• Journal of Yeungnam Medical Science
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• v.18 no.2
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• pp.239-245
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• 2001

Background: Acute idiopathic thrombocytopenic purpura(ITF) is one of the common hematologic disorders in children. Bone marrow aspiration (BMA) is often performed in children with acute ITP to rule out leukemia, aplastic anemia or other hematologic diseases. However, whether BMA is needed in children with typical clinical and hematological features of acute ITP have been questioned. This study was performed to examine the proper indication of BMA in acute childhood ITF. Materials and Methods: The medical records and BMA reports of children with the provisional diagnosis of acute ITP were reviewed from January 1984 to December 2000. Patients were divided into two groups, one with typical and another with atypical clinical and hematological features of acute ITP. Typical acute ITP group was characterized by the history of previous viral infection, well being appearance, no hepatosplenomegaly, no lymphadenopathy, normal Hb, WEC, neutrophil count and peripheral blood smear except thrombocytopenia. A platelet count of $50{\times}l0^9/L$ or lower was the cutoff level. Results: Total 120 children with the provisional diagnosis of acute ITP were included. One hundred eighteen of them were confirmed to have acute ITP by BMAs. Of these, 66 had typical and 54 had atypical features. All of typical features and 52 of 54 with atypical features of acute ITP were confirmed to have acute ITP by BMAs. Two patients with atypical features of acute ITP were diagnosed as aplastic anemia and myelodyspalstic syndrome, respectively, by BMAs. Conclusion: This study concludes that BMA is not needed for the children with typical features of acute ITP but it is needed for the children with atypical features of acute ITP to rule out other hematologic disorders.

• Journal of the Korean Society of Radiology
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• v.5 no.1
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• pp.19-25
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• 2011

Photoplethysmogram(PPG) is the method to obtain the biomedical signal using the linear relationships between the blood volume for changing the cardiac contraction and relaxation and the amount of light for absorbing the hemoglobin in the blood. In this paper, we proposed the analyzed results which show the heart rate variability and the distribution of heart rate for before and after using PPG. Moreover, this paper designed and implemented the system based on personal computer to predict cardiovascular disease in advance using the analyzed results for the autonomic balance from taking the spectral analysis of heart rate and the state of the blood vessel for analyzing APG(acceleration plethysmogram).

• The Journal of the Convergence on Culture Technology
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• v.9 no.4
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• pp.331-335
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• 2023

As the viscosity of the blood increases, the blood becomes more sticky and difficult to flow, so the possibility of thrombosis increases and the probability of ischemic cerebral infarction increases. The importance of measuring blood viscosity has recently been emphasized for the prevention of circulatory system diseases, and the need for a viscometer capable of easily and accurately measuring blood viscosity has emerged. In this study, the measured values of a viscosity standard solution and an artificial blood by a parallel-plate viscometer ARS-Medi were compared with the those by Ares-G2 of TA instrument, which is internationally recognized for its accuracy and reliability. The viscosity of N44 standard solution, which is a Newtonian solution, was almost perfectly matched between the two instruments at all shear rates. In the case of an artificial blood, which is a non-Newtonian solution, the measured values between the two instruments showed a difference of about 10% at the lowest shear rate 1 rad/s; however, at a clinically significant shear rate of 10 rad/s or higher, the measured values between them were consistent within the error range. We expect that ARS-Medi, a newly developed parallel-plate viscometer for blood, using disposable plates, will be very useful in clinical practice as it improves the convenience and hygiene of blood viscosity measurement.

• Journal of Sasang Constitutional Medicine
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• v.11 no.1
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• pp.119-135
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• 1999

The object of this study is 196 patients who had been treated in the Oriental Medical Hospital at Dong Eui Medical Center during 33 months from January 1996,3 to June 1998,11. We proceeded the judgment of Sasang Constitution by 'Questionnaire of Sasang Constitution Classification(I)' and 'Questionnaire of Sasang Constitution Classification II(QSCCII)'. The following conclusion were made in comparison with Sasang Constitution and Questionnaire about disease and style of symptoms. 1. The subject of "increase of the weight of a body(gain weight), sweatier, the body swelled out, a lame pain, more like fat food, more like salty food", has significant differences in sasang constitution classification. The frequency of Taeeum group is more than that of Soeum group and Soyang group. 2. The subject of "the complextion is bas, uncomfortable feeling in the throat, insomnia, loss of appetite, apt to be fatigued easily, gastralgia what is not connected with food, diarrhea, headache, menorrhalgia, less like fat food, more like fresh food", has significant differences in sasang constitution classification. The frequency of Soeum group is more than that of Taeeum group and Soyang group. 3. It has not significant differences, but the frequency of Soyang group is more than that of Taeeum group and Soeum group in the subject of "the cough in the disease of the respiratory organs, hypomotility of the joint in the disease of the musculo-skeletal systems, menoxenia like menorrhagia and menostaxia and itching sensation of genitals in the disease of the gynecological organs, itching or boil in the dermatological disease", and fewer in the cardio-vascular disease, urinary disease and hematic disease. The frequency of Soeum group is more than that of Taeeum group and Soyang group in the subject of "the general disease of the digestive organs, uncomfortable feeling or pain of the throat in the disease of the respiratory organs, the general hematic disease, numbness or pain of the musculo-skeletal disease, psychical disease in the psychoneurotical disease, menorrhalgia, a lump of the breasts, leukorrhea in the gynecological disease, eruption or urticaria in the dermatological disease, the general visual and auditory disease". The frequency of Taeeum group is more than that of Soyang group and Soeum group in the subject of "a hoarseness in the disease of the respiratory organs, A lame pain of the musculo-skeletal disease, neurotical disease in the psychoneurotical disease, eruption or urticaria in the dermatological disease", and fewer in the the gynecological disease.

