• 디지털융복합연구
• /
• 제11권12호
• /
• pp.615-620
• /
• 2013

이 연구은 2012년 인구보건복지협회가 검진한 일개도 통풍검사 결과를 성별을 구분하여 자료를 분석한 결과로 추후 통풍환자관리에 있어 기초 자료로 활용하기 위해 실시되었다. 분석은 SPSS 18.0을 이용하여 빈도분석, 카이제곱 분석 및 로지스틱 회귀분석을 실시하였다. 그 결과, 고요산혈증으로 정밀검사를 요하는 수진자는 남자가 월등히 많았고, 저요산혈증은 여자가 유의하게 많게 나타났다(p<0.001). 연령별 정밀검사를 요하는 수진자 및 저요산혈증은 70세 이상이 유의하게 가장 많았다(p<0.001). 고요산혈증으로 정밀검사를 요하는 수진자는 시지역이 저요산혈증은 군지역이 약간 높았으며, 고요산혈증은 내륙지역이 저요산혈증은 해안지역 약간 높은 비율이 나타났다. 이 조사를 토대로 하여 연도별, 연령별, 성별 통풍 유병률을 지속적으로 관찰한다면 통풍의 유병률 변화추세를 판단하기에는 상당히 유용할 것이며, 유소견자로 판정된 사람에 대한 추후관리 서비스 제공 및 폐경 후 여성에서 증가하는 고요산혈증 연구뿐만 아니라 저요산혈증의 원인에 대한 연구가 필요하다.

• Journal of Nutrition and Health
• /
• 제40권2호
• /
• pp.162-171
• /
• 2007

Obesity is an independent risk factor fur coronary artery disease in the postmenopausal women, which may be mediated by alteration of blood lipid metabolism. We are aimed to evaluate the effects of low energy diet, restriction of high fat foods and exercise education on weight, fat mass and blood lipid profile. Fifteen postmenopausal obese women were studied. Subjects received detailed advice about how to achieve a reduction of weight by a low-energy diet (1,200kcal), restriction of high fat food and increased exercise in every 4 wks during 8 wk. To evaluate the effectiveness for education programs, dietary fat habit and daily nutrient intakes, exercise were tested before and after intervention. Anthropometry, computerized tomography, and blood lipid profile were assessed before and after intervention. According to the nutrition education, energy intake (from 1776.1 ${\pm}$ 28.2 kcal to 1268.7 ${\pm}$ 115.2 kcal, p < 0.001) and percent of energy from fat (21.9%, p < 0.01) were significantly decreased. However, the index of nutritional quality was over 1.0. On the contrary, exercise (from 341.3 ${\pm}$ 222.1 kcal to 569.4 ${\pm}$ 309.8 kcal, p < 0.05) was increased and dietary fat habit scores (from 30.8 ${\pm}$ 5.2 to 36.1 ${\pm}$ 3.0, p < 0.01) were improved. Also, body weight (4.2%, p < 0.001), BMI (4.5%, p < 0.001), body fat mass (3.4%, p < 0.05) and waist to hip ratio (1.1%, p < 0.05) were decreased. Among abdominal fat, visceral fat (26.1%, p < 0.05) and subcutaneous fat (14.8%, p < 0.01) were decreased. But there was no difference in visceral fat to subcutaneous fat ratio. We observed HDL-cholesterol increase (11.7%, p < 0.05), triglyceride reduction(14.8%, p < 0.05) and atherogenic index improvement (from 2.7 ${\pm}$ 0.7 to 2.3 ${\pm}$ 0.7, p < 0.05) However, there was no change in LDL-cholesterol and total cholesterol. Theses results showed that low energy diet, restriction of high fat foods and exercise education could result in reduction of body weight, fat mass, visceral and subcutaneous fat, and in improvement of blood lipid profile in the postmenopausal obese women.

