• Journal of The Korean Society of Inherited Metabolic disease
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• v.24 no.1
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• pp.1-9
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• 2024

Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episode (MELAS) is a rare maternally inherited disorder primarily caused by mutations in mitochondrial DNA, notably the m.3243A>G mutation in the MT-TL1 gene. This mutation impairs mitochondrial function crucial for cellular energy production, particularly in high-energy-demanding organs such as the brain and muscles. MELAS manifests as recurrent stroke-like episodes, seizures, diabetes mellitus, cardiomyopathy, and other multisystemic symptoms that are often present in childhood. The diagnosis combines genetic testing, clinical evaluation, and neuroimaging, with elevated lactate levels and characteristic magnetic resonance imaging (MRI) findings as key indicators. Treatment focuses on symptomatic management and enhancement of mitochondrial function through L-arginine, coenzyme Q10, high-dose vitamins, and taurine supplementation. Studies have identified additional genetic variants linked to MELAS, including mutations in POLG and other mitochondrial genes, further complicating the genetic landscape. Emerging therapies, particularly gene therapy and mitochondria-targeting drugs, offer promising avenues for addressing the underlying genetic defects and improving mitochondrial functioning. Furthermore, ongoing studies continue to enhance our understanding and management of MELAS, with the aim of reducing its burden and improving patient outcomes and quality of life. This review summarizes the current knowledge on the genetics, clinical features, diagnosis, and treatment of MELAS, highlighting the latest advancements and future directions for therapeutic interventions.

• Korean Journal of School Psychology
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• v.18 no.3
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• pp.351-370
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• 2021

This study investigated the effect of parental psychological control on relational aggression among middle school students, the mediating effects of rejection sensitivity and friendship jealousy, and whether there were differences in these variables by the demographic characteristics of gender and family form. Data of 554 middle school students living in Daegu and Gyeongsangbuk-do were used for the final analysis. There were two major results. The first major result was what rejection sensitivity and friendship jealousy sequentially mediated the relationship between parental psychological control and relational aggression. The second major result was gender differences which was shown by a multi-group analysis to examine in the path from parental psychological control to rejection sensitivity, the path from parental psychological control to relational aggression, and the path from friendship jealousy to relational aggression. This study was meaningful in that it expanded the understanding of relational aggression and identified directions for therapeutic interventions.

• The Journal of the Korea Contents Association
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• v.15 no.2
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• pp.281-291
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• 2015

This study investigated the relationships between factors of aggression and satisfaction with life and the differences of irrational belief, primary secondary anger thought, and satisfaction with life among four groups classified based on the levels of hostility and verbal aggression. 268 middle school boys in Chungnam areas served as subjects. The results showed that hostility showed the most negative correlation with satisfaction with life. Stepwise regression analyses showed that hostility negatively predicted satisfaction with life, whereas verbal aggression positively predicted satisfaction with life. Factors of irrational belief, primary/secondary anger thought were negatively correlated with satisfaction with life. Analyses of variances revealed that covert hostility group showed higher scores on self-depreciation, disregard and disappointment in intimate relationship situation, hopelessness, whereas overt hostility group showed higher scores on derogation of others/revenge. In addition, covert hostility group showed lower scores on satisfaction with life than other groups. Finally, limitations of this study and suggestions for future study were discussed.

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.248-261
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• 2021

The purpose of this study is to verify the mediating effect of rejection sensitivity and relationship addiction in the relationship between abandonment anxiety and psychological dating violence. For this purpose, data of 400 adult were collected and analyzed, and the structural equations were used to verify them. The measurement tools were the Abandonment Anxiety Scale, the Rejection Sensitivity Questionnaire Scale, Relationship Addiction Questionnaire-30 and Psychological Dating Violence Scale, which were the Revised Conflict Tactics Scales-2 and Appraisal of Partner Control Scale. The results of the study are as follows: First, there was a significant corelation among abandonment anxiety, rejection sensitivity, relationship addiction, and psychological dating violence. Second, there was no direct effect on the relationship between abandonment anxiety and psychological dating violence, but it had an effect on psychological dating violence by double mediating rejection sensitivity and relationship addiction. Based on these results, we confirmed the psychological path that abandonment anxiety affects psychological dating violence, and discussed the need for therapeutic intervention and educational approach in negative interpersonal patterns that are not visible.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.199-208
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• 2016

This study examined the trends and practices of disaster welfare in Japan, particularly with the point of view of the community response. This study summarized the experiences and implications of Japan's disaster welfare. First, it is necessary to establish a foundation and linkage of support networks. In case of a disaster, the linkages among administrations, social work institutions, and community residents are required to understand the accurate situation and needs, and to develop resources. In particular, the constitution of DWAT was submitted for initial intervention. Second, the establishment of a manpower dispatching system is needed for emergency situations. In addition, the methods to cover the entire areas by system are needed. Third, the intervention of psychological treatment was shown have a low agreement rate among specialists. Fourth, it is necessary to have guidelines so that privacy protection is compatible with disaster support in a disaster welfare practice process.

• Journal of the Korea Computer Industry Society
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• v.7 no.4
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• pp.437-446
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• 2006

Mobilecomputer offers more fundamental role than role assistance enemy of modern technology equipment and new Information <중략> These main weakness puts in structural relation between elements that compose system. Therefore, dynamics research that time urea of systematic adjustment has selected method code Tuesday nerve dynamics enemy who groping of approach that become analysis point is proper and do with recycling bioelectricity signal. Nature model of do living body signal digital analysis chapter as research result could be developed and scientific foundation groping could apply HSS (Hardware-software system) by rehalibitation purpose. Special quality that is done radish form Tuesday of bioelectricity signal formation furthermore studied, and by the result, fundamental process of bodysignal in do structure circuit form of analog - digital water supply height modelling do can.

