• 화훼연구
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• 제16권2호
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• pp.93-101
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• 2008

식물재료로는 꽃차로 이용되고 있는 식물 중 한의학 서적에 약효가 기록되어 있는 55종을 대상으로 하였다. 이들 식물의 한의학적인 약효를 해표약, 이수약, 청열약, 사하약, 보익약, 보기약, 보혈약, 온리약, 이기약, 방향화습약과 활혈약 등 11군으로 분류하였다. 또한 이 식물들은 열(열, 온, 미온, 평, 량, 한), 맛(달다, 쓰다, 맵다, 시다, 짜다), 독성(있다, 없다) 별로 분류되었다. 꽃차의 음용은 일반적으로 모든 사람에게 이용가능할 것으로 알려져 있다. 그러나 꽃차를 음용 할 때는 본인의 체질과 건강상태에 맞는 꽃차를 선택하는 것이 중요하다. 독성이 있는 식물을 꽃차로 음용 할 때는 주의를 기울여야하고 몸이 허약한 사람은 음용을 금해야 한다. 앞으로 좀 더 많은 임상적인 연구가 진행된다면 꽃차의 건강학적 효능에 따른 상품화가 가능할 것으로 판단된다.

• 사상체질의학회지
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• 제33권3호
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• pp.127-137
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• 2021

Objectives The purpose of this study was to identify the effects of personality by each Sasang constitution on sleep using Positive Affect and Negative Affect Schedule(PANAS) and NEO-personality inventory(NEO-PI). Methods The subjects of this study were 2,078 people who had information on Sasang constitutional type and personality(PANAS, NEO-PI) among the data established at the Korean Medicine Data Center. Sleep time and sleep quality were investigated through self-written questionnaires. Sleep time was collected by hand-writing, and sleep quality was checked on a 4 point Likert scale. Pearson correlation analysis was conducted to see the correlation between personality and sleep in each constitutional type. Logistic regression was performed using personality as independent variables to find out how much personality affects sleep time. In order to find out how much personality affects sleep quality, regression analysis was performed using personality as independent variables. Results & Conclusions Sleep time was hardly affected by personality. As a result of Pearson correlation analysis, sleep time in all subjects did not show a significant correlation with personality. In logistic regression on sleep time as the dependent variable, no statistically significant results were obtained except for the Negative Affect(NA) in Taeeumin. Sleep quality showed a statistically significant correlation with the negative affect(NA), neuroticism(N), extraversion(E), Physical Component Summary(PCS) and Mental Component Summary(MCS). As a result of regression analysis on sleep quality as the dependent variable, neuroticism(N), negative affect(NA), positive affect(PA), and extraversion(E) were found in the factors affecting sleep quality. Besides, how much personality affected sleep quality might differ in each constitution. In all constitutions, sleep quality was affected by N, but the rank of N was different in each constitution. The sleep quality of Soyangin was not affected by E, and the sleep quality of Taeeumin was specifically affected by O.

• 대한본초학회지
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• 제32권6호
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• pp.23-29
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• 2017

Objective : Hyperuricemia is a metabolic disease characterized by elevated blood uric acid levels, and its prevalence is rapidly increasing worldwide. Alpiniae Oxyphyllae Fructus (AO) belonging to Zingiberaceae is one of well-known traditional medicines in China and Korea, and has been used to treat intestinal disorders, urosis, diuresis, and chronic glomerulonephritis traditionally. However, the effect of AO has not been studied. In this study we investigated the anti-hyperuricemic effect of AO, and the mechanisms underlying the effect in potassium oxonate (PO)-induced hyperuricemic rats. Methods : To examine the anti-hyperuricemic effects of the AO extract, serum uric acid levels were analyzed in normal and PO-induced hyperuricemic rats. The mechanism underlying the effects of the AO extract on uric acid levels was studied through xanthine oxidase (XOD) activity test and uric acid uptake assay in vitro. The chemical finger printing of the AO extract was analyzed using HPLC-DAD. Results : The AO extract significantly reduced serum uric acid levels in normal as well as PO-induced hyperuricemic rats. It also significantly inhibited the uptake of uric acid in oocytyes and human embryonic kidney cells (HEK293) expressing urate transporter (URAT)1, but not XOD activity in vitro. The chemical finger printing analysis of the AO extract showed nootkatone as a main component. Conclusion : The AO extract exhibits anti-hyperuricemic effects, and these effect were accompanied by increasing excretion of uric acid in kidney. Therefore, the AO extract could be used for prevention or treatment of hyperuicemia and gout.

