• Development and Reproduction
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• v.12 no.2
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• pp.117-124
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• 2008

The efficient strategies to cope with unpredictable and/or harmful environmental changes have been developed by every organism in order to ensure its survival and continuity of it's own species. As a results, all living things on earth maintain dynamically internal stability via a process termed 'homeostasis' among physiological parameters despite of external environment changes. Stress is an emotional and physical response to threat homeostasis. Stress may have not only transient but rather permanent effect on the organism; recent evidence clearly show that prenatal stress could organize or imprint permanently physiological systems without any change in genetic codes, a process known as 'epigenetic programming'. In this review, a series of reproduction-associated events occurred in prenatally stressed male rats such as alteration in the structure of sexually dimorphic brain regions, modification of neurotransmitter metabolism, changes in reproductive endocrine status, and finally, disorders of sexual behavior will be introduced. The fetal brain is highly sensitive to prenatal programming and glucocorticoids in particular have powerful brain-programming properties. The chronic hyperactivation of fetal brain by maternal stress-induced glucocorticoid input will provide new program via increasing the neuroplasticities. This 'increased neuroplasticities' will be the basis for the 'increased phenotypic plasticities' rendering the organism's better adaptation to environmental challenges. In conclusion, organism who experienced 'harsh' environment in his fetal life seems to give up a certain portion of reproductive competence to make good chance of survival in his future life by epigenetic (re)programming.

• The Journal of the Korea Contents Association
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• v.14 no.6
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• pp.162-173
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• 2014

Among OECD countries, Korea is the only country which has continuously recorded total birthrate below 1.3 person for over 10 years. Since 2006, the Korean government has promoted the population policy in full scale. But, the fertility rate which became low has not shown any sign to go up again. Thus, Korea can be understood as having fallen into 'low fertility trap'. Such a low fertility can cause serious problems such as weakening of national competitive power and even survival of the country. In Korea, due to studies and finding jobs among young women, their childbirths are kept being postponed. In some cases, poor working conditions where women work can cause physical conditions not appropriate for pregnancy. Thus, it is very important to let childbearing women, pregnant women take care of their health. Accordingly, conscious of this low fertility era, this study examined major international organizations and countries' health promoting strategies-with focus on motherhood and suggested some methods to effectively improve health for motherhood.

• Clinical and Experimental Pediatrics
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• v.49 no.9
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• pp.966-971
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• 2006

Purpose : 'Programming' describes the process that stimulus at a critical period of development has lifelong effects. The fact that low birth weight links to the risk of elevated blood pressures in adult life is well known. This study aims to examine whether this link is evident in the newborn by investigating the relationship of the intrauterine growth indices and neonatal blood pressure(BP). Methods : We studied 127 neonates who were born at Ewha Womans' Hospital and their mothers enrolled our cohort study during pregnancy. Data on the mothers and details of the birth records were tracked and collected from medical charts. Neonatal BP was measured within 24 hours after birth. Results : Neonatal SBP was positively correlated to intrauterine growth indices; birth weight(BW)(r=0.4), head circumference(HC)(r=0.4), and birth height(r=0.3). However, an inverse relationship existed, between HC/BW ratio and neonatal SBP(r=-0.4). After adjusting for the baby's sex, maternal BP, and gestational age, neonatal SBP still associated with intrauterine growth indices. SBP was 7 mmHg higher in the highest BW group(${\geq}90percentiles$) compared to the lowest group(<10 percentiles). On the other hand, SBP was 17 mmHg lower in the highest HC/BW group(${\geq}90percentiles$) compared in the lowest group(<10 percentiles). Conclusion : This study could not find the evidence that intrauterine growth retardation affect on elevated neonatal BP. It suggests that the initiating events of BP programming may occur during postnatal growth period. To identify the critical starting period that intrauterine growth retardation leads to elevated BP, a study tracking BP changes from birth to childhood is required.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.6
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• pp.1218-1227
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• 2004

Multi-domain engineering systems include electrical, mechanical, hydraulic, pneumatic, and thermal components, making it difficult to design a system because of their complexity and inter domain nature. In order to obtain an optimal design, a unified design approach for each domain and an automated search method are required. This paper suggests a method for automatically synthesizing designs for multi-domain systems using the combination of bond graph that is domain independent and genetic programming that is well recognized as a powerful tool for open-ended search. To investigate the effect of proposed approach, an eigenvalue design problem is tested for some sample target sets of eigenvalues with different embryos.