• Journal of Korean Physical Therapy Science
• /
• v.13 no.2
• /
• pp.99-119
• /
• 2006

Endothelin (ET) is a 21 amino acid peptide with multifunctional effects on the vasculature as well as a variety of other cell types such as respiratory, gastrointestinal, urogenital, endocrine, central nervous systems, and others. Endothelin has emerged as a modulator by autocrine and paracrine actions for many cellular activities, including vasoconstriction, cell proliferation, hormone production, neurotransmitter and/or neuromodulator. The endothelin family consists of three closely related peptides, ET-1, ET-2, and ET-3 derived from separate genes, such as chromosome 6, 1, and 20, respectively. ET-1 is the predominant isoform produced in the cardiovascular system and about which most is known. Endothelin receptors are seven-transmembrane GTP-binding protein-coupled receptors, which are classified into endothelin-A (ETA) and endothelin-B (ETB) receptors. Interestingly, recent evidence is accumulating to suggest that ET -1 may contribute to a variety of pain states such as allodynia and hyperalgesia in animals and humans. Therefore, in this review the biological characteristics and contraction-related mechanism of endothelin-1 in mammalian cells will be summarized. Especially, we focus on multifunctional roles for ET-1 in noxious stimulation-induced pain for the study of pain specialized physical therapy.

• Clinical and Experimental Pediatrics
• /
• v.50 no.6
• /
• pp.580-584
• /
• 2007

Multiple sclerosis (MS) is a demyelinating disorder that affects discrete areas of the CNS, including the optic nerves, in a quite variable relapsing-remitting fashion over a prolonged period of time. Although MS is usually considered to be a disease that affects peoples in early to middle adulthood, children do develop multiple sclerosis. The frequency of MS onset before the age of 15 years is 2.7-5% of all cases, while MS onset during infancy and early childhood was observed to be 0.2-0.7% of all cases. We report here on a Korean case of a relapsing-remitting MS female child who was treated with four rounds of intravenous methylpredinsolone pulse therapy and preventive Interferon-$\beta$-1b ($Betaferon^{(R)}$).

• Journal of Acupuncture Research
• /
• v.29 no.4
• /
• pp.25-34
• /
• 2012

Objectives : This study was conducted to investigate the effects of fixed-intensity and varied-intensity electroacupuncture in pain and sensory threshold concerning parameters visual analogue scale(VAS), brief pain inventory(BPI) and quantitative sensory testing(QST), among chronic tension headache patients. Methods : Thirty patients with chronic tension headache were randomly assigned to three groups and received different kinds of electroacupuncture at $ST_{36}$ and $ST_{37}$. Group A received fixed-intensity electroacupuncture(fixed-EA), group B received varied-intensity electroacupuncture (varied-EA), and group C received only acupuncture treatment without electrical stimulation as a control group. The intervention was given three times per week, and continued in two weeks. All the experiments were conducted blindly. Results : Fixed-EA group showed a significant decrease of VAS and BPI compared to the baseline measurement, while both varied-EA and control group did not. Of the parameters of QST, subtraction of heat pain threshold(HPT) and cold pain threshold(CPT) slightly increased in all groups, but this was not significant. Conclusions : These results suggest that fixed-EA reduce pain and improve quality of life in patients with chronic tension headache and that acupuncture may regulate patient's pain sensitivity through changing sensory threshold.

• Journal of Oral Medicine and Pain
• /
• v.26 no.3
• /
• pp.181-187
• /
• 2001

스트레스가 인체의 항상성에 영향을 미쳐 다양한 질병 및 동통을 일으킬 수 있다는 것은 선학들의 연구에 의해 증명되어 왔다. 특히 정서적으로 중요한 구강안면영역에는 스트레스와 관련된 질병 및 동통이 많이 존재하는데, 이에대한 병리적 기전은 아직 뚜렷하게 밝혀져 있지 않다. 이에 저자는 스트레스와 말초 및 중추신경과의 병리적 관계를 알아보고자, 구속스트레스하에서 구강안면영역의 감각과 운동에 중요한 역할을 하는 삼차신경의 집합체인 삼차신경절과 뇌간조직의 단백질 변화를 western blot을 통해 살펴보았다. 실험동물은 생후 8주된 Sprague-Dawley계 웅성 백서 (323-367 g/bw)를 대조군 3마리, 실험군 15마리로 배정하였고 실험군은 실험 전기간에 걸쳐 구속스트레스를 부여하였다. 실험동물의 삼차신경절과 뇌간은 희생 즉시 적출되었으며, western blot을 시행하여 다음과 같은 결론을 얻었다. 1. 삼차신경절의 모든 군에서 약 18 KDa의 단백질이 균일하게 나타났다. 2. 뇌간의 모든 군에서 약 18 KDa 단백질이 발현되었으며, 정상 대조군, 실험 즉일, 1일, 3일, 7일에서는 뚜렷한 변화가 없었으나 실험 5일군에서는 현저한 감소를 보였다. 구속스트레스에 의해 뇌간의 5일군에서 약 18 KDa의 특수한 단백질이 뚜렷이 감소된 후 7일 군에서 다시 증가되었던 것은 스트레스에 의한 뇌간세포의 반응으로 생각되며, 뇌간에서와 다르게 삼차신경절에서는 그 변화가 나타나지 않았던 것은 스트레스에 대한 조직의 반응 차이라고 생각된다. 따라서 이를 명확하게 확인하기 위해서는 향후 수종의 스트레스와 관련된 단백질 변화에 대한 추가적인 연구가 필요하리라 사료된다.