• Korean Journal of Poultry Science
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• v.40 no.4
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• pp.337-349
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• 2013

The objective of this literature review is to prove that egg cholesterol is not related with heart disease based upon research results of the past 50 years. As a result, it was reported that the dietary intake cholesterol did not affected cholesterol levels in blood. Moreover, it was reported that adding two eggs a day to a healthful diet did not significantly increase blood cholesterol levels in young or middle-aged men and women with normal or even moderately elevated blood cholesterol levels. Cholesterol feeding studies demonstrate that dietary cholesterol increases both LDL and HDL cholesterol with little change in the LDL : HDL ratio as an important risk indicator of heart disease. Especially a good indicator in the elderly from increased HDL-cholesterol, so cholesterol intake appeared to be good for the prevention of heart disease. Thus the consumption of eggs is bad for your health is not known as a fact, but rather was found to be effective in preventing heart disease. Also, all consumers may consume without worrying because there are no official standards regarding egg intake. Therefore, these evidences would clear up some misunderstanding and mistrust on egg cholesterol regarding the consumption of egg as well as give some desirable advice on how to maintain healthy life.

• The Journal of the Convergence on Culture Technology
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• v.6 no.3
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• pp.413-418
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• 2020

Neuralgia is a disease that involves severe pain and has a very strong effect on the quality of human life, and the prevalence of the disease increases with aging. To date, previous studies on neuralgia were mainly focused on associations with mental illness, demographic information, and nutrients, and studies on association with blood information were very rare. Therefore, the objectives of this study are to examine the association between neuralgia and blood parameters and find clinical indicators related to neuralgia. To analyze the data, we used binary logistic regression based on data of the Korea National Health and Nutrition Examination Survey. Our results showed that age tended to have the higher association with neuralgia in both men and women, waist circumference and hematocrit level were associated with neuralgia in women, and fasting blood glucose and hemoglobin levels were associated with neuralgia in men. Also, we found that the association of neuralgia with waist circumference and blood information differed according to gender.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.177-177
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• 1993

뇌모세혈관내피세포로 구성된 혈액-뇌관문(BBB)은 tight junction으로 구성되어 있을뿐만 아니라 fenestra가 없는 등 BBB가 가진 특성으로 인해 물질 수송에 장벽역할을 하기 때문에 주로 중추신경계 질환시의 약물요법에 많은 제한이 따른다. 따라서 뇌로의 효율적인 약물 송달방법에 대해 많은 연구가 진행중에 있는데 본 연구에서는 BBB의 hyperosmotic opening법을 이용하여 뇌로 잘 수송되지 않는 약물의 뇌송달 방법에 대해 연구하고자 하였다. 먼저 수용성으로 인해 BBB 에 잘 통과하지 않는 물질로 신장 및 뇌영상 촬영시 사용되는 방사성 의약품이 Tc-DTPA를 이용하여, hyperosmotic opening법에 의한 뇌투과 증가정도를 검토하였으며, 실험방법이 확립됨에 따라 뇌암의 항암요법을 위해 뇌로의 투과가 적은 항암제(5-Fluorouracil, 5-FU)의 뇌송달에 대해 본 방법을 적용하여 검토하였다. 실험동물로는 S.D.계 웅성 랫트를 사용하였으며, 실험방법은 다음과 같이 하였다. 랫트의 좌측 외경동맥(left external carotid artery)에 혈류의 역방향으로 혈관 분지점에서 1-2mm 전까지 PE-50 catheter를 삽입하고, 1.6 molal L－(＋)－ arabinose 고장액(1580mOsm)을 0.12ml/sec의 일정한 속도로 30초간 infusion함으로 BBB를 opening 한 다음, 5분 후에 Tc-DTPA를 대퇴 정맥으로 주사하여 0, 10, 30초, 1, 1.5, 2, 3, 4, 5, 7 및 10분 간격으로 대퇴동맥에 설치한 카테타로부터 혈액을 채취하고 마지막 혈액을 취한 후 즉시 단두하여 뇌를 적출하였다. 채취한 뇌를 액체질소에 담근 후 tissue Tek으로 고정하고 autoradiography를 하기 위한 slice와 농도측정을 위해 필요한 부위를 취한 후 감마카운터로 Tc-DTPA의 brain각 부위별 및 혈장농도를 측정하였다. 뇌조직중 혈액부피의 측정은 Tc-albumin를 이용하여 구하였다. 같은 방법으로 5-FU에 대한 실험도 행하였고, 이때 각 혈장 및 조직중의 5-FU함량은 HPLC로 하였다.

