• Journal of Korean Society of Transportation
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• v.21 no.5
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• pp.119-133
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• 2003

도로는 교통기능 외에 여러 시설물을 수용할 수 있는 사회 인프라구축의 공간으로 활용될 수 있기 때문에 서울시뿐만 아니라 각 지방자치단체에서는 이러한 공간을 활용하기 위한 도로점용공사는 매년 전국적으로 수만 건에 달하고 있다. 따라서. 매년 발생하는 도로점용공사의 차로과다 점용, 교통시설물 설치 부적절, 보행자 안전무시, 공사안내표지 부적절, 공사구간에서의 불법 주.정차 등의 문제점이 계속하여 발생.지적되고 있으나 이에 따른 관련 규정이 미흡하여 도로점용공사 시행자의 불법을 초래하고 있는 실정이다. 또한 서울시의 경우 시스템적 접근방법인 관련조례에 의해서 수행되기보다는, 교통자문회의로 운영되고 있으며, 관련 인원 및 법적 제재조치가 미약하여 도로점용공사의 효과적인 관리가 어려운 실정이다. 따라서 서울시 및 각 지방자치단체에서는 도로점용공사로 인한 보행자와 운전자의 통행권 확보와 안전상의 문제 등을 하루빨리 인식하여 도로점용공사에 따른 도로공사장 교통관리 규정을 법규화 하여 체계적으로 관리할 필요가 있다. 이에 따라, 본 논문에서는 도로점용공사에 따른 관련법 및 적용대상, 관련보고서 검토, 서울시를 사례로 한 공사중 교통처리방안 운영실태 및 문제점의 진단을 통하여 향후 도로공사장 교통관리 규정의 운영적 및 제도적 측면의 개선방안과 향후 추진방향을 제시하고자 한다.

• Annual Conference on Human and Language Technology
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• 2019.10a
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• pp.246-251
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• 2019

품사 부착 말뭉치란 문장에 포함된 각 단어에 품사 표지를 부착한 말뭉치를 말한다. 이런 말뭉치에는 다양한 형태의 오류들이 포함되어 있으며, 오류가 포함된 말뭉치를 학습 자료로 사용하는 자연언어처리 시스템의 좋은 성능을 기대할 수 없다. 따라서 말뭉치의 일관성이나 정확도는 자연언어처리 시스템의 성능에 많은 영향을 준다. 하지만 말뭉치 구축 과정에서 작업자의 실수가 발생하고 여러 작업자가 작업을 수행하다 보니 일관성을 유지하기가 쉽지 않다. 본 논문에서는 이러한 문제를 해결하기 위해서 GMM을 이용한 군집화를 수행하여 오류 후보를 추출한다. 이를 통해서 말뭉치 구축 과정에서 작업자의 실수를 방지하고 일관성을 유지하고자 한다. 세종품사부착 말뭉치를 대상으로 임의로 오류를 유발시켜 실험한 결과, 재현율 84.74%의 성능으로 오류를 탐지하였다. 향후에 좀 더 높은 재현율을 위해서 자질 확장이나 회귀 분석 방법 등을 추진할 계획이다.

• The Korean Journal of Nuclear Medicine
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• v.34 no.3
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• pp.243-251
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• 2000

Purpose: This prospective study was performed to evaluate the usefulness of preoperative radioimmunoscintigraphy and intraoperative scintimetric examination (radioimmunoguided surgery: RIGS) using $^{99m}Tc-anti-CEA\;F(ab')_2$ fragment. Materials and Methods: Nineteen patients with rectal cancer underwent preoperative whole body planar scintigraphy at 4 hours after injection of $^{99m}Tc-anti-CEA\;F(ab')_2$ fragment and SPECT imaging at 18 hours. Surgical operation was performed at 24 hours after injection. During laparotomy, radioactivities from intraabdominal viscera were measured by gamma probe. The radioactivities from excised tumor and lymph nodes were also measured and compared with pathology. Results: All nineteen patients were confirmed to have adenocarcinomas in the rectum. Twenty-seven of 97 excised lymph node groups had metastasis and 2 patients had liver metastasis in pathology Preoperative radioimmunoscintigraphy detected primary tumors in 11 patients (sensitivity 55%) and it could not detect any lymph nodes or liver metastasis. All patients showed high radioactivity in the kidneys, liver, spleen, and major vessels in intraoperative measurement by gamma probe, and tumor activity was not discriminated from background activity However, radioactivity from excised tumor was higher than normal rectum (T/B ratio; $3.47{\pm}2.25$). When excised lymph node activity/background activity ratio >1.5 was considered as positive criteria of metastasis, sensitivity, specificity, positive and negative predictive values were 78.6%, 73.9%, 55.0% and 89.5%, respectively. Conclusion: Radioimmunoscintigraphy using $^{99m}Tc-anti-CEA\;F(ab')_2$ has no additional value for preoperative staging and use of early RIGS using $^{99m}Tc-anti-CEA\;F(ab')_2$ is inappropriate. For early RIGS using $^{99m}Tc$ labeled antibodies in rectal cancer patients, further development of more specific antibodies and methods to reduce background activity are needed.

