• Journal of Korean Society of Forest Science
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• v.38 no.1
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• pp.33-45
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• 1978

The purpose of present study is to analyze the genetic variation of natural stand of Pinus densiflora. In 1975 following after the selection of 1974, twenty trees from each of three natural populations of the species were selected and their open-pollinated seeds were collected, and the locations and conditions of the populations ate presented in table 1, 2 and figure 1. Some morphological traits of the populations were already detailed in our second report of this series, in which Myong-Ju and Ul-Jin populations were regarded to be superior phenotypically to suweon population. The morphological traits of cone, seed and seed-wing, and also the growth performances and needle characters of the seedling were observed in the present study according to the previous methods. The results obtained are summarized as follows; 1. The meteorological data obtained by averaging the records of 30 year period (1931~1960) measured from the nearest meteorological stations to each population are shown in fig.2, 3, 4. The distributional patterns of investigated climate factors are generally considered to be similar among the locations. However, the precipitation density during growing season and the air temperature during dormant season on Suweon area, population 6, were quite different from those of the other areas. 2. The measurements of fresh cone weight, length, diameter and cone index, i.e., length to diameter ratio are presented in table 7. As shown in table 7, all these traits except for cone diameter seem to be highly significant in population differences and family differences within population. 3. The morphological traits of seed and seed-wing are detailed in table 8, 9, and highly significant differences are recognized among the populations and the families within population in seed-wing length, seed-wing index, seed weight, seed-length and seed index but not among the populations in the other observed traits. The values of correlation coefficient between the characters of cone and seed are given in table 10 and the positive significant correlations can be observed in the most parts of the compared traits. 4. Significant statistical differences among populations and families within population are observed in the growth performances of 1-0 and 1-1 seedling height of these progenies. But the differences in root collar diameter are shown only among families within population. As shown in table 13, the most parts of correlations are not significant statistically between the growth performances of seedling and the seed characters. 5. The number of stomata row on both sides of needle and the serration density were measured in the seedlings from each of the families of the three populations. As shown in table 15, statistical differences are considered to be significant among the populations and among the families within population in serration density but not among the populations in stomata row on both sides of the needle. The results differ from those of the third report of this series. Even if one of the reason seems to be the diversity of selected populations, it could not be confirmed definitely. The correlations between progenies and parents are not generally observed in the investigated traits of needle as shown in table 16.

• Clinical and Experimental Pediatrics
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• v.45 no.2
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• pp.240-246
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• 2002

Purpose : It is not clear that the development of glomerular injury and aggravation by tumor necrosis factor alpha($TNF-{\alpha}$) is related to intrarenal or serum concentration of $TNF-{\alpha}$. So, we studied the relationship between the concentration of $TNF-{\alpha}$ and aggravation of glomerular damage in the Henoch-$Sch{\ddot{o}}nlein$ nephritis(HSN) and idiopathic nephrotic syndrome(INS). Methods : We collected the sera and urines of 21 patients with Henoch-$Sch{\ddot{o}}nlein$ purpura(HSP) and 22 patients with INS visited Chungbuk National University hospital from March 1998 to March 2001. The concentration of $TNF-{\alpha}$ in the sera and urines were measured by sandwich ELISA. Results : Serum $TNF-{\alpha}$ levels in the HSP patients with renal involvement were significantly higher than those without renal involvement(P=0.009). But urine $TNF-{\alpha}$ levels have no correlation with renal involvement(P=0.088). In the HSN patients, proteinuria have a significant correlation with serum $TNF-{\alpha}$ levels(P=0.004) but less correlation with urine $TNF-{\alpha}$ levels(P=0.053). Otherwise, proteinuria have no correlation with serum $TNF-{\alpha}$ levels(P=0.763) but have a significant correlation with urine $TNF-{\alpha}$ levels(P=0.007) in INS. Conclusion : These result suggest that the serum concentration of $TNF-{\alpha}$ would be important to glomerular involvement in HSP. And, it is interesting that proteinuria shows a significant relation with serum $TNF-{\alpha}$ levels in the HSN, but with urine $TNF-{\alpha}$ levels in the INS. This means the major production of $TNF-{\alpha}$ may be originated by extrarenal inflammation in the HSN and by intrarenal tubulo-interstitial damage due to proteinuria in the INS.