• 사상체질의학회지
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• 제34권4호
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• pp.27-37
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• 2022

Objectives The purpose of this study is to propose a method to more specifically identify Sasang constitutional risk factors of metabolic syndromes by adjusting the cut-off value of Korea Sasang Constitutional Diagnostic Questionnaire (KS-15). Methods Data of 1997 participants in Korean medicine Daejeon Citizen Cohort study (KDCC) were analyzed. Metabolic syndrome was defined according to the NCEP-ATP III, lifestyle information, and hematologic information including KS-15 and demographic characteristics were used as covariates. Results The 179 subjects with metabolic syndrome accounted for 9.0% of the total. As a result of determining the Sasang constitution for the KS-15 response based on the cut-off values (approximate 0.33), 0.5, and 0.6 of the constitutional score, when performed at the 0.6 cut-off model, the odds ratio of TE was 2.46 which showed a statistically significantly higher risk than the borderline group. For the accuracy of the model and the Area under the curve (AUC), the model accuracy based on the original cut-off of the KS-15 was 0.902 and AUC was 0.737. The accuracy of the model with cut-off of 0.5 and with of 0.6 were 0.904 and 0.902, respectively, and the AUCs were 0.687 and 0.741, respectively. Conclusion In this study, we confirmed that it is effective to increase the cut-off value of KS-15 to 0.6 in the metabolic syndrome risk model. It is expected that this could increase the accuracy of identifying high-risk groups for metabolic syndrome.

• 한국한의학연구원논문집
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• 제15권2호
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• pp.125-130
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• 2009

동의보감(東醫寶鑑) "내경편(內景篇)"에 "사람의 형은 긴 것이 짧은 것만 못하며, 큰 것이 작은 것만 못하고, 살찐 것이 마른 것만 못하다. 사람의 색은 흰 것이 검은 것만 못하고, 옅은 것이 짙은 것만 못하며, 엷은 것이 두터운 것만 못하다. 더욱이 살찐 사람은 습이 많고, 마른 사람은 화가 많으며, 흰 사람은 폐기가 허하고, 검은 사람은 신기가 넉넉하다. 사람마다 형색이 다르면 오장육부 역시 다르기 때문에 외증이 같더라도 치료방법을 달리해야 한다."고 하였다. 이것은 "동의보감(東醫寶鑑)"의 체 병 증을 서로 결합하여 진단 치료하는 사상으로 "이체질동병이치", "이체질동증이치"의 체질진료사상을 나타낸 것이다. "동의보감(東醫寶鑑)" "탕액편(湯液篇)"에서 "약이란 병을 치료하는 것이다. 변화하는 것은 병에 있고, 병 치료를 주관하는 것은 약에 달렸으며, 약을 만들어 쓰는 것은 사람에게 달려 있다. 이 셋 중 하나라도 빠지면 안된다."고 하였다. 이것은 체 병 증과 방약이 서로 대응하는 용약사상을 보여주는 것으로 동의약의 진료체계를 건립하였는데 이 점이 바로 동의약학의 장점이자 특색이라 할 수 있다.

• Journal of Nutrition and Health
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• 제54권2호
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• pp.224-237
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• 2021

본 연구는 백작약 열수 추출물의 in vitro 항산화능을 평가하였으며, TAA를 유발한 급성 간손상 동물 모델을 이용하여 항산화 활성으로 인한 산화적 스트레스 억제 효과와 간 기능 보호효과 여부를 검증하였다. 총 폴리페놀, 총 플라보노이드 함량, DPPH 및 ABTS 자유 라디칼 소거능 측정 결과 높은 항산화능을 나타냈으며, 체중, 간무게 및 간중량 비율 (%)이 대조군에 비해 S100군과 PR100군보다 PR200군에서 더욱 감소하였다. 약물투여군의 혈중 암모니아, GOT 및 GPT 수준의 유의적인 감소를 확인하였으며, western blot 실시 후 대부분의 인자에서 유의적인 차이를 확인하였다. 이 결과를 토대로 백작약 열수 추출물이 Nrf2-Keap1경로의 활성화를 통해 항산화 효소를 증가시켰으며, 항산화능을 통한 산화적 스트레스 개선에 긍정적인 효과가 있음을 확인할 수 있었다. 따라서 백작약 열수 추출물은 급성 간손상시 간보호 효과를 위한 후보 소재로서 가능성이 있다고 판단된다.