• Journal of Life Science
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• v.24 no.9
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• pp.1030-1038
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• 2014

Platelet products are used to treat hemorrhagic or platelet dysfunction diseases. Plateletpheresis involves collecting the platelet components of blood using an apheresis blood-collection system. Various indicators are available for evaluating the qualities of the apheresis platelets. The productivity of platelet collection is evaluated through both the collection efficiency and collection rates. Platelet storage quality can be evaluated in vitro using several indicators, including visual appearance, metabolic activities, volume, platelet count, white blood cell count, microparticles, and various platelet activation markers. Platelet activation markers have been used as indicators of storage quality in various studies. Post-transfusion platelet quality can be evaluated based on the corrected count increment and the percentage of platelet recovery. Although various studies have investigated the aspects of plateletpheresis, no article has systemically presented assessments of the platelet products obtained from different plateletpheresis devices. The present study provides a review of plateletpheresis, including the specifics of the process, the types of devices employed, the platelet quality, the overall efficacy, and the evaluation indicator qualities. Furthermore, the differences in functionality among the different apheresis devices are discussed. Although adverse reactions to the citrate anti-coagulant have been reported, apheresis processing may provide a safer option for donors who are at a high risk for presyncopal or syncopal reactions related to whole blood collection.

• The Korean Journal of Nuclear Medicine
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• v.4 no.1
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• pp.19-26
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• 1970

1. Sixteen normal healthy subjects free from occult blood in the stool were selected and administered with their $^{51}Cr$ labeled own blood via duodenal tube and the recovery rate of radioactivity in feces and urine was measured. The average fecal recovery rate was 90.7 per cent ($85.7{\sim}97.7%$) of the administered radioactivity, and the average urinary excretion rate was 0.8 per cent ($0.5{\sim}1.5%$) 2. There was a close correlation between the amount of blood administered and the recovery rate from the feces; the more the blood administered, the higher the recovery rate was. It was also found that the administration of the tagged blood in the amount exceeding 15ml was suitable for measuring the radioactivity in the stools. 3. In five normal healthy subjects whose circulating erythrocytes had been tagged with $^{51}Cr$, there was little fecal excretion of radioactivity (average 0.9 ml of blood per day). This excretion is not related to hemorrhage and the main route of excretion of such an negligible radioactivity was postulated as gastric juice and bile. 4. A comparison of the radioactivity in the blood and feces of the patients with $^{51}Cr$ labeled erythrocytes seems to be a valid way of estimating intestinal blood loss.

• Tuberculosis and Respiratory Diseases
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• v.42 no.6
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• pp.846-854
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• 1995