• Journal of Nutrition and Health
• /
• 제36권6호
• /
• pp.603-612
• /
• 2003

Postmenopausal women are at an increased risk of developing coronary artery disease. This is due to primarily dyslipidemia accompanying the loss of estrogen secretion. Soy isoflavones are known to have weak estrogenic effects. The purpose of this study is to investigate whether isoflavone supplement improves the risk of cardiovascular disease in hypercholesterolemic postmenopausal women. Subjects consisted of 39 Korean postmenopausal women with hypercholesterolemia (total cholesterol $\geq$ 200 mg/㎗ or LDL cholesterol $\geq$ 130 mg/㎗). Subjects were divided into 2 groups; placebo group (PG), isoflavone supplement group (IG). During 12 weeks, subjects were given placebo and 80mg isoflavone daily. Anthropometric measurement, blood sample analysis and dietary intake measurement were taken at baseline and after 12 weeks. After 12 weeks, systolic blood pressure was decreased significantly (p ＜ 0.01) and plasma HDL cholesterol level was increased significantly (p ＜ 0.05) in IG. But there were no significant changes in plasma total cholesterol, LDL cholesterol and triglyceride levels after isoflavone supplementation. There was a negative correlation between initial plasma HDL cholesterol level and the extent of plasma HDL cholesterol reduction in IG (r＝-0.572, p＝0.012). Atherogenic index (AI), total-/LDL- cholesterol ratio and LDL/HDL cholesterol ratio were improved significantly after isoflavone supplementation. In subjects whose initial plasma LDL cholesterol level were above 160 mg/㎗, plasma malondialdehyde (MDA) level were decreased and total antioxidant status (TAS) were increased significantly after isoflavone supplement (p ＜ 0.05). However there were no significant changes in flow-mediated dilator (FMD), the marker of endothelium-dependent vasodilation and nitroglycerine-mediated dilator (NMD), the marker of endothelium-independent vasodilation and the extent of DNA damage after isoflavone supplement. In conclusion, these results indicate that isoflavone supplement may decrease the risk of cardiovascular disease via improving blood pressure, HDL cholesterol level and AI in hypercholesterolemic postmenopausal women. Futhermore, in case of subjects with elevated LDL cholesterol level, isoflavone supplementation may have more antiatherogenic effects via improving antioxidant status.

• 대한지역사회영양학회지
• /
• 제16권5호
• /
• pp.569-579
• /
• 2011

The purpose of this study was to determine the urinary Ca, P, Mg, Zn, Cu, and Mn levels and bone mineral density (BMD) in sixty-two postmenopausal women. The study was conducted through anthropometric checkup, 24-hour recall, 24-hour urine and bone mineral density using DEXA. Average age, height, weight and body fat of the subjects were respectively 65.39 years, 150.19 cm, 58.03 kg and 37.22%. The average spine and femoral neck BMD of subjects were -2.19, -3.13. The mean intakes of Ca, P and Mg were 524.7 mg, 993.10 mg, and 254.6 mg and those of Zn, Cu and Mn were 8.6 mg, 1.5 mg, and 3.5 mg. The average 24-hour urinary excretion of Ca (UCa), P (UP) and Mg (UMg) were 161.07 mg, 673.68 mg, and 99.87 mg. The average 24-hour urinary excretion of Zn (UZn), Cu (UCu) and Mn (UMn) were 366.50 ${\mu}g$, 22.57 ${\mu}g$, and 1.55 ${\mu}g$. Ca intake showed significantly positive correlations with urinary UCa (p < 0.05), UMg (p < 0.01) and spine BMD (p < 0.05). P intake showed significantly positive correlations with UCa (p < 0.05), UMg (p < 0.05) and UZn (p < 0.05). Mg intake showed significantly positive correlations with UZn (p < 0.05) and Mn intake showed significantly positive correlations with UCa (p < 0.05). Multiple regression analysis indicates that Ca intake and UMg is the most important factor to increase spine BMD. On the other hand, UCa is the most important factor to decrease spine BMD. Higher femoral neck BMD was related to UP, while lower femoral neck BMD was related to UCa. In conclusion, Dietary intake of Ca showed positive effect of spine BMD, while excessive P intake showed negative effect on BMD due to increases in UCa, UMg and UZn. Further studies are required to investigate the relationship between bone metabolism and mineral excretion.