• 생명과학회지
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• 제32권7호
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• pp.550-566
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• 2022

뇌졸중은 세계적으로 사망과 장기간인 신체적, 인지적 장애의 주요 원인들 중 하나이며, 매년 약 1,500만명의 사람들에게 영향을 미친다. 뇌졸중의 병태 생리학적 과정은 다수의 사건들이 관여하는 복잡한 과정으로, 그 중 혈액-뇌 장벽(blood-brain barrier: BBB)의 붕괴는 허혈성 뇌손상의 진행에 크게 기여하는 것으로 알려져 있다. 따라서 BBB 붕괴는 뇌졸중의 특징으로 인식되므로 허혈성 뇌졸중에서 BBB 기능 장애를 보호할 수 있는 새로운 치료 전략을 개발하는 것이 뇌졸중 치료에 매우 중요하다. 전통한약은 천연물로 구성되어 있으며, 이는 뇌졸중 치료약 개발을 위한 유망한 원천이 될 수 있다. 실제로 여러 연구에서 뇌졸중에 대한 한의학의 효능이 밝혀져 허혈성 뇌졸중에 대한 한의학적 치료 가치가 부각되고 있다. 본 리뷰에서는 허혈성 뇌졸중으로 인한 BBB 붕괴에 대한 전통적인 한의학의 처방, 탕약, 약재 및 활성 성분의 개선효과에 관한 현재 정보와 기본 메커니즘을 요약 정리하였다. 이러한 연구가 한의학의 신경보호 효과에 대한 추가 조사를 촉진하고 뇌졸중 환자에 대한 한방유래의 임상시험 시행을 활성화하는데 도움이 되기를 기대한다.

• 대한의용생체공학회:의공학회지
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• 제44권5호
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• pp.329-335
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• 2023

Perceived age is defined as age estimated based on physical appearance. Perceived age is an important indicator of the overall health status of the elderly. This is because people who appear older tend to have higher rates of morbidity and mortality than people of the same chronological age. Although perceived age is an important indicator, there is a lack of objective methods to quantify perceived age. In this paper, we construct a quantified perceived age model from face images using a convolutional neural network. The face images are enlarged to super-resolution and the skin, an important feature in perceived age, is made clear. Moreover, through Tanh-polar transformation, the central area of the face occupies a relatively larger area than the boundary area, helping the neural network better recognize facial skin features. The experimental results show mean absolute error (MAE) of 6.59, showing that the proposed model is superior to existing method.

• 대한예방한의학회지
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• 제26권1호
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• pp.1-10
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• 2022

Objectives : The aim of this study was to introduce the development process of Korean medicine health promotion program for short stature children that is suitable for applied at public health center. Methods : The draft of health promotion program was developed through literature search of previous similar programs and advice of several experts. A small conference targeted public health Korean medicine doctors was also held to introduce the developed program and discuss for improvements. Results : The details of 12-week of Korean medicine health promotion program for children growth are as follows: 4-week of taking herbal medicines (Yukmijihwang-tang or Yukgunja-tang), contactless counseling with Korean medicine doctor, self-care home kit consisting of Sogeonjung-tang tea leaf, Sogeonjung-tang with Cervi Parvum Cornu extract, ear acupressure stick, finger chuna manual, growth diary, and jump rope. Conclusions : This health promotion program can help to increase the height of children and self-esteem of children with short stature as well as decrease the stress of parents.

• 대한예방한의학회지
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• 제27권2호
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• pp.1-22
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• 2023

Objectives : The aim of this study was to introduce the development process of Korean medicine health aging program for the older that is suitable for applied at public health center. Methods : For the development of the draft of health promotion program, we conducted a literature review of previous studies through searching international and domestic databases. The opinions of several experts were also colleted. Results : The details of 8-week of Korean medicine healthy aging program are as follows: 8-week of taking herbal medicines (Yukmijihwang-tang or Palmijihwang-tang, or Jaeumganghwa-tang) based on counseling with Korean medicine doctor, qigong, acupuncture on head, abdominal hotpack, taking nuts, and health education Conclusions : This healthy aging program can help to develop the healthy lifestyle habits and increase the general health status of community seniors.