Background: Cytokeratin 19 is a subunit of cytokeratin intermediate filament expressed in simple epithelia such as respiratory epithelial cells and their malignant counterparts. An immunoradiometric assay is available to detect a fragment of the cytokeratin, referred to as Cyfra 21-1 in the serum. This study was conducted to evaluate the clinical utility of this new marker in the diagnosis of lung cancer compared with established markers of squamous cell carcinoma antigen (SCC Ag) and carcino-embryonic antigen(CEA). In addition, we compared the diagnostic sensitivity and specificity of Cyfra 21-1 with those of SCC Ag in squamous cell carcinoma of the lung. We also measured the level of Cyfra 21-1 in the different stages of squamous cell carcinoma of the lung. Method: We measured Cyfra 21-1(ELSA-CYFRA 21-1), SCC Ag(ABBOTT SCC RIABEAD) and CEA(ELSA2-CEA) in 79 patients with primary lung cancer and in 78 persons as a comparison group including 32 patients with pulmonary tuberculosis, 23 patients with benign lung disease and 23 cases with healthy individual. Cyfra 21-1 is measured by a solid-phase immunoradiometric assay(CIS Bio International, France) based on the two-site sandwich method. SCC Ag is measured by a radioimmunoassay(Abbott Laboratories, USA). CEA is measured by a immunoradiometric assay(CIS Bio International, France). All data were expressed as the mean$\pm$standard deviation. Results: 1) The mean value of Cyfra 21-1 was $18.38{\pm}3.65\;ng/mL$ in the lung cancer and $1.l6{\pm}0.53\;ng/mL$ in the comparison group(p<0.0001). SCC Ag was $3.53{\pm}6.06\;ng/mL$ in the lung cancer and $1.19{\pm}0.5\;ng/mL$ in the comparison group(p<0.01). CEA was $35.03{\pm}13.9\;ng/mL$ in the lung cancer and $2.89{\pm}1.01\;ng/mL$ in the comparison group(p<0.0001). 2) Cyfra 21-1 level in squamous cell carcinoma($31.52{\pm}40.13\;ng/mL$) was higher than that in adenocarcinoma($2.41{\pm}1.34\;ng/mL$)(p<0.0001) and small cell carcinoma($2.15{\pm}2.05\;ng/mL$)(p=0.007). SCC Ag level in squamous cell carcinoma($5.1{\pm}7.68\;ng/mL$) was higher than that in adenocarcinoma($1.36{\pm}0.69\;ng/mL$)(p=0.009) and small cell carcinoma($1.1{\pm}0.24\;ng/mL$) (p=0.024). 3) The level of Cyfra 21-1 was not correlated with the progression of stage in squamous cell carcinoma of the lung. 4) Using the cut-off value of 3.3ng/mL, the diagnostic sensitivity of Cyfra 21-1 was 83% in squamous cell carcinoma, 22% in adenocarcinoma and 17% in small cell carcinoma. The sensitivity of SCC Ag and CEA were 39% and 20%, respectively in squamous cell carcinoma, 11% and 39% in adenocarcinoma, and 0% and 33% in small cell carcinoma. 5) Comparison of the receiver operating characteristics curves(ROC curve) for Cyfra 21-1, SCC Ag and CEA revealed that Cyfra 21-1 showed highest diagnostic sensitivity among them in the diagnosis of lung cancer. Conclusion: Cyfra 21-1 is thought to be a better tumor marker for the diagnosis of lung cancer than SCC Ag and CEA, especially in squamous cell carcinoma of the lung.

• The Korean Journal of Nuclear Medicine
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• v.36 no.2
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• pp.121-132
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• 2002

Purpose : Taxol(Paclitaxel), an antineoplastic agent, has been used in the treatment of ovarian and breast cancers. The determination of optimal Taxol concentrations in human serum was required for enhancing therapeutic effect and maintaining the appropriate Taxol level in blood. This study was aimed to synthesizeradiolabeled Taxol derivatives as radiotracer in competitive radioimmunoassay for monitoring Taxol concentrations in blood and to determine the usefulness of its derivatives. Materials and Methods : Hemisucdcinyltaxol(HT) was synthesized by esterification of Taxol with succinic anhydride. Tyraminehemisuccinyltaxol(THT) was synthesized by coupling of HT with tyramine using isobutylchlormate as coupling agent and purified by HPLC. By using chloramine-T($5.25mg/ml,\;10{\mu}{\ell}$) as oxidant agent, THT($4mg/ml,\;30{\mu}{\ell}$) was labeled wity $^{125}I\;(37MBq,\;1mCi)$. To estimate the stability of purified THT, $^{125}I-iodotyraminehemisuccinyltaxol(^125}ITHT)$ was dissolved in 80% acetonitrile aqueous solution, and the solution was incubated at $4^{\circ}C\;and\;37^{\circ}C$ for 7 days. At various time intervals, the stability of THT and $^{125}ITHT$ was monitored. The titer of Taxol monoclonal antibody, 3G5A7, was determined by competitive radioimmunoassay using $^{125}ITHT$ as a labeled antigen. A standard dose-response curve was demonstated by Taxol competitive radioimmunoassay. Resulls : HT and THT were synthesized with 79.9% and 19.5% yield, respectively. The labeling yield of $^{125}ITHT$ was 93%. After 7 days, the chemical purity of THT was 96.5% at $4^{\circ}C$, and 97.5% at $37^{\circ}C$. After 3 days, $^{125}ITHT$ was stable with 94.7% at $4^{\circ}C$ and 93.4% at $37^{\circ}C$. After 7 days, fadiochemical purity was diminished to 88.1% at $37^{\circ}C$. The titer of Taxol monoclonal antibody, 3G5A7, was determined to 1:256. A standard dose-response curve demonstated good collinearity ($R^2=0.971$) as Taxol concentration-dependent manner. Conclusion : Competitive radioimmunoassay using $^{125}I-iodotyraminehemisuccinytaxol$ as radiotracer could be used to monitor for concentration of Taxol in the human serum.