• Journal of Nutrition and Health
• /
• 제39권5호
• /
• pp.485-493
• /
• 2006

The purpose of this study was to investigate the relationships among nutrient intakes, BMD, serum copper, zinc and manganese contents in Korean postmenopausal women residing in Seoul and Kyunggi-do. Nutrient intakes analyses and anthropometric measurements were performed for 64 postmenopausal women. Also, fasting blood samples were collected. The BMDs of the lumbar spine (L2-L4) and femoral neck were measured by dual energy X-ray absorptiometry (DEXA). Subjects were classified into three groups: osteoporosis (T-score ${\leq}$ -2.5, n = 20), osteopenia (-2.5 < T-score ${\leq}$ -1, n = 24), and normal (T-score) -1, n = 20). The results are summarized as follows; the mean age, height and weight were 62.1 yrs, 153.8 em, and 56.1 kg, respectively, with no significant difference among three groups. On the other hand, the mean BMI $(23.7\;g/m^2)$ of normal group was significantly higher than those of other two groups. The mean energy intake was 1,395.3 kcal (77.5% of Dietary referance intakes for koreans (KDRls)). The average daily intakes of vitamin $B_2$, calcium and zinc did not reach KDRIs. The mean intakes of iron, copper, zinc and manganese were 10.9 mg, 1.6 mg, 7.8 mg and 5.1 mg respectively, with no significant difference among three groups, The mean serum levels of copper, zinc and manganese were 96.4 mg/dl, 91.5 mg/dl and 39.5 ng/dl, respectively with no significant differences among three groups. The BMD of lumbar spine showed a significantly negative correlation intakes of animal protein, fat and iron intakes after adjusting for age, Bill. However, the BMD of lumbar spine was not significantly correlated with animal iron intakes after adjusting for animal protein, and fat intakes, indicating animal food intake is a possible confounding factor. Proper intakes of vitamin $B_2$, vitamin C are required to protect osteoporosis in postmenopausal women. These results suggest that excessive animal food intakes may have adverse effect on bone mineral density. Further studies arc necessary to elucidate the role of serum minerals in BMD.

• 대한가정학회지
• /
• 제26권1호
• /
• pp.83-96
• /
• 1988

科學의 발전과 經濟의 高度成長으로 食生活의 向上은 人間의 수명을 크게 연장시키고 있다. 韓國에 있어서도 이러한 傾向은 같은 樣相이며 더욱이 보건형태가 차차 변경되어 가고 있다. 女性의 平均수명은 男性보다 길며 近來에 이르러 女性人口의 95%가 閉經을 經驗할 때까지 生存하고 있다고 한다. 이러한 실정임에도 불구하고 우리나라 女性의 閉經年令, 更年期에 處한 婦人들의 건강 및 營養攝取狀態, 食生活 態度등에 關한 情報가 파악되어 있지 않고 있다. 本 硏究는 이 點을 감안하여 우리나라의 中年女性의 건강管理의 指針을 세우기 위하여 생물학적 요인 및 환경적 요인이 閉經年令 및 更年期婦人의 건강狀態와 食行動에 어떠한 영향을 미치는지를 검토하여 보았다. 本 硏究는 1980년 12월에서 1981년 2월까지 3개월간 韓國의 2個의 大都市와 5個의 小都市에 거주하는 40歲에서 60歲까지의 女性을 대상으로 설문지를 통해 다음과 같은 사항을 조사하였다. 조사내용으로 1) 폐경연령, 주거환경, 사회경제적 조건, 체위, 임신횟수, 유산경험의 유무 2) 건강상태, 갱년기 자각증상, 유경시 월경의 순, 불순상태 그리고 3) 영양섭취상태와 식행동 등이다. 本論文은 調査內容 中 第 2 報로 更年期女性의 영양섭취상태와 식생활 행동 그리고 更年期 현상과의 關係를 關例시켜 검토하였다. 간이식품 섭취 사항 조사표를 사용하여 영양소의 섭취상태를 조사한 결과 大都市群은 energy, 지방, thiamin 및 ascorbic acid 의 섭취상태가 그 對照群에 比하여 높은 경향을 나타냈다. 열양 구성비에 대한 검토를 보면 糖質:蛋白質:脂肪(C:P:E)의 比가 64~67%:14%:19%~22%였으며 大都市群은 小都市群에 比해 脂肪에서의 energy섭취가 유의적으로 높았다. 더욱이 사회 경제적 측면으로 보아도 지방섭취는 저소득층에서 낮은 경향을 보여주었다. 更年期女性의 음식에 대한 기호變化의 검토를 통해 관찰한 것에 의하면 閉經者가 未閉經者에 比해 더 많이 食品嗜好의 變化를 경험하고 있다고 지적\ulcorner\ulcorner있다. 37.4%와 28.1%가 각기 기호의 變化를 경험하고 있었으며 이는 兩群間에 有意차가 높음을 보여주었다. 閉經 후 2年頃부터 食品의 嗜好變化를 느끼고 있다고 하는 사람이 많았으며 음식은 기름기 있는 것보다 담백한 것, 肉類보다는 生鮮, 果實, 野菜를 더 선호하는 경향이라고 하였다. 자극성이 있는 것에서 덜 자극성 있는 것을 찾는 경향이었다. 이들의 食品선택구조를 파악하는 것은 그 지역의 특수한 영양문제뿐만 아니라 그들의 영양교육, 더 나아가서는 그 지역의 식량영양정책 수립을 위해 중요한 정보를 제공할 수 있다. 大都市群은 肉類, 卵類, 乳類 및 그 製品등의 선택과 빵이나 butter 등의 食品과 正의 相關性을 나타내고 있었으나(p<0.01) 김치와 같은 韓國의 傳統的 食品의 선택時는 乳類, 果實, 빵과 같은 近代的 感覺의 食品과는 負의 相關性을 나타냈다. 한편 김치는 밥 및 기타 곡류 그리고 서류와는 正 相關性을 시사하였다. 小都市群은 對照群과는 多少 상이한 식품선택 구조를 보이고 있다. 즉 卵類나 乳類를 섭취할 수 있는 사회경제적 조건, 그리고 기호를 갖는 사람들은 서류를 제외한 모든 식품과 正의 相關性을 나타냈다. 어느 群이든 밥과 김치는 높은 相關性을 나타내고 있으며, 이 두 식품은 韓國人의 食生活의 基本이 되고 있으며 이를 土臺로 다른 食品의 선택은 地域的, 社會經濟的, 그리고 個人의 기호에 따라 다르게 나타난다는 것이 시사되었다. 閉經前 後의 更年期라는 것은 30餘年 間의 性 hormone의 周期的分泌에 依한 月周期가 停止하는 時期이며, 內分泌環境의 變化에 依한 生體 리듬의 異常은 各種 更年期증상의 원인이 되고 있다. 有經時의 月經주기의 이상을 경험하는 사람에게 특히 更年期증상中 食慾不振이나 不眠 등의 不平 數가 많았다. 이러한 점으로 미루어 보아 estrogen과 食慾과의 相關性은 높음이 시사되었다. 이는 不眠症과는 연관성이 있으며 性홀몬 分泌의 亂脈은 食事攝取의 리듬을 흐틀어 놓으며 이것이 生體리듬의 變化를 유발한다고 본다.

