• The Journal of Korean Medicine
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• v.45 no.1
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• pp.17-43
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• 2024

Objectives: Underpinned by the context of a Korean traditional medicine cohort study on healthy aging, this research primarily aims to guide the selection of Clinical Outcome Assessments (COAs) for elderly healthy aging patient registry research, offering insights into the selection process; and secondly, to streamline the resource-intensive process of obtaining permissions for validated COAs, benefiting future traditional Korean medicine clinical researchers. Methods : In this study, we identified outcomes through a review of previous studies, followed by a process involving expert consultations to select the final outcomes. Subsequently, for the selected outcomes that were Clinical Outcome Assessments (COAs) developed tools, we searched in commercial databases to confirm the availability of Korean versions and the necessity of obtaining permissions. Finally, we obtained permissions for their utilization and, when needed, acquired the original instrument questionnaire through payment. Results: Through a literature review of existing observational studies, a total of 57 outcomes were selected, with 19 of them identified as COA instruments. Upon verifying usage permissions for these 19 instruments, it was found that 17 required author-specific permissions, and among these, 2 needed a purchase as they were commercially available. Conclusion: This study provides a detailed overview of outcome selection and permission acquisition for elderly patient registry research. It underscores the importance of Clinical Outcome Assessment (COA) tools and the rigorous approval process, aiming to enhance research reliability. Continuous verification of COA information is essential, and future research should explore Core Outcome Set (COS) development through consensus-building approaches like Delphi studies.

• Journal of the Korean Society of Food Culture
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• v.25 no.3
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• pp.350-356
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• 2010

When extracts of KMG (Korean mountain ginseng) leaf tea and fermented KMG leaf tea were compared, the fermented KMG leaf tea extract showedhigher activity at each stage of density. Among the material groups, the KMG extract hadthe least profound SOD-like activity, and similar SOD-like activities were noted in the fermented KMG, KMG leaf tea, and fermented KMG leaf tea extracts. With regard to nitrite scavenging ability at a pH of 1.2, the KMG, fermented KMG, and KMG leaf tea groups exhibited similar results, and at pH 3.0, the KMG and KMG leaf tea extract groups exhibited more profound nitrite scavenging ability compared to the fermented groups. In the case of HeLa cell treatments, the KMG and fermented KMG leaf tea extracts exhibited cancer cell propagation restraint rates in excess of 30%, at a density of 1 mg/mL. And MCF-7 cells treated with fermented KMG and KMG leaf tea showedsimilar propagation restraint rates at more than 27% of cancer cells, at a density of 1 mg/mL. Among the materials, the KMG extract hadthe lowest cancer cell propagation restraint rate at 21%, and the fermented KMG leaf tea extract had the highest rate at more than 70%.

• The Journal of Korean Medicine
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• v.24 no.2
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• pp.213-218
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• 2003

Objectives : There has been little report on the treatment of pulmonary hypertension on the basis of Oriental medicine. Several weeks ago we had a case of pulmonary hypertension, and found something in the treatment of the disease. A 60-year old man with hemoptysis was admitted to the Kyunghee Oriental Medical Center on April 23, 2002 and discharged May 4, 2002. During that time, we saw good results. Methods : On the oriental medical basis that Chuongsangboha-tang (Qingshangbuxia-tang) has an effect on chronic pulmonary disease, we treated him with that medicine three times a day for 12 days along with Roxithromycin 150mg/tab 1T qd, Digoxin 0.25mg/tab 0.5T qd, and Bambuterol Hel 1T qd. He was also given acupuncture therapy daily with tonifying SP3(太白), L9(太淵) and sedating H8(少府), L10(魚際). Results : The following data was observed from the therapy : hemoptysis volume decreased by 90%, general weakness by 40%m and ABGA results improved. Conclusions : As we managed pulmonary hypertension, we came to the conclusion that the oriental medical therapy can be of assistance to western medical therapy and can mitigate hemoptysis.