• Journal of Oral Medicine and Pain
• /
• v.26 no.3
• /
• pp.225-241
• /
• 2001

구취에 대한 환자의 주관적 감각은 다양한 심리학적 요소들에 의하여 영향을 받을 가능성이 있다. 본 연구에서는 구취 환자의 심리학적 특징을 살펴보기 위하여, 구취를 주소로 내원한 환자 446명과 일반적인 치과 치료를 위하여 내원한 환자 63명을 대상으로 간이정신진단검사 (SCL-90-R), 구취 설문검사, 구취 측정 검사를 시행하여 분석한 결과 아래와 같은 결론을 얻었다. 1. 남성 구취 환자와 여성 구취 환자의 연령분포는 통계학적으로 유의한 차이를 보였다 (p<0.001). 남성에서는 20대, 30대, 40대에 고르게 분포한 반면, 여성에서는 20대와 30대에 집중되어 분포하였다. 2. 구취의 인식 유형은 남녀간에 통계학적으로 유의한 차이를 보였다 (p<0.01). 구취 인식 유형 중 타인에 의한 지적이나 타인의 행동으로 인한 추측 없이 스스로 구취를 인지하는 유형은 여성 구취 환자에서만 관찰되었다. 3. 구취 환자는 대조군에 비하여 강박증, 불안, 적대감, 전체심도지수에서 높은 수치를 보였다 (p<0.05). 4. 여성 구취 환자는 남성 구취 환자에 비하여 강박증(p<0.05), 불안 (p<0.05), 편집증 (p<0.001)에서 높은 수치를 보였다. 5. 남성 구취 환자에서는 표출증상합계를 (p<0.05) 제외한 모든 간이정신진단검사 항목에서 고농도 VSC군과 저농도 VSC군간에 유의한 차이를 보이지 않았다. 여성 구취 환자에서는 저농도 VSC군이 신체화를 제외한 모든 간이정신진단검사 항목에서 고농도 VSC군에 비하여 높은 수치를 보였다 (p<0.05). 6. 여성 구취 환자에서 주관적 구취심도는 강박증, 대인예민성, 불안, 적대감, 공포불안, 전체심도지수, 표출증상심도지수 들과 유의한 상관관계를 보였고 (p<0.05), 주관적 구취불편감은 모든 간이정신진단검사 항목들과 유의한 상관관계를 보였다 (p<0.05).

• Journal of Chest Surgery
• /
• v.38 no.3 s.248
• /
• pp.241-244
• /
• 2005

A 57-year-old man with numbness and paresthesia of left arm is presented. There was no pulse in the left arm was absent and his chest radiograph suggested right-sided aortic arch. The aortogram showed right-sided aortic arch with Kommerell's diverticulum. The proximal portion of left subclavian artery was totally occluded and blood was being supplied through vertebral arteries to distal subclavian artery. He underwent bypass grafting between both subclavian arteries by an expanded polytetrafluoroethylene graft. Because the size of Kommerell's diverticulum was small, it need to be observed closely.

