• Journal of Gastric Cancer
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• v.2 no.2
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• pp.63-68
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• 2002

위의 parietal cell 혹은 대식세포와 유사한 세포 내부에서 H. pylori가 발견된다는 보고가 있기는 하나 일반적으로 H. pylori는 Shigella와 같은 침습성 세균은 아닌 것으로 알려져 있다. 그럼에도 불구하고 H. pylori에 감염된 위점막에는 많은 수의 호중구를 위시한 염증세포의 침윤이 관찰되는데 H. pylori가 위상피세포에 부착할 경우 위상피세포를 자극하여 interleukin-8을 위시한 cytokine을 발현케하고 이에 의하여 호중구 등의 염증세포가 몰려들게 된다. 한편 고유층에 몰려든 호중구에서는 다시 interleukin-8을 위시한 일련의 호중구 활성화 chemokine을 분비하여 염증반응을 증폭해 나갈 것이다. 호중구에서 발현되는 myeloperxidase나 활성산소 등도 위점막의 조직 손상에 기여할 것이다. 위상피세포를 덮고 있는 점액층은 위상피세포를 보호한다고 알려져 있으나 H. pylori 감염의 경우 점액층에 의하여 H. pylori의 운동성이 증가하고 이것이 위상피세포로부터의 cytokine 발현을 자극하여 염증반응을 증폭하는 데 관여할 가능성도 있다. H. pylori는 위상피세포에 대하여 apoptosis를 유도함과 동시에 고유층에 몰려든 호중구에 대하여는 apoptosis를 억제케하여 궁극적으로 염증반응을 증폭 및 지속시켜 나가는 쪽으로 작용한다. 한편 H. pylori는 위상피세로로부터 COX-2의 발현을 증가시키는데 이는 위상피세포의 APOPTOSIS를 억제하는 방향으로 작용한다. 이외에 H. pylori의 urease에 의하여 발생한 암모니아나 H. pylori 자신이 분비하는 세포독소가 세포 손상을 유발할 가능성도 있다. 상술한 여러 독성 인자들 중 어느 하나가 단독으로 작용하기보다는 여러 인자가 같이 동시에 또는 시차를 두고 작용할 가능성이 많다고 생각된다.

• Journal of Advanced Marine Engineering and Technology
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• v.39 no.9
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• pp.903-910
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• 2015

The purpose of this research is to develop a full-spectral fatigue analysis program, based on rigid-body ship motion analysis, in order to perform a full-spectral fatigue analysis that considers hydroelasticity effects. To gain credibility, fatigue analysis results of two ship types, performed by the developed program, were compared with those of a classification society, and it was found that both are identical. Full-spectral fatigue analysis considering hydroelasticity effects would be developed in further studies by including flexible-body ship motion analysis results and by supplementing the developed program with a wide-band fatigue damage model.

• Journal of Korean Society of Steel Construction
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• v.18 no.4
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• pp.417-426
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• 2006

Various fatigue damages have been reported in orthotropic steel deck structures put upon girders. These damages are caused by complex behaviors of the deck, which is directly subjected to vehicle loads. To estimate the causes of fatigue cracks at the welded connected parts of the trough rib and the flor beam, and the trough rib and the deck plate, in orthotropic steel deck structures, FE analyses were first, performed in this study. Parameter studies were carried out to suggest effective structural details that consider fatigue, in which the main parameters are the thickness of the deck plate, the shape of the connection of the trough rib and the flor beam such as the slit form, and the welding length. This study suggests that the effective structural details improved the fatigue strength and discusses.

• Journal of Korean Society of Steel Construction
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• v.22 no.6
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• pp.589-597
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• 2010

Steel structures have a higher probability of being damaged by fatigue than by other causes of deterioration. As such, their maintenance to prevent fatigue damage is essential to sustain their safety and performance during their service period. In their maintenance, the current state of their fatigue cracks must be assessed to determine appropriate reinforcement methods and the suitable time intervals of periodic inspections when fatigue cracks are detected. Determining the crack growth rate is a successful method of predicting fractures, but it requires technical knowledge on fracture mechanics and experience in numerical methods and software for finite element analysis. In this study, a fatigue crack growth test on through-thickness cracked steel plates was conducted to assess the crack growth rate without superior technical knowledge and experience. The relationship between the Crack Opening Displacement (COD) and the crack growth rate was found in relatively long fatigue cracks.

• Journal of Korean Society of Steel Construction
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• v.15 no.5 s.66
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• pp.475-487
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• 2003

This study developed an analysis model of estimating fatigue damage using the linear elastic fracture mechanics method. Stress history occurring to an element when a truck passed over a bridge was defined as block loading and crack closure theory explaining load interaction effect was applied. Stress range frequency analysis considering dead load stress and crack opening was done. Probability of stress range frequency distribution was applied and the probability distribution parameters were estimated. The Monte Carlo simulation of generating the probability various of distribution was performed. The probability distribution of failure block numbers was obtained. With this the fatigue reliability of an element not occurring in failure could be calculated. The failure block number divided by average daily truck traffic remains the life of a day. Fatigue reliability analysis model was carried out for the welding member of cross beam flange and vertical stiffener of steel box bridge using the proposed model. Consequently, a 3.8% difference was observed between the remaining life in the peak analysis method and in the proposed analysis model. The proposed analysis model considered crack closure phase and crack retard.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.10
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• pp.1251-1259
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• 2013

