• Tuberculosis and Respiratory Diseases
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• v.63 no.4
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• pp.362-367
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• 2007

Hormonal replacement therapy (HRT) has been proven for treatment of postmenopausal symptoms such as hot flushes, night sweats and urologic symptoms. HRT became very popular in the 1990's, when there were several reports showing that it also helped with other menopausal complications such as osteoporosis and cardiovascular disease. Recent studies report that the incidence of breast cancer, endometrial cancer, cerebral infarction, coronary artery diseases, deep vein thrombosis and pulmonary thrombembolism could rise after HRT. Among these side effects of HRT, the risk of pulmonary thromboembolism increases 2 to 4 fold after HRT, but can vary with the use of different doses and preparations. Here, we summarize the risk factors and clinical courses for 5 patients who developed pulmonary thromboembolism after postmenopausal HRT.

• KSBB Journal
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• v.19 no.1
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• pp.83-87
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• 2004

This research was designed to investigate the effects of Estromon including FGF271 (Female Growth Factor 271) which was developed as a phytoestrogen for post- and pre-menopausal syndrome (PMS). The oral administration of two capsules of Estromon twice a day for 3 months significantly improved PMS (Post-/Premenopausal Syndrome) about 5 times more than placebo group (OR=5.04, 95% C.1. 1.40-18.14). In the group of 24 patients having taken Estromon, the concentration of alkaline phosphatase asn the bone marker decreased by -9.3${\pm}$9.5 IU/L after 3 months with a statistic significance. Since the concentration of osteocalcin as the other bone marker also decreased in more patients in Estromon group than in placebo group, the bone density might be expected to be improved in long-term treatment. Serum human growth hormone level increased in 17 out of 24 patients. Triglycerides decreased by -8.0${\pm}$40 (mg%) after 1 month and by -4.4${\pm}$36 (mg%) after 3 months in Estomon group while triglycerides increased in both cases in placebo group (p.0.01). Therefore, PMS patients might benefit from Estromon as a phytoestrogen supplement without any serious side effects.

• Proceedings of the KSCN Conference
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• 2003.11a
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• pp.1030-1033
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• 2003

• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.39-40
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• 2004

• Women's Health Nursing
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• v.9 no.4
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• pp.369-378
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• 2003

Purpose: To identify factors influencing women's intention to take hormone replacement therapy(HRT). Method: A cross-sectional survey design was utilized. A total of 116 married women aged 40 to 60 were recruited from women's groups in communities. They completed a structured questionnaire containing demographic characteristics, Orientation to Life Questionnaire, Menopausal Symptom Checklist, Health Belief of Korean Adult, Sexrole Idea of Kim, Dong-il, chronic illnesses, and a single item measuring marital satisfaction. Result: Thirteen percents of the women were currently taking HRT and 28.4% had intention to take HRT. Education, sense of coherence, and sex role attitude were related to women's susceptibility to menopause. Hysterectomy status and the level of sense of coherence explained women's perception of seriousness regarding menopause. In addition, chronic health conditions accounted for the variances of benefits and barriers to HRT. Factors influencing women's intention to take HRT were education, menopausal symptoms, and perceived benefits of HRT. Conclusion: Women's chronic health conditions, psychosocial characteristics as well as menopausal discomforts were associated with women's choice regarding HRT. Other factors related to decision making process of women's health seeking behaviors need to be explored.

• The Journal of Korean Obstetrics and Gynecology
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• v.15 no.4
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• pp.193-201
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• 2002

Purpose : Premature ovarian failure, characterized by amenorrhea or oligomenorrhea, estrogen defieciency and elevated gonadotropins in woman less than 40 years of age, affects approximately 1% of woman and is associated with autoimmune phenomena or genetic abnormalities, but mostly idiopathic. This disease is loss of ovarian function seems not to be always permenent. Method : We investigated herb medication was effective in patient of premature ovarian failure. Results: Signs and symtoms of estrogen deficiency were improved and mensturation occurred monthly and the elevated during treatment of herb medication. As a result of our case recovering of ovarian function, we hope more investigtions about treating premature ovarian failure by oriental medicine will be gained.

