• Journal of Life Science
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• v.26 no.10
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• pp.1137-1152
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• 2016

Cells sense, respond, and adapt to a low oxygen environment called hypoxia, which is widely involved in a variety of human diseases. Adaptation to low oxygen concentrations includes gene expression changes by inducing hypoxic genes and reducing aerobic genes. Recently, the mitochondrial respiratory chain has been implicated in the control of these oxygen-regulated genes when cells experience hypoxia. In order to obtain an insight into an effect of the mitochondrial respiratory chain on cellular response to hyxpoxia, we here examined whole genome transcript signatures of respiration-proficient and respiration-deficient budding yeasts exposed to hypoxia using DNA microarrays. By comparing whole transcriptomes to hypoxia in respiration-proficient and respiration-deficient yeasts, we found that there are several classes of oxygen-regulated genes. Some of them require the mitochondrial respiratory chain for their expression under hypoxia while others do not. We found that the majority of hypoxic genes and aerobic genes need the mitochondrial respiratory chain for their expression under hypoxia. However, we also found that there are some hypoxic and aerobic genes whose expression under hypoxia is independent of the mitochondrial respiratory chain. These results indicate a key involvement of the mitochondrial respiratory chain in oxygen-regulated gene expression and multiple mechanisms for controlling oxygen-regulated gene expression. In addition, we provided gene ontology analyses and computational promoter analyses for hypoxic genes identified in the study. Together with differentially regulated genes under hypoxia, these post-analysis data will be useful resources for understanding the biology of response to hypoxia.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.4
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• pp.505-511
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• 2014

Purpose: This study was to investigate the effect of breath alcohol concentration (BrAC) increase with drinking alcohol on contrast sensitivity in the conditions of restricted BrAC. Methods: 23 males in 20s (average age $21.17{\pm}2.19$ years, body mass index (BMI) $22.09{\pm}2.16$) were selected and administered the amount of alcohol to reach 0.05% and 0.08% BrAC calculated by BAC (blood alcohol concentration) Dosing Software program, which was developed as basis of Watson's formula. Then, the contrast sensitivity in various luminance conditions (photopic, mesopic, and mesopic with glare) was measured and compared between these conditions. Results: The contrast sensitivity in all spatial frequency was decreased with BrAC increase. Although BrAC was increased, the peak of contrast sensitivity didn't change as 6 cycle per degree (cpd) in the photopic condition and 3 cpd in the mesopic condition, respectively. But, in the mesopic condition with glare, the peak of contrast sensitivity was shifted from 6 cpd at 0% and 0.05% BrAC to 3 cpd at 0.08% BrAC with increase of alcohol concentration. Conclusions: The increase of BrAC by drinking alcohol induces the decrease of contrast sensitivity in all spatial frequency and the shift of peak of contrast sensitivity, which can cause safety accidents, and may have an effect on various visual tasks.

• Sleep Medicine and Psychophysiology
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• v.12 no.1
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• pp.64-67
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• 2005

Obstructive sleep apnea syndrome(OSAS) is a common disease in the field of otorhinolaryngology and is characterized by repeated upper airway occlusions occurring during sleep. OSAS can occur due to various etiologies of the nasal, oral, pharyngeal and laryngeal airway in adults. Nasal obstruction can be caused by septal deviation, nasal polyps, concha bullosa, choanal atresia, neoplasms, foreign body, postoperative/post-traumatic synechiae, various rhinitis and so on. There are various kinds of surgical treatment of OSAS including nasal surgery, LAUP, UPPP, surgery of tongue base, tracheostomy and so on, but the effect of nasal surgery on snoring and OSAS is controversial. The authors report the case of a patient who had experienced nasal obstruction, moderate snoring and OSAS and who improved after septoplasty and turbinoplasty.

