• Journal of Korea Water Resources Association
• /
• v.53 no.10
• /
• pp.903-915
• /
• 2020

Long-term high-resolution hydro-meteorological data has been recognized as an essential element in establishing the water resources plan. The increasing demand for spatial precipitation in various areas such as climate, hydrology, geography, ecology, and environment is apparent. However, potential limitations of the existing area-weighted and numerical interpolation methods for interpolating precipitation in high altitude areas remains less explored. The proposed PRISM (Precipitation-Elevation Regressions on Independent Slopes Model) model can produce gridded precipitation that can adequately consider topographic characteristics (e.g., slope and altitude), which are not substantially included in the existing interpolation techniques. In this study, the PRISM model was optimized with SCEM-UA (Shuffled Complex Evolution Metropolis-University of Arizona) to produce daily gridded precipitation. As a result, the minimum impact radius was calculated 9.10 km and the maximum 34.99 km. The altitude of coastal weighted was 681.03 m, the minimum and maximum distances from coastal were 9.85 km and 38.05 km. The distance weighting factor was calculated to be about 0.87, confirming that the PRISM result was very sensitive to distance. The results showed that the proposed PRISM model could reproduce the observed statistical properties reasonably well.

• The Korean Journal of Nuclear Medicine
• /
• v.38 no.4
• /
• pp.325-329
• /
• 2004

Purpose: Usefulness of mouse liver S9 fraction was evaluated for the measurement of the metabolites in the in vitro metabolism study of $^{18}F$-labeled radiotracers. Materials and Methods: Mouse liver S9 fraction was isolated at au early step in the course of microsome preparation. The in vitro metabolism studies were tarried out by incubating a mixture containing the radiotracer, S9 fraction and NADPH at $37^{\ciirc}C$, and an aliquot of the mixture was analyzed at the indicated time points by radio-TLC. Metabolic defluorination was further confirmed by the incubation with calcium phosphate, a bone mimic. Results: The radiotracer $[^{18}F]1$ underwent metabolic defluorination within 15 min, which was consistent with the results of the in vivo method and the in vitro method using microsome. Radiotracer $[^{18}F]2$ was metabolized to three metabolites including $4-[^{18}F]fluorobenzoic$ acid within 60 min. It is likely that the one of these metabolites at the origin of radio-TLC was identical with the one that obtained from the in vivo and in vitro (microsome) method. Compared with the in vitro method using microsome, the method using S9 fraction gave a similar pattern of the metabolites but with a different ratio, which can be explained by the presence of cytosol in the S9 fraction. Conclusion: These results suggest that the findings of the in vitro metabolism studies using S9 fraction can reflect the in vivo metabolism of novel radiotracers in the liver. Moreover, this method can be used as a tool to determine metabolic defluorination along with calcium phosphate absorption method.

• Journal of Korean Society of Environmental Engineers
• /
• v.35 no.3
• /
• pp.165-170
• /
• 2013

In this study, physico-chemical properties and environmental fate were investigated and ecotoxicity tests using fish, daphnia and algae were conducted for an initial ecological risk assessment of 1,2-Benzisothiazol-3-one. Due to low volatility of the test substance under environmental conditions, it is likely to distributed in soil and water environment. The compound has low adsorption in the soil, with low bioconcentration potential. Acute toxicity results showed that 96 h-$LC_{50}$ for Oryzias laties was 4.7 mg/L (measured) and 48h-$EC_{50}$ for Daphnia magna was 3.3 mg/L (measured). In a growth inhibition test with Pseudokirchneriella subcapitata, 72 h-$EC_{50}$ was 0.456 mg/L (growth rate, nominal) and 0.262 mg/L (yield, nominal). Using the acute toxicity value of algae, predicted no-effect concentration (PNEC) in the aquatic environment was determined to be 2.62 ${\mu}g/L$ using an factor of 100. According to globally harmonized system (GHS), the compound was categorized as aquatic acute 1 for algae, while it was categorized as aquatic acute 2 for fish and daphnia. This screening assessment suggests that the test substance may pose ecological risks in the aquatic environment.