• 대한한방부인과학회지
• /
• 제23권1호
• /
• pp.42-52
• /
• 2010

Purpose: This report aims to administer methodologic issues around recently conducted multicenter study for evaluating the effects of acupuncture on menopusal hot flashes and discuss practical issues for further implementation of acupuncture clinical trial for hot flashes. Methods: Study process were mentioned, and issues related to avoiding risk of bias, designing appropriate control group, optimal outcome measurement, potential different effects of menopausal status on study outcomes, and suggestions for developing future clinical trials are discussed. Results: Shortcomings of our multicenter study include lack of allocation concealment and assessor blinding, subjective outcome measurement, short-term follow-up, and fixed acupuncture regimen despite pragmatic purpose of this study. Improving trial design, using objective or validated outcomes, assessing long-term effects of acupuncture, and individualizing acupuncture regimen are needed in future clinical trials. Conclusion: We expect these practical discussions to enable researchers to plan and develop future well-designed clinical trials for evaluating the effects of acupuncture on hot flashes or other women's health issues.

• Journal of Nutrition and Health
• /
• 제37권5호
• /
• pp.352-363
• /
• 2004

Lipid-lowering effects of the inulin have been demonstrated in animal, yet attempts to reproduce similar effects in humans have generated conflicting results. In this study, the lipid-lowering potential of inulin and especially its effect on bile acid and neutral sterol excretion were investigated in Korean postmenopausal women. Nineteen postmenopausal women were randomly divided into two groups in a double-blind parallel design and consumed one of two supplements for 12 weeks; placebo of 8g maltodextrins/sucrose mixture (placebo group) or 8g inulin (inulin group). There were no significant changes in body weight during the supplementation period in either inulin or placebo group. Dietary consumption of animal fat in both group tended to decrease after 12 weeks of experiment. Intake of cholesterol was lower in placebo group, whereas the decrease of cholesterol intake in inulin group did not reach statistical significance after 12 weeks. The levels of serum total cholesterol (TC) and LDL-cholesterol (LDL-C) were significantly decreased in both placebo (p＜0.05) and inulin group (p＜0.01) after supplementation for 12 weeks compared with the baseline. The levels of serum triglyceride (TG) and HDL-cholesterol (HDL-C) were not significantly affected by inulin supplements, but atherogenic index (AI) and LDL-C/HDL-C ratio (LHR) as a predictor for coronary heart disease were improved (p＜0.01) significantly after inulin supplementation. Therefore, inulin supplement may decrease the risk of cardiovascular disease via improving blood cholesterol level. Fecal weight and pH were not changed after 12 weeks of supplementation. There were no statistically significant changes for the fecal short-chain fatty acids (SCFAs). In inulin group, fecal deoxycholic acid (DCA) was significantly lowered compared with the baseline (p＜0.05) whereas other bile acids were not changed. During the 12 weeks of intervention, no differences were found in fecal excretion of neutral sterol in the two groups. In summary, dietary inulin decreases serum TC, LDL-C, AI, LHR and lowers excretion of fecal DCA in the Korean postmenopausal women. These results support the use of inulin for reducing risk factors for hyperlipidemic postmenopausal women. However, the exact mechanism (s) responsible for the blood lipid lowering action of inulin including altered fecal bile acid remain to be elucidated.

