• Title/Summary/Keyword: 형제

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Comparisons of Kruglyak and Lander's Nonparametric Linkage Test and Weighted Regression Incorporating Replications (KRUGLYAK과 LANDER의 유전연관성 비모수 방법과 반복 자료를 고려한 가중 회귀분석법의 비교)

  • Choi, Eun-Kyeong;Song, Hae-Hiang
    • The Korean Journal of Applied Statistics
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    • v.21 no.1
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    • pp.1-17
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    • 2008
  • The ordinary least squares regression method of Haseman and Elston(1972) is most widely used in genetic linkage studies for continuous traits of sib pairs. Kruglyak and Lander(1995) suggested a statistic which appears to be a nonparametric counterpart to the Haseman and Elston(1972)'s regression method, but in fact these two methods are quite different. In this paper the relationships between these two methods are described and will be compared by simulation studies. One of the characteristics of the sib-pair linkage study is that the explanatory variable has only three different values and thus dependent variable is heavily replicated in each value of the explanatory variable. We propose a weighted least squares regression method which is more appropriate to this situation and the efficiency of the weighted regression in genetic linkage study was explored with normal and non-normal simulated continuous traits data. Simulation studies demonstrated that the weighted regression is more powerful than other tests.

Comparison of the Family Based Association Test and Sib Transmission Disequilibrium Test for Dichotomous Trait (이산형 형질에 대한 가족자료 연관성 검정법 FBAT와 형제 전달 불균형 연관성 검정법 S-TDT의 비교)

  • Kim, Han-Sang;Oh, Young-Sin;Song, Hae-Hiang
    • The Korean Journal of Applied Statistics
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    • v.23 no.6
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    • pp.1103-1113
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    • 2010
  • An extensively used approach for family based association test(FBAT) is compared with the sib transmission/disequilibrium test(S-TDT), and in particular the adjusted S-TDT, in which the covariance among related siblings is taken into consideration, can provide a more sensitive test statistic for association. A simulation study comparing the three test statistics demonstrates that the type I error rates of all three tests are larger than the prespecified significance level and the power of the FBAT is lower than those of the other two tests. More detailed studies are required in order to assess the influence of the assumed conditions in FBAT on the efficiency of the test.

Analysis of Coen Brothers's Directing Style: Centering around Crime Movies (코엔 형제의 연출 스타일 분석 :범죄 영화를 중심으로)

  • Lee, Jeong-Gook
    • The Journal of the Korea Contents Association
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    • v.10 no.6
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    • pp.236-248
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    • 2010
  • Through this thesis, I analyzed Coen brothers's directing style centering around Crime movies: Blood simple, Barton Fink, Fargo, The man who wasn't thers, No country for old man. About directing style of Coen brothers, plot is an epic depiction, habitual use of narration, refusal of happy ending. They concern subject matters about human original nature and tragedy by greed. And as motifs, they often use misunderstanding, crossing over, chase. Also they likes characters of ordinary people who is destroyed by greed. How about their technical style? They usually use steady-cam and wide lens in camera, and in his early crime movies he used expressionistic lights, but after that they usually used realistic natural lights. About sound, they likes more sound effects than music. Also they directed realistic acting and emphasized actor's personality. Coen brothers has been directed many crime movies and comedy films. But their unique directing style was particularly outstanding in the crime movies