• Proceedings of the KSME Conference
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• 2003.04a
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• pp.1915-1918
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• 2003

Atherosclerosis, which is a degenerate disease, is believed to occur in the vascular system due to deposition of cholesterol and low density lipoprotein(LDL) or thrombosis on the blood vessel. Atherosclerosis narrows arterial lumen, which is known as stenosis phenomenon of blood vessel. Pathogenesis of atherosclerosis is thought to occur mainly by aging. Restenosis phenomenon is observed in the same site of insertion of a stent and balloon angioplasty after treatment of interventional theraphy. Several hypothetical theories related to the generation of atherosclerosis have been reported: high shear stress theory, low shear stress theory, high shear stress gradient theory, flow separation and turbulence theory and high pressure theory. However, no one theory clearly explains the causes of atherosclerosis. In the present study the generation of atherosclerosis in the left coronary artery is investigated. The hypotheses are verified by using the computer simulation.

• 순환기질환의공학회:학술대회논문집
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• 2004.11a
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• pp.11-12
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• 2004

본 연구에서는 동맥경화증의 발생에 관한 가설들을 혈류역학적 관점에서 비교/검토하였다. 혈류의 와류 현상, 분리현상 등도 역시 저전단응력 위치에서 발생하게 되며 동맥경화의 발생이 되기 시작하며 동맥내 형태학적 변화로 인해 이러한 현상이 좀더 복잡한 유동을 거치게 된다. 이로 인해 동맥내의 형태적 재형성이 일어나게 되는데 유동의 변화가 역할을 하는 것으로 생각된다. 생물학적으로 동맥경화는 질병의 성격이 만성 염증성 질환으로 알려져 있는데 이러한 생물학적 변성이 발생하는데 형태적 특성에 따른 혈류역학적 변화가 그 기전에 중요한 것임을 확인되었다. 본 연구자 등은 동맥경화가 발생하기 시작하는 곳은 혈관의 만곡부, 분지부 등에서 발생하는 것을 임상적 database를 통해 확인하였고 이 위치에서 영상을 simulation model을 동생 분석하여 전단응력의 영향과 시간에 따른 역동적 변화가 큰 것을 확인하였다.

• The Korean Journal of Pharmacology
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• v.24 no.1
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• pp.135-145
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• 1988

Dopamine when given icv induces antidiuresis along with transient natriuretic tendency, and it has been suggested that both subtypes of central dopamine receptors may influence renal function differentially. This study was undertaken to delineate the role of central $D_2$ receptors employing domperidone (DOM), a selective $D_2$ antagonist. DOM icv elicited antidiuresis and antinatriuresis in doses ranging from 15 to $135{\mu}g/kg$. GFR and RPF as well as sodium excretion decreased. Systemic blood pressure increased slightly. Intravenous DOM did not elicit significant changes in sodium excretion. Denervation of the kidney abolished the hemodynamic change induced by icv DOM, but sodium excretion decreased on both innervated and denervated kidneys. No diuretic tendency was uncovered by the denervation. Dopamine, $150{\mu}g/kg$ icv, produced antidiuresis along with decreases in hemodynamics. These effects were not affected by DOM-pretreatment, and no natriuretic tendency was unveiled. Bromocriptine, a $D_2$ receptor agonist, $200{\mu}g/kg$ icv, elicited marked diuresis and natriuresis, which were completely abolished by DOM-pretreatment. Apomorphine, another prototype of $D_2$ agonist, $150{\mu}g/kg$ icv, produced diuresis and natrituresis with increases in renal hemdoynamics, followed by decreases in all parameters. DOM-pretreatment did not affect the renal hemodynamic effects, wherease the increases in urine flow and sodium excretion were markedly reduced by DOM, Present study suggests that central $200{\mu}g/kg$ receptors mediate natriuretic and diuretic influence to the kidney, possibly through mediation of natriuretic humoral factor, and provide further evidence supporting the hypothesis that central $200{\mu}g/kg$ receptors mediate antidiuretic influence via nerve pathway, whereas natriuresis are brought about through mediation of central $200{\mu}g/kg$ receptors.