• 한국식품영양과학회지
• /
• 제31권2호
• /
• pp.290-294
• /
• 2002

본 연구에서는 인위적 폐경을 유발시킬 수 있는 난소 절제 쥐에서와 돌나물 에탄을 추출물과 분획물의 혈 중 지질 함량 변화에 미치는 영향을 검토하였다. 난소 절제로 인해 야기되는 혈중 콜레스테를 함량의 증가는 돌나물 추출물 및 ethyl acetate 분획물의 투여에 의해 감소하는 경향이 나타났다. 혈중 중성지방 농도에서도 돌나물 분획물 투여가 유의적 감소 효과를 나타내었다. 한편, 혈 중 HDL-콜레스테를 함량은 난소 절제군에 비해 난소 절제 후 ethyl acetate 분획물을 투여한 군에서 그 수치가 유의적으로 증가 하였고, Sham군에 비해 오히려 더 증가하는 경향을 나타내었다. 혈중 중성지방 농도에서도 돌나물 분획물 투여가 유의적 감소 효과를 나타내었다. 돌나물 추출물과 분획물이 에스트로겐 감소로 인한 혈중 지질 대사에 효과를 나타낸 본 실험 결과를 미루어 보아, 돌나물 중의 에스트로겐 유사 효과를 나타내는 phytoestrogen이 있을 것으로 추론되고 이로 인해 외인성 에스트로겐 투여로 인한 부작용을 줄여 줄 수 있을 것으로 기대된다. 이상과 같은결과는 돌나물의 섭취가 폐경기 여성에게 폐경기 증상의 호전 및 순환계질환의 위험도를 감소시킬수 있을것으로 사료되어진다.

• 동아시아식생활학회지
• /
• 제27권4호
• /
• pp.408-419
• /
• 2017

This study was carried out to compare the relationship between biochemical indices and bone mineral density (BMD) in 50 pre-menopausal and 50 post-menopausal women. The subjects were divided into normal and risk groups according to their bone status, as determined by T-scores of the lumbar spine and femur. The average T-score of the lumbar spine was higher (p<0.05) in pre-menopausal women ($0.42{\pm}0.18$) than post-menopausal women ($-0.08{\pm}0.21$). Serum levels of HDL-cholesterol, P, and Fe were significantly higher in the risk group than the normal group in pre-menopausal women (p<0.05). Serum levels of total protein, globulin, alkaline phosphatase (ALP), and osteocalcin were lower in the risk group than the normal group, whereas the level of estrogen was higher in the normal group than the risk group in post-menopausal women (p<0.05). In pre-menopausal women, P was positively correlated with Ca (p<0.01), and ALP was positively correlated with osteocalcin (p<0.01) and parathyroid hormone (PTH) (p<0.05). Further, insulin-like growth factor-I (IGF-I) was negatively correlated with the vitamin $25(OH)D_3$ and vitamin K (p<0.05). In post- menopausal women, the Ca was positively correlated with vitamin $25(OH)D_3$ (p<0.05) and vitamin K (p<0.01), and P was positively correlated with vitamin K (p<0.01), Ca (p<0.01), and IGF-I (p<0.05) and negatively correlated with PTH (p<0.05). IGF-I was negatively correlated with PTH (p<0.01) and estrogen (p<0.05), and ALP was positively correlated with osteocalcin (p<0.01) and negatively correlated with vitamin K and estrogen (p<0.05). In pre-menopausal women, the lumbar spine BMD was positively correlated with vitamin K level (p<0.01) and negatively correlated with P level (p<0.05). In post-menopausal women, the femur BMD was positively correlated with estrogen level and negatively correlated with PTH leves (p<0.05). These results suggest that vitamin K and P levels are associated with bone health in pre-menopausal women, and estrogen and PTH levels are associated with bone health in post-menopausal women.