• Title/Summary/Keyword: 피부생리활성

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A Study of Physiological Activities of the Thermal Treated Eggplant on the Skin (가지 열수추출물의 피부생리활성에 관한 연구)

  • Kim, Ran
    • KSBB Journal
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    • v.31 no.3
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    • pp.151-157
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    • 2016
  • The purpose of the present research was to investigate the physiological activities of the thermal treated eggplant on the skin. Five minute of thermal treatment at $100^{\circ}C$ had the highest polyphenol content of eggplant. However, below and over 5 min of thermal treatment time, they did not increase. When water and ethanol extracts were used, the maximum DPPH radical scavenging activities were obtained, 66.3 and 62.8%, respectively. Among various extracts, the acetone extract gave the highest cosmetic activity. Especially, when acetone extract (15.0 mg/mL) was used, the maximum inhibition activities of tyrosinase, elastase, and collagenase were obtained, 83.4, 78.2 and 62.5%, respectively. These results suggest the anti-wrinkle and whitening and effects of acetone extract were excellent. Therefore, it is should be considered as a promising candidate for novel cosmetic agents.

Physiological Activities of Cudrania tricuspidata Extracts on the Skin (꾸지뽕나무 추출물의 피부 생리 활성)

  • Choi, Hak Joo;Kim, Cheong Taek;Do, Min Yeon;Rang, Moon Jeong
    • Journal of the Korean Applied Science and Technology
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    • v.32 no.2
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    • pp.260-274
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    • 2015
  • This paper has shown the experimental results about the physiological activities of water-, ethanol-, ethyl acetate-soluble fractions from ethanolic extracts of leaves, stems and roots of Cudrania tricuspidata on the skin, which has been used for a long time as a traditional herb medicine in Korea and China. The effects of these fractions on the secretion of nitric oxide and cytokines from macrophage(RAW 264.7 cell) exhibited that the ethyl acetate and water fractions from leaves inhibited the release of nitric oxide, all fractions inhibited thoses of inflammatory cytokine $IL-1{\alpha}$, and the ethyl acetate fractions of leaves, stems and roots inhibited thoses of inflammatory cytokine IL-6. The only ethylacetate fraction of leaves demonstrated significantly the reduction of melanin synthesis in melanoma cells. In order to evaluate the efficacy of collagen synthesis, the treatment with extracts on the human normal fibroblast cell(CCD-986sk cell) resulted in finding that the water fractions of leaves, stems and roots and the ethanol fractions of leaves and stems showed the increased synthesis of collagen.

Effect of Ethanol Extract of Belamcandae Rhizoma on Dermal Bioactive Properties (사간(射干) 에탄올추출물이 피부생리활성에 미치는 영향)

  • Sung, Byung-Gon;Lee, Seong-Jin;Kim, Pill-Joo;Seo, Hyun-Chol;Kim, Dae-Sung;Mun, Yeun-Ja;Woo, Won-Hong;Lim, Kyu-Sang
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.21 no.1
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    • pp.104-112
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    • 2008
  • Objective : This experimental study was preformed to investigate the effect of ethanol extract of Belamcandae Rhizoma (EBR) on dermal bioactive properties related to cosmeceuticals such as radical scavenging activity and depigmentation. Methods : The free radical scavenging activity of EBR was assayed in cell free systems using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Antibacterial potency was measured by the size of inhibition zone with change of volume. Cell viability was measured by MTT assay and tyrosinase activity was assessed using L-DOPA. Results : EBR showed slightly radical scavenging activity and protected against UVB-induced cell cytotoxicity. Futhermore, EBR showed antibacterial activities on S. epidermidis and S. aureus. Although the proliferation of B16/F10 cells was decreased by EBR, necrosis was not revealed. EBR augmented tyrosinase activity and dendrite outgrowth in B16/F10 cells. Conclusions : These results suggest that EBR has antioxidative & antibacterial activities, and stimulate melanogenesis.

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Anti-aging and Anti-melanogenesis Efficacy by Antioxidative Mineral-bio Water (항산화성 바이오 미네랄 활성수에 의한 항노화 및 미백효과)

  • Choi, Hyun-Kyung;Oh, Myoung-Jin;Her, Myeong-Jun;Kyeong, Kyeong-Hwan;Park, Chang-Seo
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.35 no.1
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    • pp.57-63
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    • 2009
  • UV irradiated skin cells produce reactive oxygen species (ROS). ROS is known to be the primary cause of skin inflammation that is eventually leading to skin aging through decrease of collagen in the dermis. In this study, we evaluated basic efficacy of anti-aging, anti-inflammation and anti-melanogenesis using two antioxidative mineral-bio waters (Mineral-bio water 1 (MIBA-W1) and Mineral-bio water 2 (MIBA-W2)). Both antioxidative mineral-bio waters reduced TNF-${\alpha}$ expression which was induced upon UV irradiation. MIBA-W 1 increased collagen synthesis from UVB irradiated fibroblast at 0.01 % concentration but MIBA-W2 shows slight, but linear increase. Stimulation of melanogenesis by ${\alpha}$-MSH treatment in the cultured B16-F1 melanoma was significantly reduced by the treatment of MIBA-W2 in a dose dependent manner. Taken together, antioxidative MIBA-W1 and 2 seem to have potential applications as functional cosmetic materials.