• Journal of Convergence for Information Technology
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• v.11 no.12
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• pp.201-210
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• 2021

The purpose of this study was to verify the moderating effects of psychological flexibility on the relationship between perceived stress and depression in university administration staff. A total of 186 participants completed the questionnaire. This data was analyzed using the SPSS program. The results of the analysis showed that perceived stress, positive perception and psychological flexibility had significant effects on depression, but negative perception didn't have significant effect on depression. The results verified the moderating effects of psychological flexibility on the relationship between perceived stress and depression. We discussed that the stress of university administration staff was more closely related to positive perception such as a decrease in positive functioning than negative perception such as loss of control. We also discussed that psychological flexibility can reduce the effect of stress on depression and prevent it. We suggested acceptance commitment therapy to improve psychological flexibility as an intervention method for stress and depression issues in university administration staff.

• Korean Journal of Psychosomatic Medicine
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• v.25 no.1
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• pp.46-55
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• 2017

Objectives : Outpatient treatment orders refer to a mandatory social program in which mentally ill persons are ordered by the court to participate in specified outpatient treatment programs. This study aimed to investigate the factors that affect outpatient treatment orders and adherence to outpatient treatment in mental health patients. Methods : A survey on outpatient treatment orders and adherence to outpatient treatment was conducted on 60 psychiatrists between October and November 2016. The questionnaire items were drafted based on a literature review, and they were then evaluated by 3 psychiatrists and 1 law school professor before being finalized. Answers from the respondents were analyzed using descriptive statistics, and the median, maximum, and minimum values of the effectiveness scores of outpatient treatment orders were calculated. Results : Among the 60 psychiatrists, 45(75.0%) were aware of outpatient treatment orders; however, only 2 out of the 45(4.0%) had actually used the program in the last 12 months. The subjective effectiveness was very low, with only 40 points out of 100. Furthermore, of the readmitted patients, 37.7% had received continued outpatient treatment, whereas 53.1% chose to quit the outpatient treatment programs, meaning that the number of dropouts was higher. Among the discharged patients, approximately two-thirds were receiving continued treatment. With regard to follow-up for dropouts, majority of the responses were either "Not taking any action"(n=27) or "Not following up"(n=15). Only two respondents answered "Contact the community mental health promotion center," meaning that this response was very rare. Meanwhile, when asked about efficient measures to be implemented for dropouts, a vast majority of the respondents(n=30) selected the answer "Work with the community mental health promotion center." Conclusions : The outpatient treatment orders currently being administered were found to be ineffective, and the associated adherence to outpatient treatment was also found to be extremely poor. Hence, the effectiveness of the therapeutic interventions could benefit from institutional as well as administrative improvements. Community mental health promotion centers are expected to have an important role in the future.

• The KIPS Transactions:PartC
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• v.10C no.5
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• pp.625-634
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• 2003

More than a decade after its initial proposal, deployment of IP Multicast has been limited due to the problem of traffic control in multicast routing, multicast address allocation in global internet, reliable multicast transport techniques etc. Lately, according to increase of multicast application service such as internet broadcast, real time security information service etc., overlay multicast is developed as a new internet multicast technology. In this paper, we describe an overlay multicast protocol and propose fast join mechanism that considers switching of the tree. To find a potential parent, an existing search algorithm descends the tree from the root by one level at a time, and it causes long joining latency. Also, it is try to select the nearest node as a potential parent. However, it can't select the nearest node by the degree limit of the node. As a result, the generated tree has low efficiency. To reduce long joining latency and improve the efficiency of the tree, we propose searching two levels of the tree at a time. This method forwards joining request message to own children node. So, at ordinary times, there is no overhead to keep the tree. But the joining request came, the increasing number of searching messages will reduce a long joining latency. Also searching more nodes will be helpful to construct more efficient trees. In order to evaluate the performance of our fast join mechanism, we measure the metrics such as the search latency and the number of searched node and the number of switching by the number of members and degree limit. The simulation results show that the performance of our mechanism is superior to that of the existing mechanism.

• Journal of the korean veterinary medical association
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• v.30 no.10
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• pp.592-615
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• 1994

1. 체세포점수(SCS)는 적절히 사용되었을 때 큰 이익을 가져다 주는 가치있는 조사항목이다. 2. 권장된 유방염 예방관리계획을 잘 적용할 수 있는 대부분의 우군에서는 SCS 목표를 3.0으로 잡는 것이 바람직하다. 3. 체세포점수(SCS)자료는 비유횟수, 착유일수와 신규감염, 만성감염, 중증감염된 그 해의 달 그리고 평균 SCS별로 정돈하면 아주 유용하다. 4. 체세포점수(SCS)양상과 SCS치가 높은 젖소들은 우군의 유방염 문제를 진단하는데 유용하며 목표를 세우고 유방염 예방대책을 수립하는데 도움을 준다. 5. 임상관찰과 치료기록, 원인균 검사성적자료와 연관시킨 SCS 자료는 가장 좋은 유방염 평가기록일 수 있다. 6. 목장에 근무하는 전직원이 유방염에 관한 자료의 이용에 있어 전문적 지식을 갖추고 있으면 초기에 유방염 문제에 개입할 수 있게 되어 비유기중에 항생제에 사용을 줄일 수 있다. 따라서 유질이 향상되고 농가의 수입증대를 도모할 수 있다.