• KSBB Journal
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• v.17 no.4
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• pp.409-415
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• 2002

A certain group of phytochemicals such as isoflavone have been proven to act as a phytoestrogen. After thorough the study of different bibliographic herbs excluding soybeans, dates, pomegranates, and other publicized plants, three different edible herbs by Korean Food Regulation were extracted for the animal study on the effect of estrogen replacement. The herbal extract(FGF271) has been orally administered into 51 weeks old partial ovariectomized rats for 5 weeks with the different dosages of 100 and 1,000 mg/kg, respectively. It was observed that 1) serum estrogen level was increased in both 100 and 1,000 mg/kg group, 2) the distension of uterus was made dose dependently and significantly different in 1,000 mg/kg group (p.0.05) from control in the gross findings, 3) the weight of uterus was increased in 1,000 mg/kg group, and 4) the action on reproductive tissues was clear in the microscopic findings in terms of hyperplasia of endometrial epithelial cell, cystic change of submucosa, dilatation of uterus (significantly increased in 1,000 kg/mg), and follicular cystic changes in ovary. As a result, FGF271 seemed to act as a phytoestrogen by inducing the change in ovary and uterus and by increasing the serum estrogen concentration.

• Proceedings of the KAIS Fall Conference
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• 2010.05b
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• pp.1057-1060
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• 2010

현재 사용되고 있는 갱년기 증상 치료에는 호르몬요법등과 같은 방법이 사용 되고 있으나, 일부의 부작용으로 인하여 선진국에서는 다른 방법을 모색하는 단계에 이르렀다. 이에 본 연구자는 대체 의학적인 방법으로 고대로 부터 자연요법 으로 사용 되어진 향기요법을 사용하여 갱년기 증상에 미치는 효과를 연구 하였다. 실험 군 23명과 대조 군 22명 에게 향기요법 적용여부에 따른 차이를 조사한 결과 관절, 골격 통증에 대하여는 유의한 효과를 발견하지 못하였으나 신경, 정신 증상에 있어서는 괄목 할만 한 차이를 발견할 수 있었다.

• Bulletin of Food Technology
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• v.14 no.3
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• pp.3-16
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• 2001

대두에 함유되어 있는 생리활성 성분에 대한 과학적 규명에 뒤이어 몇 년 전 부터 대두와 인체생리와 관련한 여러 임상 데이터들과 대사시험에 관한 연구가 최근 집중적으로 수행되고 있다. 대두의 이소플라본은 특히 여성의 유방암, 남성의 전립선 암 등 성호르몬 관련 질환에 탁월한 효과가 있고 폐경과 관련된 호르몬 치료요법의 대체 수단으로 활발한 연구가 진행되고 있다. 그중 본문에서는 식이요인이 질병예방에 매우 중요한 인자로 작용하는 분야인 체내 지질대사 개선 및 유방암 예방과 관련된 최근 연구내용을소개한다.

• Clinical and Experimental Pediatrics
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• v.52 no.10
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• pp.1061-1068
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• 2009

The treatment of pediatric patients with chronic renal disease comprises management of nutritional imbalance, fluid, electrolyte, and acid-base disturbances, mineral bone disease, anemia, hypertension, and growth retardation. The treatment also includes administration of appropriate renal replacement therapy, if required. Adequate dietary intake of carbohydrates, fats, and proteins and caloric intake must be encouraged in such patients to ensure proper growth and development. In addition, fluid, electrolyte, and acid-base status must be regularly monitored and should be well maintained. Serum calcium, phosphorus, and parathyroid hormone levels must be maintained at their target range, which are determined on the basis of the glomerular filtration rate, to avoid the development of mineral bone disease. This can be achieved by using phosphorus binders and vitamin D analogues. An erythropoiesis-stimulating agent must be administered along with iron supplementation to maintain the hemoglobin level of the patients between 11-12 g/dL. Hypertension must be controlled with adequate water and sodium balance and appropriate antihypertensive agents. Administration of recombinant human growth hormone is recommended to improve the final adult heights.