• Journal of Convergence for Information Technology
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• v.9 no.8
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• pp.260-267
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• 2019

The purpose of this study is to find out how underwater rehabilitation exercises affect physical fitness and blood lipids for 10 weeks and provide basic data to help prevent middle-aged women from cardiovascular diseases. The subjects of this study were middle-aged women living in Seoul, Korea. The underwater rehabilitation exercise was performed for 1 week and 3 times for 10 weeks, and the exercise time was 60 minutes for 1 time including the warm up, the main exercise and the cool down. The exercise intensity was set at 60-70% of the heart rate reserve calculated from the pre-exercise test. The measurement variables were physical fitness and blood lipid. In the data processing, descriptive statistics were presented for each measurement item and a 2-way RGRM ANOVA was conducted to examine the interaction effects between groups. The results have shown significant interaction effects in physical fitness(Flexibility, Cardiorespiratory Endurance, Muscular Endurance) and the blood lipids(TG, TC, HLD-C, LDL-C). This study found that the 10-week underwater rehabilitation exercise program of middle-aged women increased physical fitness level and decreased and increased blood lipid, which could be an effective and convergent program to prevent and reduce cardiovascular disease.

• Journal of the Korea Convergence Society
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• v.12 no.1
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• pp.111-118
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• 2021

This study used raw data from the 2016-2018 National Health and Nutrition Survey to study the correlation between blood lipid and periodontal disease in Korean men and women, and selected the final 11,797 people as subjects of analysis. A stratified analysis of smoking and residential areas was conducted to see the link between blood lipid and periodontal disease in Korean men. In men, non-smokers had a significant correlation of 1.38(95% CI:1.09-1.76), and in men, the risk group had a odds ratio of 1.49(95% CI:1.16-1.91), and in smokers, the risk group had odds ratio of 1.76 (95% CI:1.39-2.23) shows that the warning group is significant in relation to the intersecting ratio 1.14(95% CI:1.16-1.70) and the risk group 1.60(95% CI:1.32-1.94) periodontal disease. In conclusion, men's blood lipids and periodontal diseases are associated with smoking or residential areas, and are especially intended to be used as basic data in developing health education programs related to systemic and periodontal diseases for men in urban areas. In developing education programs for men in urban areas in the future, we want to use them as basic data.

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.9
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• pp.1279-1285
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• 2010

This study was conducted to investigate the effects of green tea or coffee consumption on the serum lipids profiles. This study analyzed data of 1,343 participants (753 males and 590 females) among the people who underwent medical check-up. The subjects were divided by three groups as pattern of green tea or coffee consumption. Anthropometric measurements, biochemical analysis and nutrient intake using a food frequency questionnaire were performed. There were no significant differences among groups in height, % body fat, waist circumference, and body mass index. There was no significant difference among groups in energy intake. Fat intake was significantly higher in green tea and coffee group than the control group in men subjects. The intakes of dietary Fe, vitamin A, $\beta$-carotene, and folate was the lowest in coffee group (p<0.05). The intakes of dietary fat was the highest in coffee group in male subjects (p<0.05). Serum concentrations of total cholesterol and LDL-cholesterol were green tea< control< coffee group in order by multivariate analysis after adjusting for confounding factors. The serum concentrations of total cholesterol and LDL-cholesterol were significantly lower in green tea group than coffee group by multivariate analysis after adjusting for confounding factors (p<0.05). However, there was no significant difference in the serum concentrations of total cholesterol and LDL-cholesterol between green tea and control group. These results suggest that green tea consumption didn't show positive effects in preventing hyperlipidemia but coffee consumption showed negative effects in hyperlipidemia.

• Journal of Nutrition and Health
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• v.29 no.6
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• pp.642-650
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• 1996

Apo E polymorphism (e2, e3, e4) was among the first reported genetic polymorphism that explained part of the normal variation in plasma cholesterol concentrations. Both alleles E2 and E4 are significantly more frequent in patients with mixed forms of hyperlipidemia and contribute on the observed differences in CHD risk among different populations. Effects of apo E polymorphism on the distribution of plasma lipid profiles were studied in 105 normolipidemic healthy women. The relative frequencies of common alleles for gene locus of apo E in this study were that E3 allele was 0.848, E4 allels was 0.087, and E2 allele was 0.067. SBP and DBP were slightly more elevated in E2 allele than those in E3 and E4. The pulsation was also significantly (p<0.016) increased by E2 allele with excess body fat % in E2 allele. There were no differences in total-, total HDL-, VLDL+LDL-, VLDL- and LDL cholesterol among the apo E alleles. However, apo E2 allele subject had lower level of total HDL and HDL2 cholesterol (P<0.047) and significantly higher lev디 of HDL3 cholesterol (P<0.05) than those in apo E3 and E4 allele subject. The conclusion is that first, it seems that apo E4-mediated alteration through LDL B/E receptors or E receptors in cholesterol metabolism results in lower plasma TG or remanate particles and in higher levels of VLDL+LDL or LDL. Second, apo E2 allele shows reciprocal effects of E4 on the plasma lipid metabolism, respecitvely. Third, apo E2 allele was more atherogenic than apo E4 because the higher levels of HDL3/HDL2 ratio and atherogenic index[(TC-HDL)/HDL]were criticized.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.1
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• pp.98-103
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• 2002