In this study, high temperature design and creep-fatigue damage evaluation of a decay heat exchanger (DHX) in the decay heat removal systems of a sodium-cooled fast reactor (SFR) have been performed. Detail design and 3D finite element analysis have been conducted for the DHXs to be installed in active and passive decay heat removal systems in Korean Generation IV SFR, and the DHX installed in the STELLA-1(Sodium integral effect test loop for safety simulation and assessment) at KAERI (Korea Atomic Energy Research Institute). Evaluations of creep-fatigue damage based on full 3D finite element analyses were conducted for the two Mod.9Cr-1Mo steel heat exchangers according to the elevated temperature design codes of ASME Section III Subsection NH and RCC-MR code. Code comparisons were made based on the creep-fatigue damage evaluation and issues on conservatisms of the design codes were discussed.

• Journal of the Korean Society for Nondestructive Testing
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• v.33 no.5
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• pp.452-458
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• 2013

Impedance based monitoring technique was investigated to evaluate the damage occurring in wind turbine blade. In this study, PVDF film piezo sensors were patched on the 10 kW wind turbine blade, and impedance was measured over the frequency range of 1~200 MHz under fatigue loading. With applying fatigue loads on the blade, change in maximum deflection of the blade and local strain values could be obtained from the strain gages attached on the blade, and difference of the impedance signatures was also observed. From these data, it could be found that local damage or geometrical change in the blade structure happened. To quantitatively compare the impedance signature patterns, a statistical algorithm, scalar damage metric M was used. It was calculated from the impedance signatures considering fatigue loads and location of the sensors. The metric values were compared to correlate the metrics with damage in the blade.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.4
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• pp.447-452
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• 2011

It is well known that the dominant damage mechanisms in high-temperature steam turbine facilities such as rotor and casing are creep and fatigue damages. Even though coupling of creep and fatigue should be considered while predicting the life of turbine facilities, the remaining life of large steam turbine facilities is generally determined on the basis of creep damage because the turbines must generate stable base-load power and because they are operated at a high temperature and pressure for a long time. Almost every large steam turbine in Korea has been operated for more than 20 years and is made of steel containing various amounts of principal alloying elements nickel, chromium, molybdenum, and vanadium. In this study, creep damage model of 1Cr1Mo1/4V steel for turbine rotor is proposed and that can assess the high temperature creep life of large steam turbine facilities is proposed.

• 한국방재학회:학술대회논문집
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• 2011.02a
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• pp.94-94
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• 2011

배관 구조물에서는 내부 미세 균열에서부터 국부 좌굴, 볼트 풀림, 피로 균열 등과 같이 다양한 형태의 손상이 복합적으로 발생 가능하다. 이러한 복합 손상은 배관 구조물의 누수, 누유 등의 사고를 야기할 수 있다. 하지만 기존의 단일 스케일 계측 시스템으로부터 복합 손상에 의한 실시간 누수를 진단하기는 매우 어렵다. 본 연구 단계에서는 누수를 야기하는 복합 손상을 효율적으로 진단하기 위하여 선행 연구에서 제안된 압전센서를 이용한 자가 계측 회로 기반의 다중 스케일 계측 시스템을 구조물의 복합 손상 진단에 적용하였다. 자가 계측 회로 기반 다중 스케일 계측 시스템은 크게 두 가지 형태의 신호를 계측한다. 첫 번째 스케일은 임피던스 계측으로부터 특정 주파수 대역폭에 대한 구조 응답을 계측하며, 두 번째 스케일은 유도 초음파 계측으로부터 단일 중심 주파수에 해당하는 구조물의 응답을 계측한다. 복합 손상을 손상 유형별로 분류하기 위하여 E/M 임피던스(Electro-mechanical impedance)및 유도 초음파(Guided wave) 계측으로부터 추출한 특성을 이용하여 2차원 손상지수를 계산하고 이를 지도학습 기반 패턴인식 기법(Supervised learning based pattern recognition) 중 확률론적 신경망 기법(Probabilistic Neural Network, PNN)에 적용한다. 제안된 기법의 적용성 검토를 위하여 파이프 구조물에 인위적으로 다중 손상을 생성시켜 시험을 수행하였다. 본 연구에서 제안된 기법이 실제 배관 구조물에 성공적으로 적용된다면 손상 부재의 거동 및 구조물 성능의 손상에 대한 영향을 효율적으로 진단하고 평가함으로써 배관 구조물의 효과적인 유지관리가 가능할 것으로 예상된다.

• Computational Structural Engineering
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• v.11 no.2
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• pp.36-39
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• 1998

국내의 피로파괴(fatigue fracture)나 파괴역학(fracture mechanics)과 같은 분야는 많은 발전이 있었으나 손상역학(damage mechanics)분야의 발전은 미흡하여 이 분야에 대한 이해를 돕기 위하여 손상역학의 역사적 배경, 용어의 정의, 현재의 연구동향, 손상역학의 적용 및 한계에 대하여 간략히 소개하고자 한다. 이 글에서는 전문학술적인 내용은 피하였으며 손상역학 분야에 관심이 있는 이들을 위하여 이 글에서 인용된 저자들의 대표적인 문헌들을 중심으로 간략히 소개하였다.