• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.352-360
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• 2016

Objective: This study reports on traditional Korean medicine therapy used for pneumonia among elderly patients.Method: Two patients diagnosed with pneumonia were treated with herbal medicine and acupuncture, as well as cupping along the back. We checked chest X-rays, coughing and sputum on the visual analogue scale (VAS), and lab evaluations in order to evaluate the effectiveness of the treatment.Results: Following treatment with traditional Korean medicine therapy, VAS scores for coughing and sputum decreased and the chest X-rays and inflammation markers improved.Conclusion: Traditional Korean medicine therapy treatment appears to be effective for treating pneumonia in elderly patients.

• Korean Journal of Clinical Pharmacy
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• v.3 no.1
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• pp.71-78
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• 1993

The antipyretic effect of Sibsin-Tang in rabbits by injected typhoid vaccine was studied. The results are summarized as follows; 1. Maximum temperature was $39.76\pm0.28^{\circ}C$ after 60-240 minutes by injected typhoid vaccine. 2. Sibsin-Tang did not make normal temperature low but aminopyrine made normal temperature low in rabbits. 3. Increased temperature by typhoid vaccine was decreased by administration of Sibsin-Tang at 150 minutes. 4. Pretreated Sibsin-Tang did not affect on increased temperature by typhoid vaccine. 5. Propranolol did not affect on increased temperature by typhoid vaccine.

• Journal of Korean Medical classics
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• v.19 no.2 s.33
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• pp.11-29
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• 2006

${\ulcorner}$동의수세보원(東醫壽世保元)${\lrcorner}$소음인편(少陰人篇), 유신수열표열병화위수한리한병양대부분조성(由賢受熱表熱病和胃受寒畵寒病兩大部分組成). 신수열표열병(賢受熱表熱病), 분위울광증(分爲鬱狂證), 망양증(亡陽證), 태양병궐음증등삼개병증(太陽病厥陰證等三個病證). 상한론적하초축혈증시사기재하조적혈증(傷寒論的下焦血證是邪氣在下蕉魚的血證), 용저당탕(用抵當湯), 도인승기탕등파열해열지제치료(桃仁承氣湯等破血解熱之劑治療). 단동무인위상한하초축혈증위울축방광증(但東武認爲傷寒下蕉蓄血證爲鬱蓄醫謗胱證) 기병기시신국양기피사소거(其病機是賢局陽氣被邪所拒), 불능상소어비국(不能上疏於脾局), 울축방광(鬱蓄膀胱). 고동무장양기울축적병증시(故東武將陽氣鬱蓄的縮的病證視), 위울광증(爲鬱狂證), 장양기누설적한출시위망양증(將陽氣漏泄的汗出視寫亡陽證). 동무장태양상풍무한증(東武將太陽傷風無汗證), 하조축혈증(下蕉蓄血證), 귀속우울광초증(歸屬于鬱狂初證), 장열입혈실증(將熱入血室證), 양명병위가가실증(陽明病胃家實證), 귀속우울광중증(歸屬于鬱狂中證), 장양명병조열광언증(將陽明病湖熱狂言證), 귀속우울광말증(歸屬手驚狂末證), 장태양상풍한출증(將太陽傷風出證), 귀속우망양초증(歸屬于亡陽初證), 장양명병(將陽明病), 불오한(不惡寒) 반오열(反惡熱) 한자출증(汗自出證), 귀속우망양중증(歸屬手亡陽中證), 장양명병(將陽明病), 발열한다증(發熱汗多證), 귀속우망양말증(歸屬手亡陽末證). 타인위소음인음병당유복만자리(他認爲少陰人陰病當有腹題滿自利), 시병등증상(時病等症狀). 초기약무복통자리적증상이견궐음증(初起若無複痛自利的症狀而見厥歐陰證), 인위시정사상지일구이경기쇠갈소치(認爲是正邪相持日久而正氣衰竭所致).

• The Journal of Internal Korean Medicine
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• v.29 no.2
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• pp.334-347
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• 2008

Background and Objective : Haeyeol-tang, composed of Houttuyniae Herba, Lonicerae Flos, Taraxaci Herba, and Scrophulariae Radix, is widely used for alleviating the symptom of various kinds of inflammatory pulmonary disease, including asthma and COPD. We want to know whether Haeyeol-tang has an anti-inflammatory effect by analyzing expression of pro-inflammatory cytokines. Materials and Methods : We differentiated the THP-1 cells into macrophage-like cells by treatment with PMA. Inflammation was induced by treatment with LPS and PMA. We found the safe concentration of Haeyeol-tang by using MTS assay and used PD98059 as a negative control for comparison of anti-inflammatory effect of Haeyeol-tang. Results : The RT-PCR analysis results show that the cell survival rate is over 100% within 1 ng/mL to 1 ug/mL of Haeyeol-tang and begins to decrease under 100% at 10 ug/mL. The gene expression of $IL-1{\beta}$, IL-6, IL-8, IL-10, $TNF-{\alpha}$ and $TGF-{\beta}$ levels were down-regulated when Haeyeol-tang was treated at concentrations between 1 ng/mL an 1 ug/mL on monocyte-derived macrophages. Interestingly, 1 ug/mL Haeyeol-tang-treated samples showed that the transcriptional activities of IL-8, $TNF-{\alpha}$, IL-10 and $TGF-{\beta}$ were more down-regulated than those of PD098059 $(TNF-{\alpha}$ inhibitor). At protein level, the ELISA analysis results showed that there were more remarkable (p<0.001) decreases in expression of $IL-1{\beta}$, IL-6, IL-8 and $TNF-{\alpha}$ on both the 1 ug/mL Haeyeol-tang-treated group and the PD98059-treated group than the LPS-treated group. Conclusion : We conclude that Haeyeol-tang has an anti-inflammatory effect by inhibiting expression of pro-inflammatory cytokines and chemokines at mRNA and protein levels. These results may provide us a promising way to care for general inflammatory diseases as well as inflammatory pulmonary disease, including asthma and COPD, with further clinical study.

• The Journal of Internal Korean Medicine
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• v.28 no.4
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• pp.671-680
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• 2007

Objectives : The purpose of this study was to examine the effect of Haeyeol-tang on infectious disease of respiratory system. Methods : Haeyeol-tang was used by cold storage after dilution with 1, 10 and $100{\mu}g/ml$ of PBS, from dried material as extracted material with extraction with 50% ethanol. Statistical significance was examined through measuring TNF-$\alpha$, RT-PCR, DPPH, nitric oxide(NO), and MTT of Raw264.7 cells activated with LPS. Results : For the toxicity experiment of Haeyeol-tang, almost no toxicity was shown on cells in the concentration ranges of 1, 10 and $100{\mu}g/ml$. For the effect of NO production, Haeyeol-tang showed significant (p<0.001) decrease of NO production, according to its concentration. For the effect on the eliminating activity of DPPH radical, Haeyeol-tang showed increasing tendency of eliminating activity of DPPH radical, according to its concentration. For the effect on revelation of NOS2 enzyme, Haeyeol-tang showed inhibiting tendency against the revelation of NOS2, according to its concentration. For the effect on the TNF-$\alpha$ production, Haeyeol-tang showed significant (p<0.001) decrease of TNF-$\alpha$ production. Conclusions : This result means that Haeyeol-tang is effective for anti-inflammation, as well as excellent effect for anti-oxidation and anti-aging.