• Journal of the Korean Society of Radiology
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• v.83 no.5
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• pp.1090-1103
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• 2022

Purpose To evaluate the diagnostic performance of digital breast tomosynthesis (DBT) with the two-dimensional synthesized mammogram (2DSM), compared to full-field digital mammography (FFDM), for suspicious microcalcifications in the breast ahead of stereotactic biopsy and to assess the diagnostic image visibility of the images. Materials and Methods This retrospective study involved 189 patients with microcalcifications, which were histopathologically verified by stereotactic breast biopsy, who underwent DBT with 2DSM and FFDM between January 8, 2015, and January 20, 2020. Two radiologists assessed all cases of microcalcifications based on Breast Imaging Reporting and Data System (BI-RADS) independently. They were blinded to the histopathologic outcome and additionally evaluated lesion visibility using a fivepoint scoring scale. Results Overall, the inter-observer agreement was excellent (0.9559). Under the setting of category 4A as negative due to the low possibility of malignancy and to avoid the dilution of malignancy criteria in our study, McNemar tests confirmed no significant difference between the performances of the two modalities in detecting microcalcifications with a high potential for malignancy (4B, 4C, or 5; p = 0.1573); however, the tests showed a significant difference between their performances in detecting microcalcifications with a high potential for benignancy (4A; p = 0.0009). DBT with 2DSM demonstrated superior visibility and diagnostic performance than FFDM in dense breasts. Conclusion DBT with 2DSM is superior to FFDM in terms of total diagnostic accuracy and lesion visibility for benign microcalcifications in dense breasts. This study suggests a promising role for DBT with 2DSM as an accommodating tool for stereotactic biopsy in female with dense breasts and suspicious breast microcalcifications.

• Tuberculosis and Respiratory Diseases
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• v.45 no.5
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• pp.962-974
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• 1998

Background: Alteration of p53 tumor suppressor genes is most frequently identified in human neoplasms, including lung carcinoma. It is well known that bcl-2 oncoprotein protects cells from apoptosis. Recent studies have demonstrated that bcl-2 expression is associated with favorable prognosis for patients with non-small cell lung carcinoma. However, the precise biologic role of bcl-2 in the development of these tumors is still obscure. p53 and bcl-2 have important regulatory influence in the apoptotic pathway and thus their relationship is of interest in tumorigenesis, especially lung cancer. Purpose: The author investigated to know the prognostic significance of the expression of p53 and bcl-2 in radically resected non-small cell lung cancer. Method: 84 cases of formalin-fixed paraffin-embedded blocks from resected primary non-small cell lung cancer from 1980 to 1994 at Hanyang University Hospital were available for both clinical follow-up and immunohistochemical staining using monoclonal antibodies for p53 and bcl-2. Results : The histologic classification of the tumor was based on WHO criteria., and the specimens included 45 squamous cell carcinomas(53.6%), 28 adeonocarcinomas(33.3%) and 11 large cell carcinomas(13.1 %). p53 immunoreactivity was noted in 47 cases of 84 cases(56.0%). bcl-2 immunoreactivity was noted in 15 cases of 84 cases(17.9%). The mean survival duration was $64.23{\pm}10.73$ months in bcl-2 positive group and $35.28{\pm}4$. 39 months in bcl-2 negative group. The bcl-2 expression was significantly correlated with survival in radically resected non-small cell lung cancer patients(p=0.03). The mean survival duration was $34.71{\pm}6.12$ months in p53 positive group and $45.35{\pm}6.30$ months in p53 negative group(p=0.21). The p53 expression was not predictive for survival. There was no correlation between combination of the different status of p53 and bcl-2 expression in our study. Conclusions : The interaction and the regulation of new biologic markers, such as those involved in the apoptotic pathway, are complex. bcl-2 overexpression is a good prognostic factor in non-small cell lung cancer and p53 expression is not significantly associated with the prognostic factor in non-small cell lung cancer.

• Korean Journal of Environment and Ecology
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• v.24 no.5
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• pp.539-546
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• 2010

To investigate the variation of anion concentrations in relation to forest type, forest-related factors, forest survey and anion concentrations measurement were carried out on the 52 quadrats located at the national forest areas in Yangyang-gun, Kangwon-do. The relationship between anion concentrations and forest-related factors were correlated. Total mean of anion concentration was 2,405 ea/$cm^3$, which was slightly higher than general figures 2,000ea/$cm^3$. Highly significant positive correlations were observed between anion concentrations and soil moisture contents, and also between anion concentrations and altitude. Significant positive correlations were observed between anion concentrations and topography. Anion concentrations were significantly different among soil moisture levels. Mean anion concentration were highest at 4,524.4ea/$cm^3$ in on wet sites, and followed slightly wet sites and moderate sites. Mean anion concentrations was highest on valley sites at 3,372.4ea/$cm^3$, followed by slope and ridge areas. Mean anion concentrations measured before noon was highest at 3,133.4ea/$cm^3$, and measurements during 12:00~15:00 and after 15:00, showed relatively low anion concentrations. Mean anion concentrations was highest at mixed deciduous forests at 3,503.9ea/$cm^3$, followed by oak forests, pine forests, and pine-oak forests. Results of this study are expected to be used in planning therapeutic forests.

