• Title/Summary/Keyword: 혈액화학

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빈산소 노출에 의한 넙치, Paralichthys olivaceus의 혈액화학적 변화

  • 강주찬;이정식;조규석
    • Proceedings of the Korean Society of Fisheries Technology Conference
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    • 2000.05a
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    • pp.308-309
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    • 2000
  • 천연해역 및 양식장 등의 환경변동은 수산동물에 많은 저해영향을 미치게 되는데, 최근 환경변화에 대한 수산동물의 생리 및 생화학적 지표를 개발하려는 시도가 부분적으로 이루어지고 있다(McCin et al., 1996). 이들 중에 어류의 혈액 구성은 일반적으로 환경수 중에 존재하는 stress를 유발하는 물질에 의해 변동하기 때문에 적혈구수, 혈색소농도 및 상대혈구용적 등의 혈액성상, 혈청내의 무기 및 유기성분의 변화는 환경변화를 감시하는 유용한 수단으로 활용되고 있다(Ma et al., 1995; Khattak and Hafeez, 1996). (중략)

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백서에서 Paraquat가 장기 Glutathione 농도에 미치는 영향

  • Go, Chun Nam;Go, Chun Nam;Yu, Ui Gyeong
    • Journal of the Korean Chemical Society
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    • v.38 no.1
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    • pp.69-73
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    • 1994
  • The effects of paraquat administration on glutathione was studied in rats. The contents of glutathione in the liver, kidney and lung were significantly decreased but the alteration was not significant in blood by paraquat administration. The decrease occured without concomitant increases in oxidized glutathione (GSSG) or in the GSH/GSSG ratio. The activities of γ-glutamylcysteine synthetase in liver and kidney were decreased by paraquat administration. And γ-glutamyl transpeptidase activities were significantly decreased in kidney and lung of paraquat treated-rats. These results suggest that the decreased synthesis of glutathione by paraquat were an important mechanism of the decreased level of glutathione in liver and kidney, and decreased glutathione transport was a factor on the changes of glutathione contents in lung.

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Analysis of the Factors Relating Nutritional Status in Discharging of Leukemia Patients Receiving Chemotherapy (항암화학요법을 받고 있는 혈액암 환자의 퇴원시 영양 상태와 관련한 요인 분석)

  • So, Eun-Jin;Kim, Jee-Yeon;Jung, Su-Jin;Park, Sook
    • Journal of Nutrition and Health
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    • v.43 no.1
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    • pp.26-33
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    • 2010
  • This study was performed to investigate the changes of oral diet intake during the admission period and identify the factors related with nutritional status in discharging of leukemia patients. This is a retrospective cross sectional study on 46 leukemia patients receiving chemotherapy at the Catholic University of Korea Seoul St. Mary's Hospital from July to September 2009. The patients' charts were surveyed on the general characteristics and factors relating chemotherapy. The calorie count method was used to investigate diet intake during admission period. Multivariate logistic regression analysis was used to identify possible confounding factors. A p < 0.05 was considered statistically significant. The mean age was $42.8\;{\pm}\;14.6$ years and the average length of stay was $30.4\;{\pm}\;7.0$ days. The incidence of malnourished patients was 60.9% in discharging. There was a significant difference in chemotherapy sessions and chemotherapy period between well-nourished and malnourished patients. The average energy intake was 1,525.9 kcal in well-nourished patients and 1,143 kcal in malnourished patients, which was significant different. From repeated measures ANOVA test, the changes of oral intake during admission period were significant by groups. In addition, there were significant differences in oral intake according to each period between well-nourished and malnourished patients. In multivariate logistic regression analysis, both the ratio of total oral energy intake to recommended energy intake and chemotherapy sessions were significantly associated with nutritional status in discharging. The results of this study could be used to establish a protocol of nutritional management for leukemia patients receiving chemotherapy.

Analysis of the Accuracy about Abdominal Ultrasonography and Clinical Chemical Test with Fatty Liver Patients on the Medical Examination (종합검진 후 지방간 환자의 복부 초음파 검사와 임상화학적 검사결과의 정확성 분석)

