• Proceedings of the Korean Institute of Industrial Safety Conference
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• 2002.11a
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• pp.287-290
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• 2002

경제와 전력사용이 호전됨에 따라 냉장기술의 개발이 크게 촉진되면서 진공단열 기술개발을 통한 단열효과 등으로 가전제품의 기술이 세계수준에 도달하였고, 지속적인 기술의 발달로 사용량이 증가하고 있다. 이런 가전제품의 사용증가는 필연적으로 수명이 다한 폐가전 제품이 발생하게되고, 이들을 방치함으로서 환경오염을 일으키게 되었고 정부는 폐가전 제품을 재활용하고 폐기물을 최소화하는 방법을 기업에 요구함과 동시에 폐기물관리법과 자원의 절약과 재활용 촉진에 관한 법률을 제정 공포하게 되었다.(중략)

• Journal of agricultural medicine and community health
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• v.3 no.1
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• pp.5-9
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• 1978

이제까지 알려진 바에 의(依)하면 우리 나라에서 간(肝) 및 폐(肺)디스토마 분포양상(分布樣相)은 강원도지역(江原道地域)이 가장 저율(低率)로 나타난 것을 볼 수 있다. 그 이유(理由)로서는 이들 양흡충은 반드시 제(第)1 및 제(第)2중간숙주(中間宿主)를 통한 生活環(생활환)이 완성(完成)되어야만 하는데, 이들 중간숙주분포(中間宿主分布)가 강원도지역(江原道地域)이 낮은 까닭인듯 하다. 우연(偶然)한 기회(機會)에 저자(著者)는 강원도(江原道)의 일부지역(一部地域)은 폐(肺)디스토마의 감염(感染)이 적지 않다는 정보(情報)를 입수(入手)하고 이에 흥미(興味)를 갖게 되었으며, 특(特)히 농후감염지역(濃厚感染地域)으로 예상(豫想)되는 횡성군(橫城郡)의 일부지역(一部地域), 폐(肺), 청일면(廳日面) 신대리(里) 일대(一帶)와 서원면(面) 유현리(里)에서의 간(肝) 및 폐(肺)디스토마의 감염상(感染相)을 파악(把握)할 목적(目的)으로 본(本) 조사(調査)를 전도(全圖)하였다. 검사방법(檢査方法)으로는 일단(一旦) 간(肝) 및 폐(肺)디스토마의 VBS 항원(抗原)으로 피내반응검사(皮內反應檢査)를 실시(實施)하여 간(肝)디스토마 피내반응검사(皮內反應檢査)에 대(對)해서는 객담검사(喀痰檢査)와 면역혈청반응으로 보체결합반응(補體結合反應), 간접형광항체반응(間接螢光抗體反應) 및 Ouchterlony 반응(反應)을 하여 좀더 정확(正確)한 감염상황(感染狀況)을 파악(把握)하고저 하였다. 그 결과(結果)의 개요(槪要)는 아래와 같다. 1. 횡성군(橫城群) 신대리(里)와 우현리(里)의 주민(住民) 680명(名)에 대(對)한 폐(肺)디스토마의 VBS항원(抗原)에 의(依)한 피내반응양성율(皮內反應陽性率)은 12.4%이었고 간(肝)디스토마의 피내반응양성율(皮內反應陽性率)은 12.5%이었다. 2. 성별(性別)에 따른 피내반응양성율(皮內反應陽性率)의 차이(差異)는 간(肝)디스토마의 경우, 여자(女子) 7.4%에 비(比)하여 남자(男子)가 17.1%이었고, 폐(肺)디스토마의 경우는 여자(女子)가 20.7%인데 반(反)하여 남자(男子)가 42.9%로서 2배(倍) 이상(以上)의 고율(高率)이었다. 3. 연령별(年令別)로 보면, 간(肝)디스토마 피내반응양성율(皮內反應陽性率)은 31~40재(才)가 22.1%로 가장 고율(高率)이었고, 폐(肺)디스토마 양성율(陽性率)은 21~30재(才) 사이가 58.5%로서 가장 높았다. 4. 폐(肺)디스토마 피내반응양성자(皮內反應陽性者)에 대(對)하여 객담검사(喀痰檢査)를 실시(實施)한 바 105명(名) 중 11명(名)(10.5%)의 충란검출자(蟲卵檢出者)를 볼 수 있었다. 또 이들에 대(對)한 면역혈청반응(免疫血淸反應)으로 보체결합반응(補體結合反應), 간접형광항체반응(間接螢光抗體反應) 및 Ouchterlony 반응(反應)을 실시(實施)한 바, 각각 42.5%, 50.3% 및 45.8%로서 거의 일치(一致)된 성적(成績)을 나타내어 피내반응양성자(皮內反應陽性者)의 약반수(約半數)에서 이들 혈청반응(血淸反應)이 양성(陽性)으로 나타났다.

