks. Skin glow increased by 4.74% from 55.94 ± 5.49 (a.u.) to 58.59 ± 4.66 (a.u.), and the probability of significance was p<0.001, indicating a significant increase in the improvement rate of both items. It was found that all subjects were 100% satisfied with the improvement of elasticity and 95.5% satisfied with the improvement of radiance, and no skin abnormalities were found during the trial period. These results are expected to be used as basic data for future research and product development of anti-aging functional cosmetics using Coptis Japonica extract.

• Composites Research
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• v.24 no.1
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• pp.24-30
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• 2011

Low-velocity impact can cause various damages which are mostly hidden inside the laminates or occur in the opposite side. Thus, these damages cannot be easily detected by visual inspection or conventional NDT systems. And if they occurred between the scheduled NDT periods, the possibilities of extensive damages or structural failure can be higher. Due to these reasons, the built-in NDT systems such as real-time impact monitoring system are required in the near future. In this paper, we studied the impact monitoring system consist of impact location detection and damage assessment techniques for composite flat and stiffened panel. In order to acquire the impact-induced acoustic signals, four multiplexed FBG sensors and high-speed FBG interrogator were used. And for development of the impact and damage occurrence detections, the neural networks and wavelet transforms were adopted. Finally, these algorithms were embodied using MATLAB and LabVIEW software for the user-friendly interface.

• Journal of the Korean Recycled Construction Resources Institute
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• v.10 no.1
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• pp.101-110
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• 2022

In this study, water content tests were performed on various fresh concretes subjected to different binder compostions to review the estimation errors and reliability of water content test methods. Micro-oven drying method, air-meter method, capacitance method and microwave penetration method were used to estimate water content of fresh concrete. Errors in water content estimation were analyzed by each test method. Regardless of the test method of water content, the estimation error was less than 5 %, and in the case of the test using mortar, the error in the estimation value was relatively large. In addition, based on the test results of water content of various concrete, the probability density function in which the estimation error for each test method becomes the population was analyzed. Water content test methods of fresh concrete which using concrete samples showed high estimate reliability of 97 % within the estimation error range of ± 10 kg/m³. On the other hand, the reliability of water content test method using mortar samples was lower.

• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.6
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• pp.509-523
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• 2023

The high-level nuclear waste (HLW) repository is exposed to complex environmental conditions consisting of high temperature, high humidity, and radiation, resulting in structural deterioration. Therefore, structural health monitoring is essential, and piezo sensors are used to detect cracks and estimate strength. However, since the monitoring sensors installed in the disposal tunnel and disposal container cannot be replaced or removed, the quantitative life of the monitoring sensor and its suitability must be assessed. In this study, the life of a piezo sensor for monitoring was assessed using an accelerated life test (ALT). The failure mode and mechanism of the piezo sensor under high temperature conditions were determined, and temperature stress's influence on the piezo sensor's life was analyzed. ALT was conducted on temperature stress and the relationship between temperature stress and piezo sensor life was suggested. The life of the piezo sensor was assessed using the Weibull probability distribution and the Arrhenius acceleration model. The suggested relationship can be used in multiple stress ALT designs for more precise life assessment.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.12
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• pp.2317-2323
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• 2015

In this paper, we analyze the performance of dual-hop amplify-and-forward (AF) relaying in cooperative networks with partial relay selection. An AF relay gain considered in this paper includes channel-noise-assisted relay gain. Leveraging a received signal-to-noise ratio (SNR) model, we derive exact closed-form expressions for the probability density function (pdf) and cumulative distribution function (cdf) of the end-to-end SNR. Moreover, an exact closed-form expression of the ergodic capacity for dual-hop AF relaying with channel-noise-assisted relay gain and partial relay selection is investigated. The analytical results shown in this paper are confirmed by Monte-Carlo simulations.