  • Kim, Young-Jae;Song, Jong-Nam;Kim, Min-Eui
    • Journal of the Korean Society of Radiology
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    • v.6 no.3
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    • pp.183-189
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    • 2012
  • Ultrasonography is one of the fields on the imaging studies within intra-abdominal organs. A blood test is a typical method of clinical chemical examination on the in vivo test of clinical symptoms. Fatty liver is performed simultaneously two kinds of diagnostics methods, intra-abdominal ultrasound and blood tests. At an implementing this, the standard of blood tests value was the TBIL, TC, AST, ALT, ALP, GGT, TG, HDL-C, GLU. In this study analyzing the accuracy of the two kinds of test, ultrasonography and blood test, on patients with fatty liver. From January to March 2012, patients 459 determined fatty liver within 1350, who received health examination simultaneously on the intra-abdominal ultrasonography and blood tests. Same result of ultrasonography and blood test's patients were 459 ie, 60.8%. and different result of those examinations was 280 ie, 39.2%. Consequently diagnostic accuracy was 60.8%. It presumably caused by differences in the diagnostic performance of ultrasound professionals(Radiologist or Radiological Technologist). In order to overcome this, ongoing educational and study will be needed.

Secondary Acute Myeloid Leukemia after Chemotherapy in an Osteosarcoma Patient - A Case Report - (골육종 환자에서 항암화학요법후 발생한 이차성 급성 골수성 백혈병 - 증례 보고 -)

  • Kim, Jae-Do;Kim, Seong-Dae;Son, Jung-Hwan
    • The Journal of the Korean bone and joint tumor society
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    • v.6 no.2
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    • pp.98-105
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    • 2000
  • In the case of osteosarcoma, secondary acute myeloid leukemia which occurs as the consequences of the complication of chemotherapy, is rare. We are reporting the case that we have recently experienced in the laboratory. A case of secondary acute myeloid leukemia have been occurred to among 77 patients who have been diagnosed as osteosarcoma and received chemotherapy from 1995 to 1999. This case was compared with the cases of other reports for the analysis of its cause and results. A 17-year-old man was diagnosed as a osteosarcoma in the distal part of femur, and recieved chemotherapy. Within 28months, the hematological analysis of the case indicated the severe increase in the number of the white cell (over 200,000) and the profound decrease in the number of platelets. A test of bone marrow needle aspiration and peripheral blood smear showed a tremendous increase in the number of the monocytoid immature cell, which mostly are blasts and promonocytes. Due to this clinical results, the case was diagnosed as the secondary acute myeloid leukemia after the chemotherapy. The frequency of occurrence of secondary acute myeloid leukemia after chemotherapy is quite phenomenal. But the disease could be fatal leading to a high rate of morbidity and mortality without early diagnosis and treatment. Hence, an enough recognition of the possibility of its development, the periodical observation and inspection after chemotherapy and an immediate treatment in the case of occurrence are essential.

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재조합 인간 GM-CSF의 정제 및 특성조사

  • 김규돈;윤세웅;이상미;권선훈;김범수;송지용
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.66-66
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    • 1993
  • 혈액 세포 형성 과정인 조혈 작용은 콜로니 자극인자 (Colony Stimulating Factor, CSF)라 불리는 몇 종류의 당 단백질에 의해 조절된다. 이들 자극인자 중, GM-CSF는 다계통에 작용하는 조절인자로서 과립구와 거식세포의 생성을 조절한다고 알려져 있다 한편 GM-CSF는 생체내에서 백혈구의 형성을 조절하는 인자이기 때문에 골수이식을 한 환자 및 화학요법이나 방사선 치료를 받는 암환자에게서 발생하는 백혈구의 감소현상을 완화시키는 역할을 한다. 혈액의 보조화와 관련하여 의학적 효능을 나타낼 것으로 간주되는 GM-CSF를 유전자 재조합 기술로 효모에서 발현, 정제하여 물리화학적 특성 및 역가를 측정하는 것이 이 연구의 기본목적이다.

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해외뉴스

  • Korean Federation of Science and Technology Societies
    • The Science & Technology
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    • v.16 no.11 s.174
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    • pp.22-24
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    • 1983
  • - 국제화학생태학회 창립 - 컴퓨터로 흑백필름을 컬러화 - 새로운 인공혈액 - 유기컴퓨터는 부피가 100만분의1 - 야구선수와 심리치료 - 수소자동차 개발 - 토성에도 천둥이 있다 - 뇌의 크기는 한계가 있다

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화학의 세계-혈액형과 유전병

  • Jin, Jeong-Il
    • The Science & Technology
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    • v.31 no.6 s.349
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    • pp.71-71
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    • 1998
  • 혈액형에 따라 사람의 성품도 차이가 나며 특수질병과도 관련이 있는 것으로 알려져있다. 이에 따라 배우자를 선택할 때 상대방 혈액형을 한번쯤 알아보는 것이 보통이며 이를 성격과 연관지어 생각하기도 한다. 혈액형은 혈액내 적혈구막을 형성하는 당단백질의 형태의 의해 결정된다.

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