• Korean Journal of Organic Agriculture
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• v.7 no.1
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• pp.137-146
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• 1998

Various rhizobacteria was isolated, and was bacterialized into the substrates to clarify the plant growth promoting effects of rhizobacteria on the early growth of red peper seedlings. Total 125 bacterial isolates were primarily isolated and purified from the soils in greenhouse. And four strains were finally screened, based on the antifungal activities against Fusarium sp., Pythium sp. and Rhizoctonia sp. of red pepper plants. The strongest antifungal strain RB 109 has a antagonistic activity against Fusarium sp., Pythium sp. and Rhizoctonia sp. in terms of 66.0%, 65.0% and 66.1%. Early growth of red pepper seedlings was promoted, when cultured solution of rhizobacteria RB 109 was bacterialized into the substrates. Antifungal rhizobacteria RB 109 was identified as Pseudomonas sp. related strains, which has a similarity of 82% to the Pseudomonas sp.

• Microbiology and Biotechnology Letters
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• v.10 no.3
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• pp.171-175
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• 1982

An oxytetracycline as being a tetracycline-antibiotic substance displayed a general synergism in the antimicrobial activity by the interaction of ginseng saponin and antibiotics, but did not to Sarcina maginata. Penicillin G.Na as being a $\beta$-lactam-antibiotic substance displayed a synergism in the antimicrobial activities by the addition of ginseng saponin to microorganisms used, but changed the effects in the antimicrobial activity of penicillin G.Na against the genus Serratia. An antimicrobial activity by the addition of ginseng saponin to antibiotics showed a non-specificity, and it varied synergism or antagonism to Gram-positive or Gram-negative bacterium. It was assumed that a drug-resistance could be eliminated by the dual administration of ginseng saponin and antibiotics.

• Microbiology and Biotechnology Letters
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• v.10 no.3
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• pp.163-169
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• 1982

The possible effects in vivo on the duel usage of sinseng saponin and antibiotics were studied in vitro with microorganisms. Streptomycin.sulfate, kanamycin.sulfate and gentamycin.sulfate as being an aminoglycoside-antibiotic substance showed a general synergism by the interaction of ginseng saponin and these antibiotics. But kanamycin.sulfate and gentamycin.sulfate did not show a synergism in their original antimicrobial activity against Er-winia aroideoe. Chloramphenicol as being a benzene derivative displayed an increased antimicrobial activity by the interactions of ginseng saponin and this antibiotic against Salmonella typhi, Aerobacter aerogenes and the genus Serrotia. This antibiotic also showed the decreased antimicrobial activity against Bacillus subtilis, Bacillus megaterium and Escherichia coli, but did not show an uniform antimicrobial activity against others.

• Proceedings of the KAIS Fall Conference
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• 2011.12a
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• pp.259-261
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• 2011

생약제제 중에서 연은 수련과의 식물로서 예로부터 위염, 출혈, 설사, 치질, 두통, 해독작용 등에 사용되어 왔으며, 민들레는 국화과에 속하는 식물로 천식, 해열, 강장, 부인병 등에 사용되어왔다. 최근에는 이들 생약제제의 약리작용에 대한 연구도 활발하게 이루어져 항산화작용, 항알레르기효과. 항균작용, 항암활성 등에 관한 연구가 보고되고 있다. 이에 본 연구에서는 연잎과, 민들레의 추출물이 치아우식 원인균인 S. mutans에 미치는 항균효과를 연구하고자 하였다. 추출물의 첨가에 따른 S. mutans의 성장억제율을 측정한 결과, 추출물의 농도가 높아질수록 S. mutans의 성장억제율도 높아지는 결과를 얻었다. 이로써 연잎과 민들레 추출물은 S. mutans의 성장을 억제하는 항균효과를 가지고 있음을 본 연구에서 확인 할 수 있었다.

• Journal of Life Science
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• v.7 no.3
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• pp.180-185
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• 1997

Methylelaiophylin generated superoxide radicals in Bacillus subtilis and showed antibacterial activity against a broad range of gram positive bacteria. The inhibition of DNA synthesis was more sensitive than one of RNA synthesis. A recombination-deficient mutant strain of B. subtilis was 2-fold more sensitive than a wild strain, and this sensitivity was reduced in the presence of an antioxidant, dithiothreitol. Methylelaiophylin generated superoxide radicals in B. subtilis lysates, and this suggests that the antibacterial activity of methylelaiophylin is related to the generation of active oxygen species in the cells.

