• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.11 s.254
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• pp.1027-1034
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• 2006

In order to investigate flow characteristics of chicken blood in a micro tube of 100$\mu$m in diameter, in-vitro experiments were carried out using a micro-PIV technique. The micro-PIV system consists of a microscope, 2-head Nd:YAG laser, 12 bit cooled CCD camera and a delay generator. Chicken blood with 40% hematocrit was supplied into a micro tube using a syringe pump. The blood flow shows clearly the cell free layer near the tube wall and its thickness is increased with increasing the flow speed. The hemorheological characteristics of chicken blood, including shear rate and shear stress were estimated from the PIV velocity field data obtained. Since the aggregation index of chicken blood is less than 50% of human blood, non-Newtonian flow characteristics of chicken blood are smaller than those of human blood. As the flow rate increases, the degree of flatness in the velocity profile at the center region is decreased and the parabola-shaped shear stress distribution becomes to have a linear profile. Under the same flow rate, chicken blood shows higher shear stress, compared with human blood.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.318-323
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• 2001

Characteristics of the pulsatile flow in a 3-dimensional elastic blood vessel are investigated to understand the blood flow phenomena in the human body arteries. In this study, a model for the elastic blood vessel is proposed. The finite volume prediction is used to analyse the pulsatile flow in the elastic blood vessel. Variations of the pressure, velocity and wall shear stress of the pulsatile flow in the elastic blood vessel are obtained. The magnitudes of the velocity waveforms in the elastic blood vessel model are larger than those in the rigid blood vessel model. The wall shear stresses on the elastic vessel vary with the blood vessel motions. Amplitude indices of the wall shear stress for blood in the elastic blood vessel are $4\sim5$ times larger than those of the Newtonian fluid. As the phase angle increased, point of the phase angle is are moved forward and the wall shear stresses are increased for blood and the Newtonian fluid.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.11
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• pp.3607-3619
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• 1996

Experimental and numerical studies for three-dimensional pulsatile flows are conducted to investigate the flow characteristics in the bifurcated tubes. Velocity measurements in experimental study were made by both Pulsed Doppler Ultrasound(PDU) machine and Laser Doppler Anemometer(LDA) system. Glycerin is used for experimental study. Experimental results are used to verify the results of the numerical simulation. Flow characteristics of Newtonian fluid and blood in the bifurcated tubes under the steady and pulsatlie flows are numerically investigated. Finite volume method is employed for three-dimensional numerical simulations. Blood is considered as a non-Newtonian fluid and the constitutive equation of blood is used for the numerical analysis. Numerical analyses are focused on the flow patterns for various branch angles ranging from 30.deg. to 90.deg. and diameter ratios such as 1.0, 0.8, and 0.6. Pulsatile flow characteristics of blood are compared with those of Newtonian fluid. Parameter effects on axial velocity, pressure and wall shear stress distribution along the bifurcated tubes are discussed in terms of the branch angle, diameter ratio, and Reynolds number.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.11 s.242
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• pp.1182-1188
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• 2005

An x-ray PIV (Particle Image Velocimetry) technique was developed to measure quantitative information on flows inside opaque conduits and on opaque-fluid flows. At first, the developed x-ray PIV technique was applied to flow in an opaque Teflon tube. To acquire x-ray images suitable for PIV velocity field measurements, refraction-based edge enhancement mechanism was employed using detectable tracer particles. The optimal distance between with the sample and detector was experimentally determined. The resulting amassed velocity field data were in reasonable agreement with the theoretical prediction. The x-ray PIV technique was also applied to blood flow in a microchannel. The flow pattern of blood was visualifed by enhancing the diffraction/interference -bas ed characteristic s of blood cells on synchrotron x-rays without any contrast agent or tracer particles. That is, the flow-pattern image of blood was achieved by optimizing the sample (blood) to detector distance and the sample thickness. Quantitative velocity field information was obtained by applying PIV algorithm to the enhanced x-ray flow images. The measured velocity field data show a typical flow structure of flow in a macro-scale channel.

• Tribology and Lubricants
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• v.14 no.1
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• pp.94-98
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• 1998

혈관내피세포는 혈관의 내벽에 단일 층을 구성하고 있는 상피세포로 동맥경화나 혈관협착의 원인에 매우 중요한 역할을 하는 것으로 알려져 있다. 그리고, 모든 혈관 질환의 발생장소가 혈관이 나뉘는 분지부에 집중되고 있어, 혈류역학과 혈관질환 간에 상호연관성이 있음을 짐작할 수 있다. 특히, 최근에 와서 혈관내피세포가 혈액유동에 의해 발생하는 전단응력을 인지하여 혈관의 제반 생리적 반응을 조절한다는 연구결과가 속속 발표되고 있어, 혈관질환의 극복을 위한 연구 개발에 혈관내피세포에 대한 이해의 중요성이 증대되고 있다. 이에 본 연구에서는 혈관내피세포에 혈류와 같은 크기의 전단응력을 부가하여 세포의 생리적 반응을 고찰할 수 있는 평판형 층류발생장치를 설계, 제작하였다. 설계된 평판형 층류발생장치는 유동환경 하에서의 혈관내피세포의 동적반응을 고찰 할 수 있도록 유동액의 온도, 산도, 전단응력의 크기를 조절할 수 있도록 설계하였으며, 제작된 실험장치를 이용하여 전단응력에 의한 혈관내피세포의 형태변화를 고찰하였다. 개발된 층류발생장치는 혈관내피세포의 연구 뿐 아니라, 백혈구의 점착, 암세포의 전이등에도 다양하게 활용이 가능하다.