• Korean Journal of Food Science and Technology
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• v.39 no.4
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• pp.412-418
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• 2007

The physicochemical properties and mixograph characteristics of soft white winter (SWW) and club wheat, as well as their product potentiality, were investigated. There were no significant differences between the SWW wheat and club wheat regarding their Single Kernel Characterization System (SKCS) properties. The straight-grade flour yield, break flour yield, ash content, and milling score of the SWW wheat were similar to those of the club wheat, and the straight-grade flour yield had a significant positive correlation to the break flour yield (r = 0.805**). The Rapid Visco-Analyzer (RVA) peak viscosity and swelling volume of the SWW wheat flour were very similar to those of the club wheat flour, and there was a significant positive correlation between the RVA peak viscosity and the swelling volume (r = 0.662**). The average mixograph absorption of the SWW wheat was higher than that of the club wheat. The club wheat resulted in a higher cookie diameter than the SWW wheat, but the difference was not significant. The sponge cake volume using the SWW wheat flour was higher than that with the club wheat flour. In addition, there was a significant correlation between the cookie diameter and the sponge cake volume (r = 0.745**).

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.104-104
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• 2018

이수안전도의 기준이 되는 갈수량에 대해 기후변화 시나리오에 따른 전망을 제시하였다. 충주 댐 유역을 대상으로 기준기간(1986~2000년)에서의 기상청의 관측 기상자료와 IPCC 보고서의 RCP 4.5/8.5 시나리오를 대상으로 CMIP5(Coupled Model Intercomparison Project Phase 5)에서 제공하는 기후변화 자료 중 5개의 모델(ACCESS1.3 CanESM2, CNRM-CM5, GFDL-ESM2G, HadGEM2-AO)의 기준기간과 미래기간(2011~2100년)의 기상자료를 수집하였다. 기후변화 자료는 정상성/비정상성 분위사상법과 베이지안 모델 평균기법을 통해 불확실성과 통계적 오차를 저감하였다. 미래기간에서, 강우는 RCP 4.5에서 1.74mm/year, RCP 8.5에서 3.22mm/year, 실제증발산은 RCP 4.5에서 1.09mm/year, RCP 8.5에서 1.78mm/year의 증가율을 보였다. 실제증발산을 입력자료로 활용할 수 있도록 IHACRES모델의 CMD(Catchment Moisture Deficit) 비선형 모듈의 매개변수를 변이하여 유효강우량 산정 과정을 개선하였다. 기준기간에서 관측유량자료와 IHACRES의 시뮬레이션을 통해 산정된 유량자료의 R-squared는 0.65이다. 기준기간에서의 매개변수를 고정하여 미래기간의 유량을 산정하고 유황분석을 통해 갈수량 전망하였다. 유량은 RCP 4.5에서 4.41MCM/year, RCP 8.5에서 9.66MCM/year의 증가율을 보였다. 갈수량은 RCP 4.5에서 0.30MCM/year, RCP 8.5에서 -0.47MCM/year의 증감율을 보였다. 연간 강수량 대비 실제증발산의 비율의 추세분석 결과, RCP 4.5에서는 홍수기에는 0.014%/year, 비홍수기에는 0.027%/year의 증가율을 보이며 거의 변화가 없는 추세를 확인할 수 있었다. RCP 8.5의 홍수기에는 -0.042%/year, 비홍수기에서는 0.167%/year의 증감율을 보이며 홍수기에는 실제증발산에 비해 강수량의 증가가 확연히 보였으며 비홍수기에는 강수량에 비해 실제증발산의 증가가 뚜렷이 확인되었다. RCP 8.5에서 비홍수기의 강수량 대비 실제증발산의 증가가 갈수량의 감소로 반영된 것을 확인할 수 있었다. 미래기간의 RCP 4.5/8.5에서 실제증발산의 증가로 인하여 강수량이 증가함에 따라 유입량이 증가함에도 불구하고 갈수량의 증가로 이어지지 않았다. 미래 갈수량의 감소는 하천의 건전성과 이수안전도의 위협이 될 수 있다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.2
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• pp.130-136
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• 2008