• The Journal of Korean Medical History
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• v.34 no.2
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• pp.89-96
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• 2021

This research aims to find a way to utilize the literature to select the herbs to be added or subtracted according to the condition of the patient after determining the basic prescription to be used for the patient. The study is based on data concerning the herbal composition and application of prescriptions described in the Donguibogam. The composition herbs was expressed as a weight ratio, the standard deviation of the weight ratio was calculated for each prescription, and the case where the weight ratio was greater than the base value (highest weight ratio - standard deviation) was designated as a principal herb. The various expressions of applications were changed to representative terms by the researcher and used to calculate the frequency. Of the 4,373 prescriptions for Donguibogam, 3,307 were able to be expressed in terms of weight ratios with 640 prescriptions using Rehmannia glutinosa, Cnidium officinale, Angelica gigas and Paeonia lactiflora as the principle herb. Of the 640 prescriptions, 508 prescriptions included applied information. Rehmannia glutinosa can also be used for symptoms such as fetal leakage(胎漏), short ingestion(食少), fever(發熱), dazed expression(眼花). Cnidium officinale can also be used for symptoms such as migraine(偏頭痛), stroke(中風癱瘓), tetanus(破傷風). Angelica gigas can also be used for symptoms such as forgetfulness(健忘), incontinence of urination(小便不通), palpitations(驚悸). Paeonia lactiflora can also be used for symptoms such as heart pain and abdominal pain(心腹痛), cough(咳嗽).

• Journal of Society of Preventive Korean Medicine
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• v.24 no.3
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• pp.27-38
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• 2020

Background : The study aimed at examining the awareness and satisfaction level of Korean medicine treatment of musculoskeletal patients and non-musculoskeletal patients. Method : The frequency and percentage were calculated to identify the overall characteristics, and to identify the characteristics of the respondents who visited the hospital to treat musculoskeletal diseases and those who visited for the treatment of non-musculoskeletal diseases, the correlation between the variables was analyzed using the chi-square analysis (χ2-test). Furthermore, analysis items were compared depending on detailed diseases within the musculoskeletal disorder (lumbar pain, sprains, arthritis, frozen shoulders, spondylitis, disc) Result : Respondents who used Korean medicine for the purpose of treating musculoskeletal diseases had answered that costs involved in Korean medicine was expensive, and answered that herbal decoction was the preferred Korean medicine treating method for expanding health insurance benefits. Regarding the safety awareness of Korean medicinal herbs, responses that said it was safe was high, and their willingness to use and recommend Korean medicine in future was also high. Respondents who used Korean medicine for the purpose of treating musculoskeletal diseases said they were overall satisfied along with the attitude of Korean medical doctors, treatment results, and costs of treatments. Conclusion : The study was aimed at securing basic data to indirectly identify the national demand for Korean medicine, through investigating the level and degree of differences that exist in the perception and satisfication level and further find a point where policy intervention is possible in future.

• Herbal Formula Science
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• v.31 no.1
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• pp.67-79
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• 2023

Objectives : The purpose of this study was to confirm the consumption trends of Korean medicine for health food consumption of consumers by using the Naver DataLab Shopping Insight service. Methods : In this study, the search data for the category of Korean herbal ingredients in the health food field of Naver Datalab shopping insight site was collected and sorted in order of frequency from August 1st, 2017 to June 22nd, 2022. The frequently searched keywords were organized based on the inclusion of Korean Pharmacopoeia (KP), Korean Herbal Pharmacopoeia (KHP), and Food Code. Results : 67,804 keywords were collected, and the most frequent keywords appearing for more than 200 days among the top 500 were 827 (1.184%). Among the frequent keywords, there were 149 keywords related to traditional medicine names included in the KP and KHP, and five prescriptions were included. 60 keywords were not included in the KP and KHP, and the keyword with the highest search frequency was "kujibbongnamu" (Maclura tricuspidata). Conclusions : The findings of this study provide information on the consumer's interest in traditional korean medicine (TKM) and natural products (NP), and can be used as a basis for understanding the demand for TKM and NP in the online shopping market.

• Herbal Formula Science
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• v.31 no.2
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• pp.81-98
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• 2023

Objectives : This study aimed to analyze the trends in research and development projects related to herbal medicine and natural products in the field of traditional Korean medicine (TKM) over the past 20 years. Methods : Research projects were identified using "Korean medicine" as the subject heading in the National Science and Technology Information Service. The included projects investigated Korean medicine, natural products, or were related to the TKM industry. Data pre-processing and network analysis were performed using Python and Networkx package, and the network was visualized using the ForceAtlas2 visualization algorithm. Results : 1. Over the study period, 4,020 projects were conducted with a research budget of KRW 835.2 billion. Seven institutions performed over 100 projects each, accounting for 2.4% of all participating institutions, and the top 10 institutions accounted for 58.9% of total projects. 2. Obesity was the most frequently mentioned disease-related keyword. Chronic or age-related diseases such as diabetes, osteoporosis, dementia, parkinson's disease, cancer, inflammation, and asthma were also frequent research topics. Clinical research, safety, and standardization were also frequently mentioned. 3. Centrality analysis found that obesity was the only disease-related keyword identified, alongside TKM-related keywords. Standardization, safety, and clinical trials were identified as central keywords. Conclusions : The study found that research projects in TKM have focused on standardizing and ensuring the safety of herbal medicine, as well as on chronic and age-related diseases. Clinical studies aimed at verifying the effectiveness of herbal medicine were also frequent. These findings can guide future research and development in herbal medicine.