• YAKHAK HOEJI
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• v.10 no.2_3
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• pp.8-11
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• 1966

항인결핵균성및 streptomycin, isoniazid및 para-aminosalicylic acid에 대한 내성인결핵균주에 현저한 항균작용 있는 dextro-2,2'-(ethylenediimino)-di-1- butanol(Ethambutol) 계열 및 thioureido(-NHCSNH-) 함유화 합물 계열인 2,2'-(ethylenediimino)-di-1-butyric acid및 2,2'-(thioureido)-di-1-butyric acid를 합성했으며 이들 약물의 구조와 작용간의 상호관계를 설명코저 이들 화합물과 류사한 구조인 2,2'-(thioureido)-di-acetic acid를 합성했기에 보고함.

• YAKHAK HOEJI
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• v.35 no.1
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• pp.7-10
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• 1991

For the purpose of developing of anticariogenic agents, P-phenylphenol derivatives were synthesized and determined their antibacterial activities against a cariogenic bacterium, Streptococcus mutans. Among synthetic compounds, 2-nitro-6-bromo-p-phenylphenol showed as potent antibacterial activity as magnolol and honokiol.

• The Microorganisms and Industry
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• v.15 no.1
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• pp.16-17
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• 1989

우리들의 주변환경에는 어느 곳에나 여러가지 미생물이 무수하게 존재하며 이들 미생물들은 그 환경조건이 이들의 서식에 적합하기만 하면 증식한다. 이들 미생물들 가운데서 섬유재료에 영향을 주는 것으로는 주로 일부의 세균과 곰팡이(사상균)류가 있다. 섬유에 영향을 주는 작용을 대별하면 1) 섬유재료의 파괴(부패작용), 2) 섬유제품의 착색오염, 3) 섬유중에서 증식되는 병원균에 의한 질병 유발, 4) 악취발생 등이라고 할 수 있다. 우리의 환경은 각종 미생물에 오염되기 쉬운 상태에 있으므로, 섬유재료의 파괴를 방지하고 될 수 있는대로 건강하고 쾌적한 의생활을 영위하려는 목적으로, 세균과 곰팡이의 증식을 억제 또는 저지 할 수 있는 항균제를 섬유제품에 처리하게 되었다.

• Journal of fish pathology
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• v.13 no.1
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• pp.45-51
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• 2000

Bacterial diseases with mixed infection have recently occurred at land-based flounder farms in Korea. Thus, single antibacterial is not effective for therapy of mixed bacterial diseases of fish because of their different causative bacteria. The purpose of the present study was to obtain basic data for positive usefulness of a combination of antibacterials used for synergism to mixed bacterial diseases of fish. Snergistic interaction in combination of antibacterials was determined by in vitro antimicrobial activity against selected fish-pathogenic bacteria, Vibrio anguillarum, Edwardsiella tarda, Streptococcus sp., Staphylococcus epidermidis, on the basis of Checkerboard assay using fractional inhibitory concentration (FIC) indices. Synergistic interactions were observed in combinations of (oxytetracycline HCL+lincomycin), (tetracycline HCL+florfenicol), (oxytetracycline HCL+florfenicol) against V. anguillarum, (sodium nifurstyrenate+florfenicol), (tetracycline HCL+florfenicol), (sodium nifurstyrenate+oxolinic acid), (oxytetracycline HCL+florfenicol) against E. tarda, (ciprofloxacine+oleandomycin), (oxytetracycline HCL+oleandomycin), (tetracycline HCL+oleandomycin), (oxytetracycline HCL+lincomycin), (oxytetracycline HCL+spiramycin), (oxytetracycline HCL+erythromycin), (doxycycline HCL+oleandomycin), (tetracycline HCL+spiramycin) against Streptococcus sp., and (ciprofloxacine+erythromycin), (florfenicol+erythromycin), (doxycycline HCL+oleandomycin), (ciprofloxacine+oleandomycin) against S. epidermidis.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.2
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• pp.127-131
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• 2006

A study was carried out to produce antimicrobial peptides from zein treated with pretenses of six kinds. Among the pretenses of six kinds, zein hydrolysate treated with pepsin showed the highest antimicrobial activity. The zein hydrolysate with pepsin was fractionated with membrane filter (30,000 10,000 and 3,000 molecular weight cut-off) and antimicrobial activity was measured for each fractions. Antimicrobial activity appeared greatly in the fraction below 3,000 (molecular weight cut-off) . The fraction was re-fractionated by HPLC and substances of two peaks collected as a sample to measure antimicrobial activity. All of both peaks showed the antimicrobial activity but 1st peak exhibited a consistently higher antimicrobial activity than 2nd peak. Minimum inhibitory concentrations (MIC) were between 2.5 and 3.0 mg/mL. The peptide was heat-stable since antimicrobial activity was maintained after treated with heat for 20 min at $121^{\circ}C$. N-terminal amino acid sequence of peptide fractionated by HPLC was leucine, glutamic acid, proline, phenylalanine, aspartic acid and argenine. These results indicated that peptide isolated from zein hydrosate with pepsin can use as a natural preservative ingredient in food industry.