Purpose: Lamivudine is known to be effective for the treatment of chronic hepatitis B in adults. However, data on lamivudine therapy in pediatrics is limited. The aim of this study was to evaluate the efficacy and durability of lamivudine therapy for chronic hepatitis B in Korean children. Methods: A total of 44 children (27 males and 17 females, ages 6 months to 14.8 years, mean age 6.7 years) with chronic hepatitis B who received lamivudine (3 mg/kg/day, max 100 mg) for at least 12 months were enrolled. We evaluated the serum AST, ALT and serological HBV markers (HBsAg and anti-HBs, HBeAg and anti HBe, and HBV DNA) periodically. Predictive three year cumulative seroconversion rates were obtained using the Kaplan-Meier method. Results: Twenty one (48%) of 44 children achieved seroconversion of HBeAg by three years, while 23 (42%) children did not. HBV DNA was cleared in 34 (77%) children and the serum ALT levels were normalized in 41 children (93%). The three year cumulative seroconversion rates were 60% for HBeAg, and the clearance rates were 76% for HBV DNA. Eighteen children who discontinued lamivudine after HBeAg seroconversion maintained the therapeutic response for three years (treatment duration 13~58 months mean 24 months). Viral breakthrough developed in 12 children (27%) during the therapy and the YMDD mutation was documented in 11 children (25%). The mean duration for the development of a mutation was 22.7 months. Loss of HBsAg occurred in 6 children (14%). The pretreatment ALT levels were higher in responders; however, the differences were not statistically significant (p>0.05). Conclusion: The results of this study showed that lamivudine treatment had a favorable effect and durable therapeutic response in children with chronic hepatitis B. Long term follow-up and alternative therapy are warranted for those patients who do not respond to this treatment.

• The Korean Journal of Nuclear Medicine
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• v.35 no.3
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• pp.131-141
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• 2001

Purpose: We evaluated the sensitivity of the F-18 FDG PET by visual assessment and statistical parametric mapping (SPM) analysis for the localization of the epileptogenic zones in frontal lobe epilepsy. Materials and Methods: Twenty-four patients with frontal lobe epilepsy were examined. All patients exhibited improvements after surgical resection (Engel class I or II). Upon pathological examination, 18 patients revealed cortical dysplasia, 4 patients revealed tumor, and 2 patients revealed cortical scar. The hypometabolic lesions were found in F-18 FDG PET by visual assessment and SPM analysis. On SPM analysis, cutoff threshold was changed. Results: MRI showed structural lesions in 12 patients and normal results in the remaining 12. F-18 FDG PET correctly localized epileptogenic zones in 13 patients (54%) by visual assessment. Sensitivity of F-18 FDG PET in MR-negative patients (50%) was similar to that in MR-positive patients (67%). On SPM analysis, sensitivity decreased according to the decrease of p value. Using uncorrected p value of 0.05 as threshold, sensitivity of SPM analysis was 53%, which was not statistically different from that of visual assessment. Conclusion: F-18 FDG PET was sensitive in finding epileptogenic zones by revealing hypometabolic areas even in MR-negative patients with frontal lobe epilepsy as well as in MR-positive patients. SPM analysis showed comparable sensitivity to visual assessment and could be used as an aid in the diagnosis of epileptogenic zones in frontal lobe epilepsy.

• Korean Journal of Remote Sensing
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• v.39 no.5_1
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• pp.715-727
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• 2023

To provide detailed and appropriate meteorological information in mountainous areas, the Korea Forest Service has established an Automatic Mountain Meteorology Observation Station (AMOS) network in major mountainous regions since 2012, and 464 stations are currently operated. In this study, we proposed an optimal kriging technique with lapse rate correction to produce gridded temperature data suitable for Korean forests using AMOS point observations. First, the outliers of the AMOS temperature data were removed through statistical processing. Then, an optimized theoretical variogram, which best approximates the empirical variogram, was derived to perform the optimal kriging with lapse rate correction. A 500-meter resolution Kriging map for temperature was created to reflect the elevation variations in Korean mountainous terrain. A blind evaluation of the method using a spatially unbiased validation sample showed a correlation coefficient of 0.899 to 0.953 and an error of 0.933 to 1.230℃, indicating a slight accuracy improvement compared to regular kriging without lapse rate correction. However, the critical advantage of the proposed method is that it can appropriately represent the complex terrain of Korean forests, such as local variations in mountainous areas and coastal forests in Gangwon province and topographical differences in Jirisan and Naejangsan and their surrounding forests.