Phosphatidylserine Enhances Skin Barrier Function Through Keratinocyte Differentiation (포스파티딜세린의 각질세포 분화 유도를 통한 피부장벽 기능 강화)

  • Chung, So-Young;Nam, Sang-June;Choi, Wang-Keun;Seo, Mi-Young;Kim, Jin-Wook;Lee, Seung-Hun;Park, Chang-Seo
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.32 no.1 s.55
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    • pp.17-22
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    • 2006
  • Phosphatidyiserine (PS) is a phospholipid which plays the structural role in membranes and serves as a cofactor of signaling enzymes for diverse cellular functions. In this study, we observed that topical treatment with PS significantly decreased trans-epidermal water loss (TEWL) induced by tape-stripping in hairless mice. Also, ceramides in epidermis were increased in PS-treated group compared to vehicle-treated one in vivo. the amounts of non-hydroxyl ceramide (NHCER) (1.4 fold) and glucosylceramide (glucosylCER) (1.6 fold), in the skin of hairless mice, were increased by topical treament with PS. Also, we demonstrated that PS stimulated keratinocyte differentiation. We observed that PS treatment morphologically altered normal human keratinocyte (NHK) from the proliferating phase to the differentiating one, suggesting that PS stimulated epidermal differentiation in NHK. We also showed that the expressions of the specific markers for epidermal differentiation, involucrin (INV) (3.5 fold up) and transglutaminase 1 (TG'ase 1) (3 fold up), were significantly increased by PS treatment, compared to untreated control in vitro. In addition, topical treatment with PS resulted in a progressive increase in INV and loricrin protein levels in vivo. In conclusion, we provide the first evidence for the physiological activities of PS in skin, and we suggest that PS strengthen the epidermal permeability harrier by stimulation of keratinocyte differentiation.

7, 8, 4'-Trihydroxyisoflavone from Fermented Soybean Food and Its Biological Activity (전통 콩발효 식품 유래 7, 8, 4'-Trihydroxyisoflavone의 피부 생리활성 연구)

  • Park, Jun-Seong;Kim, Dong-Hyun;Shim, Jin-Sup;Kim, Ji-Seong;Choi, Kwon-Young;Kim, Byung-Gee;Kim, Duck-Hee;Kim, Han-Kon
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.36 no.3
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    • pp.221-226
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    • 2010
  • A rare isoflavone, 7, 8, 4'-trihydroxyisoflavone, was isolated from a 10-year-old fermented soybean food. 7, 8, 4'-trihydroxyisoflavone was isolated for the first time from a Korean fermented soybean food. Evaluation tests of biological activity showed significantly inhibition activity for free radical scavenging on both non-enzymatic (DPPH system) and enzymatic method (xanthine oxidase system). DPPH radical scavenging effect of 7, 8, 4'-trihydroxyisoflavone was similar with vitamin C in a dose-dependent manner. In xanthine oxidase (XO) system 7, 8, 4'-trihydroxyisoflavone showed superoxide radical inhibition activity of 50 % at a concentration of $6.6{\pm}0.4\;{\mu}M$. Also, the compound significantly suppressed cellular MMP-1 formation. These results suggest that 7, 8, 4'-trihydroxyisoflavone could be developed as a potential preventive or therapeutic agent against skin aging.

A Research Trend of Natural Product on Well-Being Industry (웰빙산업에서의 천연물 연구 동향)

  • Kim Ki Ho;Ko Kang Il;Kang En Jung;Yang En Kyung;Park Soo Nam
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.30 no.3 s.47
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    • pp.329-343
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    • 2004
  • Recently, our society has prominently raised the desire to well-being life since not only our economical situations are better than before, but environmental pollution become serious. In well-being trends, the natural or nature-related products are also issued on their usages as bio-/raw materials for our living industries, such as cosmetics, household goods, and so on. Especially, various materials which comes from medicinal plants has been discovered their physiological properties and validated their functions. Thus, they have been subjected to several processes, including extraction, isolation and concentration, and popularly introduced to cosmetic industry. In these reasons, a variety of cosmetic Products using natural materials has been developed, which are focused on whitening, wrinkle improvement, and anti-aging. In this report, we present a brief review of the function and classification of natural products interested in until now, and introduce the natural materials for cosmetics having physiological activities on skin, including Fructan, Acrea extract, Portulaca extract, Licorce extract, Dandelion extract, Ulmus extract, SC-glucan, Arbutin, and Sophora extract.