• Journal of the korean academy of Pediatric Dentistry
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• v.32 no.4
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• pp.589-594
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• 2005

With the progress of medical treatment techniques of bleeding control, dental care of the patient with hemophilia has become more convenient. So many surgical treatments can be performed with out-patient. 2 cases of intraoral surgical treatment of children, one with hemophilia 3, sever, the other with hemophilia A, severe. While the former was treated under general anesthesia, the latter was treated under local anaesthesia. There are principles : 1. When a patient with hemophilia need dental treatment, the dentist must consult to his physician, pediatrician, or hematologist before dental treatment. 2. When the dentist make a treatment plan, there should be consideration of the general condition, cooperation of the patient and risk of the treatment needed. 3. Minimize the number of times of coming for dental treatment so that reduce the times that need replacement therapy of coagulation factor. And during the treatment, dentist should care for infection and bleeding.

• 건강소식
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• v.26 no.11 s.288
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• pp.6-13
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• 2002

지난 30여년 동안 급속한 경제 성장과 생활 양식의 변화는 우리 사회에 많은 변화를 초래하였고 한국인의 질병 양상에도 많은 영향을 주었다. 동물성 식품과 지방질 섭취의 증가, 신체활동 감소,노령인구 증가, 생활양식의 서구화 및 도시화 등은 한국인에서 만성질환의 발생과 이환을 증가시키고 있다. 통계청의 2001년 사망원인통계를 보면 1위가 암, 2위가 뇌혈관 질환, 3위가 심장질환, 4위가 당뇨병, 5위가 간질환으로 모두 잘못된 생활습관으로 인한 만성질환이다. 이중에서도 당뇨병은 지난 1991년 이후 암 다음으로 많이 증가한 질병으로 인구 10만명 당 23.8명이 당뇨병으로 사망했으며 하루 평균 당뇨병으로 31명이 사망한다. 2002년 4월, 대한당뇨병학회의 "한국인의 당뇨병 발생 현황 보고"에 따르면 우리나라 성인의 당뇨병 유병률은 10%선으로 최소 3백만명에서 최대 5백만명 정도가 당뇨병을 앓고있다. 우리나라는 식생활의 서구화, 고령화 등으로 당뇨병 환자가 급증하고 있어 생활 양식의 개선이 이루어지지 않을 경우 앞으로 10년 안에 전체 국민의 1/4정도인 1천2백만명 가량이 당뇨병으로 고통을 받게 될 것이라 한다. 당뇨병은 당뇨뿐만 아니라 그에 따른 만성 합병증이 매우 무서운 병으로 일단 발병하면 적극적인 치료에도 불구하고 정상으로 회복되기 어렵다. 따라서 합병증의 효과적인 예방을 위해서는 특별한 임상 증상이 없더라도 당뇨병을 처음 진단 받은 날부터 주기적인 검진을 통하여 조기에 발견해 낼수 있도록 노력하여야 한다. 이와 더불어 주기적인 혈액 검사와 주치의 면담을 통하여 정상 혈당을 유지할 수 있는 혈당 조절 방법과 함께 만성 합병증을 예방할 수 있는 생활 습관 개선(금연, 금주,표준체중 유지,규칙적 운동,정상 혈압 유지,정상 혈중 지질 유지등)을 반드시 실천하여야 한다.

• Annual Conference of KIPS
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• 2022.11a
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• pp.462-464
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• 2022

의료영상기반의 인공지능 연구는 질환의 조기진단 및 예측 분야에 눈부신 기술발전이 되어왔다. 장기 섬유증은 만성 염증성 질환의 질병 진행을 특징짓고 전 세계적으로 모든 원인으로 인한 사망률의 45%에 기여하며, 그중 간 섬유증은 주로 삶의 질과 예후를 결정한다. 해당 질환은 임상 현장에서 혈액데이터 분석 그리고 간생검을 통해 진단을 하고 있으나 최근 의료영상 분석을 통해 진단에 활용하고 있는 추세이다. 본 논문에서는 인공지능을 기반으로 하여, 간 섬유화를 진단하기 위해 MRI영상을 학습하여 질환에 대한 중증도 진단을 돕는 인공지능 모델을 제시하고자 한다. 이를 위해 인공지능 모델을 개발하는 과정과 그 결과를 보인다. 본 논문에서 제시한 모델을 통해 간 섬유화를 빠르게 진단할 수 있을 것으로 기대한다.