The serum lipid-lowering effect of garlic was examined in hypercholesterolemic rats. The food intake was not significantly different by garlic powder supplementation. The inclusion of 1% garlic powder in a diets containing 1% cholesterol brought a reduction in the serum cholesterol and triglyceride. Liver lipids were not affected by the addition of l% garlic Powder in hypercholesterolemic rats. Earlier studies have suggested that the effect of garlic on serum cholesterol may be related to the sulfur-containing amino acids of products released during protein digestion. However, our results in rats fed garlic powder diet showed no specific effect on plasma free amino acid concentrations. In conclusion. this study clears shows that garlic intake is able to reduce the levels of serum cholesterol in hypercholesteroolemic rats. However, further studies have to be done in order to elucidate the mechanism underlying this phenomenon.

• Proceedings of the Korean Society for Food Science of Animal Resources Conference
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• 2004.10a
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• pp.349-353
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• 2004

본 연구에서는 ${\beta}-CD$를 이용하여 우유에서 콜레스테롤을 제거한 후 혈중 콜레스테롤 저하를 위해 EPO을 첨가하였다. EPO의 첨가량에 따른 우유의 저장 중 이화학적 변화와 관능적 특성들을 살펴보았으며 동물실험을 통해 랫트 사료의 섭취량에 따른 체중 증가량, 총 콜레스테롤의 함량과 중성지질, HDL-cholesterol의 함량 변화로 혈중 콜레스테롤 저하효과를 증명하였다. 우유의 지방산화도는 EPO의 첨가량이 증가되고 저장기간이 경과할수록 높아지는 결과가 나타났다. 관능평가에서는 저장 기간동안 EPO를 첨가한 우유는 소량 첨가시 매우 양호 하였으나 첨가량이 많을수록, 저장기간이 경과할수록 바람직하지 않은 결과를 나타내었다. 동물실험에서 EPO를 첨가한 우유를 매일 섭취시킨 랫트에서 HDL-cholesterol의 증가를 나타냈다. 결과적으로 ${\beta}-CD$로 콜레스테롤을 제거한 후 EPO를 첨가시킨 우유는 저장기간이 경과함에 따라 이화학적, 관능적 특성에 적은 변화가 있었고 관능평가에서도 적은 영향을 주었으며 동물실험에서는 혈중 콜레스테롤 저하기능이 있는 HDL-cholesterol의 수치가 대폭 증가하는 결과가 나타났으므로 EPO를 첨가한 우유는 혈중 콜레스테롤 저하 기능성 우유로서의 개발이 가능할 것이라고 사료된다.

• Proceedings of the Korean Journal of Food and Nutrition Conference
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• 2003.07a
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• pp.78-78
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• 2003

