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Effectiveness of Short-Course Antibiotic Treatment in Uncomplicated, Non-Bacteremic Pediatric Urinary Tract Infections: A Rapid Systematic Review

Han Ho Kim;Young June Choe
- Pediatric Infection and Vaccine
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- v.30 no.2
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- pp.55-61
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- 2023
Purpose: Urinary tract infections (UTIs) pose a significant disease burden in children. This study aims to determine whether a short-course regimen is non-inferior to a standard-course regimen in children with UTIs without complication and presence of bacteremia, and to define, in the optimal way possible, the term "short-course" in this context. Methods: We conducted a rapid systematic review of research up to April 2021 in PubMed, Embase, and Cochrane databases. We included studies that compared clinical outcomes in pediatric UTIs treated with short-course(≤4 days) or standard (≥5-7 days) courses. Results: Our analysis suggests that short-course regimes have equivalent efficacy to standard-course regimens, with similar clinical cure rates and recurrence rates. All 10 studies comparing the clinical cure rates of short- and standard-course regimens reported comparable outcomes. The study evaluating renal scarring indicated no inferiority of short-course regimens compared to standard-course ones. Regarding UTI relapse, 8 out of 10 studies reported no significant difference in outcomes between short- and standard-course regimens. Conclusions: Our results purpose that short-course UTI regimens of 6 days or less are just as effective as standard-term regimens of 7 days or more in terms of infection cure and prevention of recurrence. Considering the equivalent rates of clinical cure and relapse between short- and standard-course regimens, it could be inferred that short-course regimens might be a more optimal strategy for managing pediatric UTIs without increasing the risk of complications.
https://doi.org/10.14776/piv.2023.30.e10 인용 PDF

Overview of Helicobacter pylori and Treatment Options (헬리코박터 파일로리(Helicobacter pylori) 감염 및 치료법 개요)

Song, Young Goo
- Economic and Environmental Geology
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- v.48 no.3
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- pp.241-246
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- 2015
Helicobacter pylori is an important transmissible human pathogen found on the luminal surface of the gastric epithelium. The organism can persist in the stomach indefinitely and causes gastroduodenal inflammation that may proceed to atrophic gastritis, peptic ulcer, gastric MALT lymphoma, and gastric cancer. Standard triple therapy which consists of proton pump inhibitor (PPI) plus two antibiotics (amoxicillin and clarithromycin) is now generally used in Korea, however, eradication rates of H. pylori has been decreasing due to increasing antibiotic resistance. In this review, current second-line treatment regimens, difficult problems on treatment, necessity of local target therapy, applicability of clay minerals as a drug delivery system (DDS), and a new therapeutic strategy and its study plans will be discussed.
https://doi.org/10.9719/EEG.2015.48.3.241 인용 PDF KSCI

Therapeutic Effect of Pipemidic Acid on OMPC (만성중이염에 대한 Pipemidic Acid의 치료효과)

장인원;이종원;정종진;조용범;국태진;이정헌;염시경;김종욱;조재식
- Proceedings of the KOR-BRONCHOESO Conference
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- 1981.05a
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- pp.39.2-39
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- 1981
Recently, there has been many problems in the treatment of OMPC, because of inadequate and abuse of antibiotics, and resistant strain of pathogenic organisms to antibiotics. Authors studied on the culture and sensitivity of otorrhea obtained from 50 patients with OMPC, and evaluated the therapeutic effect of PPA, which is a new derivative of piromidic acid and active against gram (-) bacteria including pseudomonas aeruginosa as well as some gram (+) bacteria. We observed good therapeutic effect on OMPC with pseudomonas and other gram (-) bacteria, and considerable effect on OMPC with gram (+) bacteria.
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