• Journal of Life Science
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• v.19 no.7
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• pp.878-885
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• 2009

Serum ferritin levels are elevated in subjects with acute lung injury (ALI), and abnormalities in plasma and lung iron chemistry have also been demonstrated in ALI and acute respiratory distress syndrome (ARDS). Stress-inducible heme oxygenase-1 (HO-1), as well as ferritin, had shown anti-inflammatory actions. Biomarkers for early detection in patients who are likely to develop ARDS would give several therapeutic chances to the patients. In order to verify the predictability in severe hemorrhage-induced ALI in rats, we measured serum ferritin and HO-1 concentrations before and after hemorrhage. Severe hemorrhages significantly increased the number of leukocytes in bronchoalveolar lavage (BAL) fluid and lung tissue myeloperoxidase activity. Both serum ferritin and HO-1 levels increased following hemorrhage, but ferritin levels were elevated earlier than HO-1. In BAL cell immunohistochemical studies, ferritin and HO-1 expressions increased after hemorrhage and localized in the cytoplasm of leukocytes. These findings suggest that inflammatory leukocytes in BAL fluid can secrete ferritin and HO-1, and serum ferritin levels might be more valid factor in predicting ARDS than HO-1 levels in hemorrhage-induced ALI.

• Journal of Chest Surgery
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• v.40 no.2 s.271
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• pp.103-108
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• 2007

Background: Surgical resection is an important modality in the treatment of pulmonary metastases from various solid tumors. We analyzed 37 patients who underwent surgical treatments of pulmonary metastases in our hospital from 1996 to 2005. Material and Method: Age, sex, disease free interval, operative procedure, the number of pulmonary metastases, and lymphatic metastasis were investigated with admission and operative records, and pathologic reports. Actuarial survival and comparisons between each survival rate were calculated according to Kaplan-Meier method and log-rank test, respectively, Result: Complete resections were carried out in 34 of 37 patients. The primary tumor was carcinoma in 25 cases, sarcoma in 10, and others in 2. The number of pulmonary metastases was 1 in 25 cases and 2 or more in 12 cases. 3-year and 5-year survival rates after complete resection were 50.5% and 35.9%, respectively. 3-year and 5-year survival rates for carcinoma were 64.5% and 45.0%, respectively, and 3-year survival rate for sarcoma was 17.5%. Otherwise, none of the operative procedures, the number of pulmonary metastases, lymphatic metastasis, adjunctive therapy and the disease free interval in the case of carcinoma significantly affected the survival rates. Conclusion: Complete resection of pulmonary metastasis in well selected patients allows high long term survival rate with low mortality and morbidity. Long-term follow up and randomized prospective studies were necessary to determine the prognostic factors of pulmonary metastases after surgical resection.

• Journal of Chest Surgery
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• v.32 no.7
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• pp.637-647
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• 1999