• Journal of Yeungnam Medical Science
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• v.24 no.2
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• pp.137-147
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• 2007

Background : Interpretative reporting is an important aspect of laboratory medicine. The large menu of laboratory tests available today makes it increasingly difficult for the non-specialist to order and interpret all laboratory tests. The aim of this study was to determine the usefulness of an expert system to interpret laboratory tests and help physicians order the appropriate tests. Materials and Methods : In order to interpret laboratory tests, a rules-based expert system was developed. In this module, if-then rules were used to interpret the given test result patterns (e.g. urinalysis, anemia, hepatitis B virus, hypercholesterolemia, glucose, syphilis, and tumor markers) and select matching text elements. The system was used to evaluate 535 subjects who visited a health-check program. Results : The overall abnormal rate was 50.5% in the expert system; 34% for cholesterol, 9.9% for urinalysis, 8.0% for anemia, 7.7% for thyroid function tests, 4.5% for tumor marker study, 4.7% for hepatitis virus antigen, 4.3% for serum glucose, and 1.1% for syphilis. Conclusion : These results indicate that the application of the expert system for the interpretation of laboratory tests may provide a useful method for the interpretation of reports. However more rules are needed for the application to in-patients.

• Research in Community and Public Health Nursing
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• v.13 no.3
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• pp.574-583
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• 2002

'채석(quarrying)'산업은 노천광산에서 광물을 캐내는 작업을 모두 포함하는 광범위한 산업을 의미한다. 1900년대에 들어오면서 채석작업에 홈연소기(channel burner)을 이용한 불꽃절개법(flame cutting)이 이용하여 근로자의 먼지 노출이 많이 감소하였다. 채석작업으로 인한 주 된 건강문제는 먼지, 소음, 진동 노출이며, 노천작업장으로 작업환경이 개방되어 있어 환경측정 및 관리가 불가능하므로 개별근로자의 먼지와 소음 노출 측정 및 예방이 중요하다. 본 연구는 미국의 일개 채석회사의 근로자 건강관리사업을 평가하였다. 연구자료는 저자가 현장 방문을 통하여 구한 자료와 연구대상 회사의 안전관리자의 의견 및 미국 산업안전보건국 전산자료를 이용하였다. 채석사업장에서 이루어지는 작업은 크게 채석작업과 실내에서 이루어지는 가공작업 및 운반과 보관이며, 미국 산업안전보건국(OSHA)의 표준산업분류(SIC)에서 1411(채석업)과 3281(채석가공업)에 해당한다<표 1>. 연구 대상 사업장에서 이루어지는 산업보건프로그램은 먼지 노출 예방을 위해 석재 채취시 물분사법(water jet quarrying)과 국소환기법을 사용하고 소음 노출 예방을 위해 귀마개를 사용하며 사고 예방을 위하여 안전모와 철모, 보안경, 안전조끼, 보호장갑, 안전끈(harness)을 착용하였다. 평가 결과로 나온 연구 대상 사업장에서 적용하여야 할 산업보건 프로그램은 첫째, 먼지 노출로 인한 건강문제를 예방하기 위하여 근로자 개별 노출 측정을 하고, 둘째 실내가공작업장의 근로자를 대상으로 한 먼지와 소음 노출 측정 및 환경측정이 필요하며, 셋째 안전관리를 위해 채석장에 안전표지판을 설치하여야 하며, 실내가공 작업장의 자동이동시스템을 작업별로 채색하여 식별을 용이하게 하여야 하겠다. 또한 이 연구 결과를 영세사업장의 산업간호프로그램인 'Clean 3D'사업에서 적용하여 우리나라 채석사업장 근로자 건강관리를 발전시켜야 하겠다.

• Journal of the Korea Society of Computer and Information
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• v.29 no.1
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• pp.51-59
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• 2024

In this paper, we propose a novel traffic safety system designed to reduce pedestrian traffic accidents and enhance safety on university campuses. The system involves real-time detection of vehicle speeds in designated areas and the interaction between vehicles and pedestrians at crosswalks. Utilizing the YOLOv5s model and Deep SORT method, the system performs speed measurement and object tracking within specified zones. Second, a condition-based output system is developed for crosswalk areas using the YOLOv5s object detection model to differentiate between pedestrians and vehicles. The functionality of the system was validated in real-time operation. Our system is cost-effective, allowing installation using ordinary smartphones or surveillance cameras. It is anticipated that the system, applicable not only on university campuses but also in similar problem areas, will serve as a solution to enhance safety for both vehicles and pedestrians.