Evaluation of Dermal Bioactive Properties of the Gastrodiae Rhizoma Extract by Steaming Times (증숙 횟수에 따른 천마 추출물의 피부 생리 활성 평가)

  • Lee, AhReum;Kim, GeonHyeong;Kwon, OJun;Kim, SooHyun;Kim, KyeongJo;Roh, Seong-Soo
    • The Korea Journal of Herbology
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    • v.33 no.1
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    • pp.27-35
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    • 2018
  • Objectives : Gastrodiae Rhizoma extract (GE) is possess the various bioactive compounds such as gastrodin, vanilyl alcool and p-hydroxybenzyl alcohol. Various processing methods such as steaming have been widely applied to ease ingestion and enhance the therapeutic effects of plant materials including GE in East-Asia area. The aim of this study was to evaluate the dermal bioactive properties of GE. Methods : First, total phenol, total flavonoid, gastrodin and ergothionein contents of GE were measured. In order to evaluate the dermal bioactive properties of steamed GE compared with not-steamed GE, tyrosinase, collagenase and elastase inhibitory activity were tested. Furthermore, the anti-oxidant activity of GE assessed based on DPPH and ABTS radical scavenging assay. Results : In results, total phenol and total flavonoid contents were increased when 9 times steamed compared to not-steamed GE. Also, GE increased gastrodin contents, in proportion to the number of steaming times and ergothioneine content was abolished in the steaming state. The DPPH radical scavenging activity of GE increased by steaming, but the ABTS radical scavenging activity was not related to the steaming process. In addition, the tyrosinase inhibitory activity was increased as the number of steaming times of GE increased. Collagenase was most inhibited by 4 times steamed GE, and elastase was inhibited by 8 times steamed GE. Conclusion : In conclusion, these results suggest that steamed GE extract has the potential as a cosmetic material which possess anti-oxidant and whitening activities than not steamed GE.

Physiological activity and efficacy of cosmetic products in bio-converted soybean embryo extract (생물전환 콩 배아추출물의 생리활성 및 화장품의 효능 연구)

  • Min, Kyung-Nam;Lee, Gun-Hee;Park, Sung-Jin;Choe, Tae-Boo
    • Journal of the Korea Convergence Society
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    • v.10 no.3
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    • pp.211-220
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    • 2019
  • This study was to investigate the physiological activities of bioconversion soybean embryo extract and the effects of sleeping pack containing extract on skin. The aglycone isoflavones of the soybean embryo extract bioconversed with pectinase were identified by HPLC. in vitro tests showed that they were non-toxic, anti-inflammatory, anti-melanin and anti-aging activity. After 4 weeks of human body application with the sleeping pack using extract, the skin surface roughness and eye wrinkles were so improved by low stimulation that the sleeping pack containing bioconversion soybean embryo extract has a positive effect on the skin. We confirmed that the bioconversion soybean embryo extract was effective in enhancing the physiological activity and was useful as a cosmetic material of various formulations.

Collagen Increasing and Hair Growth Effect of Supramolecular Cosmetic Materials Containing Phytochemicals (식물성 유용물질을 함유하는 초분자체 화장제재의 콜라겐 증가 및 육모효과)

  • Cho, Hyun-Nam;Yoo, Dong-Chan;Kim, Kyoung-Ran;Byun, Hae-Jung;Kim, Jung-Hyun;Park, Hye-Bin;Bang, Dae-Suk;Yang, Seun-Ah;Khang, Gong-Won;Jhee, Kwang-Hwan
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.38 no.1
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    • pp.83-89
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    • 2012
  • Medicinal herbs have been shown to have protective functions for skin and hair. We investigated the effects of complex of soluble ${\beta}$-cyclodextrin and phytochemicals on the functions of skin and hair. In previous report, we evaluated the safety of supramolecules and found their anti-microbial effects and anti-fungal effect against Gram (+) and Malassezia furfur which is known to cause dandruff. Here we present that functional supramolecules-containing cream promotes the biological skin activity by inducing the collagen formation. And treatment of supramolecules-containing hair tonic increased the rate of hair growth of mouse. Taken together, supramolecular cosmetic compounds containing water insoluble phytochemicals and water soluble ${\beta}$-cyclodextrin exhibit the potential ability for hair growth promotion and delaying the aging of skin.