심혈관계질환의 예방과 영양교육의 기초자료를 제공하기 위하여 성인 남녀를 대상으로 규칙적인 운동 습관과 음주, 흡연, 폐경, 비만 여부에 따라 신체계측치와 콜레스테롤, 중성지방, LDL-cholesterol, LDL-cholesterol 등의 혈청지질 및 영양소 섭취량을 비교 조사한 결과는 다음과 같다. 1)체중이나 신장, 비만 정도 및 WHR 등 신체계측지수는 음주나 흡연 여부에 따른 차이가 없었으나, 혈청 중성지방 농도를 유의적으로 상승시켰다. 2)음주군은 비음주군에 비하여 단백질의 열량비율(% RDA)이 유의적으로 높았으며(p<0.05), 흡연군은 비타민 A와 나이아신, 비타민 B6, 엽산, 비타민 C, 비타민 E의 섭취량에 있어서 비흡연자들보다 낮은 경향을 보였다. 3)운동에 의한 혈청지질 농도에는 뚜렷한 차이가 없었으나, 남성들의 경우 현재의 체중과 PIBW, Quetlet index, 엉덩이둘레가 비운동자들보다 많은 것으로 나타났다. 영양소 섭취량에 있어서 남성의 경우 운동군이 비운동군에 비해 콜레스테롤과 나이아신 및 인을 더 섭취하고 있었으며, 당질의 섭취비율은 유의적으로 더 낮았다(p<0.05). 여성의 경우에는 불포화지방에 유의적 차이를 보여 비운동군의 불포화지방 섭취량이 더 많았다(p<0.05). 4)폐경한 여성의 경우 폐경 전 여성에 비하여 신장은 더 작고 WHR은 더 높았다. 폐경 이후 estrogen 분비의 변화로 인하여 혈중 지질 성분 중에서는 cholesterol이 198.4$\pm$36.3mg/dl, LDL이 119.5$\pm$34.9mg/dl로 폐경 전의 수치보다 유의적으로 높았다(p<0.01). 5)비만 여부는 남자의 경우 콜레스테롤 농도에(p<0.01)), 여자의 경우 중성지방 농도(p<0.01)에 대해 의미있는 설명력을 보이는 변수로 작용하고 있었다. 그러나 식이 섭취상태와의 관련성은 나타나지 않았다. 이상에서 생활습관이 신체계측치 및 혈중 지질 농도와 일부 상관을 보이는 것을 알 수 있었으며, 건강위험 요인도 관찰할 수 있었다. 고지혈증은 심혈관계질환의 주요한 위험 인자로 알려져 있으며, 그 유발 요인에는 여러 환경적인 요인과 식이 요인이 있다. 또한 생활습관은 영양소의 섭취량에도 영향을준다. 이처럼 식이 요인과 생활습관은 단독 혹은 상호 영향을 주게 되므로 고지혈증 및 심혈관계질환을 개선하려면 식사요법과 생활습관 교정을 병행하여야 한다. 고지혈증의 원인 중의 하나로 지적되고 있는 음주와 흡연은 상호 유도작용이 있으므로 금연이나 절주를 하고자 할 경우 두가지를 동시에 자제해야 효과적일 것으로 생각된다. 폐경후 여성들에게 발생 빈도가 높은 심혈관질환의 위험요인인 고지혈증을 예방하고자 하는 노력은 폐경후 여성들의 삶의 질적 향상을 위해서도 매우 중요하다. 또한 균형식 섭취와 운동을 통해 혈중 지질 수준을 건강하게 유지하고, 비만으로의 이행을 방지함으로써 심혈관계질환을 예방하도록 하여야겠다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.6
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• pp.829-836
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• 1995

This study was performed to evaluate the relationship between dietary, blood and urinary levels of lead and blood pressure and serum lipids in 30 healthy adult living in rural area of Korea. Analysis for the nutritional status of subjects were performed by 3-day dietary intake record, duplicated diet collection, 24-hour urine collection, and venous blood sampling before anthropometry. The mean daily intakes of lead estimated for 3 days was $120.1{\pm}22.0\mu\textrm{g}$. The blood levels and 24-hour urinary excretion of lead were $10.8{\pm}3.6\mu\textrm{g}/dl\;and\;36.5{\pm}9.5\mu\textrm{g}$, respectively. The systolic and diastolic blood pressure were $113.0{\pm}16.9mmHg\;and\;76.7{\pm}12.1\;mmHg$. The serum levels of total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and ${\beta}-lipoprotein$ were $158.8{\pm}32.9mg/dl,\;104.6{\pm}48.8mg/dl,\;45.7{\pm}9.9mg/dl,\;92.2{\pm}28.5mg/dl\;and\;426.4{\pm}141.5mg/dl$, respectively. There was no significance in the relation between lead and blood pressure. In the relation between lead and serum lipids, it showed negative correlation with lead intake and HDL-choleterol at the level of significance of p<0.01. But there was no significance in the relation between lead and serum levels of otehr lipids.

• Clinical and Experimental Reproductive Medicine
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• v.35 no.3
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• pp.223-229
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• 2008

Objective: This pilot study was performed to investigate the effect of metformin on insulin resistance, hormone levels, and lipid profiles in non-obese patients with polycystic ovary syndrome. Methods: This study included 16 non-obese patients with polycystic ovary syndrome diagnosed at our hospital from June 2006 to September 2007. Blood samples were collected before and 6 months after metformin treatment for analysis of fasting serum glucose levels, fasting serum insulin levels, a glycemic response to 75 g oral glucose tolerance test (OGTT), and hormonal blood profile including FSH, LH, estradiol, testosterone, free testosterone, serum lipid profiles. Insulin resistance was estimated by calculating fasting glucose/insulin ratio (FGIR), 2 hr glucose/insulin ratio after 75 g glucose load. And we investigated insulin resistance and pancreatic beta cell function by calculating HOMA beta cell function and HOMA IR. Results: After the treatment of metformin, there was significant increase in 2 hr glucose/insulin ratio after 75 g glucose load (p=0.04) and decrease in HOMA IR (p=0.000). But serum lipid profiles did not change significantly. Also the metformin treatment induced a significant reduction in serum free testosterone and LH levels, and LH/FSH ratio (p=0.001, p=0.000, p=0.034). Conclusion: This pilot study showed that metformin might be effective in improving insulin sensitivity, ameliorating hyperandrogenemia in non-obese patients with polycystic ovary syndrome. Further investigations with larger number of patients and long-term observations are necessary to determine the role of metformin.

• Proceedings of the KSCN Conference
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• 2002.05a
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• pp.436.2-437
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• 2002