• The Journal of Korean Medicine
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• v.44 no.3
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• pp.189-200
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• 2023

Objectives: The purpose of this study is to analyze the current state of quantitative literature evidence for the prescription of 56 herbal medicines covered by health insurance that have been studied in Korea for the past 30 years, to evaluate the reliability of the evidence, and to find out the research direction of herbal medicine prescription in the future. Methods: 56 kinds of herbal medicine prescriptions were searched in domestic literature search databases OASIS, DBpia, and overseas PubMed, classified into chemistry, toxicity, cells, animals, clinical cases, and clinical trial studies, and built into an EBM pyramid structure. Results: When classified according to research contents, there were 61 cases (7.5%) of physicochemical analysis to identify constituent substances, 80 cases (9.8%) of toxicity evaluation, and 672 cases (82.7%) of efficacy evaluation. The efficacy evidence was classified according to the evidence-based medical pyramid structure: 196 cell trials (29.1%), 372 animal trials (55.4%), 89 case and case reporting series (13.3%), 7 comparative case studies (1.1%), and 8 randomized control clinical trials (1.2%). In the pyramid composition, the basis for the validity of 56 kinds of herbal medicines prescribed was 568 cases (84.5%) in cell and animal units, which could not be said to be highly reliable. There was no relationship between the ranking of quantitative literature evidence for herbal medicine prescriptions and the ranking of salary administration. Conclusions: In an era that continues to require scientific evidence for herbal medicine, traditional herbal medicine should secure the basis for safety validity even for the 10th most frequent prescription among 56 herbal medicine prescriptions for consumers. In particular, traditional herbal medicine should increase the quantitative and qualitative level of case reports on related herbal medicine prescriptions, focusing on each clinical society, and move toward comparative case studies and randomized clinical trial so that traditional herbal medicine is positioned as Evidence-based medicine.

• The Journal of Internal Korean Medicine
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• v.41 no.6
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• pp.1245-1254
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• 2020

Introduction: The aim of this study was to report the effect of Korean medicine treatments on a stroke patient with acute cerebral infarction. Method: A 63-year-old male with anterior and middle cerebral artery infarction had symptoms of dizziness and disorientation. The patient was treated with Korean medicine therapy, including the herbal medicine "Sunghyuangjunggi-san-gamibang." Treatment progress was assessed using the Korean version of the Modified Barthel Index (K-MBI) and the Korean dizziness handicap inventory (K-DHI). Results: After 14 days of treatment, the K-DHI score decreased from 78 to 7 and the K-MBI score increased from 18 to 24. The patient's main symptoms were improved after the treatment, and no side effects were observed. Conclusion: Korean medicine treatment, including Sunghyuangjunggi-san, might be a recommended therapeutic option for dizziness and disorientation in stroke patients.

• Journal of Society of Preventive Korean Medicine
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• v.26 no.3
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• pp.41-48
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• 2022

Objectives : This study aimed to investigate the adequacy and satisfaction of the school doctor program of Korean medicine (especially sex education) for elementary school students, to examine differences in parents' perception or satisfaction according to the use of Korean Medicine. Methods : The participants were parents of one elementary school that provided sex education as the Seoul school doctor program of Korean medicine. A self-reported online survey was conducted. The questionnaire consisted of parents and children's experience in using Korean medicine, perception of the school doctor program of Korean Medicine, evaluation and satisfaction of school sex education. Results : The survey was conducted on May 14^th, 2022 during the school doctor program of Korean Medicine briefing session. A total of 92 parents participated in the survey, and the 88 respondents analyzed who voluntarily gave consent. Of the experience of Korean Medicine, 71 parents (80.68%) had lifetime, 16 (18.18%) respondents had within the last three months, and 40 (45.45%) said their children had. Parents' experience of using Korean medicine was related to that of their children's, but there was no difference in the satisfaction the school doctor program of Korean Medicine. Conclusions : The survey showed that parents of an elementary school where Korean Medicine doctors carried out school doctor program evaluated that the school doctor program of Korean Medicine had a positive effect on students' health. There was no difference between parents' satisfaction on school doctor program by the use of Korean medicine.