• Progress in Medical Physics
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• v.15 no.4
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• pp.179-185
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• 2004

To deal with tumor motion from respiration is one of the important issues for the advanced treatment techniques, such as the intensity modulated radiation therapy (IMRT), the image guided radiation therapy (IGRT), the three dimensional conformal therapy (3D-CRT) and the Cyber Knife. Studies including the active breath control (ABC) and the gated radiation therapy have been reported. Authors have developed the device for reducing the respiration effects and the diaphragm motions with this device were observed to determined the effectiveness of the device. The device consists of four belts to immobilize diaphragm motion and the vacuum cushion. Diaphragm motions without and with device were monitored fluoroscopically. Diaphragm motion ranges were found to be 1.14 ～ 3.14 cm (average 2.14 cm) without the device and 0.72～1.95 cm (average 1.16 cm) with the device. The motion ranges were decreased 20 ～ 68.4% (average 44.9%.) However, the respiration cycle was increased from 4.4 seconds to 3.7 seconds. The CTV-PTV margin could be decreased significantly with the device developed in this study, which may be applied to the treatments of the tumor sited diaphragm region.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.8
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• pp.2134-2140
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• 2009

The purpose of this study is to compare relationship among pulmonary function, dyspnea, and health-related quality of life in patients with COPD. The instruments were used FEV1(%), the Baseline Dyspnea Index(BDI), the Medical Research Council Scale(MRCS), and the St. George's respiratory questionnaire(SGRQ). Dyspnea of patients with moderate and severe stage were deeper than one of patients with mild stage(BDI F=5.452, p=.007; MRCS F=4.925, p=.011). And health-related quality of life of patients with severe stage were poorer than one of patients with mild stage(F=3.778, p=.030). There were significant, but weak, correlations between scores of the BDI(r=.471), the MRCS(r=-.403), the SGRQ(r=-.476) and FEV1. There were strong correlations between scores of the BDI(r=-.752), the MRCS(r=.645) and the SGRQ. And FEV1 didn't correlated with the BDI, the MRCS, and the SGRQ scores in patient of moderate stage and severe stage. But there were also strong correlations between the BDI(r=-.719), the MRCS(r=.607) and the SGRQ in patient of moderate stage and severe stage. Specially, correlation between the BDI and the SGRQ were higher than one between the MRCS and the SGRQ. In conclusion, Using the BDI for evaluation of the subjective dyspnea with objective pulmonary functional test in patients with COPD, it will able to grasp the health-related quality of life.

• Journal of Chest Surgery
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• v.39 no.4 s.261
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• pp.304-309
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• 2006

Background: Interstitial pneumonia is associated with an increased risk of lung cancer but the outcome of surgical resection in this setting is unknown. The purpose of this study was to determine the relationship between pre-operative interstitial pneumonia (IP) and post-operative respiratory failure. Material and Method: A retrospective review of 672 patients with lung cancer who underwent curative pulmonary resection at the Hospital of Catholic University Medical College between 1997 and 2005 was undertaken. The patients were divided into two groups according to preexisting interstitial pneumonia and not by the pre-operative chest HRCT or findings of pathologic papers. The pre-operative data and cancer-related findings were analyzed between the IP group and non-IP group, and between the respiratory failure group and non-failure group in IP patients. Result: Twenty-eight patients (4.2%) of the developed post-operative respiratory failure and this proved to be fatal in 21 of these patients. We could find preoperative interstitial pathology in 53 patients (7.9%) among the 672 patients. The incidences of respiratory failure were 11.3% (6/53 cases) and 3.6% (22/619 cases) in IP group and non-IP group respectively, Conclusion: Interstitial pneumonia was considered one of the risk factors for developing postoperative acute respiratory failure in patients with lung cancer.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.119-123
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• 2019

Obstructive sleep apnea (OSA) is a sleep disorder with no breathing symptoms due to repetitive upper airway resistance. OSA is a disease that can have significant effects on the cerebral cardiovascular system. Active treatment is needed to prevent these complications. The use of continuous positive airway pressure (CPAP), the standard therapy of OSA, has comparative therapeutic effects. On the other hand, there is no comparison report of the polysomnography (PSG) results before and after CPAP therapy without using a mask. This paper reports a patient who was diagnosed as OSA and used CPAP every night for more than 2 years. The patient showed a decrease in the apnea-hypopnea index from 64.7/h to 12.9/h. In addition, other sleep-related indicators improved significantly. The daily use of CPAP as a treatment for OSA for more than 2 years may improve the PSG results. Constant follow up of PSG will be needed to adjust the appropriate CPAP pressure to patients because there might be a change in the Apnea-Hypopnea Index and other sleep-related indicators for constant CPAP users for at least 2 years.

