• Journal of Life Science
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• v.30 no.10
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• pp.835-843
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• 2020

Obesity, the world's leading metabolic disease, is a serious health problem in both industrialized and developing countries. Natural substances are of great interest in preventative medicine, especially in the field of metabolic syndromes-from insulin resistance to obesity and diabetes. In the present study, we investigated the effect of A. pullulans SM-2001 Extract (Polycan^®) on the adipocyte differentiation of 3T3-L1 preadipocytes and the anti-obesity effect of 3T3-L1 adipocytes. Although β-glucan has been found to have health benefits in the regulation of the immune system and blood cholesterol levels, its role in obesity has not been fully investigated. Polycan^® suppressed lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity without affecting cell viability in 3T3-L1 preadipocytes and adipocytes. Polycan^® also inhibited cellular lipid accumulation through down-regulation of transcription factors, such as PPARγ and C/EBPα, and induced dose-dependent phosphorylation of AMP-activated protein kinase (AMPK)-a cellular energy sensor-while the total AMPK protein content remained unchanged. Taken together, this shows that the activation of AMPK by Polycan^® in adipocytes plays a critical role in Polycan^®-induced inhibition of adipocyte differentiation. Our results show that Polycan^® has an anti-obesity action in vitro, suggesting a potential novel preventative agent for obesity and other metabolic diseases.

• Magazine of korean Tunnelling and Underground Space Association
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• v.20 no.3
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• pp.27-32
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• 2018

• The Bulletin of The Korean Astronomical Society
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• v.33 no.1
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• pp.52.2-52.2
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• 2008

• The Bulletin of The Korean Astronomical Society
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• v.33 no.1
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• pp.53.1-53.1
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• 2008

• Proceedings of the KSME Conference
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• 2005.11a
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• pp.36.1-36.1
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• 2005

• 건강소식
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• v.28 no.1 s.302
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• pp.44-45
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• 2004

드넓은 유라시아대륙을 민족도 종교도 국경도 없는 "하나의 세계"를 꿈꿨던 위대한 정복자. 미국의 유력 일간지 "워싱턴포스트" 등은 '지난 1천년의 인류사에서 가장 중요한 인물'로 칭기즈칸을 선정하였다. 이는 중국은 물론 중앙아시아와 동유럽에 이르는 인류 최대의 대제국을 건설했던 그의 업적에 역사적 의의를 둔 것이다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2009.06a
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• pp.339-340
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• 2009

• Digital Contents
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• no.11 s.126
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• pp.134-138
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• 2003

어스 앤 비욘드는 광활한 우주를 한 척의 우주선으로 날아다니는 게임으로, 웨스트우드(Westwood)사에서 만든 우주를 배경으로 하는 SF MMORPG이다. 어스 앤 비욘드에서 플레이어는 목성, 토성 등 아름다운 행성들과 인공위성들 사이를 여행하며, 때로는 화물칸에 물건을 가득 싣고 무역을 하기도 하고, 때로는 우주해적과 외계 생명체를 빔과 미사일로 공격하며 신나는 우주 전투도 즐길 수 있다.

• The Bulletin of The Korean Astronomical Society
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• v.33 no.2
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• pp.41.2-41.2
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• 2008

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.40 no.6
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• pp.76-86
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• 2003

We define a string stability heuristically and divide the board into group territory in computer Go. Elements of string stability are eye(E), eye-like(EL), special-eye(SE), extension-point(EX), liberty(L) and connection-point(CP). A string stability have 5 levels that are complete alive, alive, unsettled, danger and killed level. A group is made strings and link-points and have the territory. Territory division of a group is acquired by strings stability and link-points which are marym-mo, hankan, nalil-ja, and twokan between string and string. We compare our method with the result of evaluation of professional player. As a result, the mean error is 8.7.