• Title/Summary/Keyword: 피부질환

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Study on the Efficacy of Paeonia Japonica, Cucurbita Moschata and Prunus Cerasus Complex Extract for Alleviating Stress Associated with Chronic Skin Conditions (만성 피부 질환으로 발생하는 스트레스 개선을 위한 호박, 작약, 타트체리 복합물의 효능 연구)

  • Su-Jin Park;Dong-Hee Kim;Ki-Sung Kwak;Hyun-Jeong Kim
    • Journal of the Korean Applied Science and Technology
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    • v.41 no.2
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    • pp.459-471
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    • 2024

  • In modern society, where tension and stress are ubiquitous, individuals often experience psychological imbalances. These stressors not only affect mental well-being but also manifest physically, through the skin. Consequently, a new term psychodermatology combining psychiatry and dermatology, has emerged, garnerning attention and research focus. In this study, we aimed to develop materials improving chronic skin conditions caused by stress by utilizing a compound of Cucurbita moschata, Paeonia japonica, and Prunus cerasus known to alleviate skin disorders. We sought to develop and validate the efficacy of materials alleviating chronic skin conditions induced by stress in keratinocytes..Therefore, in this study we analyzed the effects of a complex extract using Cucurbita moschata, Paeonia japonica, and Prunus cerasus on HaCaT keratinocyte cells to understand how it influences them. The complex extract on HaCaT keratinocyte cells showed a concentration-dependent decrease in the expression levels of TNF-α, IL-1β, IL-6, MDC, and TARC at concentrations of 12.5, 25, 50 and 100 ㎍/mL. Particularly noteworthy was the efficacy observed in inhibiting IL-1β, with a reduction of over 40% at a concentration of 100 ㎍/mL. Additionally, the production levels of AQP-3, HA, and filaggrin exhibited a significant concentration-dependent increase. The protein expression of p-ERK, p-JNK, and p-p38, which were elevated by TNF-α/IFN-γ, was significantly decreased with the treatment of the complex extract. These findings suggest that the compound extract may be utilized as a material for treating and preventing skin conditions, potentially mitigating the adverse effects of the mutual relationship between skin disorders and stress.

  • https://doi.org/10.12925/jkocs.2024.41.2.459 인용 PDF

WANNA be care - 약제의 부작용 완화법(2) - 피부질환

  • 대한결핵협회
    • 보건세계
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    • v.63 no.2
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    • pp.22-23
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    • 2014

  • 세상 모든 양면성을 지니고 있듯 약제 또한 마찬가지. 즉, 약제도 복용했을 시 우리 몸에 이롭게 작용하는 성분이 있다면, 개인의 체질, 복용량의 과량 등의 차이로 인해 부작용을 동반하기도 한다. 그 일례로 지난 호에서는 손 발이 저린 현상을 다뤘다면, 이번 호에서는 피부질환에 대해 알아보고자 한다.

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