• The Korean Journal of Pain
• /
• v.13 no.1
• /
• pp.84-88
• /
• 2000

Background: An increase in the maximum level of sensory blockade (MLSB) following an epidural top-up in combined spinal epidural anesthesia (CSE) may be achieved by a volume effect as the volume of local anesthetic compresses the dural sac, by a local anesthetic effect, or by a combination of both effects. This study was conducted to investigate the contribution of each of these effects. Methods: Sixty patients scheduled for lower limb surgery under CSE were randomly allocated to one of three groups of twenty patients each. Using the needle-through needle technique, all patients received a subarachnoid dose of 10 mg hyperbaric 0.5% bupivacaine. At 30 min after subarachnoid injection, an epidural top-up with saline 10 ml (group II) or 0.5% bupivacaine 10 ml (group III) was administered; patients in group I received no epidural top-up. The level of sensory blockade was assessed at 5, 10, 15, 20, 25, 30 min after subarachnoid injection and at 5, 10, 15, 20, 25, 30 min after epidural top-up. Results: There was no significant difference in the MLSB and the onset time of MLSB among group I-III. Conclusions: We concluded that the epidural top-up with saline 10 ml or 0.5% bupivacaine 10 ml which injected at 30 min after subarachnoid injection did not significantly increase the level of subarachnoid block in lower extremity surgical patients.

• Physical Therapy Korea
• /
• v.22 no.3
• /
• pp.1-11
• /
• 2015

The purpose of this study was to investigate the effect of lumbar stabilization training and additional thoracic mobilization on pain, proprioception and static balance in patients with chronic low back pain. The subjects of this study were 48 chronic low back pain patients who were randomly allocated to an experimental group 1 ($n_1=16$, lumbar stabilization and thoracic mobilization, thoracic hypomobility), experimental group 2 ($n_2=16$, lumbar stabilization and thoracic mobilization, thoracic normal mobility), and a control group ($n_3=16$, lumbar stabilization, thoracic hypomobility) after a thoracic mobility test. Both experimental groups underwent lumbar stabilization training and additional thoracic mobilization. The control group underwent only lumbar stabilization training. The intervention was performed 3 times per week, 30 minutes each time, for a total of 6 weeks. Thoraco-lumbar joint reposition error was measured using an electrogoniometer and static balance ability was measured using the Tetrax posture analysis system. Subjects' pain level was measured using a 100 mm visual analogue scale. Statistical analyses were performed using a one-way analysis of variance and a paired t-test. Post-hoc testing was carried out with a Bonferroni test. The pain level was significantly lower in both experimental groups compared to the control group. Both experimental groups showed significant reductions in joint reposition error angle (flexion, extension, and side bending) compared to the control group. The static balance level was significantly lower in both experimental groups than in the control group. In summary, lumbar stabilization exercises and additional thoracic mobilization significantly improved the pain level, proprioception, and static balance in patients with chronic low back pain.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2015.05a
• /
• pp.374-375
• /
• 2015

Modern people is generated as musculoskeletal diseases due to incorrect posture and habit. In the case of persistent abnormal posture outbreak inconvenient to musculoskeletal diseases in daily life. musculoskeletal diseases, which began as fatigue, pain, sensory paralysis, convulsions are developed symptoms of movement disorders, depression, deformities, etc. In this paper, the unrestrained abnormal posture and habit of occurring in the seat life, have implemented a system which can be determined in less unconscious way. By placing eight pressure sensors in the seat part, determines the posture over the distribution of the weight, it is possible to determine one normal posture and eight abnormal posture that occurs frequently in daily life. To evaluate the performance of the implemented system, the attitude determination experiment was performed. The results confirmed the high performance of 97%.

• The Korean Journal of Pain
• /
• v.12 no.1
• /
• pp.43-47
• /
• 1999

Backgroud: Systemic administration of opioid can prolong the duration of epidural anesthesia. The authors examined the effect of nitrous oxide ($N_2O$) on the level of sensory block induced by epidural lidocaine. Methods: Twenty minutes after epidural injection of 2% lidocaine (below 70 years : 20 ml, 70 years and above : 15 ml), the level of sensory block was assessed (2nd stage). Patients were randomly assigned to receive either medical air (control group, n=15) or 50% $N_2O$ in oxygen ($N_2O$ group, n=15) for 10 minutes, the level of block was reassessed (3rd stage). Pateints were given room air (control group) or 100% oxygen for 5 minutes and room air for 5 minutes ($N_2O$ group), and the level of block was reassessed (4th stage). Results: At the 3rd stage, $N_2O$ group showed 4.3 cm cephalad increase in the level of sensory block (p=0.005), but control group revealed 1.43 cm regression. After discontinuation of gas, the level of block regressed in both group (p=0.000). At the 4th stage, $N_2O$ group revealed 3.5 cm cephalad increase (p=0.048) and control group 1.97 cm regression (p=0.001) as compared with the 2nd stage. Conclusions: The level of sensory block induced by epidural lidocaine was significantly increased cephalad by concommitant use of 50% $N_2O$ for 10 minutes.