• Proceeding of EDISON Challenge
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• 2013.04a
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• pp.403-408
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• 2013

본 논문은 EDISON_CFD를 이용하여 관상동맥 분지관에서 점도에 따른 유체의 유동현상에 관하여 연구를 하였다. 뉴턴유체인 물의 점성계수 일때와 비뉴턴유체인 혈액의 Carreau model에서의 영전단율 점성계수(${\eta}_0$)와 무한전단율 점성계수(${\eta}_{\infty}$)일 때의 유동현상을 살펴보았다. 그 결과 점도가 증가할수록 재순환 영역에서 유체의 속도가 감소하였고 CF 및 CP값이 감소하는 구간의 수가 증가하여 벽면의 저전단응력으로 인해 생기는 재순환영역의 수가 증가하는 것으로 나타났다.

• The KSFM Journal of Fluid Machinery
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• v.7 no.3 s.24
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• pp.14-22
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• 2004

Bileaflet mechanical valves have the complications such as hemolysis and thromboembolism, leaflet damage, and leaflet break. These complications are related with the fluid velocity and shear stress characteristics of mechanical heart valves. The first aim of the current study is to introduce fluid-structure interaction method for calculation of unsteady and three-dimensional blood flow through bileaflet valve and leaflet behavior interacted with its flow, and to overcome the shortness of the previous studies, where the leaflet motion has been ignored or simplified, by using FSI method. A finite volume computational fluid dynamics code and a finite element structure dynamics code have been used concurrently to solve the flow and structure equations, respectively, to investigate the interaction between the blood flow and leaflet. As a result, it is observed that the leaflet is closing very slowly at the first stage of processing but it goes too fast at the last stage. And the results noted that the low pressure is formed behind leaflet to make the cavitation because of closing velocity three times faster than opening velocity. Also it is observed some fluttering phenomenon when the leaflet is completely opened. And the rebounce phenomenon due to the sudden pressure change of before and after the leaflet just before closing completely. The some of time-delay is presented between the inversion point of ventricle and aorta pressure and closing point of leaflet. The shear stress is bigger and the time of exposure is longer when the flow rate is maximum. So it is concluded that the distribution of shear stress at complete opening stage has big effect on the blood damage, and that the low-pressure region appeared behind leaflet at complete closing stage has also effect on the blood damage.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.6-9
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• 2008

Analyzing the characteristics of blood flow in the blood vessels is very important to diagnose the circulatory diseases. In order to investigate the hemodynamic characteristics in vivo, the measurements of blood flows inside the extraembryonic arterial and venous blood vessels of chicken embryos were carried out using an in vivo micro-PIV technique. The circulatory diseases are closely related with the formation of abnormal hemodynamic shear stress regions, thereby it is important to get blood velocity and vessel's morphological information according to the vessel configuration and the flow conditions. In this study, the flow images of RBCs in blood vessels were obtained using a high-speed CMOS camera with a spatial resolution of approximately 14.6${\mu}$m${\times}$14.6${\mu}$m in the whole circulation network of blood vessels. The blood flows in the veins and arteries show steady laminar and unsteady pulsatile flow characteristics, respectively. The mean blood flows merged (in veins) and bifurcated (in arteries) smoothly into the main blood vessel and branches, respectively, without any flow separation or secondary flow which accompanying large variation of shear stress. Vorticity was high in the inner regions for both types of vessels, where the radius of curvature varied greatly. The instantaneous flows in the arterial blood vessels showed noticeable pulsatility due to the heart beat, and the main features of the velocity waveforms, including pulsatile shape, retrograde flow, mean velocity, maximum velocity and pulsatile frequency, were significantly dependent on the pulsatile condition which dominates the arterial blood flow. In near future, these in vivo experimental results of blood flow measured in various extraembryonic blood vessels would be very useful to understand the hemodynamic characteristics of human blood flows and various blood flow researches for clinically useful hemodynamic discoveries as well.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.05
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• pp.109-112
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• 1995

The three dimensional, steady flows of blood and blood analogue fluids in the abdominal aortic bifurcation are simulated using the finite volume method. The objective of this investigation is to understand the generation and progression of site-specific atherosclerosis from a hydrodynamic point of view. Due to complexity of blood in conducting experimental study, aqueous polymer solutions are used as the substitutional fluids. For comparison purpose of the flow characteristics of blood and substitutional fluids, rheologically different fluids such as water soluble polymers of Carbopol-934 and Separan AP-273 are employed for the numerical simulation. In order to understand the role of hydrodynamics in the formation and development of atherosclerosis lesions flow velocities, pressures and shear stresses along the vessel are calculated for steady flows.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.643-646
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• 2001

This paper investigates the structural analysis and design of mechanical heart valve through the numerical analysis methodology. In a numerical analysis methodology application to the thickness minimization structural design of mechanical heart valve, structural analysis is performed for the blood flow through a bileaflet mechanical heart valve. The structural static analysis is carried out to confirm the thickness minimization structural condition (minimum thickness shape of leaflet).