• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.148-148
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• 2001

목적： 자기 공명 혈관 영상(MR Angiography)법으로 혈관 촬영시, 혈관 협착으로 인하여 난류 현상이 발생되는 곳에서는 영상 자체가 얻어지지 않는다. 기존에 TE를 줄이거나 또는 projection reconstruction 방법은 2차원 TOF(Time of Flight)에 적용이 되어서 좋은 결과를 얻었다. 그런데, 2차원 TOF보다는 3차원 TOF으로 보다 좋은 혈관 영상을 얻을 수가 있다. 하지만, 3차원 TOF 방법에 projection reconstruction 방법을 적용하는 데는 여러 가지 문제점이 있어서 개발되어 있는 것이 거의 없다. 본 연구에서는 3차원 TOF 방법에 projection reconstruction 방법을 적용하여서 혈관내의 난류 현상에 의한 영상의 왜곡을 극복하는 방법을 개발한다. 대상 및 방법： 3차원 projection reconstruction을 위한 pulse sequence를 실제 진단에 사용하는 GE사의 자기공명영상장치(1.5T)에 맞게 독자적으로 개발한다. GE사의 장비에서 자료를 얻어서 일반 컴퓨터에서 영상을 재구성하는 알고리즘을 자체 개발한다. 혈관에서와 비슷한 형태의 난류를 발생시킬 수 있는 기구를 만들어서 실제 혈관영상에 사용하는 방법과 개발한 방법으로 영상을 비교한다.

• Progress in Medical Physics
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• v.10 no.3
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• pp.151-157
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• 1999

The GafChromic film was used for the dosimetry of a balloon angio catheter filled with the radioisotope HO-166 for endovascular irradiation. The balloon angio catheter was 2 cm long and 3 mm in diameter when inflated. The isotope, Ho-166, was produced by the neutron bombardment using the research reactor in Korea Atomic Energy Research Insititute. Co-60 teletherapy beam was used for making H-D curve for the Gaf-Chromic film. The film dosimetry was measured with a videodensitometer. The radial dose distribution indicated that the absorbed dose dropped to about 20% of the surface dose at the 1 mm away from the balloon surface and at 5 mm position the dose decreased to below 1% of the surface dose. The result also shows that with the specific activity of Ho-l66, 250 mCi/ml it takes 230 seconds to deliver 1200 cGy to the region where is 1mm away from the balloon surface. The concentric isodose curves were also presented. The Ho-166 is an another alternative for endovascualr irradiation to prevent restenosis after PTCA (Percutaneous Trans Coronary Angioplasty)

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.545-550
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• 2017

When the systolic blood pressure is high, intermittent turbulence in blood flow appears in the aorta and carotid artery with stenosis during the systolic period. The turbulent blood flow is difficult to analyze using the Newtonian turbulence model due to the viscous characteristics of blood flow. As the shear rate is increased, the blood viscosity decreases by the viscoelastic properties of blood and a drag reduction phenomenon occurs in turbulent blood flow. Therefore, a new non-Newtonian turbulent model is required for viscoelastic fluid and hemodynamics. The main aims of this study were to develop a non-Newtonian turbulence model using the drag reduction phenomenon based on the standard $k-{\varepsilon}$ turbulent model for a general non-Newtonian fluid. This was validated with the experimental data and has a good tendency for non-Newtonian turbulent flow. In addition, the computation time and resources were lower than those of the low Reynolds number turbulent model. A modified turbulent model was used to analyze various turbulent blood flows.

• Journal of Chest Surgery
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• v.34 no.10
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• pp.797-799
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• 2001

Open heart surgery with hypothermia in patients with cold agglutinin can cause severe complications by hemolysis and hemagglutination of red blood cells. A 41 year-old male patient with mitral stenosis was admitted due to fever and cough. After antibiotics treatment, he was scheduled to undergo mitral valve replacement. In the operation room, we found agglutination of blood cardioplegia during lowering temperature of cardioplegia. And then, the cardioplegia was changed to warm cardioplegia and the operation was performed under normothermia due to the suspicion of the cold reactive protein. The operation was performed uneventfully. Postoperatively, cold agglutinin was confirmed by immunochemistry of the patient\`s serum.

• Korean Journal of Clinical Laboratory Science
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• v.49 no.3
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• pp.316-321
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• 2017

The occurrence of subclavian steal syndrome is possible in patients with either severe stenosis or occlusion in the left proximal subclavian or brachiocephalic arteries. Limited and insufficient blood flow in the vessel with a lesion induces blood supply from the opposite side via any of the connected vessels, which is called a subclavian steal phenomenon. The duplex sonography is useful for detecting this phenomenon. Some patients who experience this phenomenon complain of vertebrobasilar insufficiency, such as headache or numbness and weakness in the arm, and so on. Subclavian steal syndrome means subclavian steal phenomenon accompanied by these symptoms. We present a patient with focal severe stenosis of the brachiocephalic artery, manifested as blood flow reversal in the vertebral, and a "to-and-fro" waveform pattern in the external carotid, internal carotid, and common carotid arteries.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.3
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• pp.370-374
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• 2018