Background: Ischemia-reperfusion injury is one of the major contributing causes of early graft failure in lung transplantation. It has been suggested that triiodothyronine (T3) may ameliorate ischemia-reperfusion injury to various organs in vivo and in vitro. Predicting its beneficial effect for ischemic lung injury, we set out to demonstrate it by administering T3 into the in situ canine ischemia-reperfusion model. Material and Method: Sixteen adult mongrel dogs were randomly allocated into group A and B. T3 $(3.6\mug/kg)$ was administered before the initiation of single lung ischemia in group B, whereas the same amount of saline was administered in group A. Ischemia was induced in the left lung by clamping the left hilum for 100 minutes. After reperfusion, various hemodynamic parameters and blood gases were analyzed for 4 hours while intermittently clamping the right hilum in order to allow observation of the injured left lung function. Result: Arterial oxygen partial pressure $(PaO_2)$ decreased 30 minutes after reperfusion and recovered gradually thereafter in both groups. In group B the decrease of $PaO_2$ was less marked than in group A. The recovery of $PaO_2$ was faster in group B than in group A. The differences between the two groups were statistically significant from 30 minutes after reperfusion $(125\pm34$ mmHg and $252\pm44$ mmHg, p<0.05) until the end of the experiment $(178\pm42$mmHg and $330\pm37$ mmHg, p<0.05). The differences in the arterial carbon dioxide pressure, airway pressure and lung compliance showed no statistical significance. The malondialdehyde (MDA) level, measured from the tissue obtained 240 minutes after reperfusion, was lower in group B $(0.40\pm0.04\mu$M) than in group A $(0.53\pm0.05\mu$M, p<0.05). The ATP level of group B $(0.69\pm0.07\mu$M/g) was significantly higher than that of group A $(0.48\pm0.07\mu$M/g, p<0.05). The microscopic exami nation revealed varying degrees of injury such as perivascular neutrophil infiltration, capillary hemorrhage and interstitial congestion. There were no differences in the microscopic findings between the two groups. CONCLUSION T3 has beneficial effects on the ischemic canine lung injury including preservation of oxygenation capacity, less production of lipid peroxidation products and a higher level of tissue ATP. These results suggest that T3 is effective in pulmonary allograft preservation.

• Journal of Chest Surgery
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• v.40 no.7 s.276
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• pp.467-472
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• 2007

Background: Lung transplantation is the definitive therapy for end stage lung disorders. The success of allogenic lung transplantation has led to an increasing shortage of donor lungs from humans, including cadavers, and attention has now turned to transplantation of lungs from other species. However, there are many biological hurdles when using organs from other species because of hyperacute rejection after discordant xenotransplantation. Material and Method: Pigs (n=6, weighing $20{\sim}30kg$ each) for the donors and mongrel dogs (n=6, weighing $20{\sim}28kg$ each) for the recipients were used in this experiment. The left kidney of a pig was perfused to a mongrel dog for 30 minutes through the femoral artery and vein of the dog, and the right kidney was perfused for 30 minutes sequentially. Then, both lungs of the pig were perfused to the dog through the pulmonary artery and left atrium with using the same time intervals. The levels of IgM and IgG were measured from the blood and specimens of the kidney and lung. Result: The average levels of serum IgM gradually decreased after the perfusion, but the average levels of serum IgG did not charge from before to after perfusion. The immunohistochemical findings revealed decreased deposition of IgG and IgM after the perfusion. Conclusion: We conclude that the levels of the serum natural antibodies would be decreased with pre-transplantation xenograft perfusion in the recipient and the occurrence rate of hyperacute rejection after transplantation would be decreased.

• Applied Microscopy
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• v.29 no.2
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• pp.137-147
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• 1999

Comparative differences between the fine structure of cultured LL/2 cell in vitro and tumor cells in vivo which were induced in the lung by inoculation of LL/2 cells to C57 BL/6 mouse via tail vein during 21 days are not observed except for cell configuration which was changed spindle shape into oval shape. At first tumor cells appeared at lymphatic nodules and around capillary in the lung. Tumor cells divided actively by mitosis, so they became tumor nodules. The pulmonary aveoli around tumor nodules were observed somewhat flattened in shape but the cells in the aveoli appeared to be in normal condition. Furthermore the normal lung cells were observed in the tumor nodules and some apoptotic tumor cells appeared in the large tumor nodules. A lot of neutropiles were observed in the aveoli and tumor nodules of C57 BL/6 mouse lung after inoculation 22 days and 31days.

• 대한세포병리학회:학술대회논문집
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• 1992.06a
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• pp.15-15
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• 1992

• Magazine of RCR
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• v.11 no.4
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• pp.40-45
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• 2016

• 대한세포병리학회:학술대회논문집
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• 1991.06a
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• pp.17.1-17.1
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• 1991