• Proceedings of the KIEE Conference
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• 2008.10b
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• pp.149-150
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• 2008

u-Healthcare는 유비쿼터스와 원격의료 기술을 활용한 건강관리 서비스를 말한다. 목표는 삶의 질 향상 추에 있다. 경제수준이 향상되면서 삶의 질에 대한 중요성이 대두되고 있으며, 만성질환자 및 인성 질환의 예방 및 효율적 관리는 개인 및 사회적으로도 중요한 의의를 가진다고 할 수 있다. u-Healthcare 서비스를 제공하기 위해서는 언제 어디서나 이용사의 건강상태를 진단할 수 있는 생체계측기술이 필요하기 때문에 u-Healthcare 측정 모듈의 개발은 매우 중요하다. 본 논문에서는 개발한 모바일 연동 다기능 u-Healthcare 측정 모듈을 이응하여 심전도, 체지발, 호흡수, 체온 및 운동량 측정 등의 신호를 측정하였다. 측정된 신호를 Bluetooth 기반의 transceiver를 통해 u-Healthcare Center로 전송하며, Diagnostic Monitor를 통해 신호를 분석하여 건강상태를 모니터링 할 수 있는 검증모니터를 구현하였다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2002.11a
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• pp.177-181
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• 2002

본 연구에서는 동적환경 감성 시험평가 시스템(driving simulator)을 이용하여 다양한 운전속도(40, 70, 100km/h)에서 주행시 운전자의 감성평가를 실시하였다. 그 결과, 주행속도가 증가할수록 쾌활성, 쾌적감, 긴장감, 각성감, 속도감이 높게 나타났고, 심박수는 증가하였다. 안정시에 비하여 주행시에 뇌파의 알파파는 감소하고 베타파는 증가하였으며 호흡수가 증가하였으나, 조건간의 유의차는 나타나지 않았다. 또한 70km/h이상에서 GSR의 증가와 SKT의 감소가 인정되었으며, 70km/h이하에서 눈깜박임율이 증가하였다. 이상의 결과로부터, 운전자는 속도가 증가할수록 주관적으로 긍정적인 감성을 느끼지만, 70km/h이상에서 자율신경계 반응에 차이가 있음을 알 수 있었다. 또한 이러한 결과는 실제차량 및 시뮬레이터에서 수행한 선행연구의 결과와 대체로 일치하여 본 시스템으로 운전자 감성평가가 충분히 수행될 수 있음을 시사하였다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2014.07a
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• pp.417-418
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• 2014

본 논문에서는 무선 바이오센서 기반에서 동물 생체측정 정보를 이용한 질병 예방 감시 시스템을 설계하였다. 제안 시스템은 바이오센서를 이용하여 동물의 심박, 호흡수, 운동량을 측정할 수 있는 모듈을 개발하고 생체 신호를 계측하여 신호 처리된 정보를 Zigbee 무선 통신모듈을 이용하여 원격 데이터베이스에 전송하도록 설계하였다. 모니터링 시스템에서는 수집된 생체 정보의 연속적인 변화를 통하여 가축의 이상여부를 판단하고 질병 발생여부를 조기에 발견할 수 있게 가축의 상태정보를 제공한다. 본 연구결과는 향후 축산 농가의 질병 감시를 통하여 질병의 확산을 차단할 수 있는 긴급대처시스템을 구축하는데 활용 될 것이다.