Subclavian steal syndrome is a type of obstructive artery disease caused by severe stenosis and occlusion of a left proximal subclavian artery or brachiocephalic trunk. The resulting vertebro-basilar insufficiency symptoms are due to retrograde blood flow from the contralateral vertebral and basilar arteries into the low-pressure ipsilateral upper extremity vessels. For that reason, patients usually experience dizziness or arm ischemic symptoms. Neurointervention is an effective treatment for ischemic stroke, including the subclavian artery stenosis. This paper reports a patient with subclavian steal syndrome who had a vertebral artery Doppler waveform change in duplex sonography and a 12 mmHg difference in interarm systolic blood pressure. A stenotic lesion of the subclavian artery was treated effectively by inserting a precise stent. The follow up examination showed that the vertebral artery Doppler waveform change disappeared and recovered and that the 12 mmHg difference in interarm systolic blood pressure decreased to 5 mmHg after treatment.

• 한국전산유체공학회:학술대회논문집
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• 1995.10a
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• pp.31-36
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• 1995

비유선형의 물체 주위의 유동은 정체유동, 경계층 박리 및 주기적 와열 생성 등의 복잡한 유동현상이 공존한다. 본 연구에서는 비교적 단순한 형상인 정사각주 주위의 비정상 난류 유동을 2-방정식 와점성 난류모델인 표준 $k-{\varepsilon}$ 모델과 RNG $k-{\varepsilon}$ 모델을 이용하여 예측할 수 있는지를 검증하였다. 정교하게 수행된 최근의 실험과 대와류모사(LES)의 결과를 검증을 위한 비교의 자료로 삼았다. 적절한 난류모델의 선정과 더불어 시간 정확도, 공간 정확도 및 대류항 처리법 등이 해석결과에 미치는 영향도 살펴보았다. 기존의 표준 $k-{\varepsilon}$모델은 정체점 부근에서 난류 운동에너지를 과도하게 생성하는 근본적인 문제점 때문에 실험 및 LES의 결과를 제대로 예측할 수 없었다. 난류운동에너지의 초과 예측에 따른 운동량의 과도한 혼합으로 인해, 항력계수 및 양력계수의 비정상성 뿐 아니라 평균 항력계수도 부정확하게 예측하였다. RNG $k-{\varepsilon}$ 모델을 사용한 경우에는 정체점 주위 유동현상의 예측이 상당히 향상되어 항력계수 및 양력계수의 평균치, 진폭 및 비정상성의 주기 등을 정확하게 예측하는 것이 가능하였다. 그러나 이 경우에도 예측의 정확도가 시간 증분과 격자의 크기 및 대류항 처리법등에 영향을 받으며, 특별히 대류항 처리법에 상당히 민감하게 변하는 것을 알 수 있었다. 향상된 유동예측은 RNG $k-{\varepsilon}$ 모델의 난류에너지 소산율 방정식의 개선된 항이 과도하게 생성된 난류에너지를 정체점 부근에서 제거하기 때문에 가능하다는 것을 알 수 있었다.의 20세 이하 골절 및 탈구가$30.3\%까지 감소하게되어 년도가 증가함에 따라 청장년 층에 비하여 소아골절 및 탈구가 전체적으로 감소하는 경향을 보였다. 스키골절의 부위별 발생빈도는 1990년 이전까지 하지골절 및 탈구가 많았으나 이후 점차 상지의 골절 탈구가 증가하였다 하지에서 가장 많은 골절은 경골 골절이었으며, 경골골절은 회전력에 의한 나선형골절이 $76.5\%로 가장 많았고 년도에 따른 변화는 보이지 않았다. 스키손상의 발생빈도는 초기에 비하여 점차 감소하는 경향을 보였으며, 손상의 특성도 부위별, 연령별로 다양한 변화를 나타내었다.해가능성을 가진 균이 상당수 검출되므로 원료의 수송, 김치의 제조 및 유통과정에서 병원균에 대한 오염방지에 유의하여야 할 것이다. 확인할 수 있었다. 이상의 결과에 의하면 고농도의 유기물이 함유된 음식물쓰레기는 Hybrid Anaerobic Reactor (HAR)를 이용하여 HRT 30일 정도에서 충분히 직접 혐기성처리가 가능하며, 이때 발생된 $CH_{4}$를 회수하여 이용하면 대체에너지원으로 활용 가치가 높은 것으로 판단된다./207), $99.2\%$(238/240), $98.5\%$(133/135) 및 $100\%$ (313)였다. 각각 두 개의 요골동맥과 우내흉동맥에서 부분협착이나 경쟁혈류가 관찰되었다. 결론: 동맥 도관만을 이용한 Off pump CABG를 시행하여 감염의 위험성을 증가시키지 않으면서 영구적인 신경학적 합병증을 일으키지 않았고 좋은 혈관 개존율을 보여주었다. 따라서 동맥 도관을 이용한 Off pump CABG는 관상동맥의 협착의 정도에 따라 효율적으로 시행

• Proceedings of the KOR-BRONCHOESO Conference
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• 1982.05a
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• pp.10.3-11
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• 1982

Recently through the advancement of medical and surgical managements and the development of low pressure cuffed endotracheal tube, incidence of tracheal stenosis was decreased significantly. Though its incidence was decreased markedly, stenosis was developted unfortunately in the situations such as long term use of respirator, heavy infection, trauma of the trachea and long term intubation etc. Tracheal stenosis had been handled with various methods such as mechanical dilatation, tissue graft techniques, luminal augumentation and end to end anastomosis due to their individual advantages but their effects were not satisfactory. In 1959 Lester had been found the regenerated cartilage from the perichondrium of the rib incidentaly. Since then Skoog, Sohn and Ohlsen were reported chondrogenic potential of perichondrium through the animal experiments. Though many different materials have been tried to rebuild stenosis and gaping defect of trachea, tracheal reconstruction has been a perplexing clinical problems. We choose the perichondrium as the graft material because cartilage is the normal supporting matrix of that structure and it will be an obvious advantage to be able to position perichondrium over a defect and obtain new cartilage there. The young rabbits, which were selected as our experimental animals, were sacrified from two to eight weeks after surgery. The results of our experiment were as follows; 1) In control group, the defect site of trachea was covered with fibrosis and vessels but graft site was covered with hypertrophied perichondrium and vessels. 2) Respiratory mucosa was completely regenerated in defect sites both control and grafted groups. 3) The histologic changes of the grafted sites were as follows: 2 weeks- microvessel dilatation, inflammatory reaction, initiation of fibrosis 4 weeks- decreased microvessel engorgement, submucosal fibrosis, decreased inflammatory reaction immatured cartilage island was noted in the grafted perichondrium (one specimen) 6 weeks- mild degree vascular engorgement submucosal fibrosis. chronic inflamatory reaction cartilage island and endochondrial ossification was noted in the grafted perichondrium (Two specimens) 8 weeks- minute vascular engorgement dense submucosal fibrosis. loss of inflammatory reaction. cartilage island was noted in the grafted perichondrium (two specimens) 4) There was no significant differences in regeneration between active surface in and out groups. 5) We observed immatured cartilage islands and endochondrial ossification in the perichondrial grafted groups where as such findings were not noted in control groups except fibrosis. We concluded that perichondrium was the adequate material for the reconstruction of defected trachea but our results was not sufficient in the aspect of chondrogenic potential of perichondrium. So further research has indicated possibility of chondrogenic potential of perichondrium.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.2
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• pp.112-119
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• 2009

Purpose: This study was performed to investigate the clinical significance of reverse redistribution(RR) phenomenon detected on delayed Tc-99m tetrofosmin myocardial single photon emission computed tomography(SPEG) in patients with acute myocardial infarction after revascularization. Materials and Methods: A Tc-99m tetrofrosmin myocardial SPECT was performed in 67 consecutive patients after revascularization for acute myocardial infarction. Myocardial SPECT imaging was performed for early imaging at 40 min and for delayed imaging at 180 min after reinjection at myocardial stress. Regional myocardial uptakes were scored by 4-point scoring in the left ventricular wall divided into 17 segments. Reverse redistribution was defined as an increase of more than 2 point in the activity score on the delayed image. Follow-up myocardial SPECT and coronary angiography(CAG) were performed 9 months later. Results: On myocardial SPECT performed following revascularization, RR was observed in 100 of all 319 segments(31%) and in 43 patients(64%). The abnormalities of perfusion and regional wall motion were more severe in the patients with RR compared to those without RR(p<0.05). On follow-up myocardial SPECT, the myocardial perfusion, regional wall motion, and myocardial thickness were significantly improved in the patients with RR(p<0.05) however, these changes were not significant in those without RR. There was no significant difference between the patients with RR and those without RR in the occurrence of restenosis on CAG. Conclusions: In patients with acute myocardial infarction, the regions showing the RR phenomenon on delayed Tc-99m tetrofosmin SPECT may reflect viable myocardium and indicate recovery of salvaged myocardium.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.471-474
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• 1997

Recently, many studies have shown clinically the detection of proximal arterial stenosis through evaluation of a Doppler waveform alternation, the so-called pulsus tardus and parvus, that often occurs distal to the stenosis. However the cause of the tardus-parvus phenomenon remains obscure. To analyze its cause, we modeled the blood-flow circuit as simple electrical circuit. This shows that pulsus tardus-parvus effect is caused as a result of high-frequency waveform component attenuation from low-pass filtering by capacitance(complience of the poststenotic vessel wall) and resistance(stenosis). As a result, the degree of pulsus tardus-parvus increased as the complience of the poststenotic segment of vessel increased, as well as increasing stenosis.